Developing drugs that target the Wnt pathway: recent approaches in cancer and neurodegenerative diseases
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Title
Developing drugs that target the Wnt pathway: recent approaches in cancer and neurodegenerative diseases
Authors
Keywords
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Journal
Expert Opinion on Drug Discovery
Volume 12, Issue 2, Pages 169-186
Publisher
Informa UK Limited
Online
2016-12-19
DOI
10.1080/17460441.2017.1271321
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- (2016) Jie Dong et al. CNS Neuroscience & Therapeutics
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- (2016) Limin Zhang et al. PLoS One
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- (2015) Soo Yei Ho et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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- (2015) Gayathri Chandrasekaran et al. BRITISH JOURNAL OF CANCER
- Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates -Catenin Signaling and Tumorigenesis in Multiple Cancer Types
- (2015) C. Chartier et al. CANCER RESEARCH
- Integration of molecular pathology, epidemiology and social science for global precision medicine
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- A first-in-human phase I dose-escalation, pharmacokinetic, and pharmacodynamic evaluation of intravenous LY2090314, a glycogen synthase kinase 3 inhibitor, administered in combination with pemetrexed and carboplatin
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- (2015) Naoko Takebe et al. Nature Reviews Clinical Oncology
- Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells
- (2015) Li Ma et al. Oncotarget
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- (2015) Annalucia Serafino et al. Oncotarget
- Progress and Opportunities in Molecular Pathological Epidemiology of Colorectal Premalignant Lesions
- (2014) Paul Lochhead et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Safely targeting cancer stem cells via selective catenin coactivator antagonism
- (2014) Heinz-Josef Lenz et al. CANCER SCIENCE
- Molecular Pathways: Aspirin and Wnt Signaling--A Molecularly Targeted Approach to Cancer Prevention and Treatment
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- (2014) W. de Lau et al. GENES & DEVELOPMENT
- Phase II Randomized Trial Comparing Sequential First-Line Everolimus and Second-Line Sunitinib Versus First-Line Sunitinib and Second-Line Everolimus in Patients With Metastatic Renal Cell Carcinoma
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- Aspirin and COX-2 Inhibitor Use in Patients With Stage III Colon Cancer
- (2014) Kimmie Ng et al. JNCI-Journal of the National Cancer Institute
- Can we safely target the WNT pathway?
- (2014) Michael Kahn NATURE REVIEWS DRUG DISCOVERY
- Wnt/β-Catenin Signaling Is Required to Rescue Midbrain Dopaminergic Progenitors and Promote Neurorepair in Ageing Mouse Model of Parkinson's Disease
- (2014) Francesca L'Episcopo et al. STEM CELLS
- Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease
- (2014) Ernest Arenas Journal of Molecular Cell Biology
- Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotection/repair in Parkinson's disease
- (2014) Francesca L'Episcopo et al. Journal of Molecular Cell Biology
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- (2014) Wenbin Wan et al. Biomed Research International
- Therapeutic prospects for Parkinson disease
- (2013) C. Warren Olanow et al. ANNALS OF NEUROLOGY
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- (2013) T. Morikawa et al. CANCER RESEARCH
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- (2012) S. J. Harrison-Uy et al. Cold Spring Harbor Perspectives in Biology
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- (2012) K. Willert et al. Cold Spring Harbor Perspectives in Biology
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- (2012) J. L. Whyte et al. Cold Spring Harbor Perspectives in Biology
- Wnt Signaling in the Vertebrate Central Nervous System: From Axon Guidance to Synaptic Function
- (2012) P. C. Salinas Cold Spring Harbor Perspectives in Biology
- Cardiac hormones are potent inhibitors of secreted frizzled-related protein-3 in human cancer cells
- (2012) WILLIAM P. SKELTON et al. Experimental and Therapeutic Medicine
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- (2011) J. Munding et al. CARCINOGENESIS
- Chemical ‘Jekyll and Hyde’s: small-molecule inhibitors of developmental signaling pathways
- (2011) Tomoyo Sakata et al. CHEMICAL SOCIETY REVIEWS
- Association of CTNNB1 (β-Catenin) Alterations, Body Mass Index, and Physical Activity With Survival in Patients With Colorectal Cancer
- (2011) Teppei Morikawa JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Synaptic Wnt signaling—a contributor to major psychiatric disorders?
- (2011) Nathan D. Okerlund et al. Journal of Neurodevelopmental Disorders
- A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection
- (2011) Francesca L'Episcopo et al. Molecular Neurodegeneration
- Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease
- (2011) Sonja Kriks et al. NATURE
- Cancer immunology—analysis of host and tumor factors for personalized medicine
- (2011) Shuji Ogino et al. Nature Reviews Clinical Oncology
- An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway
- (2011) F. C. Gonsalves et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Switching the Microglial Harmful Phenotype Promotes Lifelong Restoration of Subtantia Nigra Dopaminergic Neurons from Inflammatory Neurodegeneration in Aged Mice
- (2011) Francesca L'Episcopo et al. REJUVENATION RESEARCH
- The Wnt /β-catenin signaling pathway in the adult neurogenesis
- (2010) Lin Zhang et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field
- (2010) S. Ogino et al. GUT
- Lifestyle Factors and Microsatellite Instability in Colorectal Cancer: The Evolving Field of Molecular Pathological Epidemiology
- (2010) S. Ogino et al. JNCI-Journal of the National Cancer Institute
- Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
- (2010) F. L'Episcopo et al. NEUROBIOLOGY OF DISEASE
- Wnt Isoform-Specific Interactions with Coreceptor Specify Inhibition or Potentiation of Signaling by LRP6 Antibodies
- (2010) Yan Gong et al. PLoS One
- Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies
- (2010) S. A. Ettenberg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats
- (2010) G. Hargus et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sulindac Inhibits Canonical Wnt Signaling by Blocking the PDZ Domain of the Protein Dishevelled
- (2009) Ho-Jin Lee et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Wnt-Related Molecules and Signaling Pathway Equilibrium in Hematopoiesis
- (2009) Sachin Malhotra et al. Cell Stem Cell
- Towards an integrated view of Wnt signaling in development
- (2009) R. van Amerongen et al. DEVELOPMENT
- Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
- (2009) Bryan T. MacDonald et al. DEVELOPMENTAL CELL
- Pathophysiological aspects of Wnt-signaling in endocrine disease
- (2009) Sven Schinner et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Wnt-signalling and the Metabolic Syndrome
- (2009) S. Schinner HORMONE AND METABOLIC RESEARCH
- Role of Wnt/β-catenin signaling in liver metabolism and cancer
- (2009) Satdarshan Pal Singh Monga INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Discovery and Characterization of a Small Molecule Inhibitor of the PDZ Domain of Dishevelled
- (2009) David Grandy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
- (2009) Shih-Min A. Huang et al. NATURE
- Proximal events in Wnt signal transduction
- (2009) Stephane Angers et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Emerging roles of Wnts in the adult nervous system
- (2009) Nibaldo C. Inestrosa et al. NATURE REVIEWS NEUROSCIENCE
- β-Catenin Expression in the Bone Marrow Microenvironment Is Required for Long-Term Maintenance of Primitive Hematopoietic Cells
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- Resveratrol Exerts Antiproliferative Activity and Induces Apoptosis in Waldenstrom's Macroglobulinemia
- (2008) A. M. Roccaro et al. CLINICAL CANCER RESEARCH
- Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice
- (2008) Clare L. Parish et al. JOURNAL OF CLINICAL INVESTIGATION
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