The physiological role of drug transporters

Functional characterization of a Na+-dependent dicarboxylate transporter fromVibrio cholerae

(2014) Christopher Mulligan et al.   JOURNAL OF GENERAL PHYSIOLOGY

Crystal structure of the human glucose transporter GLUT1

(2014) Dong Deng et al.   NATURE

Zinc transport and diabetes risk

(2014) Ewan Pearson   NATURE GENETICS

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

(2014) Jason Flannick et al.   NATURE GENETICS

OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin

(2014) Ligong Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transporter Studies in Drug Development: Experience to Date and Follow-Up on Decision Trees From the International Transporter Consortium

(2013) D Tweedie et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance

(2013) Motoyuki Tamaki et al.   JOURNAL OF CLINICAL INVESTIGATION

The SLC22 family with transporters of organic cations, anions and zwitterions

(2013) Hermann Koepsell   MOLECULAR ASPECTS OF MEDICINE

The SLCO (former SLC21) superfamily of transporters

(2013) Bruno Hagenbuch et al.   MOLECULAR ASPECTS OF MEDICINE

The SLC26 gene family of anion transporters and channels

(2013) Seth L. Alper et al.   MOLECULAR ASPECTS OF MEDICINE

Investigation of Endogenous Compounds for Assessing the Drug Interactions in the Urinary Excretion Involving Multidrug and Toxin Extrusion Proteins

(2013) Koji Kato et al.   PHARMACEUTICAL RESEARCH

Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1

(2013) E. G. Geier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

(2013) Thomas Gaj et al.   TRENDS IN BIOTECHNOLOGY

MalaCards: an integrated compendium for diseases and their annotation

(2013) Noa Rappaport et al.   Database-The Journal of Biological Databases and Curation

SLC30A8 (ZnT8) variations and type 2 diabetes in the Chinese Han population

(2012) J. Xu et al.   GENETICS AND MOLECULAR RESEARCH

High Selectivity of the γ-Aminobutyric Acid Transporter 2 (GAT-2, SLC6A13) Revealed by Structure-based Approach

(2012) Avner Schlessinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Potent, Selective Multidrug and Toxin Extrusion Transporter 1 (MATE1, SLC47A1) Inhibitors Through Prescription Drug Profiling and Computational Modeling

(2012) Matthias B. Wittwer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure and mechanism of a bacterial sodium-dependent dicarboxylate transporter

(2012) Romina Mancusso et al.   NATURE

Genetic and functional analyses implicate the NUDT11, HNF1B, and SLC22A3 genes in prostate cancer pathogenesis

(2012) C. Grisanzio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice

(2011) Andreas L. Birkenfeld et al.   Cell Metabolism

Determination of OATP-, NTCP- and OCT-mediated substrate uptake activities in individual and pooled batches of cryopreserved human hepatocytes

(2011) Tom De Bruyn et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The use ofXenopusoocytes in drug screening

(2011) Trine Kvist et al.   Expert Opinion on Drug Discovery

Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition

(2011) L. B. Ramsey et al.   GENOME RESEARCH

Multimerization and Aggregation of Native-State Insulin: Effect of Zinc

(2011) Yisheng Xu et al.   LANGMUIR

Structure and mechanism of the uracil transporter UraA

(2011) Feiran Lu et al.   NATURE

Human metabolic individuality in biomedical and pharmaceutical research

(2011) Karsten Suhre et al.   NATURE

ABCG2 is a High-Capacity Urate Transporter and its Genetic Impairment Increases Serum Uric Acid Levels in Humans

(2011) Akiyoshi Nakayama et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET

(2011) A. Schlessinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BSEP inhibition – In vitro screens to assess cholestatic potential of drugs

(2011) Emese Kis et al.   TOXICOLOGY IN VITRO

Cholestasis and the Role of Basolateral Efflux Pumps

(2011) D. Keppler   ZEITSCHRIFT FUR GASTROENTEROLOGIE

Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion

(2010) N. Wijesekara et al.   DIABETOLOGIA

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Zinc and cardiovascular disease

(2010) Peter J. Little et al.   NUTRITION

Role of Organic Cation Transporter 1, OCT1 in the Pharmacokinetics and Toxicity of cis-Diammine(pyridine)chloroplatinum(II) and Oxaliplatin in Mice

(2010) Shuanglian Li et al.   PHARMACEUTICAL RESEARCH

Function of human Rh based on structure of RhCG at 2.1 A

(2010) F. Gruswitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes-Associated Variants

(2009) T. J. Nicolson et al.   DIABETES

Zinc, a regulator of islet function and glucose homeostasis

(2009) N. Wijesekara et al.   DIABETES OBESITY & METABOLISM

Effect of Membrane Cholesterol on BSEP/Bsep Activity: Species Specificity Studies for Substrates and Inhibitors

(2009) E. Kis et al.   DRUG METABOLISM AND DISPOSITION

Genome-wide association meta-analysis for total serum bilirubin levels

(2009) A. D. Johnson et al.   HUMAN MOLECULAR GENETICS

Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia

(2009) Serena Sanna et al.   HUMAN MOLECULAR GENETICS

Germline Genetic Variation in an Organic Anion Transporter Polypeptide Associated With Methotrexate Pharmacokinetics and Clinical Effects

(2009) Lisa R. Treviño et al.   JOURNAL OF CLINICAL ONCOLOGY

Zinc in Cancer Prevention

(2009) Ananda S. Prasad et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Down-Regulation of ZnT8 Expression in INS-1 Rat Pancreatic Beta Cells Reduces Insulin Content and Glucose-Inducible Insulin Secretion

(2009) Yi Fu et al.   PLoS One

Long-lived Indy and calorie restriction interact to extend life span

(2009) P.-Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice

(2009) K. Lemaire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout

(2009) O. M. Woodward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Mechanism of an Amino Acid Antiporter

(2009) X. Gao et al.   SCIENCE

Structure and Mechanism of a Na+-Independent Amino Acid Transporter

(2009) P. L. Shaffer et al.   SCIENCE

Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion

(2008) K. Kirchhoff et al.   DIABETOLOGIA

Cholesterol but not association with detergent resistant membranes is necessary for the transport function of MRP2/ABCC2

(2008) Kousei Ito et al.   FEBS LETTERS

SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Zinc signalling and subcellular distribution: emerging targets in type 2 diabetes

(2008) Eugenio Mocchegiani et al.   TRENDS IN MOLECULAR MEDICINE