The utility of α-synuclein as biofluid marker in neurodegenerative diseases: a systematic review of the literature

Cerebrospinal Fluid α-Synuclein Does Not Discriminate Between Dementia Disorders

(2017) Petra E. Spies et al.   JOURNAL OF ALZHEIMERS DISEASE

CSF α-Synuclein Does Not Discriminate Dementia with Lewy Bodies from Alzheimer's Disease

(2017) Fransje E. Reesink et al.   JOURNAL OF ALZHEIMERS DISEASE

Interference from Heterophilic Antibodies in Amyloid-β Oligomer ELISAs

(2017) Dag Sehlin et al.   JOURNAL OF ALZHEIMERS DISEASE

CSF Neurofilament Light Chain but not FLT3 Ligand Discriminates Parkinsonian Disorders

(2015) Megan K. Herbert et al.   Frontiers in Neurology

Increased CSF α-synuclein levels in Alzheimer's disease: Correlation with tau levels

(2014) Sylvie Slaets et al.   Alzheimers & Dementia

Detection of disease-associated α-synuclein in the cerebrospinal fluid: a feasibility study

(2014) Ursula Unterberger et al.   CLINICAL NEUROPATHOLOGY

CSF α-synuclein and UCH-L1 levels in Parkinson's disease and atypical parkinsonian disorders

(2014) Stefania Mondello et al.   PARKINSONISM & RELATED DISORDERS

Elevated levels of cerebrospinal fluid α-synuclein oligomers in healthy asymptomatic LRRK2 mutation carriers

(2014) Jan O. Aasly et al.   Frontiers in Aging Neuroscience

Differential role of CSF alpha-synuclein species, tau, and Aβ42 in Parkinson's Disease

(2014) Lucilla Parnetti et al.   Frontiers in Aging Neuroscience

CSF α-synuclein improves diagnostic and prognostic performance of CSF tau and Aβ in Alzheimer’s disease

(2013) Jon B. Toledo et al.   ACTA NEUROPATHOLOGICA

Axonopathy in an α-Synuclein Transgenic Model of Lewy Body Disease Is Associated with Extensive Accumulation of C-Terminal–Truncated α-Synuclein

(2013) Dora Games et al.   AMERICAN JOURNAL OF PATHOLOGY

May the Evaluation of Nitrosative Stress Through Selective Increase of 3-Nitrotyrosine Proteins Other Than Nitroalbumin and Dominant Tyrosine-125/136 Nitrosylation of Serum α-Synuclein Serve for Diagnosis of Sporadic Parkinson's Disease?

(2013) Emilio Fernández et al.   ANTIOXIDANTS & REDOX SIGNALING

Heterophilic antibody interference in immunometric assays

(2013) Nils Bolstad et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Reduced α-synuclein levels in cerebrospinal fluid in Parkinson's disease are unrelated to clinical and imaging measures of disease severity

(2013) K. D. van Dijk et al.   EUROPEAN JOURNAL OF NEUROLOGY

Cerebrospinal fluid biomarkers in Parkinson disease

(2013) Lucilla Parnetti et al.   Nature Reviews Neurology

Nonmotor and diagnostic findings in subjects with de novo Parkinson disease of the DeNoPa cohort

(2013) B. Mollenhauer et al.   NEUROLOGY

Low CSF Levels of Both α-Synuclein and the α-Synuclein Cleaving Enzyme Neurosin in Patients with Synucleinopathy

(2013) Malin Wennström et al.   PLoS One

The Diagnostic Value of CSF α-Synuclein in the Differential Diagnosis of Dementia with Lewy Bodies vs. Normal Subjects and Patients with Alzheimer’s Disease

(2013) Elisabeth Kapaki et al.   PLoS One

An antibody with high reactivity for disease-associated α-synuclein reveals extensive brain pathology

(2012) Gabor G. Kovacs et al.   ACTA NEUROPATHOLOGICA

Accuracy of a Panel of 5 Cerebrospinal Fluid Biomarkers in the Differential Diagnosis of Patients With Dementia and/or Parkinsonian Disorders

(2012) Sara Hall et al.   ARCHIVES OF NEUROLOGY

Recommendations to standardize preanalytical confounding factors in Alzheimer’s and Parkinson’s disease cerebrospinal fluid biomarkers: an update

(2012) Marta del Campo et al.   Biomarkers in Medicine

Novel One-step Immunoassays to Quantify α-Synuclein

(2012) Michael Bidinosti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated Levels of α-Synuclein Oligomer in the Cerebrospinal Fluid of Drug-Naïve Patients with Parkinson's Disease

(2012) Min Jeong Park et al.   Journal of Clinical Neurology

α-Synuclein in human cerebrospinal fluid is principally derived from neurons of the central nervous system

(2012) Brit Mollenhauer et al.   JOURNAL OF NEURAL TRANSMISSION

Cerebrospinal fluid α-synuclein levels are elevated in multiple sclerosis and neuromyelitis optica patients during replase

(2012) Honghao Wang et al.   JOURNAL OF NEUROCHEMISTRY

Development of electrochemiluminescence-based singleplex and multiplex assays for the quantification of α-synuclein and other proteins in cerebrospinal fluid

(2012) Niels Kruse et al.   METHODS

Naturally occurring  -synuclein autoantibody levels are lower in patients with Parkinson disease

(2012) D. Besong-Agbo et al.   NEUROLOGY

Total CSF α-synuclein is lower in de novo Parkinson patients than in healthy subjects

(2012) Brit Mollenhauer et al.   NEUROSCIENCE LETTERS

α-Synuclein Levels in Blood Plasma from LRRK2 Mutation Carriers

(2012) Ana Gorostidi et al.   PLoS One

Alpha-synuclein in the Cerebrospinal Fluid Differentiates Synucleinopathies (Parkinson Disease, Dementia With Lewy Bodies, Multiple System Atrophy) From Alzheimer Disease

(2011) Fuyuki Tateno et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Salivary α-synuclein and DJ-1: potential biomarkers for Parkinson's disease

(2011) Ivana Devic et al.   BRAIN

Decreased α-Synuclein Serum Levels in Patients with Lewy Body Dementia Compared to Alzheimer’s Disease Patients and Control Subjects

(2011) Christoph Laske et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Phosphorylated α-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease

(2011) Penelope G. Foulds et al.   FASEB JOURNAL

Enzyme-linked immunosorbent assays for alpha-synuclein with species and multimeric state specificities

(2011) He-Jin Lee et al.   JOURNAL OF NEUROSCIENCE METHODS

α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study

(2011) Brit Mollenhauer et al.   LANCET NEUROLOGY

Cerebrospinal fluid Tau/α-synuclein ratio in Parkinson's disease and degenerative dementias

(2011) Lucilla Parnetti et al.   MOVEMENT DISORDERS

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

DJ-1 and αSYN in LRRK2 CSF do not correlate with striatal dopaminergic function

(2011) Min Shi et al.   NEUROBIOLOGY OF AGING

CSF α-synuclein does not differentiate between parkinsonian disorders

(2011) M.B. Aerts et al.   NEUROBIOLOGY OF AGING

Detection of elevated levels of  -synuclein oligomers in CSF from patients with Parkinson disease

(2011) K. A. Bruggink et al.   NEUROLOGY

CSF α-synuclein concentrations do not fluctuate over hours and are not correlated to amyloid β in humans

(2011) Petra E. Spies et al.   NEUROSCIENCE LETTERS

Assessment of α-Synuclein Secretion in Mouse and Human Brain Parenchyma

(2011) Evangelia Emmanouilidou et al.   PLoS One

The Parkinson Progression Marker Initiative (PPMI)

(2011) Kenneth Marek et al.   PROGRESS IN NEUROBIOLOGY

Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson’s disease

(2010) Kelly Del Tredici et al.   ACTA NEUROPATHOLOGICA

Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression

(2010) Min Shi et al.   ANNALS OF NEUROLOGY

SNCA Variant Associated With Parkinson Disease and Plasma α-Synuclein Level

(2010) Ignacio F. Mata et al.   ARCHIVES OF NEUROLOGY

Quantification of α-synuclein in cerebrospinal fluid as a biomarker candidate: review of the literature and considerations for future studies

(2010) Brit Mollenhauer et al.   Biomarkers in Medicine

DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson’s disease

(2010) Zhen Hong et al.   BRAIN

Differential levels of  -synuclein,  -amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer's disease

(2010) K. Kasuga et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Plasma α-synuclein in patients with Parkinson's disease with and without treatment

(2010) Raquel Duran et al.   MOVEMENT DISORDERS

Detection of elevated levels of  -synuclein oligomers in CSF from patients with Parkinson disease

(2010) T. Tokuda et al.   NEUROLOGY

Detection of elevated levels of soluble  -synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies

(2009) K. E. Paleologou et al.   BRAIN

Amyloid-  Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

(2009) J.-E. Kang et al.   SCIENCE

CSF α-synuclein levels in dementia with Lewy bodies and Alzheimer's disease

(2008) Moeko Noguchi-Shinohara et al.   BRAIN RESEARCH

Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration

(2008) Brit Mollenhauer et al.   EXPERIMENTAL NEUROLOGY

Lymphomonocyte alpha-synuclein levels in aging and in Parkinson disease

(2008) Laura Brighina et al.   NEUROBIOLOGY OF AGING

Red Blood Cells Are the Major Source of Alpha-Synuclein in Blood

(2008) Robin Barbour et al.   Neurodegenerative Diseases

Cerebrospinal fluid α-synuclein in neurodegenerative disorders—A marker of synapse loss?

(2008) Annika Öhrfelt et al.   NEUROSCIENCE LETTERS

GATA transcription factors directly regulate the Parkinson's disease-linked gene  -synuclein

(2008) C. R. Scherzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A more efficient enzyme-linked immunosorbent assay for measurement of α-synuclein in cerebrospinal fluid

(2007) Wieneke J.A. van Geel et al.   JOURNAL OF NEUROSCIENCE METHODS