Microglia, synaptic dynamics and forgetting

Preservation of a remote fear memory requires new myelin formation

(2020) Simon Pan et al.   NATURE NEUROSCIENCE

Microglia mediate forgetting via complement-dependent synaptic elimination

(2020) Chao Wang et al.   SCIENCE

Memory engrams: Recalling the past and imagining the future

(2020) Sheena A. Josselyn et al.   SCIENCE

Novel Ocellatin Peptides Mitigate LPS-induced ROS Formation and NF-kB Activation in Microglia and Hippocampal Neurons

(2020) Nayara A. Sousa et al.   Scientific Reports

Molecular mechanisms of forgetting

(2020) Andrea Moreno   EUROPEAN JOURNAL OF NEUROSCIENCE

Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity

(2020) Phi T. Nguyen et al.   CELL

The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development

(2020) Qifei Cong et al.   NATURE NEUROSCIENCE

Astrocytes contribute to remote memory formation by modulating hippocampal–cortical communication during learning

(2020) Adi Kol et al.   NATURE NEUROSCIENCE

Sensory Experience Engages Microglia to Shape Neural Connectivity through a Non-Phagocytic Mechanism

(2020) Lucas Cheadle et al.   NEURON

Light-induced engagement of microglia to focally remodel synapses in the adult brain

(2020) Carla Cangalaya et al.   eLife

Neuroprotective versus Neuroinflammatory Roles of Complement: From Development to Disease

(2020) Marlene Kanmogne et al.   TRENDS IN NEUROSCIENCES

Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer’s Disease Model

(2019) Mario Merlini et al.   NEURON

Neuron-Glia Signaling in Synapse Elimination

(2019) Daniel K. Wilton et al.   Annual Review of Neuroscience

T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses

(2019) Charise Garber et al.   NATURE NEUROSCIENCE

Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling

(2019) Georgia Gunner et al.   NATURE NEUROSCIENCE

Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain

(2019) Li-Jun Zhou et al.   Cell Reports

Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling

(2019) Yong U. Liu et al.   NATURE NEUROSCIENCE

Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex

(2019) Rianne D. Stowell et al.   NATURE NEUROSCIENCE

Disruption of Oligodendrogenesis Impairs Memory Consolidation in Adult Mice

(2019) Patrick E. Steadman et al.   NEURON

Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice

(2019) Claudia P. Figueiredo et al.   Nature Communications

Microglial Pruning of Synapses in the Prefrontal Cortex During Adolescence

(2018) Allyson P Mallya et al.   CEREBRAL CORTEX

Memory formation depends on both synapse-specific modifications of synaptic strength and cell-specific increases in excitability

(2018) John Lisman et al.   NATURE NEUROSCIENCE

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics

(2018) Mark A. Petersen et al.   NATURE REVIEWS NEUROSCIENCE

Sociability and synapse subtype-specific defects in mice lacking SRPX2, a language-associated gene

(2018) Breeanne M. Soteros et al.   PLoS One

Local apoptotic-like mechanisms underlie complement-mediated synaptic pruning

(2018) Balázs A. Györffy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synapse-specific representation of the identity of overlapping memory engrams

(2018) Kareem Abdou et al.   SCIENCE

Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development

(2018) Ilia D. Vainchtein et al.   SCIENCE

Microglia play an active role in obesity-associated cognitive decline

(2018) Elise C. Cope et al.   JOURNAL OF NEUROSCIENCE

Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice

(2018) Monica R. P. Elmore et al.   AGING CELL

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

(2018) Borislav Dejanovic et al.   NEURON

Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease

(2018) Alexandra Litvinchuk et al.   NEURON

CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development

(2018) Emily K. Lehrman et al.   NEURON

Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting

(2018) Ankit Awasthi et al.   SCIENCE

Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity

(2017) Eva Czirr et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibiting the microglia activation improves the spatial memory and adult neurogenesis in rat hippocampus during 48 h of sleep deprivation

(2017) Meetu Wadhwa et al.   Journal of Neuroinflammation

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

The Biology of Forgetting—A Perspective

(2017) Ronald L. Davis et al.   NEURON

Criteria for identifying the molecular basis of the engram (CaMKII, PKMzeta)

(2017) John Lisman   Molecular Brain

Dynamic microglial modulation of spatial learning and social behavior

(2016) Luisa Torres et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia regulate hippocampal neurogenesis during chronic neurodegeneration

(2016) Chiara De Lucia et al.   BRAIN BEHAVIOR AND IMMUNITY

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

(2016) Hansen Lui et al.   CELL

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Microglia engulf viable newborn cells in the epileptic dentate gyrus

(2016) Cong Luo et al.   GLIA

Blocking Synaptic Removal of GluA2-Containing AMPA Receptors Prevents the Natural Forgetting of Long-Term Memories

(2016) P. V. Migues et al.   JOURNAL OF NEUROSCIENCE

TNF-α Differentially Regulates Synaptic Plasticity in the Hippocampus and Spinal Cord by Microglia-Dependent Mechanisms after Peripheral Nerve Injury

(2016) Yong Liu et al.   JOURNAL OF NEUROSCIENCE

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

(2016) H. Lian et al.   JOURNAL OF NEUROSCIENCE

A complement–microglial axis drives synapse loss during virus-induced memory impairment

(2016) Michael J. Vasek et al.   NATURE

IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline

(2016) Amy K. Y. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Complement C1q-C3-associated synaptic changes in multiple sclerosis hippocampus

(2015) Iliana Michailidou et al.   ANNALS OF NEUROLOGY

Interleukin-33 ameliorates ischemic brain injury in experimental stroke through promoting Th2 response and suppressing Th17 response

(2015) Yi Luo et al.   BRAIN RESEARCH

Memory engram storage and retrieval

(2015) Susumu Tonegawa et al.   CURRENT OPINION IN NEUROBIOLOGY

C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   IMMUNITY

Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice

(2015) Nabil N. Dagher et al.   Journal of Neuroinflammation

Microglial Activation Enhances Associative Taste Memory through Purinergic Modulation of Glutamatergic Neurotransmission

(2015) J.-C. Delpech et al.   JOURNAL OF NEUROSCIENCE

Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline

(2015) Q. Shi et al.   JOURNAL OF NEUROSCIENCE

Microglia-Dependent Alteration of Glutamatergic Synaptic Transmission and Plasticity in the Hippocampus during Peripheral Inflammation

(2015) K. Riazi et al.   JOURNAL OF NEUROSCIENCE

Labelling and optical erasure of synaptic memory traces in the motor cortex

(2015) Akiko Hayashi-Takagi et al.   NATURE

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Finding the engram

(2015) Sheena A. Josselyn et al.   NATURE REVIEWS NEUROSCIENCE

The Glia-Derived Alarmin IL-33 Orchestrates the Immune Response and Promotes Recovery following CNS Injury

(2015) Sachin P. Gadani et al.   NEURON

Microglia activation regulates GluR1 phosphorylation in chronic unpredictable stress-induced cognitive dysfunction

(2015) Mingchao Liu et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Microglia: Dynamic Mediators of Synapse Development and Plasticity

(2015) Yuwen Wu et al.   TRENDS IN IMMUNOLOGY

Microglia and their CX3CR1 signaling are involved in hippocampal- but not olfactory bulb-related memory and neurogenesis

(2014) Ronen Reshef et al.   BRAIN BEHAVIOR AND IMMUNITY

Long-term potentiation decay and memory loss are mediated by AMPAR endocytosis

(2014) Zhifang Dong et al.   JOURNAL OF CLINICAL INVESTIGATION

Local Pruning of Dendrites and Spines by Caspase-3-Dependent and Proteasome-Limited Mechanisms

(2014) A. Erturk et al.   JOURNAL OF NEUROSCIENCE

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Engineering a memory with LTD and LTP

(2014) Sadegh Nabavi et al.   NATURE

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

(2014) Yang Zhan et al.   NATURE NEUROSCIENCE

Microglial CR3 Activation Triggers Long-Term Synaptic Depression in the Hippocampus via NADPH Oxidase

(2014) Jingfei Zhang et al.   NEURON

Cortical Representations Are Reinstated by the Hippocampus during Memory Retrieval

(2014) Kazumasa Z. Tanaka et al.   NEURON

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy

(2014) K. G. Akers et al.   SCIENCE

Activation of microglia bolsters synapse formation

(2014) Gonçalo Cristovão et al.   Frontiers in Cellular Neuroscience

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Adaptive phenotype of microglial cells during the normal postnatal development of the somatosensory “Barrel” cortex

(2013) Isabelle Arnoux et al.   GLIA

A Dramatic Increase of C1q Protein in the CNS during Normal Aging

(2013) A. H. Stephan et al.   JOURNAL OF NEUROSCIENCE

TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement

(2013) Allison R Bialas et al.   NATURE NEUROSCIENCE

Microglia: New Roles for the Synaptic Stripper

(2013) Helmut Kettenmann et al.   NEURON

The Dynamic Synapse

(2013) Daniel Choquet et al.   NEURON

Neuronal Synapse Formation Induced by Microglia and Interleukin 10

(2013) So-Hee Lim et al.   PLoS One

The Human Language-Associated Gene SRPX2 Regulates Synapse Formation and Vocalization in Mice

(2013) G. M. Sia et al.   SCIENCE

Decay happens: the role of active forgetting in memory

(2013) Oliver Hardt et al.   TRENDS IN COGNITIVE SCIENCES

Activated microglia mediate synapse loss and short-term memory deficits in a mouse model of transthyretin-related oculoleptomeningeal amyloidosis

(2013) E P Azevedo et al.   Cell Death & Disease

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages

(2012) Guillaume Hoeffel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Deficiency of the Microglial Receptor CX3CR1 Impairs Postnatal Functional Development of Thalamocortical Synapses in the Barrel Cortex

(2012) M. Hoshiko et al.   JOURNAL OF NEUROSCIENCE

Optogenetic stimulation of a hippocampal engram activates fear memory recall

(2012) Xu Liu et al.   NATURE

Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology

(2012) Bradley T. Hyman et al.   NATURE REVIEWS NEUROSCIENCE

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Synapses and Memory Storage

(2012) M. Mayford et al.   Cold Spring Harbor Perspectives in Biology

Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases

(2011) Joshua A. Smith et al.   BRAIN RESEARCH BULLETIN

The Role of Microglia in the Healthy Brain

(2011) M.-E. Tremblay et al.   JOURNAL OF NEUROSCIENCE

Microglia and Memory: Modulation by Early-Life Infection

(2011) L. L. Williamson et al.   JOURNAL OF NEUROSCIENCE

CX3CR1 Deficiency Leads to Impairment of Hippocampal Cognitive Function and Synaptic Plasticity

(2011) J. T. Rogers et al.   JOURNAL OF NEUROSCIENCE

Complement in the brain

(2011) Robert Veerhuis et al.   MOLECULAR IMMUNOLOGY

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

(2011) Guo-li Ming et al.   NEURON

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

(2010) Amanda Sierra et al.   Cell Stem Cell

Suppression of the Intrinsic Apoptosis Pathway by Synaptic Activity

(2010) F. Leveille et al.   JOURNAL OF NEUROSCIENCE

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

Activation and deactivation of periventricular white matter phagocytes during postnatal mouse development

(2009) Mariya Hristova et al.   GLIA

Stably maintained dendritic spines are associated with lifelong memories

(2009) Guang Yang et al.   NATURE

CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala

(2009) Yu Zhou et al.   NATURE NEUROSCIENCE

Selective Erasure of a Fear Memory

(2009) J.-H. Han et al.   SCIENCE

C1q: the perfect complement for a synaptic feast?

(2008) V. Hugh Perry et al.   NATURE REVIEWS NEUROSCIENCE