Modulation of macrophage functions by ECM-inspired wound dressings – a promising therapeutic approach for chronic wounds

Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity

(2021) Sophia Hauck et al.   Bioactive Materials

3D Extracellular Matrix Mimics: Fundamental Concepts and Role of Materials Chemistry to Influence Stem Cell Fate

(2020) Julien Nicolas et al.   BIOMACROMOLECULES

Transcriptomic Analysis of Monocyte-Derived Non-Phagocytic Macrophages Favors a Role in Limiting Tissue Repair and Fibrosis

(2020) Sergei Butenko et al.   Frontiers in Immunology

Soft extracellular matrix enhances inflammatory activation of mesenchymal stromal cells to induce monocyte production and trafficking

(2020) Sing Wan Wong et al.   Science Advances

Mesenchymal Stem Cells Adaptively Respond to Environmental Cues Thereby Improving Granulation Tissue Formation and Wound Healing

(2020) Dongsheng Jiang et al.   Frontiers in Cell and Developmental Biology

Single-cell RNA sequencing uncovers heterogenous transcriptional signatures in macrophages during efferocytosis

(2020) Connor Lantz et al.   Scientific Reports

Enhanced Proliferation of Ly6C+ Monocytes/Macrophages Contributes to Chronic Inflammation in Skin Wounds of Diabetic Mice

(2020) Jingbo Pang et al.   JOURNAL OF IMMUNOLOGY

Extracellular matrix-based biomaterials as adipose-derived stem cell delivery vehicles in wound healing: a comparative study between a collagen scaffold and two xenografts

(2020) Héctor Capella-Monsonís et al.   Stem Cell Research & Therapy

Neutrophils and Macrophages as Targets for Development of Nanotherapeutics in Inflammatory Diseases

(2020) Yujie Su et al.   Pharmaceutics

Airway macrophages as the guardians of tissue repair in the lung

(2019) Franz Puttur et al.   IMMUNOLOGY AND CELL BIOLOGY

Hyaluronan/collagen hydrogel matrices containing high-sulfated hyaluronan microgels for regulating transforming growth factor-β1

(2019) Sandra Rother et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Newly Defined ATP-binding cassette subfamily B member 5 Positive Dermal Mesenchymal Stem Cells Promote Healing of Chronic Iron-Overload Wounds via Secretion of Interleukin-1 Receptor Antagonist

(2019) Seppe Vander Beken et al.   STEM CELLS

A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves

(2019) Julia Kolter et al.   IMMUNITY

Diabetes induces myeloid bias in bone marrow progenitors associated with enhanced wound macrophage accumulation and impaired healing

(2019) Pijus K. Barman et al.   JOURNAL OF PATHOLOGY

Extracellular Matrix-Based Biomaterials and Their Influence Upon Cell Behavior

(2019) Madeline C. Cramer et al.   ANNALS OF BIOMEDICAL ENGINEERING

Glycosaminoglycan-based biomaterials for growth factor and cytokine delivery: Making the right choices

(2019) Daniel Hachim et al.   JOURNAL OF CONTROLLED RELEASE

Modulation of macrophage phenotype and protein secretion via heparin-IL-4 functionalized supramolecular elastomers

(2018) V. Bonito et al.   Acta Biomaterialia

Local Administration of Interleukin-1 Receptor Antagonist Improves Diabetic Wound Healing

(2018) David P. Perrault et al.   ANNALS OF PLASTIC SURGERY

Ly6CHiBlood Monocyte/Macrophage Drive Chronic Inflammation and Impair Wound Healing in Diabetes MellitusHighlights

(2018) Andrew Kimball et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine AtherosclerosisNovelty and Significance

(2018) Clément Cochain et al.   CIRCULATION RESEARCH

Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression

(2018) David B Gurevich et al.   EMBO JOURNAL

Myeloid Cell–Restricted STAT3 Signaling Controls a Cell-Autonomous Antifibrotic Repair Program

(2018) Nhu-Nguyen Do et al.   JOURNAL OF IMMUNOLOGY

The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication

(2018) Pardis Pakshir et al.   MATRIX BIOLOGY

Stabilized collagen matrix dressing improves wound macrophage function and epithelialization

(2018) Mohamed S. El Masry et al.   FASEB JOURNAL

Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen

(2018) Hwee Ying Lim et al.   IMMUNITY

Impaired wound healing in type 1 diabetes is dependent on 5-lipoxygenase products

(2018) Theresa Ramalho et al.   Scientific Reports

Transcriptional and functional diversity of human macrophage repolarization

(2018) Sina A. Gharib et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair

(2018) Brett A. Shook et al.   SCIENCE

Chronic venous insufficiency - a review of pathophysiology, diagnosis, and treatment

(2017) Bettina Santler et al.   JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT

Dermal Fibroblasts Promote Alternative Macrophage Activation Improving Impaired Wound Healing

(2017) Rubén A. Ferrer et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Physiological roles of macrophages

(2017) Siamon Gordon et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Sulfated hyaluronan attenuates inflammatory signaling pathways in macrophages involving induction of antioxidants

(2017) Florent Jouy et al.   PROTEOMICS

Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice

(2017) Nadine Lohmann et al.   Science Translational Medicine

Tissue-specific contribution of macrophages to wound healing

(2017) Carlos M. Minutti et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Instructing Human Macrophage Polarization by Stiffness and Glycosaminoglycan Functionalization in 3D Collagen Networks

(2017) Markus Friedemann et al.   Advanced Healthcare Materials

Notch Regulates Macrophage-Mediated Inflammation in Diabetic Wound Healing

(2017) Andrew S. Kimball et al.   Frontiers in Immunology

Glycosaminoglycan-Based Biohybrid Hydrogels: A Sweet and Smart Choice for Multifunctional Biomaterials

(2016) Uwe Freudenberg et al.   ADVANCED MATERIALS

Spatially localized recruitment of anti-inflammatory monocytes by SDF-1α-releasing hydrogels enhances microvascular network remodeling

(2016) J.R. Krieger et al.   BIOMATERIALS

Transition from inflammation to proliferation: a critical step during wound healing

(2016) Ning Xu Landén et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tissue-Resident Macrophage Ontogeny and Homeostasis

(2016) Florent Ginhoux et al.   IMMUNITY

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

Delivery strategies to control inflammatory response: Modulating M1–M2 polarization in tissue engineering applications

(2016) Mario Moisés Alvarez et al.   JOURNAL OF CONTROLLED RELEASE

CD301b+ Macrophages Are Essential for Effective Skin Wound Healing

(2016) Brett Shook et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

IL4 induces IL6-producing M2 macrophages associated to inhibition of neuroinflammation in vitro and in vivo

(2016) Giacomo Casella et al.   Journal of Neuroinflammation

Tissue biology perspective on macrophages

(2016) Yasutaka Okabe et al.   NATURE IMMUNOLOGY

Response of human macrophages to wound matrices in vitro

(2016) Claire E. Witherel et al.   WOUND REPAIR AND REGENERATION

StarPEG-Heparin Hydrogels to Protect and Sustainably Deliver IL-4

(2016) Lucas Schirmer et al.   Advanced Healthcare Materials

Controlled Release of Interleukin-1 Receptor Antagonist from Hyaluronic Acid-Chitosan Microspheres Attenuates Interleukin-1β-Induced Inflammation and Apoptosis in Chondrocytes

(2016) Bo Qiu et al.   Biomed Research International

Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair

(2016) Olga Barreiro et al.   eLife

The role of myofibroblasts in wound healing

(2016) B. Hinz   Current Research in Translational Medicine

TGFβ functionalized starPEG-heparin hydrogels modulate human dermal fibroblast growth and differentiation

(2015) Akira Watarai et al.   Acta Biomaterialia

Multilayer hydrogel coatings to combine hemocompatibility and antimicrobial activity

(2015) Marion Fischer et al.   BIOMATERIALS

Suppressed recruitment of alternatively activated macrophages reduces TGF-β1 and impairs wound healing in streptozotocin-induced diabetic mice

(2015) Shin-ichiro Okizaki et al.   BIOMEDICINE & PHARMACOTHERAPY

Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair

(2015) Johanna A. Knipper et al.   IMMUNITY

Heparin desulfation modulates VEGF release and angiogenesis in diabetic wounds

(2015) Uwe Freudenberg et al.   JOURNAL OF CONTROLLED RELEASE

Glycosaminoglycan derivatives: promising candidates for the design of functional biomaterials

(2015) Dieter Scharnweber et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Macrophage PPARγ and impaired wound healing in type 2 diabetes

(2015) Rita E Mirza et al.   JOURNAL OF PATHOLOGY

SDF-1 liposomes promote sustained cell proliferation in mouse diabetic wounds

(2015) Melissa A. Przyborowski Olekson et al.   WOUND REPAIR AND REGENERATION

Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer

(2015) Suniti Misra et al.   Frontiers in Immunology

The Use of Biologic Scaffolds in the Treatment of Chronic Nonhealing Wounds

(2015) Neill J. Turner et al.   Advances in Wound Care

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

Epigenetic Changes in Bone Marrow Progenitor Cells Influence the Inflammatory Phenotype and Alter Wound Healing in Type 2 Diabetes

(2014) Katherine A. Gallagher et al.   DIABETES

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Understanding macrophage diversity at the ontogenic and transcriptomic levels

(2014) Emmanuel L. Gautier et al.   IMMUNOLOGICAL REVIEWS

Progressive replacement of embryo-derived cardiac macrophages with age

(2014) Kaaweh Molawi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Biology of the Extracellular Matrix

(2014) Beatrice Yue   JOURNAL OF GLAUCOMA

Engulfment of Apoptotic Cells by Macrophages: A Role of MicroRNA-21 in the Resolution of Wound Inflammation

(2014) A. Das et al.   JOURNAL OF IMMUNOLOGY

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice

(2014) Calum C Bain et al.   NATURE IMMUNOLOGY

Wound repair and regeneration: Mechanisms, signaling, and translation

(2014) S. A. Eming et al.   Science Translational Medicine

Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells

(2014) Kanakadurga Singer et al.   Molecular Metabolism

Phenotypic Transitions of Macrophages Orchestrate Tissue Repair

(2013) Margaret L. Novak et al.   AMERICAN JOURNAL OF PATHOLOGY

Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice

(2013) R. E. Mirza et al.   DIABETES

Blocking Interleukin-1  Induces a Healing-Associated Wound Macrophage Phenotype and Improves Healing in Type 2 Diabetes

(2013) R. E. Mirza et al.   DIABETES

Diabetes induces stable intrinsic changes to myeloid cells that contribute to chronic inflammation during wound healing in mice

(2013) P. Bannon et al.   Disease Models & Mechanisms

Biological therapies for the treatment of cutaneous wounds: Phase III and launched therapies

(2013) Robert C Rennert et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Origins and Functional Specialization of Macrophages and of Conventional and Monocyte-Derived Dendritic Cells in Mouse Skin

(2013) Samira Tamoutounour et al.   IMMUNITY

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

TSG-6 Released from Intradermally Injected Mesenchymal Stem Cells Accelerates Wound Healing and Reduces Tissue Fibrosis in Murine Full-Thickness Skin Wounds

(2013) Yu Qi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Perivascular macrophages mediate neutrophil recruitment during bacterial skin infection

(2013) Arby Abtin et al.   NATURE IMMUNOLOGY

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

Proteome analysis reveals antiangiogenic environments in chronic wounds of diabetes mellitus type 2 patients

(2013) Christoph Krisp et al.   PROTEOMICS

Artificial extracellular matrices composed of collagen I and high-sulfated hyaluronan promote phenotypic and functional modulation of human pro-inflammatory M1 macrophages

(2012) Sandra Franz et al.   Acta Biomaterialia

CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair

(2012) S. Willenborg et al.   BLOOD

TGFβ signaling plays a critical role in promoting alternative macrophage activation

(2012) Dapeng Gong et al.   BMC IMMUNOLOGY

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

Biomaterials that Regulate Growth Factor Activity via Bioinspired Interactions

(2011) Gregory A. Hudalla et al.   ADVANCED FUNCTIONAL MATERIALS

Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF- B signaling in resident macrophages

(2011) H. Choi et al.   BLOOD

Dysregulation of monocyte/macrophage phenotype in wounds of diabetic mice

(2011) Rita Mirza et al.   CYTOKINE

An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice

(2011) Anca Sindrilaru et al.   JOURNAL OF CLINICAL INVESTIGATION

Therapeutic siRNA silencing in inflammatory monocytes in mice

(2011) Florian Leuschner et al.   NATURE BIOTECHNOLOGY

Novel Sulfated Polysaccharides Disrupt Cathelicidins, Inhibit RAGE and Reduce Cutaneous Inflammation in a Mouse Model of Rosacea

(2011) Jianxing Zhang et al.   PLoS One

Skin Iron Deposition Characterises Lipodermatosclerosis and Leg Ulcer

(2010) A. Caggiati et al.   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Differential Roles of Macrophages in Diverse Phases of Skin Repair

(2010) T. Lucas et al.   JOURNAL OF IMMUNOLOGY

Macrophage Dysfunction Impairs Resolution of Inflammation in the Wounds of Diabetic Mice

(2010) Savita Khanna et al.   PLoS One

Selective and Specific Macrophage Ablation Is Detrimental to Wound Healing in Mice

(2009) Rita Mirza et al.   AMERICAN JOURNAL OF PATHOLOGY

A Transgenic Mouse Model of Inducible Macrophage Depletion

(2009) Itamar Goren et al.   AMERICAN JOURNAL OF PATHOLOGY

Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix

(2009) Farshid Guilak et al.   Cell Stem Cell

The phenotype of murine wound macrophages

(2009) Jean M. Daley et al.   JOURNAL OF LEUKOCYTE BIOLOGY

When two is better than one: macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system

(2009) Manuel T. Silva   JOURNAL OF LEUKOCYTE BIOLOGY

Interrelation of immunity and tissue repair or regeneration

(2009) Sabine A. Eming et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Human skin wounds: A major and snowballing threat to public health and the economy

(2009) Chandan K. Sen et al.   WOUND REPAIR AND REGENERATION

Metalloproteinases and their inhibitors: Regulators of wound healing

(2007) S GILL et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY