Pyroptosis, a new bridge to tumor immunity

A review of cancer immunotherapy toxicity

(2020) Lucy Boyce Kennedy et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Top 10 Challenges in Cancer Immunotherapy

(2020) Priti S. Hegde et al.   IMMUNITY

Self‐Boosting Catalytic Nanoreactor Integrated with Triggerable Crosslinking Membrane Networks for Initiation of Immunogenic Cell Death by Pyroptosis

(2020) Junjie Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8

(2020) Robin Schwarzer et al.   CURRENT OPINION IN CELL BIOLOGY

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

A bioorthogonal system reveals antitumour immune function of pyroptosis

(2020) Qinyang Wang et al.   NATURE

Curcumin: an inflammasome silencer

(2020) Shima Hassanzadeh et al.   PHARMACOLOGICAL RESEARCH

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

(2020) Zhiwei Zhou et al.   SCIENCE

Role of GSDMB in Pyroptosis and Cancer

(2020) Lisha Li et al.   Cancer Management and Research

Sea Hare Hydrolysate-Induced Reduction of Human Non-Small Cell Lung Cancer Cell Growth through Regulation of Macrophage Polarization and Non-Apoptotic Regulated Cell Death Pathways

(2020) Marie Merci Nyiramana et al.   Cancers

Helicobacter pylori Avoids the Critical Activation of NLRP3 Inflammasome-Mediated Production of Oncogenic Mature IL-1β in Human Immune Cells

(2020) Suneesh Kumar Pachathundikandi et al.   Cancers

Characterizing caspase-1 involvement during esophageal disease progression

(2020) Gillian Barber et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Cancer immunotherapy: Current applications and challenges

(2020) Jin-Yu Sun et al.   CANCER LETTERS

Therapeutic modulation of inflammasome pathways

(2020) Dhruv Chauhan et al.   IMMUNOLOGICAL REVIEWS

The Multifaceted Function of Granzymes in Sepsis: Some Facts and a Lot to Discover

(2020) Marcela Garzón-Tituaña et al.   Frontiers in Immunology

Methotrexate-loaded tumour-cell-derived microvesicles can relieve biliary obstruction in patients with extrahepatic cholangiocarcinoma

(2020) Yunfeng Gao et al.   Nature Biomedical Engineering

Programming cell pyroptosis with biomimetic nanoparticles for solid tumor immunotherapy

(2020) Pengfei Zhao et al.   BIOMATERIALS

Arctigenin disrupts NLRP3 inflammasome assembly in colonic macrophages via downregulating fatty acid oxidation to prevent colitis-associated cancer

(2020) Simiao Qiao et al.   CANCER LETTERS

PD-L1 controls cancer pyroptosis

(2020) María Teresa Blasco et al.   NATURE CELL BIOLOGY

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

(2020) Junwei Hou et al.   NATURE CELL BIOLOGY

Activation of the CARD8 Inflammasome Requires a Disordered Region

(2020) Ashley J. Chui et al.   Cell Reports

N-terminal degradation activates the NLRP1B inflammasome

(2019) Ashley J. Chui et al.   SCIENCE

The emerging roles of inflammasome‐dependent cytokines in cancer development

(2019) Hanne Van Gorp et al.   EMBO REPORTS

Sorafenib Induces Pyroptosis in Macrophages and Triggers Natural Killer Cell–Mediated Cytotoxicity Against Hepatocellular Carcinoma

(2019) Carina Hage et al.   HEPATOLOGY

High-frequency irreversible electroporation is an effective tumor ablation strategy that induces immunologic cell death and promotes systemic anti-tumor immunity

(2019) Veronica M. Ringel-Scaia et al.   EBioMedicine

Nivolumab plus ipilimumab versus chemotherapy as first-line treatment in advanced non–small-cell lung cancer with high tumour mutational burden: patient-reported outcomes results from the randomised, open-label, phase III CheckMate 227 trial

(2019) Martin Reck et al.   EUROPEAN JOURNAL OF CANCER

Alkaliptosis: a new weapon for cancer therapy

(2019) Jiao Liu et al.   CANCER GENE THERAPY

GSDMD is required for effector CD8+ T cell responses to lung cancer cells

(2019) Guangmin Xi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome

(2019) Parimal Samir et al.   NATURE

The role of pyroptosis in cancer: pro-cancer or pro-“host”?

(2019) Xiaojing Xia et al.   Cell Death & Disease

The Diversification of Cell Death and Immunity: Memento Mori

(2019) Arnaud J. Legrand et al.   MOLECULAR CELL

Epigenetics-Based Tumor Cells Pyroptosis for Enhancing the Immunological Effect of Chemotherapeutic Nanocarriers

(2019) Jin-Xuan Fan et al.   NANO LETTERS

NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis

(2019) Nour Ershaid et al.   Nature Communications

Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis

(2019) Dan A. Erkes et al.   Cancer Discovery

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

Therapeutically active RIG-I agonist induces immunogenic tumor cell killing in breast cancers

(2018) David L Elion et al.   CANCER RESEARCH

Alcohol accumulation promotes esophagitis via pyroptosis activation

(2018) Fengjiao Wang et al.   International Journal of Biological Sciences

Siglec-7 engagement by GBS β-protein suppresses pyroptotic cell death of natural killer cells

(2018) Jerry J. Fong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammasome: A Double-Edged Sword in Liver Diseases

(2018) Jingyun Luan et al.   Frontiers in Immunology

Comparing the effects of different cell death programs in tumor progression and immunotherapy

(2018) Michelle N. Messmer et al.   CELL DEATH AND DIFFERENTIATION

Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

(2018) J. Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti–PD-1 for tumor abrogation

(2018) Irena Kaplanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

(2018) Sebastian Rühl et al.   SCIENCE

A novel pathway of LPS uptake through syndecan-1 leading to pyroptotic cell death

(2018) Shigetoshi Yokoyama et al.   eLife

Cell death and immunity in cancer: From danger signals to mimicry of pathogen defense responses

(2017) Abhishek D. Garg et al.   IMMUNOLOGICAL REVIEWS

The renaissance of anti-neoplastic immunity from tumor cell demise

(2017) Yuting Ma et al.   IMMUNOLOGICAL REVIEWS

NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma

(2017) Donnele Daley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β

(2017) Benjamin Weichand et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

(2017) Paul M Ridker et al.   LANCET

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Pore formation by GSDMD is the effector mechanism of pyroptosis

(2016) Moritz M Gaidt et al.   EMBO JOURNAL

ΔPK oncolytic activity includes modulation of the tumour cell milieu

(2016) Dominique Bollino et al.   JOURNAL OF GENERAL VIROLOGY

DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis

(2016) Marian C Okondo et al.   Nature Chemical Biology

Cooperation among heterogeneous prostate cancer cells in the bone metastatic niche

(2016) K Shahriari et al.   ONCOGENE

Key roles of necroptotic factors in promoting tumor growth

(2016) Xinjian Liu et al.   Oncotarget

Hepatitis C Virus Infection of Cultured Human Hepatoma Cells Causes Apoptosis and Pyroptosis in Both Infected and Bystander Cells

(2016) H. M. Kofahi et al.   Scientific Reports

Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium

(2015) Vivien I. Maltez et al.   IMMUNITY

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Unknown

(2014) Charles Dinarello   MOLECULAR MEDICINE

Post-Translational Control of IL-1β via the Human Papillomavirus Type 16 E6 Oncoprotein: A Novel Mechanism of Innate Immune Escape Mediated by the E3-Ubiquitin Ligase E6-AP and p53

(2013) Martina Niebler et al.   PLoS Pathogens

Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis

(2012) S. K. Drexler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Green tea polyphenol epigallocatechin-3-gallate suppresses melanoma growth by inhibiting inflammasome and IL-1β secretion

(2011) Lixia Z. Ellis et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS