Airway macrophages as the guardians of tissue repair in the lung

Alveolar Macrophages

(2018) Nikita Joshi et al.   CELLULAR IMMUNOLOGY

Airway microbiota signals anabolic and catabolic remodeling in the transplanted lung

(2018) Stéphane Mouraux et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mer-mediated eosinophil efferocytosis regulates resolution of allergic airway inflammation

(2018) Jennifer M. Felton et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease

(2018) Jodie Birch et al.   PHARMACOLOGY & THERAPEUTICS

The mitochondria in lung fibrosis: friend or foe?

(2018) Elizabeth S. Malsin et al.   Translational Research

Lung Interstitial Macrophages: Past, Present, and Future

(2018) Joey Schyns et al.   Journal of Immunology Research

Roles of Myeloid and Lymphoid Cells in the Pathogenesis of Chronic Obstructive Pulmonary Disease

(2018) Ling Ni et al.   Frontiers in Immunology

The micromechanics of lung alveoli: structure and function of surfactant and tissue components

(2018) Lars Knudsen et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The Cytokine TGF-β Promotes the Development and Homeostasis of Alveolar Macrophages

(2017) Xueyang Yu et al.   IMMUNITY

Human asthma is characterized by more IRF5+ M1 and CD206+ M2 macrophages and less IL-10+ M2-like macrophages around airways compared with healthy airways

(2017) Christina Draijer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

(2017) Alexander V. Misharin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nitric Oxide Modulates Macrophage Responses toMycobacterium tuberculosisInfection through Activation of HIF-1α and Repression of NF-κB

(2017) Jonathan Braverman et al.   JOURNAL OF IMMUNOLOGY

Location, function, and ontogeny of pulmonary macrophages during the steady state

(2017) Natalio Garbi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

(2017) Lidia Bosurgi et al.   SCIENCE

Inflammation and metabolism in tissue repair and regeneration

(2017) Sabine A. Eming et al.   SCIENCE

Specific repair by discerning macrophages

(2017) Tiffany Bouchery et al.   SCIENCE

Local amplifiers of IL-4Rα–mediated macrophage activation promote repair in lung and liver

(2017) Carlos M. Minutti et al.   SCIENCE

Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice

(2017) Wenqian He et al.   Nature Communications

Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology

(2017) Chloe J. Pyle et al.   PLoS Pathogens

Human Lung Mononuclear Phagocytes in Health and Disease

(2017) Faezzah Baharom et al.   Frontiers in Immunology

Macrophage phagocytosis cracking the defect code in COPD

(2017) Jamil Jubrail et al.   Biomedical Journal

Commensal microbiota maintains alveolar macrophages with a low level of CCL24 production to generate anti-metastatic tumor activity

(2017) Min Cheng et al.   Scientific Reports

Classically Activated Macrophages Protect against Lipopolysaccharide-induced Acute Lung Injury by Expressing Amphiregulin in Mice

(2016) Younian Xu et al.   ANESTHESIOLOGY

Advanced Age Alters Monocyte and Macrophage Responses

(2016) Joslyn M. Albright et al.   ANTIOXIDANTS & REDOX SIGNALING

Alveolar macrophage development in mice requires L-plastin for cellular localization in alveoli

(2016) E. M. Todd et al.   BLOOD

Extracellular Matrix Proteolysis by MT1-MMP Contributes to Influenza-Related Tissue Damage and Mortality

(2016) Dalit Talmi-Frank et al.   Cell Host & Microbe

Control of lung defence by mucins and macrophages: ancient defence mechanisms with modern functions

(2016) William J. Janssen et al.   EUROPEAN RESPIRATORY JOURNAL

Bone Marrow CD11c+Cell–Derived Amphiregulin Promotes Pulmonary Fibrosis

(2016) Lin Ding et al.   JOURNAL OF IMMUNOLOGY

A critical role for IRF5 in regulating allergic airway inflammation

(2016) A J Byrne et al.   Mucosal Immunology

The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation

(2016) Aleksander M. Grabiec et al.   Seminars in Immunopathology

Pulmonary Macrophages: A New Therapeutic Pathway in Fibrosing Lung Disease?

(2016) Adam J. Byrne et al.   TRENDS IN MOLECULAR MEDICINE

Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms

(2015) Tamás Rőszer   MEDIATORS OF INFLAMMATION

Accelerated ageing of the lung in COPD: new concepts

(2015) Nicolas Mercado et al.   THORAX

Macrophage and Innate Lymphoid Cell Interplay in the Genesis of Fibrosis

(2015) Emily Hams et al.   Frontiers in Immunology

Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge

(2014) S. A. Mathie et al.   ALLERGY

The Role of Bacteria in the Pathogenesis and Progression of Idiopathic Pulmonary Fibrosis

(2014) Phillip L. Molyneaux et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Targeted Prostaglandin E2 Inhibition Enhances Antiviral Immunity through Induction of Type I Interferon and Apoptosis in Macrophages

(2014) François Coulombe et al.   IMMUNITY

The role of the microbiome in exacerbations of chronic lung diseases

(2014) Robert P Dickson et al.   LANCET

Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity

(2014) Kristin Westphalen et al.   NATURE

Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages

(2014) Christoph Schneider et al.   NATURE IMMUNOLOGY

NLRX1 prevents mitochondrial induced apoptosis and enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein

(2014) J. Jaworska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired innate immune alveolar macrophage response and the predilection for COPD exacerbations

(2014) Charles S Berenson et al.   THORAX

Alveolar Macrophages Are Essential for Protection from Respiratory Failure and Associated Morbidity following Influenza Virus Infection

(2014) Christoph Schneider et al.   PLoS Pathogens

Transcription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function

(2013) Atsushi Nakamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophages in tuberculosis: friend or foe

(2013) Evelyn Guirado et al.   Seminars in Immunopathology

Histamine may induce airway remodeling through release of epidermal growth factor receptor ligands from bronchial epithelial cells

(2012) Nobuaki Hirota et al.   FASEB JOURNAL

An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection

(2012) Fei Chen et al.   NATURE MEDICINE

Ly6ChiMonocytes Direct Alternatively Activated Profibrotic Macrophage Regulation of Lung Fibrosis

(2011) Michael A. Gibbons et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Exudate Macrophages Attenuate Lung Injury by the Release of IL-1 Receptor Antagonist in Gram-negative Pneumonia

(2011) Susanne Herold et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

(2011) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

Disordered Microbial Communities in Asthmatic Airways

(2010) Markus Hilty et al.   PLoS One

Macrophage Tumor Necrosis Factor-α Induces Epithelial Expression of Granulocyte–Macrophage Colony-stimulating Factor

(2009) Lidija Cakarova et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Alveolar macrophages and CC chemokines are increased in children with cystic fibrosis

(2009) S. Brennan et al.   EUROPEAN RESPIRATORY JOURNAL

Smoking-Dependent Reprogramming of Alveolar Macrophage Polarization: Implication for Pathogenesis of Chronic Obstructive Pulmonary Disease

(2009) R. Shaykhiev et al.   JOURNAL OF IMMUNOLOGY

Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand

(2008) Susanne Herold et al.   JOURNAL OF EXPERIMENTAL MEDICINE