Review
Chemistry, Multidisciplinary
Shahinur Acter, Michele Moreau, Robert Ivkov, Akila Viswanathan, Wilfred Ngwa
Summary: In the field of cancer treatment, multifunctional nanoparticles, specifically those made with polydopamine (PDA), are gaining attention. PDA, a nature-inspired polymer, offers various advantages such as biocompatibility, biodegradability, drug loading capability, photothermal conversion efficiency, and adhesive properties. Despite the unclear mechanism of dopamine polymerization, PDA exhibits flexibility in controlling morphology and size and is easily functionalized. It has the potential to be utilized in innovative approaches for cancer treatment. This review focuses on the application of PDA in developing multifunctional nanomaterials for photothermal therapy and discusses its potential in enhancing radiotherapy and/or immunotherapy.
Article
Immunology
Kajal H. Gupta, Christina Nowicki, Eileena F. Giurini, Amanda L. Marzo, Andrew Zloza
Summary: Cancer currently ranks as the sixth leading cause of death globally, with immunotherapy showing significant advancements in combating cancer. The use of bacteria and bacterial products as cancer therapy has promising potential to address ongoing challenges in cancer treatment.
Review
Biochemistry & Molecular Biology
Si-Wei Wang, Chao Gao, Yi-Min Zheng, Li Yi, Jia-Cheng Lu, Xiao-Yong Huang, Jia-Bin Cai, Peng-Fei Zhang, Yue-Hong Cui, Ai-Wu Ke
Summary: The CRISPR/Cas9 gene editing technology has made significant progress in oncological research, providing a powerful tool for exploring the mechanism of cancer, establishing tumor models, and studying drug targets.
Review
Oncology
Jack M. Qian, Jonathan D. Schoenfeld
Summary: Immune checkpoint inhibitors have greatly impacted cancer treatment, but response rates to monotherapy in head and neck squamous cell carcinoma patients are low. There is increasing interest in the potential synergy between radiotherapy and immunotherapy, focusing on enhancing the anti-tumor immune response and improving tumor response to radiation in the field. It is important to consider current challenges and future directions in the emerging field of radioimmunotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Katie Hanna, Emma Krzoska, Abeer M. Shaaban, David Muirhead, Rasha Abu-Eid, Valerie Speirs
Summary: Despite advancements in breast cancer management, there is a need for faster and more reliable detection methods to improve early disease diagnosis and patient outcomes.
BRITISH JOURNAL OF CANCER
(2022)
Review
Oncology
Lichan Chen, Xiafei Wei, Dayong Gu, Yong Xu, Hongzhong Zhou
Summary: Liver cancer and disease pose significant challenges to global health. Existing treatment methods such as organ transplantation, surgical resection, and anticancer drugs have limitations due to the lack of donor livers and tumor heterogeneity. Tumor organoid technology has emerged as a promising approach that can replicate the characteristics of tumorigenesis and metastasis. By combining organoids with other emerging technologies, such as CRISPR-HOT, organ-on-a-chip, and 3D bioprinting, more realistic models of tissue and organ interactions in liver cancer progression can be developed. This review discusses the generation, applications, challenges, and prospects of liver organoids, highlighting their potential in clinical model development and therapeutic research for liver diseases.
Review
Oncology
Lisa Maria Mustachio, Jason Roszik
Summary: Single-cell sequencing technologies have become increasingly important in cancer research, allowing scientists to analyze the genome, transcriptome, epigenome, and proteome of individual cells. This review summarizes the various techniques used in single-cell sequencing and provides examples of recent high-impact findings. It also discusses the translational relevance of these technologies and their potential use in clinical trials.
Review
Pharmacology & Pharmacy
Zhenyu Nie, Mei Chen, Yuanhui Gao, Denggao Huang, Hui Cao, Yanling Peng, Na Guo, Fei Wang, Shufang Zhang
Summary: This article reviews the relationship between ferroptosis and tumor drug resistance, summarizes the abnormal ferroptosis in tissues of different cancer types, explores the concept of targeting ferroptosis to improve tumor treatment outcomes.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Marije J. Voskamp, Shuang Li, Kim R. van Daalen, Sandra Crnko, Toine ten Broeke, Niels Bovenschen
Summary: Medulloblastoma (MB), a primary brain tumor in children, is commonly treated with surgery, radiotherapy, and chemotherapy, but these methods often lead to severe brain damage and high relapse rates. Immunotherapy has emerged as a potential alternative, with a focus on immune checkpoint inhibition and CAR T-cell therapy, and research in this area is ongoing to improve treatment outcomes.
Review
Biotechnology & Applied Microbiology
Niels G. A. Willemen, Shabir Hassan, Melvin Gurian, Jinghang Li, Iris E. Allijn, Su Ryon Shin, Jeroen Leijten
Summary: Oxygen plays a crucial role in the survival and function of mammalian cells, controlling cellular behavior through metabolic programming to impact processes like tissue regeneration and stem cell differentiation. Oxygen-releasing materials offer a novel strategy to control in vivo processes, providing innovative solutions in the fields of medicine and bioengineering.
TRENDS IN BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ensaf M. Al-Hujaily, Batla S. Al-Sowayan, Zeyad Alyousef, Shahab Uddin, Farah Alammari
Summary: This review article provides an overview of major immunotherapeutic methods and their clinical applications for colorectal cancer, focusing on monoclonal antibodies (mAbs) and adoptive cell therapy, their advantages, potential in combination therapy, as well as clinical trials demonstrating efficacy and toxicities. Emerging targets for intervention in CRC are summarized, along with discussions on current challenges and future directions in cancer immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Kenneth K. W. To, Winnie Fong, William C. S. Cho
Summary: Lung cancer is the leading cause of cancer-related deaths globally. Immune checkpoint inhibitors have improved survival in some NSCLC patients, but those with EGFR-mutant NSCLC show poor response. Understanding the underlying reasons and identifying new biomarkers are crucial for optimizing treatment outcomes in this subgroup of patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, Research & Experimental
Mahshad Entezam, Mohammad-Javad Sanaei, Yousef Mirzaei, Ali Hussein Mer, Meghdad Abdollahpour-Alitappeh, Fatemeh Azadegan-Dehkordi, Nader Bagheri
Summary: Gastric cancer is a severe malignancy and the third most common cause of cancer deaths worldwide. Current chemo-radiation therapy has not been effective enough in improving survival rates for patients with gastric cancer. Therefore, understanding the molecular biology of gastric cancer and developing new therapeutic strategies, including specific immunotherapy, is crucial.
Review
Biochemistry & Molecular Biology
Alessandro Posa, Andrea Contegiacomo, Francesca Romana Ponziani, Ernesto Punzi, Giulia Mazza, Annarita Scrofani, Maurizio Pompili, Shraga Nahum Goldberg, Luigi Natale, Antonio Gasbarrini, Evis Sala, Roberto Iezzi
Summary: Personalized cancer treatments aim to provide tailored and biologically driven therapies for cancer patients. Interventional oncology techniques offer locoregional treatment options for malignancies with various mechanisms of action leading to tumor necrosis. The destruction of tumors results in the release of tumor antigens that can stimulate an immune response, which has led to the investigation of combining interventional oncology treatments with immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Laurent Dercle, Jeremy McGale, Shawn Sun, Aurelien Marabelle, Randy Yeh, Eric Deutsch, Fatima-Zohra Mokrane, Michael Farwell, Samy Ammari, Heiko Schoder, Binsheng Zhao, Lawrence H. Schwartz
Summary: Immunotherapy and radiomics have great potential in the management of cancer patients, but methodological issues in the literature limit their clinical application. Studies have found that radiomics signatures have higher predictive performance for treatment response and tumor phenotype.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Cell Biology
Jing Zhu, Tailang Yin, Yong Xu, Xiao-Jie Lu
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Review
Cell Biology
Jin-Yu Sun, Tailang Yin, Xiao-Yu Zhang, Xiao-Jie Lu
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Genetics & Heredity
An-Liang Xia, Yong Xu, Xiao-Jie Lu
JOURNAL OF MEDICAL GENETICS
(2019)
Review
Cell Biology
Jin-Yu Sun, Tai-Lang Yin, Jianhua Zhou, Jiang Xu, Xiao-Jie Lu
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Cell Biology
Dong Ji, Guo-Feng Chen, Jin-Cheng Wang, Si-Han Ji, Xue-Wen Wu, Xiao-Jie Lu, Jin-Lian Chen, Jing-Tao Li
Editorial Material
Oncology
Xiao-Jie Lu
Review
Oncology
Jin-Yu Sun, Dengke Zhang, Songquan Wu, Min Xu, Xiao Zhou, Xiao-Jie Lu, Jiansong Ji
BIOMARKER RESEARCH
(2020)
Article
Oncology
Xiao-Jie Lu, Xiao-Jun Yang, Jing-Yu Sun, Xin Zhang, Zhao-Xin Yuan, Xiu-Hui Li
BIOMARKER RESEARCH
(2020)
Editorial Material
Genetics & Heredity
Xiaoling Weng, Xiao-Jie Lu
Article
Cell Biology
Jianfei Tu, Weiqian Chen, Liyun Zheng, Shiji Fang, Dengke Zhang, Chunli Kong, Yang Yang, Rongfang Qiu, Zhongwei Zhao, Chenying Lu, Xiaojie Lu, Jiansong Ji
Summary: The study revealed that circ_0021205 was up-regulated in CCA and positively correlated with tumor size and TNM stage. It promoted the proliferation, migration, and invasion of CCA cells by sponging miR-204-5p and regulating the expression of RAB22A, serving as a potential diagnostic biomarker or therapeutic target for CCA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Jin-Yu Sun, Rui Wu, Jiang Xu, Hui-Ying Xue, Xiao-Jie Lu, Jiansong Ji
Summary: The immune system plays a crucial role in recognizing and attacking non-self antigens, leading to immunity against infection. However, it also causes immune rejection during organ transplantation. Understanding the mechanisms of maternal-fetal immune tolerance can potentially improve transplantation outcomes by balancing immune tolerance and infection defense. Studies exploring the interconnection between immune tolerance in pregnancy and organ transplantation highlight the impact of pregnancy alloimmunization on transplant success.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Cell Biology
Xiaoling Weng, Xiao-Jie Lu
CELLULAR SIGNALLING
(2021)
Article
Cell Biology
Xiaochen Wang, Jianchu Wang, Haiyuan Shen, Zongjiang Luo, Xiaojie Lu
Summary: This study found that TPX2 regulates the antitumor effect of CD8 + T cells in hepatocellular carcinoma (HCC) by modulating CXCR5. Overexpression of TPX2 enhances the anticancer function of CD8 + T cells and shows synergistic effects with anti-PD-1 therapy.
CELL DEATH & DISEASE
(2022)
Review
Oncology
David Prince, Ken Liu, Weiqi Xu, Minjiang Chen, Jin-Yu Sun, Xiao-Jie Lu, Jiansong Ji
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2020)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
