The regulation of human hepatic drug transporter expression by activation of xenobiotic-sensing nuclear receptors

The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for (“squelching”) SRC-1 coactivator

(2016) Lucie Hyrsova et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transcription regulation of nuclear receptor PXR: Role of SUMO-1 modification and NDSM in receptor function

(2016) Priyanka et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Use of the LanthaScreen TR-FRET CAR Coactivator Assay in the Characterization of Constitutive Androstane Receptor (CAR) Inverse Agonists

(2015) Alejandro Carazo et al.   SENSORS

Xenosensor CAR mediates down-regulation of miR-122 and up-regulation of miR-122 targets in the liver

(2015) Yuliya A. Kazantseva et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR)

(2015) Alejandro Carazo Fernández et al.   TOXICOLOGY LETTERS

Diindolylmethane, a naturally occurring compound, induces CYP3A4 and MDR1 gene expression by activating human PXR

(2015) Satyanarayana R. Pondugula et al.   TOXICOLOGY LETTERS

Involvement of CAR and PXR in the transcriptional regulation of CYP2B6 gene expression by ingredients from herbal medicines

(2015) Cong Xu et al.   XENOBIOTICA

The physiological role of drug transporters

(2015) Yu Liang et al.   Protein & Cell

Epigenetic regulation of drug metabolism and transport

(2015) Lai Peng et al.   Acta Pharmaceutica Sinica B

Mechanism-Based Pharmacokinetic Modeling to Evaluate Transporter-Enzyme Interplay in Drug Interactions and Pharmacogenetics of Glyburide

(2014) Manthena V. S. Varma et al.   AAPS Journal

Thiazide-like diuretic drug metolazone activates human pregnane X receptor to induce cytochrome 3A4 and multidrug-resistance protein 1

(2014) Monimoy Banerjee et al.   BIOCHEMICAL PHARMACOLOGY

Transcriptional regulation of the human, porcine and bovine OCTN2 gene by PPARα via a conserved PPRE located in intron 1

(2014) Huidi Luo et al.   BMC GENETICS

Beyond the ITC White Paper: Emerging Sciences in Drug Transporters and Opportunities for Drug Development

(2014) Yurong Lai et al.   CURRENT PHARMACEUTICAL DESIGN

Phase 0 and phase III transport in various organs: Combined concept of phases in xenobiotic transport and metabolism

(2014) Barbara Döring et al.   DRUG METABOLISM REVIEWS

New insights in the biology of ABC transporters ABCC2 and ABCC3: impact on drug disposition

(2014) Lori WE van der Schoor et al.   Expert Opinion on Drug Metabolism & Toxicology

Polymorphisms of the drug transporters ABCB1, ABCG2, ABCC2 and ABCC3 and their impact on drug bioavailability and clinical relevance

(2014) Oliver Bruhn et al.   Expert Opinion on Drug Metabolism & Toxicology

Interaction of Digitalis-Like Compounds with Liver Uptake Transporters NTCP, OATP1B1, and OATP1B3

(2014) Elnaz Gozalpour et al.   MOLECULAR PHARMACEUTICS

Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4α upregulation in primary human hepatocytes

(2014) Alice Rulcova et al.   Pharmacological Reports

Gene Expression Variability in Human Hepatic Drug Metabolizing Enzymes and Transporters

(2014) Lun Yang et al.   PLoS One

Coordinated Regulation of Nuclear Receptor CAR by CCRP/DNAJC7, HSP70 and the Ubiquitin-Proteasome System

(2014) Yoav E. Timsit et al.   PLoS One

Hepatocyte nuclear factor 4-alpha involvement in liver and intestinal inflammatory networks

(2014) Jean-Philippe Babeu   WORLD JOURNAL OF GASTROENTEROLOGY

Evaluation of 309 molecules as inducers of CYP3A4, CYP2B6, CYP1A2, OATP1B1, OCT1, MDR1, MRP2, MRP3 and BCRP in cryopreserved human hepatocytes in sandwich culture

(2014) Lassina Badolo et al.   XENOBIOTICA

Echinacea purpureaup-regulates CYP1A2, CYP3A4 and MDR1 gene expression by activation of pregnane X receptor pathway

(2014) Charles Awortwe et al.   XENOBIOTICA

Signaling control of the constitutive androstane receptor (CAR)

(2014) Hui Yang et al.   Protein & Cell

Drug–Drug Interaction Studies: Regulatory Guidance and An Industry Perspective

(2013) Thomayant Prueksaritanont et al.   AAPS Journal

ATP-binding cassette transporters in liver

(2013) Katrin Wlcek et al.   BIOFACTORS

The Concise Guide to PHARMACOLOGY 2013/14: Transporters

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Emerging Transporters of Clinical Importance: An Update From the International Transporter Consortium

(2013) K M Hillgren et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the Liver

(2013) X Chu et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

International Transporter Consortium Commentary on Clinically Important Transporter Polymorphisms

(2013) K M Giacomini et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Post-translational and Post-transcriptional Modifications of Pregnane X Receptor (PXR) in Regulation of the Cytochrome P450 Superfamily

(2013) Tomas Smutny et al.   CURRENT DRUG METABOLISM

Epigenetic regulation of pregnane X receptor activity

(2013) Yanan Tian   DRUG METABOLISM REVIEWS

Nuclear-receptor–mediated regulation of drug– and bile-acid–transporter proteins in gut and liver

(2013) Jeff L. Staudinger et al.   DRUG METABOLISM REVIEWS

Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond

(2013) Xiaojuan Chai et al.   Expert Opinion on Drug Metabolism & Toxicology

Accelerating drug discovery via organs-on-chips

(2013) Chung Yu Chan et al.   LAB ON A CHIP

The SLCO (former SLC21) superfamily of transporters

(2013) Bruno Hagenbuch et al.   MOLECULAR ASPECTS OF MEDICINE

The ABCs of membrane transporters in health and disease (SLC series): Introduction

(2013) Matthias A. Hediger et al.   MOLECULAR ASPECTS OF MEDICINE

Mechanistic Modeling to Predict the Transporter- and Enzyme-Mediated Drug-Drug Interactions of Repaglinide

(2013) Manthena V. S. Varma et al.   PHARMACEUTICAL RESEARCH

Phenobarbital Indirectly Activates the Constitutive Active Androstane Receptor (CAR) by Inhibition of Epidermal Growth Factor Receptor Signaling

(2013) S. Mutoh et al.   Science Signaling

Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1

(2013) Yue-Ming Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Role of ABC transporters in lipid transport and human disease

(2013) Elizabeth J. Tarling et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1

(2013) Anne T Nies et al.   Genome Medicine

Benzoic acid and specific 2-oxo acids activate hepatic efflux of glutamate at OAT2

(2012) Till Pfennig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Pharmacological and pathophysiological roles of carnitine/organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21)

(2012) Ikumi Tamai   BIOPHARMACEUTICS & DRUG DISPOSITION

Impact of Genetic Variation in OATP Transporters to Drug Disposition and Response

(2012) Inna Y. Gong et al.   Drug Metabolism and Pharmacokinetics

Xenobiotic receptor humanized mice and their utility

(2012) Nico Scheer et al.   DRUG METABOLISM REVIEWS

Role of CAR and PXR in xenobiotic sensing and metabolism

(2012) Yue-Ming Wang et al.   Expert Opinion on Drug Metabolism & Toxicology

Identification of Novel Activators of Constitutive Androstane Receptor from FDA-Approved Drugs by Integrated Computational and Biological Approaches

(2012) Caitlin Lynch et al.   PHARMACEUTICAL RESEARCH

Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3

(2012) L Chen et al.   PHARMACOGENOMICS JOURNAL

MicroRNA-122 Down-Regulation Is Involved in Phenobarbital-Mediated Activation of the Constitutive Androstane Receptor

(2012) Ryota Shizu et al.   PLoS One

OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies

(2011) Megan Roth et al.   BRITISH JOURNAL OF PHARMACOLOGY

Identification of the Rate-Determining Process in the Hepatic Clearance of Atorvastatin in a Clinical Cassette Microdosing Study

(2011) K Maeda et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Organic Anion Transporting Polypeptides (OATPs): Regulation of Expression and Function

(2011) Martin Svoboda et al.   CURRENT DRUG METABOLISM

Genetic Polymorphisms of ATP-Binding Cassette Transporters ABCB1 and ABCC2 and their Impact on Drug Disposition

(2011) Vincent Haufroid   CURRENT DRUG TARGETS

Effect of Nuclear Receptor Downregulation on Hepatic Expression of Cytochrome P450 and Transporters in Chronic Hepatitis C in Association with Fibrosis Development

(2011) Kazuhiko Hanada et al.   Drug Metabolism and Pharmacokinetics

A living system on a chip

(2011) Monya Baker   NATURE

Post-translational modification of pregnane x receptor

(2011) Jeff L. Staudinger et al.   PHARMACOLOGICAL RESEARCH

Multi-species Analyses of Direct Activators of the Constitutive Androstane Receptor

(2011) Curtis J. Omiecinski et al.   TOXICOLOGICAL SCIENCES

Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR

(2010) Antonia H. Tolson et al.   ADVANCED DRUG DELIVERY REVIEWS

Flavonoids activate pregnane × receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells

(2010) Hanqing Dong et al.   BMC BIOCHEMISTRY

Identification of Clinically Used Drugs That Activate Pregnane X Receptors

(2010) S. J. Shukla et al.   DRUG METABOLISM AND DISPOSITION

Regulation of hepatic ABCC transporters by xenobiotics and in disease states

(2010) Xinsheng Gu et al.   DRUG METABOLISM REVIEWS

Activation of xenobiotic receptors: driving into the nucleus

(2010) Haishan Li et al.   Expert Opinion on Drug Metabolism & Toxicology

Regulation of drug transporter mRNA expression by interferon-γ in primary human hepatocytes

(2010) Marc Le Vee et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Liver X receptor α and farnesoid X receptor are major transcriptional regulators of OATP1B1

(2010) Henriette E. Meyer zu Schwabedissen et al.   HEPATOLOGY

Endogenous Ligands for Nuclear Receptors: Digging Deeper

(2010) Michael Schupp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Orphan Nuclear Receptors as Targets for Drug Development

(2010) Subhajit Mukherjee et al.   PHARMACEUTICAL RESEARCH

Human Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogens Phenobarbital and Chlordane In Vivo

(2010) Jillian Ross et al.   TOXICOLOGICAL SCIENCES

Reversal of ABC Drug Transporter-Mediated Multidrug Resistance in Cancer Cells: Evaluation of Current Strategies

(2010) Chung-Pu Wu et al.   Current Molecular Pharmacology

Activation of Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) by Herbal Medicines

(2009) Thomas K. H. Chang   AAPS Journal

Predicting Drug–Drug Interactions: An FDA Perspective

(2009) Lei Zhang et al.   AAPS Journal

Identification of Pregnane X Receptor Ligands Using Time-Resolved Fluorescence Resonance Energy Transfer and Quantitative High-Throughput Screening

(2009) Sunita J. Shukla et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective

(2009) V. Chu et al.   DRUG METABOLISM AND DISPOSITION

The role of peroxisome proliferator-activated receptor α in transcriptional regulation of novel organic cation transporters

(2009) Klaus Eder et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Phosphorylation and protein–protein interactions in PXR-mediated CYP3A repression

(2009) Satyanarayana R Pondugula et al.   Expert Opinion on Drug Metabolism & Toxicology

Epigenetic Regulation of Transcriptional Activity of Pregnane X Receptor by Protein Arginine Methyltransferase 1

(2009) Ying Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects

(2009) Alessandra di Masi et al.   MOLECULAR ASPECTS OF MEDICINE

PXR and CAR in energy metabolism

(2009) Taira Wada et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Novel Orphan Nuclear Receptors-Coregulator Interactions Controlling Anti-Cancer Drug Metabolism

(2008) Radharani Gollamudi et al.   CURRENT DRUG METABOLISM

Involvement of Hepatocyte Nuclear Factor 4alpha in Transcriptional Regulation of the Human Pregnane X Receptor Gene in the Human Liver

(2008) Norihiko Iwazaki et al.   Drug Metabolism and Pharmacokinetics

Impact of Genetic Polymorphisms of Transporters on the Pharmacokinetic, Pharmacodynamic and Toxicological Properties of Anionic Drugs

(2008) Kazuya Maeda et al.   Drug Metabolism and Pharmacokinetics

Coordinated induction of drug transporters and phase I and II metabolism in human liver slices

(2008) P. Olinga et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Tissue distribution, ontogeny and induction of the transporters Multidrug and toxin extrusion (MATE) 1 and MATE2 mRNA expression levels in mice

(2008) Andrew J. Lickteig et al.   LIFE SCIENCES

Bioactive Terpenoids and Flavonoids from Ginkgo Biloba Extract Induce the Expression of Hepatic Drug-Metabolizing Enzymes Through Pregnane X Receptor, Constitutive Androstane Receptor, and Aryl hydrocarbon Receptor-Mediated Pathways

(2008) Linhao Li et al.   PHARMACEUTICAL RESEARCH

Hepatic drug transporters and nuclear receptors: Regulation by therapeutic agents

(2008) Aldo D Mottino et al.   WORLD JOURNAL OF GASTROENTEROLOGY