Identification of Novel Activators of Constitutive Androstane Receptor from FDA-Approved Drugs by Integrated Computational and Biological Approaches

Use of comprehensive screening methods to detect selective human CAR activators

(2011) Jenni Küblbeck et al.   BIOCHEMICAL PHARMACOLOGY

In silico repositioning of approved drugs for rare and neglected diseases

(2011) Sean Ekins et al.   DRUG DISCOVERY TODAY

Finding Promiscuous Old Drugs for New Uses

(2011) Sean Ekins et al.   PHARMACEUTICAL RESEARCH

Multi-species Analyses of Direct Activators of the Constitutive Androstane Receptor

(2011) Curtis J. Omiecinski et al.   TOXICOLOGICAL SCIENCES

Automatic identification and representation of protein binding sites for molecular docking

(2010) Jim Ruppert et al.   PROTEIN SCIENCE

Novel web-based tools combining chemistry informatics, biology and social networks for drug discovery

(2009) Moses Hohman et al.   DRUG DISCOVERY TODAY

In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective

(2009) V. Chu et al.   DRUG METABOLISM AND DISPOSITION

The Constitutive Androstane Receptor Is an Anti-obesity Nuclear Receptor That Improves Insulin Sensitivity

(2009) Jie Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Single Amino Acid Controls the Functional Switch of Human Constitutive Androstane Receptor (CAR) 1 to the Xenobiotic-Sensitive Splicing Variant CAR3

(2009) T. Chen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Di(2-ethylhexyl) phthalate Is a Highly Potent Agonist for the Human Constitutive Androstane Receptor Splice Variant CAR2

(2009) J. G. DeKeyser et al.   MOLECULAR PHARMACOLOGY

Phenobarbital Elicits Unique, Early Changes in the Expression of Hepatic Genes that Affect Critical Pathways in Tumor-Prone B6C3F1 Mice

(2009) Jennifer M. Phillips et al.   TOXICOLOGICAL SCIENCES

Drug interactions between chemotherapeutic regimens and antiepileptics

(2008) K YAP et al.   CLINICAL THERAPEUTICS

Insights into Ligand-Elicited Activation of Human Constitutive Androstane Receptor Based on Novel Agonists and Three-Dimensional Quantitative Structure−Activity Relationship

(2008) Johanna Jyrkkärinne et al.   JOURNAL OF MEDICINAL CHEMISTRY