Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein

Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors

(2015) Anke Van der Perren et al.   NEUROBIOLOGY OF AGING

Dopamine Treatment and Cognitive Functioning in Individuals with Parkinson’s Disease: The “Cognitive Flexibility” Hypothesis Seems to Work

(2014) Alberto Costa et al.   BEHAVIOURAL NEUROLOGY

Differential effects of intrastriatal 6-hydroxydopamine on cell number and morphology in midbrain dopaminergic subregions of the rat

(2014) Michelle Healy-Stoffel et al.   BRAIN RESEARCH

Selective increase ofin vivofiring frequencies in DA SN neurons after proteasome inhibition in the ventral midbrain

(2014) Mahalakshmi Subramaniam et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Contributions of signaling by dopamine neurons in dorsal striatum to cognitive behaviors corresponding to those observed in Parkinson's disease

(2014) Martin Darvas et al.   NEUROBIOLOGY OF DISEASE

Molecular determinants of selective dopaminergic vulnerability in Parkinson’s disease: an update

(2014) Lars Brichta et al.   Frontiers in Neuroanatomy

Protein phosphorylation in neurodegeneration: friend or foe?

(2014) Sandra Tenreiro et al.   Frontiers in Molecular Neuroscience

Chronic l-DOPA treatment attenuates behavioral and biochemical deficits induced by unilateral lactacystin administration into the rat substantia nigra

(2013) Jolanta Konieczny et al.   BEHAVIOURAL BRAIN RESEARCH

An animal model mimicking pedunculopontine nucleus cholinergic degeneration in Parkinson’s disease

(2013) Ilse S. Pienaar et al.   Brain Structure & Function

Direct intranigral administration of an ubiquitin proteasome system inhibitor in rat: Behavior, positron emission tomography, immunohistochemistry

(2013) Scott Mackey et al.   EXPERIMENTAL NEUROLOGY

Parkinson disease: from pathology to molecular disease mechanisms

(2013) David T. Dexter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sensory aspects of movement disorders

(2013) Neepa Patel et al.   LANCET NEUROLOGY

Assessing the Subcellular Dynamics of Alpha-synuclein Using Photoactivation Microscopy

(2013) Susana Gonçalves et al.   MOLECULAR NEUROBIOLOGY

rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration

(2013) Marusela Oliveras-Salvá et al.   Molecular Neurodegeneration

Loss of dopaminergic nigrostriatal neurons accounts for the motivational and affective deficits in Parkinson’s disease

(2013) G Drui et al.   MOLECULAR PSYCHIATRY

Pathophysiology of somatosensory abnormalities in Parkinson disease

(2013) Antonella Conte et al.   Nature Reviews Neurology

Role of iron in UPS impairment model of Parkinson's disease

(2013) Weidong Le   PARKINSONISM & RELATED DISORDERS

Electro-Acupuncture Stimulation Improves Spontaneous Locomotor Hyperactivity in MPTP Intoxicated Mice

(2013) Haomin Wang et al.   PLoS One

Clinical Approach to Parkinson's Disease: Features, Diagnosis, and Principles of Management

(2013) J. Massano et al.   Cold Spring Harbor Perspectives in Medicine

Molecular Events Underlying Parkinson’s Disease – An Interwoven Tapestry

(2013) Kah-Leong Lim et al.   Frontiers in Neurology

Protein degradation pathways in Parkinson’s disease: curse or blessing

(2012) Darius Ebrahimi-Fakhari et al.   ACTA NEUROPATHOLOGICA

What ARE Parkinson disease? Non-motor features transform conception of the shaking palsy

(2012) Samay Jain et al.   NEUROBIOLOGY OF DISEASE

Cognitive impairment and dementia in Parkinson's disease

(2012) Javier Pagonabarraga et al.   NEUROBIOLOGY OF DISEASE

A Mechanistic Study of Proteasome Inhibition-Induced Iron Misregulation in Dopamine Neuron Degeneration

(2012) Xu-ping Li et al.   NEUROSIGNALS

Sensorimotor assessment of the unilateral 6-hydroxydopamine mouse model of Parkinson's disease

(2011) Kelly E. Glajch et al.   BEHAVIOURAL BRAIN RESEARCH

Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease

(2011) Susan Duty et al.   BRITISH JOURNAL OF PHARMACOLOGY

Distinct Roles In Vivo for the Ubiquitin-Proteasome System and the Autophagy-Lysosomal Pathway in the Degradation of  -Synuclein

(2011) D. Ebrahimi-Fakhari et al.   JOURNAL OF NEUROSCIENCE

Authentically Phosphorylated  -Synuclein at Ser129 Accelerates Neurodegeneration in a Rat Model of Familial Parkinson's Disease

(2011) H. Sato et al.   JOURNAL OF NEUROSCIENCE

The importance of non-motor disturbances to quality of life in Parkinson's disease

(2011) Pablo Martinez-Martin   JOURNAL OF THE NEUROLOGICAL SCIENCES

Nonmotor versus motor symptoms: How much do they matter to health status in Parkinson's disease?

(2011) Claire Hinnell et al.   MOVEMENT DISORDERS

Increased risk of leg motor restlessness but not RLS in early Parkinson disease

(2011) M. D. Gjerstad et al.   NEUROLOGY

Evolution of Extra-Nigral Damage Predicts Behavioural Deficits in a Rat Proteasome Inhibitor Model of Parkinson's Disease

(2011) Anthony C. Vernon et al.   PLoS One

Functional models of Parkinson's disease: A valuable tool in the development of novel therapies

(2010) Peter Jenner   ANNALS OF NEUROLOGY

Behavioral phenotyping of mouse models of Parkinson's disease

(2010) Tonya N. Taylor et al.   BEHAVIOURAL BRAIN RESEARCH

Non-invasive evaluation of nigrostriatal neuropathology in a proteasome inhibitor rodent model of Parkinson's disease

(2010) Anthony C Vernon et al.   BMC NEUROSCIENCE

A comparison of changes in proteasomal subunit expression in the substantia nigra in Parkinson's disease, multiple system atrophy and progressive supranuclear palsy

(2010) Salma Bukhatwa et al.   BRAIN RESEARCH

Dopaminergic neurons of system xc−-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity

(2010) Ann Massie et al.   FASEB JOURNAL

Phosphorylated α-Synuclein at Ser-129 Is Targeted to the Proteasome Pathway in a Ubiquitin-independent Manner

(2010) Youhei Machiya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasome inhibition modeling nigral neuron degeneration in Parkinson’s disease

(2010) Wenjie Xie et al.   JOURNAL OF NEUROCHEMISTRY

The specific contributions of set-shifting to freezing of gait in Parkinson's disease

(2010) Sharon L. Naismith et al.   MOVEMENT DISORDERS

Depression and anxiety in Parkinson disease

(2010) Pablo Martínez-Martín et al.   Nature Reviews Neurology

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Lactacystin requires reactive oxygen species and Bax redistribution to induce mitochondria-mediated cell death

(2009) Sergio Perez-Alvarez et al.   BRITISH JOURNAL OF PHARMACOLOGY

Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment

(2009) K Ray Chaudhuri et al.   LANCET NEUROLOGY

The adhesive removal test: a sensitive method to assess sensorimotor deficits in mice

(2009) Valentine Bouet et al.   Nature Protocols

Differential Activities of the Ubiquitin-Proteasome System in Neurons versus Glia May Account for the Preferential Accumulation of Misfolded Proteins in Neurons

(2008) S. Tydlacka et al.   JOURNAL OF NEUROSCIENCE

Differential behavioral effects of partial bilateral lesions of ventral tegmental area or substantia nigra pars compacta in rats

(2008) E.Y. Pioli et al.   NEUROSCIENCE

Neurobiology and treatment of Parkinson's disease

(2008) Anthony H.V. Schapira   TRENDS IN PHARMACOLOGICAL SCIENCES