HIV-1 envelope glycoprotein immunogens to induce broadly neutralizing antibodies

Broadly Neutralizing Antibody 8ANC195 Recognizes Closed and Open States of HIV-1 Env

(2015) Louise Scharf et al.   CELL

Rational Design of an Epstein-Barr Virus Vaccine Targeting the Receptor-Binding Site

(2015) Masaru Kanekiyo et al.   CELL

Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice

(2015) Pia Dosenovic et al.   CELL

Manipulating the Selection Forces during Affinity Maturation to Generate Cross-Reactive HIV Antibodies

(2015) Shenshen Wang et al.   CELL

Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection

(2015) Xueling Wu et al.   CELL

The HIV glycan shield as a target for broadly neutralizing antibodies

(2015) Katie J. Doores   FEBS Journal

Identification of Common Features in Prototype Broadly Neutralizing Antibodies to HIV Envelope V2 Apex to Facilitate Vaccine Design

(2015) Raiees Andrabi et al.   IMMUNITY

Immunosilencing a Highly Immunogenic Protein Trimerization Domain

(2015) Kwinten Sliepen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunogenic Display of Purified Chemically Cross-Linked HIV-1 Spikes

(2015) Daniel P. Leaman et al.   JOURNAL OF VIROLOGY

Influences on the Design and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers

(2015) Rajesh P. Ringe et al.   JOURNAL OF VIROLOGY

A Native-Like SOSIP.664 Trimer Based on an HIV-1 Subtype BenvGene

(2015) Pavel Pugach et al.   JOURNAL OF VIROLOGY

Murine Antibody Responses to Cleaved Soluble HIV-1 Envelope Trimers Are Highly Restricted in Specificity

(2015) Joyce K. Hu et al.   JOURNAL OF VIROLOGY

Single-Chain Soluble BG505.SOSIP gp140 Trimers as Structural and Antigenic Mimics of Mature Closed HIV-1 Env

(2015) Ivelin S. Georgiev et al.   JOURNAL OF VIROLOGY

Antibody responses to envelope glycoproteins in HIV-1 infection

(2015) Dennis R Burton et al.   NATURE IMMUNOLOGY

Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection

(2015) Hadi M Yassine et al.   NATURE MEDICINE

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

(2015) Young Do Kwon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens

(2015) Jean-Philippe Julien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity

(2015) Kwinten Sliepen et al.   Retrovirology

A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen

(2015) A. Impagliazzo et al.   SCIENCE

Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen

(2015) J. G. Jardine et al.   SCIENCE

HIV-1 neutralizing antibodies induced by native-like envelope trimers

(2015) R. W. Sanders et al.   SCIENCE

Virological features associated with the development of broadly neutralizing antibodies to HIV-1

(2015) Penny L. Moore et al.   TRENDS IN MICROBIOLOGY

Binding of inferred germline precursors of broadly neutralizing HIV-1 antibodies to native-like envelope trimers

(2015) Kwinten Sliepen et al.   VIROLOGY

Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env

(2015) Miklos Guttman et al.   Nature Communications

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

(2015) Young Do Kwon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Constraints Determine the Glycosylation of HIV-1 Envelope Trimers

(2015) Laura K. Pritchard et al.   Cell Reports

Cleavage-Independent HIV-1 Env Trimers Engineered as Soluble Native Spike Mimetics for Vaccine Design

(2015) Shailendra Kumar Sharma et al.   Cell Reports

Comprehensive Antigenic Map of a Cleaved Soluble HIV-1 Envelope Trimer

(2015) Ronald Derking et al.   PLoS Pathogens

Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site

(2015) Ema T. Crooks et al.   PLoS Pathogens

Well-Ordered Trimeric HIV-1 Subtype B and C Soluble Spike Mimetics Generated by Negative Selection Display Native-like Properties

(2015) Javier Guenaga et al.   PLoS Pathogens

Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy

(2014) Anthony P. West et al.   CELL

Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers

(2014) Claudia Blattner et al.   IMMUNITY

Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques

(2014) Masashi Shingai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Simulation of B Cell Affinity Maturation Explains Enhanced Antibody Cross-Reactivity Induced by the Polyvalent Malaria Vaccine AMA1

(2014) Sidhartha Chaudhury et al.   JOURNAL OF IMMUNOLOGY

Glycosylation and Disulfide Bond Analysis of Transiently and Stably Expressed Clade C HIV-1 gp140 Trimers in 293T Cells Identifies Disulfide Heterogeneity Present in Both Proteins and Differences in O-Linked Glycosylation

(2014) Eden P. Go et al.   JOURNAL OF PROTEOME RESEARCH

Hyperglycosylated Stable Core Immunogens Designed To Present the CD4 Binding Site Are Preferentially Recognized by Broadly Neutralizing Antibodies

(2014) J. Ingale et al.   JOURNAL OF VIROLOGY

Polyreactivity and Autoreactivity among HIV-1 Antibodies

(2014) Mengfei Liu et al.   JOURNAL OF VIROLOGY

Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface

(2014) Jinghe Huang et al.   NATURE

Proof of principle for epitope-focused vaccine design

(2014) Bruno E. Correia et al.   NATURE

A stamp on the envelope

(2014) Rogier W. Sanders et al.   NATURE

Structure and immune recognition of trimeric pre-fusion HIV-1 Env

(2014) Marie Pancera et al.   NATURE

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

(2014) Nicole A. Doria-Rose et al.   NATURE

Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery

(2014) E-Chiang Lee et al.   NATURE BIOTECHNOLOGY

Early development of broadly neutralizing antibodies in HIV-1–infected infants

(2014) Leslie Goo et al.   NATURE MEDICINE

Transplanting Supersites of HIV-1 Vulnerability

(2014) Tongqing Zhou et al.   PLoS One

Antibody persistence and T-cell balance: Two key factors confronting HIV vaccine development

(2014) G. K. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stable, uncleaved HIV-1 envelope glycoprotein gp140 forms a tightly folded trimer with a native-like structure

(2014) James M. Kovacs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign

(2014) K. Tran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex

(2014) Devin Sok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits

(2014) Anila Yasmeen et al.   Retrovirology

Antigen modification regulates competition of broad and narrow neutralizing HIV antibodies

(2014) A. T. McGuire et al.   SCIENCE

Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

(2014) J. B. Munro et al.   SCIENCE

Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor

(2014) A. Pegu et al.   Science Translational Medicine

CD4-Induced Activation in a Soluble HIV-1 Env Trimer

(2014) Miklos Guttman et al.   STRUCTURE

In vivo protection by broadly neutralizing HIV antibodies

(2014) Marit J. van Gils et al.   TRENDS IN MICROBIOLOGY

Eliciting neutralizing antibodies with gp120 outer domain constructs based on M-group consensus sequence

(2014) Yali Qin et al.   VIROLOGY

Multi-parameter exploration of HIV-1 virus-like particles as neutralizing antibody immunogens in guinea pigs, rabbits and macaques

(2014) Tommy Tong et al.   VIROLOGY

Why HIV Virions Have Low Numbers of Envelope Spikes: Implications for Vaccine Development

(2014) John Schiller et al.   PLoS Pathogens

Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection

(2013) Peter Hraber et al.   AIDS

HIV-1 neutralizing antibodies: understanding nature's pathways

(2013) John R. Mascola et al.   IMMUNOLOGICAL REVIEWS

Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies

(2013) Andrew T. McGuire et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of HIV-1 Broad Neutralizing Antibodies in 2F5 Knock-in Mice: Selection against Membrane Proximal External Region-Associated Autoreactivity Limits T-Dependent Responses

(2013) L. Verkoczy et al.   JOURNAL OF IMMUNOLOGY

Independent Expansion of Epitope-Specific Plasma Cell Responses upon HIV-1 Envelope Glycoprotein Immunization

(2013) M. N. E. Forsell et al.   JOURNAL OF IMMUNOLOGY

Immune Tolerance Negatively Regulates B Cells in Knock-In Mice Expressing Broadly Neutralizing HIV Antibody 4E10

(2013) C. Doyle-Cooper et al.   JOURNAL OF IMMUNOLOGY

Structural Characterization of Cleaved, Soluble HIV-1 Envelope Glycoprotein Trimers

(2013) R. Khayat et al.   JOURNAL OF VIROLOGY

Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein

(2013) P. J. Klasse et al.   JOURNAL OF VIROLOGY

Identification of an HIV-1 Clade A Envelope That Exhibits Broad Antigenicity and Neutralization Sensitivity and Elicits Antibodies Targeting Three Distinct Epitopes

(2013) S. Hoffenberg et al.   JOURNAL OF VIROLOGY

Diverse Recombinant HIV-1 Envs Fail To Activate B Cells Expressing the Germline B Cell Receptors of the Broadly Neutralizing Anti-HIV-1 Antibodies PG9 and 447-52D

(2013) A. T. McGuire et al.   JOURNAL OF VIROLOGY

Structural Basis for HIV-1 Neutralization by 2F5-Like Antibodies m66 and m66.6

(2013) G. Ofek et al.   JOURNAL OF VIROLOGY

Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies

(2013) Masaru Kanekiyo et al.   NATURE

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

(2013) Hua-Xin Liao et al.   NATURE

Antibodies expose multiple weaknesses in the glycan shield of HIV

(2013) Max Crispin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Prefusion structure of trimeric HIV-1 envelope glycoprotein determined by cryo-electron microscopy

(2013) Alberto Bartesaghi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16

(2013) Marie Pancera et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120

(2013) Leopold Kong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation

(2013) R. P. Ringe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody

(2013) J. S. McLellan et al.   SCIENCE

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

(2013) J. S. McLellan et al.   SCIENCE

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

(2013) J.-P. Julien et al.   SCIENCE

Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

(2013) D. Lyumkis et al.   SCIENCE

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

(2013) J. Jardine et al.   SCIENCE

Virus-like particle-based human vaccines: quality assessment based on structural and functional properties

(2013) Qinjian Zhao et al.   TRENDS IN BIOTECHNOLOGY

Nanoparticle vaccines

(2013) Liang Zhao et al.   VACCINE

Elicitation of HIV-1-neutralizing antibodies against the CD4-binding site

(2013) Ivelin S. Georgiev et al.   Current Opinion in HIV and AIDS

Recombinant HIV Envelope Proteins Fail to Engage Germline Versions of Anti-CD4bs bNAbs

(2013) Sam Hoot et al.   PLoS Pathogens

A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies

(2013) Rogier W. Sanders et al.   PLoS Pathogens

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA

(2012) Jean-Philippe Julien et al.   IMMUNOLOGICAL REVIEWS

Frequency and genetic characterization of V(DD)J recombinants in the human peripheral blood antibody repertoire

(2012) Bryan S. Briney et al.   IMMUNOLOGY

HIV-1 Virus-Like Particles Bearing Pure Env Trimers Expose Neutralizing Epitopes but Occlude Nonneutralizing Epitopes

(2012) T. Tong et al.   JOURNAL OF VIROLOGY

Outer Domain of HIV-1 gp120: Antigenic Optimization, Structural Malleability, and Crystal Structure with Antibody VRC-PG04

(2012) M. G. Joyce et al.   JOURNAL OF VIROLOGY

B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study

(2012) Barton F Haynes et al.   NATURE BIOTECHNOLOGY

HIV-1 envelope trimer elicits more potent neutralizing antibody responses than monomeric gp120

(2012) James M. Kovacs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction

(2012) J. J. Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broadly neutralizing antibodies against HIV-1: Templates for a vaccine

(2012) Marit J. van Gils et al.   VIROLOGY

Clinical evaluation of a soluble trimeric HIV-1 envelope glycoprotein vaccine

(2011) Rogier W Sanders   Expert Review of Vaccines

A Trimeric, V2-Deleted HIV-1 Envelope Glycoprotein Vaccine Elicits Potent Neutralizing Antibodies but Limited Breadth of Neutralization in Human Volunteers

(2011) Paul Spearman et al.   JOURNAL OF INFECTIOUS DISEASES

Structure-Based Design of a Protein Immunogen that Displays an HIV-1 gp41 Neutralizing Epitope

(2011) Robyn L. Stanfield et al.   JOURNAL OF MOLECULAR BIOLOGY

HIV-1 Envelope Glycoprotein Biosynthesis, Trafficking, and Incorporation

(2011) Mary Ann Checkley et al.   JOURNAL OF MOLECULAR BIOLOGY

Targeting HIV-1 Envelope Glycoprotein Trimers to B Cells by Using APRIL Improves Antibody Responses

(2011) M. Melchers et al.   JOURNAL OF VIROLOGY

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

(2011) Jason S. McLellan et al.   NATURE

Broad neutralization coverage of HIV by multiple highly potent antibodies

(2011) Laura M. Walker et al.   NATURE

The Glycan Shield of HIV Is Predominantly Oligomannose Independently of Production System or Viral Clade

(2011) Camille Bonomelli et al.   PLoS One

Induction of Antibodies in Rhesus Macaques That Recognize a Fusion-Intermediate Conformation of HIV-1 gp41

(2011) S. Moses Dennison et al.   PLoS One

Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures

(2011) A. Harris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold

(2011) M. L. Azoitei et al.   SCIENCE

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

(2011) R. Pejchal et al.   SCIENCE

An engineered mutant of HIV-1 gp120 formulated with adjuvant Quil A promotes elicitation of antibody responses overlapping the CD4-binding site

(2011) Fatima K. Ahmed et al.   VACCINE

Correlates of Protection Induced by Vaccination

(2010) S. A. Plotkin   Clinical and Vaccine Immunology

Mechanisms that determine plasma cell lifespan and the duration of humoral immunity

(2010) Ian J. Amanna et al.   IMMUNOLOGICAL REVIEWS

Design of a Non-glycosylated Outer Domain-derived HIV-1 gp120 Immunogen That Binds to CD4 and Induces Neutralizing Antibodies

(2010) Sanchari Bhattacharyya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross‐Reactive Neutralizing Humoral Immunity Does Not Protect from HIV Type 1 Disease Progression

(2010) Zelda Euler et al.   JOURNAL OF INFECTIOUS DISEASES

Analysis of the Disulfide Bond Arrangement of the HIV-1 Envelope Protein CON-S gp140 ΔCFI Shows Variability in the V1 and V2 Regions

(2010) Eden P. Go et al.   JOURNAL OF PROTEOME RESEARCH

Elicitation of structure-specific antibodies by epitope scaffolds

(2010) G. Ofek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens

(2010) K. J. Doores et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

(2010) X. Wu et al.   SCIENCE

Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope

(2010) Bruno E. Correia et al.   STRUCTURE

An optimally constrained V3 peptide is a better immunogen than its linear homolog or HIV-1 gp120

(2010) Adi Moseri et al.   VIROLOGY

Structure-guided design and immunological characterization of immunogens presenting the HIV-1 gp120 V3 loop on a CTB scaffold

(2010) Maxim Totrov et al.   VIROLOGY

Few and Far Between: How HIV May Be Evading Antibody Avidity

(2010) Joshua S. Klein et al.   PLoS Pathogens

Neutralizing antibodies induced by liposomal HIV-1 glycoprotein 41 peptide simultaneously bind to both the 2F5 or 4E10 epitope and lipid epitopes

(2009) Gary R Matyas et al.   AIDS

Tiered Categorization of a Diverse Panel of HIV-1 Env Pseudoviruses for Assessment of Neutralizing Antibodies

(2009) M. S. Seaman et al.   JOURNAL OF VIROLOGY

Human Immunodeficiency Virus Type 1 Elite Neutralizers: Individuals with Broad and Potent Neutralizing Activity Identified by Using a High-Throughput Neutralization Assay together with an Analytical Selection Algorithm

(2009) M. D. Simek et al.   JOURNAL OF VIROLOGY

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

(2009) Supachai Rerks-Ngarm et al.   NEW ENGLAND JOURNAL OF MEDICINE

Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target

(2009) L. M. Walker et al.   SCIENCE

Role of lipid structure in the humoral immune response in mice to covalent lipid–peptides from the membrane proximal region of HIV-1 gp41

(2009) Douglas S. Watson et al.   VACCINE

Structural and immunogenicity studies of a cleaved, stabilized envelope trimer derived from subtype A HIV-1

(2009) Yun (Kenneth) Kang et al.   VACCINE

Immunogenicity of HIV-1 envelope glycoprotein oligomers

(2009) Mattias NE Forsell et al.   Current Opinion in HIV and AIDS

Structure-Based Stabilization of HIV-1 gp120 Enhances Humoral Immune Responses to the Induced Co-Receptor Binding Site

(2009) Barna Dey et al.   PLoS Pathogens

Molecular architecture of native HIV-1 gp120 trimers

(2008) Jun Liu et al.   NATURE

An oligosaccharide-based HIV-1 2G12 mimotope vaccine induces carbohydrate-specific antibodies that fail to neutralize HIV-1 virions

(2008) J. G. Joyce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA