Siglec-7 engagement by GBS β-protein suppresses pyroptotic cell death of natural killer cells

Viewing Siglecs through the lens of tumor immunology

(2017) Isabella Fraschilla et al.   IMMUNOLOGICAL REVIEWS

Host Immune Responses in HIV-1 Infection: The Emerging Pathogenic Role of Siglecs and Their Clinical Correlates

(2017) Joanna Mikulak et al.   Frontiers in Immunology

Targeting natural killer cells in cancer immunotherapy

(2016) Camille Guillerey et al.   NATURE IMMUNOLOGY

Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites

(2016) Farokh Dotiwala et al.   NATURE MEDICINE

Precision glycocalyx editing as a strategy for cancer immunotherapy

(2016) Han Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Siglec-7 Defines a Highly Functional Natural Killer Cell Subset and Inhibits Cell-Mediated Activities

(2016) J.-Y. Shao et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Neutrophils Directly Recognize Group B Streptococci and Contribute to Interleukin-1β Production during Infection

(2016) Nastaran Mohammadi et al.   PLoS One

Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14

(2015) J. J. Fong et al.   EMBO JOURNAL

A streptococcal lipid toxin induces membrane permeabilization and pyroptosis leading to fetal injury

(2015) C. Whidbey et al.   EMBO Molecular Medicine

Host and pathogen hyaluronan signal through human siglec-9 to suppress neutrophil activation

(2015) Ismael Secundino et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Siglec receptors impact mammalian lifespan by modulating oxidative stress

(2015) Flavio Schwarz et al.   eLife

NKG2D Receptor and Its Ligands in Host Defense

(2015) L. L. Lanier   Cancer Immunology Research

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

RNA and β-Hemolysin of Group BStreptococcusInduce Interleukin-1β (IL-1β) by Activating NLRP3 Inflammasomes in Mouse Macrophages

(2014) Rahul Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions between Siglec-7/9 receptors and ligands influence NK cell–dependent tumor immunosurveillance

(2014) Camilla Jandus et al.   JOURNAL OF CLINICAL INVESTIGATION

Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group BStreptococcus

(2014) Syed Raza Ali et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1

(2014) Guo-Yun Chen et al.   eLife

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion

(2013) Jason E Hudak et al.   Nature Chemical Biology

The Yersinia Virulence Effector YopM Binds Caspase-1 to Arrest Inflammasome Assembly and Processing

(2012) Christopher N. LaRock et al.   Cell Host & Microbe

Activation of the NLRP3 Inflammasome by Group B Streptococci

(2012) A. Costa et al.   JOURNAL OF IMMUNOLOGY

Inhibitory Receptor Paired Ig-like Receptor B Is Exploited by Staphylococcus aureus for Virulence

(2012) M. Nakayama et al.   JOURNAL OF IMMUNOLOGY

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(2012) Fernando Souza-Fonseca-Guimaraes et al.   MOLECULAR MEDICINE

CEACAM1 Negatively Regulates IL-1β Production in LPS Activated Neutrophils by Recruiting SHP-1 to a SYK-TLR4-CEACAM1 Complex

(2012) Rongze Lu et al.   PLoS Pathogens

Letter to the Glyco-Forum: Since there are PAMPs and DAMPs, there must be SAMPs? Glycan "self-associated molecular patterns" dampen innate immunity, but pathogens can mimic them

(2011) A. Varki   GLYCOBIOLOGY

Human Siglec-5 Inhibitory Receptor and Immunoglobulin A (IgA) Have Separate Binding Sites in Streptococcal β Protein

(2011) Therése Nordström et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria

(2011) Yuki Kinjo et al.   NATURE IMMUNOLOGY

Ganglioside DSGb5, preferred ligand for Siglec-7, inhibits NK cell cytotoxicity against renal cell carcinoma cells

(2010) Y. Kawasaki et al.   GLYCOBIOLOGY

Activating and inhibitory receptors of natural killer cells

(2010) Hollie J Pegram et al.   IMMUNOLOGY AND CELL BIOLOGY

Activation of cytokine-producing and antitumor activities of natural killer cells and macrophages by engagement of Toll-like and NOD-like receptors

(2010) Fu Qiu et al.   Innate Immunity

Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response

(2009) A. F. Carlin et al.   BLOOD

Group BStreptococcussuppression of phagocyte functions by protein-mediated engagement of human Siglec-5

(2009) Aaron F. Carlin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY