Calcineurin determines toxic versus beneficial responses to  -synuclein

Parkinson’s disease is associated with altered expression of CaV1 channels and calcium-binding proteins

(2013) Michael J. Hurley et al.   BRAIN

A quantitative study of α-synuclein pathology in fifteen cases of dementia associated with Parkinson disease

(2013) Richard A. Armstrong et al.   JOURNAL OF NEURAL TRANSMISSION

Calcium Entry and  -Synuclein Inclusions Elevate Dendritic Mitochondrial Oxidant Stress in Dopaminergic Neurons

(2013) D. I. Dryanovski et al.   JOURNAL OF NEUROSCIENCE

Identification and Rescue of  -Synuclein Toxicity in Parkinson Patient-Derived Neurons

(2013) C. Y. Chung et al.   SCIENCE

Yeast Reveal a "Druggable" Rsp5/Nedd4 Network that Ameliorates  -Synuclein Toxicity in Neurons

(2013) D. F. Tardiff et al.   SCIENCE

Selective ATP-Competitive Inhibitors of TOR Suppress Rapamycin-Insensitive Function of TORC2 in Saccharomyces cerevisiae

(2012) Qingsong Liu et al.   ACS Chemical Biology

Use of Calcium Channel Blockers and Parkinson’s Disease

(2012) Björn Pasternak et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Neuropathologic substrates of Parkinson disease dementia

(2012) David J. Irwin et al.   ANNALS OF NEUROLOGY

Functional Analysis of VPS41-Mediated Neuroprotection in Caenorhabditis elegans and Mammalian Models of Parkinson's Disease

(2012) A. J. Harrington et al.   JOURNAL OF NEUROSCIENCE

Olfactory dysfunction in Parkinson disease

(2012) Richard L. Doty   Nature Reviews Neurology

α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases

(2011) Zane S. Martin et al.   JOURNAL OF NEUROCHEMISTRY

α-Synuclein: Membrane Interactions and Toxicity in Parkinson's Disease

(2010) Pavan K. Auluck et al.   Annual Review of Cell and Developmental Biology

Hph1 and Hph2 Are Novel Components of the Sec63/Sec62 Posttranslational Translocation Complex That Aid in Vacuolar Proton ATPase Biogenesis

(2010) Francisco J. Piña et al.   EUKARYOTIC CELL

Parkinsonian Neurotoxin 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and α-Synuclein Mutations Promote Tau Protein Phosphorylation at Ser262and Destabilize Microtubule Cytoskeletonin Vitro

(2010) Hamid Y. Qureshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular endpoints of Ca2+/calmodulin- and voltage-dependent inactivation of Cav1.3 channels

(2010) Michael R. Tadross et al.   JOURNAL OF GENERAL PHYSIOLOGY

α-Synuclein Delays Endoplasmic Reticulum (ER)-to-Golgi Transport in Mammalian Cells by Antagonizing ER/Golgi SNAREs

(2010) Nandhakumar Thayanidhi et al.   MOLECULAR BIOLOGY OF THE CELL

Enzyme-inhibitor-like tuning of Ca2+ channel connectivity with calmodulin

(2010) Xiaodong Liu et al.   NATURE

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

(2010) Jaime N. Guzman et al.   NATURE

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

Phosphoproteomic Analysis Reveals Interconnected System-Wide Responses to Perturbations of Kinases and Phosphatases in Yeast

(2010) B. Bodenmiller et al.   Science Signaling

Interaction of calcineurin with substrates and targeting proteins

(2010) Huiming Li et al.   TRENDS IN CELL BIOLOGY

Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models

(2009) L. J. Su et al.   Disease Models & Mechanisms

α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

(2009) Aaron D Gitler et al.   NATURE GENETICS

High-throughput generation of selected reaction-monitoring assays for proteins and proteomes

(2009) Paola Picotti et al.   NATURE METHODS

Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons

(2009) Eugene V. Mosharov et al.   NEURON

Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein

(2009) Xian Lin et al.   NEURON

Calcium ions in neuronal degeneration

(2008) Urszula Wojda et al.   IUBMB LIFE

A modular switch for spatial Ca2+ selectivity in the calmodulin regulation of CaV channels

(2008) Ivy E. Dick et al.   NATURE