Antibody persistence and T-cell balance: Two key factors confronting HIV vaccine development

Induction of Gag-Specific CD4 T Cell Responses during Acute HIV Infection Is Associated with Improved Viral Control

(2014) M. Schieffer et al.   JOURNAL OF VIROLOGY

Increased Mucosal CD4+ T Cell Activation in Rhesus Macaques following Vaccination with an Adenoviral Vector

(2014) I. Bukh et al.   JOURNAL OF VIROLOGY

Recombinant adenovirus type 5 HIV gag/pol/nef vaccine in South Africa: unblinded, long-term follow-up of the phase 2b HVTN 503/Phambili study

(2014) Glenda E Gray et al.   LANCET INFECTIOUS DISEASES

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

(2014) Nicole A. Doria-Rose et al.   NATURE

Clonal selection in the germinal centre by regulated proliferation and hypermutation

(2014) Alexander D. Gitlin et al.   NATURE

Preventing and Controlling Influenza with Available Interventions

(2014) Timothy M. Uyeki   NEW ENGLAND JOURNAL OF MEDICINE

DNA and Protein Co-Immunization Improves the Magnitude and Longevity of Humoral Immune Responses in Macaques

(2014) Rashmi Jalah et al.   PLoS One

Vaccine-Induced IgG Antibodies to V1V2 Regions of Multiple HIV-1 Subtypes Correlate with Decreased Risk of HIV-1 Infection

(2014) Susan Zolla-Pazner et al.   PLoS One

Immune Activation with HIV Vaccines

(2014) A. S. Fauci et al.   SCIENCE

Model based estimates of long-term persistence of inactivated hepatitis A vaccine-induced antibodies in adults

(2014) Niel Hens et al.   VACCINE

Target Cell Availability, Rather than Breast Milk Factors, Dictates Mother-to-Infant Transmission of SIV in Sooty Mangabeys and Rhesus Macaques

(2014) Ann Chahroudi et al.   PLoS Pathogens

Comparing influenza vaccine efficacy against mismatched and matched strains: a systematic review and meta-analysis

(2013) Andrea C Tricco et al.   BMC Medicine

Transcription factor interplay in T helper cell differentiation

(2013) C. M. Evans et al.   Briefings in Functional Genomics

Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

(2013) Florian Klein et al.   CELL

Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses

(2013) Michela Locci et al.   IMMUNITY

Sensitivity Analysis of Per-Protocol Time-to-Event Treatment Efficacy in Randomized Clinical Trials

(2013) Peter B. Gilbert et al.   JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION

Infectious Virion Capture by HIV-1 gp120-Specific IgG from RV144 Vaccinees

(2013) P. Liu et al.   JOURNAL OF VIROLOGY

Simian Immunodeficiency Virus Infects Follicular Helper CD4 T Cells in Lymphoid Tissues during Pathogenic Infection of Pigtail Macaques

(2013) Y. Xu et al.   JOURNAL OF VIROLOGY

Immune clearance of highly pathogenic SIV infection

(2013) Scott G. Hansen et al.   NATURE

Efficacy Trial of a DNA/rAd5 HIV-1 Preventive Vaccine

(2013) Scott M. Hammer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Analysis of V2 Antibody Responses Induced in Vaccinees in the ALVAC/AIDSVAX HIV-1 Vaccine Efficacy Trial

(2013) Susan Zolla-Pazner et al.   PLoS One

Plasma IgG to Linear Epitopes in the V2 and V3 Regions of HIV-1 gp120 Correlate with a Reduced Risk of Infection in the RV144 Vaccine Efficacy Trial

(2013) Raphael Gottardo et al.   PLoS One

Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG

(2013) G. D. Tomaras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accelerating Next-Generation Vaccine Development for Global Disease Prevention

(2013) W. C. Koff et al.   SCIENCE

T follicular helper cell diversity and plasticity

(2013) Jennifer L. Cannons et al.   TRENDS IN IMMUNOLOGY

New directions for HIV vaccine development from animal models

(2013) Michael B. McChesney et al.   Current Opinion in HIV and AIDS

Lessons in Nonhuman Primate Models for AIDS Vaccine Research: From Minefields to Milestones

(2013) J. D. Lifson et al.   Cold Spring Harbor Perspectives in Medicine

Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections

(2012) J. M. Brenchley et al.   BLOOD

Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production

(2012) Matthieu Perreau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Thai Phase III Trial (RV144) Vaccine Regimen Induces T Cell Responses That Preferentially Target Epitopes within the V2 Region of HIV-1 Envelope

(2012) M. S. de Souza et al.   JOURNAL OF IMMUNOLOGY

Extended Follow-up Confirms Early Vaccine-Enhanced Risk of HIV Acquisition and Demonstrates Waning Effect Over Time Among Participants in a Randomized Trial of Recombinant Adenovirus HIV Vaccine (Step Study)

(2012) A. Duerr et al.   JOURNAL OF INFECTIOUS DISEASES

Immunization of Macaques With Soluble HIV Type 1 and Influenza Virus Envelope Glycoproteins Results in a Similarly Rapid Contraction of Peripheral B-Cell Responses After Boosting

(2012) Christopher Sundling, Paola Martinez, Martina Soldemo, Mats Spångberg, Karin Lövgren Bengtsson, Linda Stertman, Mattias N. E. Forsell et al.   JOURNAL OF INFECTIOUS DISEASES

Risk of Immunodeficiency Virus Infection May Increase with Vaccine-Induced Immune Response

(2012) M. Tenbusch et al.   JOURNAL OF VIROLOGY

Antibodies with High Avidity to the gp120 Envelope Protein in Protection from Simian Immunodeficiency Virus SIVmac251Acquisition in an Immunization Regimen That Mimics the RV-144 Thai Trial

(2012) Poonam Pegu et al.   JOURNAL OF VIROLOGY

Risk behaviour and time as covariates for efficacy of the HIV vaccine regimen ALVAC-HIV (vCP1521) and AIDSVAX B/E: a post-hoc analysis of the Thai phase 3 efficacy trial RV 144

(2012) Merlin L Robb et al.   LANCET INFECTIOUS DISEASES

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

(2012) Julie A. Mattison et al.   NATURE

Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial

(2012) Barton F. Haynes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Merck Ad5/HIV induces broad innate immune activation that predicts CD8+ T-cell responses but is attenuated by preexisting Ad5 immunity

(2012) D. E. Zak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Living on Three Time Scales: The Dynamics of Plasma Cell and Antibody Populations Illustrated for Hepatitis A Virus

(2012) Mathieu Andraud et al.   PLoS Computational Biology

How Can HIV-Type-1-Env Immunogenicity Be Improved to Facilitate Antibody-Based Vaccine Development?

(2011) Per Johan Klasse et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

The Use of Nonhuman Primate Models of HIV Infection for the Evaluation of Antiviral Strategies

(2011) Koen K.A. Van Rompay   AIDS RESEARCH AND HUMAN RETROVIRUSES

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

The Th17 Pathway and Inflammatory Diseases of the Intestines, Lungs, and Skin

(2011) Casey T. Weaver et al.   Annual Review of Pathology-Mechanisms of Disease

HIV controllers: A multifactorial phenotype of spontaneous viral suppression

(2011) Jacques Thèze et al.   CLINICAL IMMUNOLOGY

Functional and Epigenetic Studies Reveal Multistep Differentiation and Plasticity of In Vitro-Generated and In Vivo-Derived Follicular T Helper Cells

(2011) Kristina T. Lu et al.   IMMUNITY

Low-Dose Penile SIVmac251 Exposure of Rhesus Macaques Infected with Adenovirus Type 5 (Ad5) and Then Immunized with a Replication-Defective Ad5-Based SIV gag/pol/nef Vaccine Recapitulates the Results of the Phase IIb Step Trial of a Similar HIV-1 Vaccine

(2011) H. Qureshi et al.   JOURNAL OF VIROLOGY

HIV-Specific CD4 T Cell Responses to Different Viral Proteins Have Discordant Associations with Viral Load and Clinical Outcome

(2011) S. Ranasinghe et al.   JOURNAL OF VIROLOGY

Safety and efficacy of the HVTN 503/Phambili Study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomised, placebo-controlled test-of-concept phase 2b study

(2011) Glenda E Gray et al.   LANCET INFECTIOUS DISEASES

HIV-1 Vaccines and Adaptive Trial Designs

(2011) L. Corey et al.   Science Translational Medicine

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Mechanisms that determine plasma cell lifespan and the duration of humoral immunity

(2010) Ian J. Amanna et al.   IMMUNOLOGICAL REVIEWS

Mucosal Trafficking of Vector-Specific CD4+ T Lymphocytes following Vaccination of Rhesus Monkeys with Adenovirus Serotype 5

(2010) K. Masek-Hammerman et al.   JOURNAL OF VIROLOGY

Antibody-Mediated Protection against Mucosal Simian-Human Immunodeficiency Virus Challenge of Macaques Immunized with Alphavirus Replicon Particles and Boosted with Trimeric Envelope Glycoprotein in MF59 Adjuvant

(2010) S. W. Barnett et al.   JOURNAL OF VIROLOGY

Role of nonhuman primates in the evaluation of candidate AIDS vaccines: an industry perspective

(2010) Silvija I Staprans et al.   Current Opinion in HIV and AIDS

Use of Nonhuman Primate Models to Develop Mucosal AIDS Vaccines

(2010) Meritxell Genescà et al.   Current HIV/AIDS Reports

Protection of macaques against vaginal SHIV challenge by systemic or mucosal and systemic vaccinations with HIV-envelope

(2009) Susan W Barnett et al.   AIDS

The thymus-independent immunity conferred by a pneumococcal polysaccharide is mediated by long-lived plasma cells

(2009) M. Taillardet et al.   BLOOD

Long-term persistence of anti-HPV-16 and -18 antibodies induced by vaccination with the AS04-adjuvanted cervical cancer vaccine: Modeling of sustained antibody responses☆

(2009) Marie-Pierre David et al.   GYNECOLOGIC ONCOLOGY

Peripheral Blood CCR4+CCR6+ and CXCR3+CCR6+ CD4+ T Cells Are Highly Permissive to HIV-1 Infection

(2009) A. Gosselin et al.   JOURNAL OF IMMUNOLOGY

Vaccine-Induced Cellular Responses Control Simian Immunodeficiency Virus Replication after Heterologous Challenge

(2009) N. A. Wilson et al.   JOURNAL OF VIROLOGY

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

(2009) Supachai Rerks-Ngarm et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1

(2009) A. Benlahrech et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

(2008) Susan P Buchbinder et al.   LANCET

Nonhuman primate models and the failure of the Merck HIV-1 vaccine in humans

(2008) David I Watkins et al.   NATURE MEDICINE

Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection

(2008) B. F. Keele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Use of Nonhuman Primate Models in HIV Vaccine Development

(2008) Cecilia Morgan et al.   PLOS MEDICINE