The HIV glycan shield as a target for broadly neutralizing antibodies

A New Approach to Produce HIV-1 Envelope Trimers

(2015) Wadad AlSalmi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycan Microheterogeneity at the PGT135 Antibody Recognition Site on HIV-1 gp120 Reveals a Molecular Mechanism for Neutralization Resistance

(2015) Laura K. Pritchard et al.   JOURNAL OF VIROLOGY

Cell- and Protein-Directed Glycosylation of Native Cleaved HIV-1 Envelope

(2015) Laura K. Pritchard et al.   JOURNAL OF VIROLOGY

Comparative Analysis of the Glycosylation Profiles of Membrane-Anchored HIV-1 Envelope Glycoprotein Trimers and Soluble gp140

(2015) Eden P. Go et al.   JOURNAL OF VIROLOGY

Antibody responses to envelope glycoproteins in HIV-1 infection

(2015) Dennis R Burton et al.   NATURE IMMUNOLOGY

HIV-1 neutralizing antibodies induced by native-like envelope trimers

(2015) R. W. Sanders et al.   SCIENCE

Insights into the trimeric HIV-1 envelope glycoprotein structure

(2015) Andrew B. Ward et al.   TRENDS IN BIOCHEMICAL SCIENCES

Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies

(2015) Laura K. Pritchard et al.   Nature Communications

Structural Constraints Determine the Glycosylation of HIV-1 Envelope Trimers

(2015) Laura K. Pritchard et al.   Cell Reports

Targeting host-derived glycans on enveloped viruses for antibody-based vaccine design

(2015) Max Crispin et al.   Current Opinion in Virology

Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal Antibodies

(2015) Laura E. McCoy et al.   PLoS Pathogens

Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site

(2015) Ema T. Crooks et al.   PLoS Pathogens

Gp120 on HIV-1 Virions Lacks O-Linked Carbohydrate

(2015) Elizabeth Stansell et al.   PLoS One

Glycoform Analysis of Recombinant and Human Immunodeficiency Virus Envelope Protein gp120 via Higher Energy Collisional Dissociation and Spectral-Aligning Strategy

(2014) Weiming Yang et al.   ANALYTICAL CHEMISTRY

Structural Evolution of Glycan Recognition by a Family of Potent HIV Antibodies

(2014) Fernando Garces et al.   CELL

Broadly Neutralizing HIV Antibodies Define a Glycan-Dependent Epitope on the Prefusion Conformation of gp41 on Cleaved Envelope Trimers

(2014) Emilia Falkowska et al.   IMMUNITY

Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers

(2014) Claudia Blattner et al.   IMMUNITY

Uukuniemi Phlebovirus Assembly and Secretion Leave a Functional Imprint on the Virion Glycome

(2014) M. Crispin et al.   JOURNAL OF VIROLOGY

Two Classes of Broadly Neutralizing Antibodies within a Single Lineage Directed to the High-Mannose Patch of HIV Envelope

(2014) Katie J. Doores et al.   JOURNAL OF VIROLOGY

Structure of 2G12 Fab2 in Complex with Soluble and Fully Glycosylated HIV-1 Env by Negative-Stain Single-Particle Electron Microscopy

(2014) C. D. Murin et al.   JOURNAL OF VIROLOGY

Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface

(2014) Jinghe Huang et al.   NATURE

Structure and immune recognition of trimeric pre-fusion HIV-1 Env

(2014) Marie Pancera et al.   NATURE

Deletion of the Highly Conserved N-Glycan at Asn260 of HIV-1 gp120 Affects Folding and Lysosomal Degradation of gp120, and Results in Loss of Viral Infectivity

(2014) Leen Mathys et al.   PLoS One

Emerging Principles for the Therapeutic Exploitation of Glycosylation

(2014) Martin Dalziel et al.   SCIENCE

Promiscuous Glycan Site Recognition by Antibodies to the High-Mannose Patch of gp120 Broadens Neutralization of HIV

(2014) D. Sok et al.   Science Translational Medicine

Characterization of Host-Cell Line Specific Glycosylation Profiles of Early Transmitted/Founder HIV-1 gp120 Envelope Proteins

(2013) Eden P. Go et al.   JOURNAL OF PROTEOME RESEARCH

Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16

(2013) Marie Pancera et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120

(2013) Leopold Kong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation

(2013) R. P. Ringe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A systematic study of the N-glycosylation sites of HIV-1 envelope protein on infectivity and antibody-mediated neutralization

(2013) Wenbo Wang et al.   Retrovirology

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

(2013) J.-P. Julien et al.   SCIENCE

Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

(2013) D. Lyumkis et al.   SCIENCE

Accelerating Next-Generation Vaccine Development for Global Disease Prevention

(2013) W. C. Koff et al.   SCIENCE

Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans

(2013) Jean-Philippe Julien et al.   PLoS Pathogens

A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies

(2013) Rogier W. Sanders et al.   PLoS Pathogens

PGV04, an HIV-1 gp120 CD4 Binding Site Antibody, Is Broad and Potent in Neutralization but Does Not Induce Conformational Changes Characteristic of CD4

(2012) Emilia Falkowska et al.   JOURNAL OF VIROLOGY

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

(2012) Jinghe Huang et al.   NATURE

Evolution of an HIV glycan–dependent broadly neutralizing antibody epitope through immune escape

(2012) Penny L Moore et al.   NATURE MEDICINE

Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo

(2012) B. Moldt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies

(2012) H. Mouquet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Highly Conserved Glycan at Asparagine 260 of HIV-1 gp120 Is Indispensable for Viral Entry

(2011) Katrien O. François et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors

(2011) M. Bonsignori et al.   JOURNAL OF VIROLOGY

Characterization of Glycosylation Profiles of HIV-1 Transmitted/Founder Envelopes by Mass Spectrometry

(2011) E. P. Go et al.   JOURNAL OF VIROLOGY

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

(2011) Jason S. McLellan et al.   NATURE

Broad neutralization coverage of HIV by multiple highly potent antibodies

(2011) Laura M. Walker et al.   NATURE

The Glycan Shield of HIV Is Predominantly Oligomannose Independently of Production System or Viral Clade

(2011) Camille Bonomelli et al.   PLoS One

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

(2011) R. Pejchal et al.   SCIENCE

Antibody 2G12 Recognizes Di-Mannose Equivalently in Domain- and Nondomain-Exchanged Forms but Only Binds the HIV-1 Glycan Shield if Domain Exchanged

(2010) Katie J. Doores et al.   JOURNAL OF VIROLOGY

Characterization of the Envelope Glycoproteins Associated with Infectious Hepatitis C Virus

(2010) G. Vieyres et al.   JOURNAL OF VIROLOGY

Variable Loop Glycan Dependency of the Broad and Potent HIV-1-Neutralizing Antibodies PG9 and PG16

(2010) Katie J. Doores et al.   JOURNAL OF VIROLOGY

Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens

(2010) K. J. Doores et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

(2010) X. Wu et al.   SCIENCE

Tiered Categorization of a Diverse Panel of HIV-1 Env Pseudoviruses for Assessment of Neutralizing Antibodies

(2009) M. S. Seaman et al.   JOURNAL OF VIROLOGY

Unusual Molecular Architecture of the Machupo Virus Attachment Glycoprotein

(2009) T. A. Bowden et al.   JOURNAL OF VIROLOGY

Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target

(2009) L. M. Walker et al.   SCIENCE

Broadly Neutralizing Human Anti-HIV Antibody 2G12 Is Effective in Protection against Mucosal SHIV Challenge Even at Low Serum Neutralizing Titers

(2009) Ann J. Hessell et al.   PLoS Pathogens

Glycosylation Site-Specific Analysis of HIV Envelope Proteins (JR-FL and CON-S) Reveals Major Differences in Glycosylation Site Occupancy, Glycoform Profiles, and Antigenic Epitopesʼ Accessibility

(2008) Eden P. Go et al.   JOURNAL OF PROTEOME RESEARCH

Crystal Structure and Carbohydrate Analysis of Nipah Virus Attachment Glycoprotein: a Template for Antiviral and Vaccine Design

(2008) T. A. Bowden et al.   JOURNAL OF VIROLOGY