Modulating Wnt signaling to improve cell replacement therapy for Parkinson's disease

Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells

(2013) E. R. Andersson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ryk, a Receptor Regulating Wnt5a-Mediated Neurogenesis and Axon Morphogenesis of Ventral Midbrain Dopaminergic Neurons

(2013) Brette D. Blakely et al.   STEM CELLS AND DEVELOPMENT

Activation of Wnt/β-catenin Pathway by Exogenous Wnt1 Protects SH-SY5Y Cells Against 6-Hydroxydopamine Toxicity

(2012) Lei Wei et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Cell intrinsic and extrinsic factors contribute to enhance neural circuit reconstruction following transplantation in Parkinsonian mice

(2012) Jessica Kauhausen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Fetal dopaminergic transplantation trials and the future of neural grafting in Parkinson's disease

(2012) Roger A Barker et al.   LANCET NEUROLOGY

Glycogen Synthase Kinase 3β and Activin/Nodal Inhibition in Human Embryonic Stem Cells Induces a Pre-Neuroepithelial State That Is Required for Specification to a Floor Plate Cell Lineage

(2012) Mark Denham et al.   STEM CELLS

Specification of Midbrain Dopamine Neurons from Primate Pluripotent Stem Cells

(2012) Jiajie Xi et al.   STEM CELLS

SFRP1 and SFRP2 Dose-Dependently Regulate Midbrain Dopamine Neuron Development In Vivo and in Embryonic Stem Cells

(2012) Julianna Kele et al.   STEM CELLS

Dopaminergic axon guidance: which makes what?

(2012) Laetitia Prestoz et al.   Frontiers in Cellular Neuroscience

Generation of Regionally Specified Neural Progenitors and Functional Neurons from Human Embryonic Stem Cells under Defined Conditions

(2012) Agnete Kirkeby et al.   Cell Reports

A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection

(2011) Francesca L'Episcopo et al.   Molecular Neurodegeneration

Graft-induced dyskinesias in Parkinson's disease: High striatal serotonin/dopamine transporter ratio

(2011) Marios Politis et al.   MOVEMENT DISORDERS

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

(2011) Sonja Kriks et al.   NATURE

Functional Integration of Grafted Neural Stem Cell-Derived Dopaminergic Neurons Monitored by Optogenetics in an In Vitro Parkinson Model

(2011) Jan Tønnesen et al.   PLoS One

Wnt5a Regulates Midbrain Dopaminergic Axon Growth and Guidance

(2011) Brette D. Blakely et al.   PLoS One

Wnt/Planar Cell Polarity Signaling Controls the Anterior-Posterior Organization of Monoaminergic Axons in the Brainstem

(2010) A. G. Fenstermaker et al.   JOURNAL OF NEUROSCIENCE

Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

(2010) F. L'Episcopo et al.   NEUROBIOLOGY OF DISEASE

Wnt1-lmx1a Forms a Novel Autoregulatory Loop and Controls Midbrain Dopaminergic Differentiation Synergistically with the SHH-FoxA2 Pathway

(2009) Sangmi Chung et al.   Cell Stem Cell

Multiple roles of  -catenin in controlling the neurogenic niche for midbrain dopamine neurons

(2009) M. Tang et al.   DEVELOPMENT

Reconstruction of the nigrostriatal dopamine pathway in the adult mouse brain

(2009) Lachlan H. Thompson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis

(2009) Milan Joksimovic et al.   NATURE NEUROSCIENCE

Wnt Signaling in Neural Circuit Assembly

(2008) Patricia C. Salinas et al.   Annual Review of Neuroscience

Combined use of BDNF, ascorbic acid, low oxygen, and prolonged differentiation time generates tyrosine hydroxylase-expressing neurons after long-term in vitro expansion of human fetal midbrain precursor cells

(2008) Jaroslaw Maciaczyk et al.   EXPERIMENTAL NEUROLOGY

Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice

(2008) Clare L. Parish et al.   JOURNAL OF CLINICAL INVESTIGATION

Wnt5a Regulates Ventral Midbrain Morphogenesis and the Development of A9–A10 Dopaminergic Cells In Vivo

(2008) Emma R. Andersson et al.   PLoS One

Getting connected in the dopamine system

(2008) D VANDENHEUVEL et al.   PROGRESS IN NEUROBIOLOGY

Midbrain dopaminergic neuron fate specification: Of mice and embryonic stem cells

(2008) Emily Gale et al.   Molecular Brain