Modulation of H3.3 chromatin assembly by PML: A way to regulate epigenetic inheritance

Human subtelomeric DNA methylation: regulation and roles in telomere function

(2020) Shir Toubiana et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Telomere length heterogeneity in ALT cells is maintained by PML-dependent localization of the BTR complex to telomeres

(2020) Taylor K. Loe et al.   GENES & DEVELOPMENT

Genomic Profiling by ALaP-Seq Reveals Transcriptional Regulation by PML Bodies through DNMT3A Exclusion

(2020) Misuzu Kurihara et al.   MOLECULAR CELL

The roles of histone variants in fine-tuning chromatin organization and function

(2020) Sara Martire et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PML nuclear bodies and chromatin dynamics: catch me if you can!

(2020) Armelle Corpet et al.   NUCLEIC ACIDS RESEARCH

The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection

(2019) Steven McFarlane et al.   PLoS Pathogens

Point centromere activity requires an optimal level of centromeric noncoding RNA

(2019) Yick Hin Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The expanding landscape of ‘oncohistone’ mutations in human cancers

(2019) Benjamin A. Nacev et al.   NATURE

PML modulates H3.3 targeting to telomeric and centromeric repeats in mouse fibroblasts

(2019) Jane Spirkoski et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Centromeric non-coding RNA as a hidden epigenetic factor of the point centromere

(2019) Yick Hin Ling et al.   CURRENT GENETICS

The HIRA histone chaperone complex subunit UBN1 harbors H3/H4 and DNA binding activity

(2019) M. Daniel Ricketts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting PML in triple negative breast cancer elicits growth suppression and senescence

(2019) Leire Arreal et al.   CELL DEATH AND DIFFERENTIATION

Functional crosstalk between the Fanconi anemia and ATRX/DAXX histone chaperone pathways promotes replication fork recovery

(2019) Maya Raghunandan et al.   HUMAN MOLECULAR GENETICS

PML nuclear bodies: from architecture to function

(2018) Valérie Lallemand-Breitenbach et al.   CURRENT OPINION IN CELL BIOLOGY

Rpp29 regulates histone H3.3 chromatin assembly through transcriptional mechanisms

(2018) Prashanth Krishna Shastrula et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The functional roles of PML nuclear bodies in genome maintenance

(2018) Hae Ryung Chang et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

PML nuclear bodies, membrane-less domains acting as ROS sensors?

(2018) Michiko Niwa-Kawakita et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Replication-Coupled Nucleosome Assembly in the Passage of Epigenetic Information and Cell Identity

(2018) Albert Serra-Cardona et al.   TRENDS IN BIOCHEMICAL SCIENCES

PML: Regulation and multifaceted function beyond tumor suppression

(2018) Kuo-Sheng Hsu et al.   Cell and Bioscience

H3–H4 Histone Chaperone Pathways

(2018) Prerna Grover et al.   Annual Review of Genetics

Promyelocytic leukemia (PML) nuclear bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone Axis

(2018) Camille Cohen et al.   PLoS Pathogens

ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress

(2018) Joseph M Cabral et al.   eLife

PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX

(2017) Erwan Delbarre et al.   GENOME RESEARCH

Variants of core histones and their roles in cell fate decisions, development and cancer

(2017) Marcus Buschbeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity

(2017) Taranjit Singh Rai et al.   NUCLEIC ACIDS RESEARCH

Roles of RNase P and Its Subunits

(2017) Nayef Jarrous   TRENDS IN GENETICS

CENP-B protects centromere chromatin integrity by facilitating histone deposition via the H3.3-specific chaperone Daxx

(2017) Viacheslav M. Morozov et al.   Epigenetics & Chromatin

Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX

(2017) Dominik Hoelper et al.   Nature Communications

ATRX and DAXX: Mechanisms and Mutations

(2017) Michael A. Dyer et al.   Cold Spring Harbor Perspectives in Medicine

RNase P protein subunit Rpp29 represses histone H3.3 nucleosome deposition

(2016) Alyshia Newhart et al.   MOLECULAR BIOLOGY OF THE CELL

Histone variants on the move: substrates for chromatin dynamics

(2016) Paul B. Talbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

New players in heterochromatin silencing: histone variant H3.3 and the ATRX/DAXX chaperone

(2016) Hsiao P.J. Voon et al.   NUCLEIC ACIDS RESEARCH

Stalled replication forks within heterochromatin require ATRX for protection

(2016) M S Huh et al.   Cell Death & Disease

ATRX immunostaining predicts IDH and H3F3A status in gliomas

(2016) Azadeh Ebrahimi et al.   Acta Neuropathologica Communications

Switch telomerase to ALT mechanism by inducing telomeric DNA damages and dysfunction of ATRX and DAXX

(2016) Yang Hu et al.   Scientific Reports

Reading between the Lines: “ADD”-ing Histone and DNA Methylation Marks toward a New Epigenetic “Sum”

(2015) Kyung-Min Noh et al.   ACS Chemical Biology

The Daxx/Atrx Complex Protects Tandem Repetitive Elements during DNA Hypomethylation by Promoting H3K9 Trimethylation

(2015) Quanyuan He et al.   Cell Stem Cell

Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells

(2015) Simon J. Elsässer et al.   NATURE

Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors

(2015) R. L. Flynn et al.   SCIENCE

Constitutive heterochromatin formation and transcription in mammals

(2015) Nehmé Saksouk et al.   Epigenetics & Chromatin

Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX

(2015) David Clynes et al.   Nature Communications

ATRX represses alternative lengthening of telomeres

(2015) Christine E. Napier et al.   Oncotarget

The function, regulation and therapeutic implications of the tumor suppressor protein, PML

(2015) Dongyin Guan et al.   Cell and Bioscience

The maternal nucleolus plays a key role in centromere satellite maintenance during the oocyte to embryo transition

(2014) H. Fulka et al.   DEVELOPMENT

HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia

(2014) Taranjit Singh Rai et al.   GENES & DEVELOPMENT

The PML-associated protein DEK regulates the balance of H3.3 loading on chromatin and is important for telomere integrity

(2014) Kristina Ivanauskiene et al.   GENOME RESEARCH

Oxidative stress–induced assembly of PML nuclear bodies controls sumoylation of partner proteins

(2014) Umut Sahin et al.   JOURNAL OF CELL BIOLOGY

Altered global histone-trimethylation code and H3F3A-ATRX mutation in pediatric GBM

(2014) Pankaj Pathak et al.   JOURNAL OF NEURO-ONCOLOGY

Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1

(2014) Roderick J O'Sullivan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin

(2014) Harikleia Episkopou et al.   NUCLEIC ACIDS RESEARCH

ATRX Dysfunction Induces Replication Defects in Primary Mouse Cells

(2014) David Clynes et al.   PLoS One

The PML domain of PML-RAR  blocks senescence to promote leukemia

(2014) K. Korf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone H3.3 and its proteolytically processed form drive a cellular senescence programme

(2014) Luis F. Duarte et al.   Nature Communications

Hira-Dependent Histone H3.3 Deposition Facilitates PRC2 Recruitment at Developmental Loci in ES Cells

(2013) Laura A. Banaszynski et al.   CELL

Transcription Recovery after DNA Damage Requires Chromatin Priming by the H3.3 Histone Chaperone HIRA

(2013) Salomé Adam et al.   CELL

Dynamics of histone H3.3 deposition in proliferating and senescent cells reveals a DAXX-dependent targeting to PML-NBs important for pericentromeric heterochromatin organization

(2013) Armelle Corpet et al.   CELL CYCLE

The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression

(2013) K.-M. Chan et al.   GENES & DEVELOPMENT

Single Cell Analysis of RNA-mediated Histone H3.3 Recruitment to a Cytomegalovirus Promoter-regulated Transcription Site

(2013) Alyshia Newhart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alpha Thalassemia/Mental Retardation Syndrome X-linked Gene Product ATRX Is Required for Proper Replication Restart and Cellular Resistance to Replication Stress

(2013) Justin Wai-Chung Leung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Seeing Is Believing: Visualizing Transcriptional Dynamics in Single Cells

(2013) Alyshia Newhart et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells

(2013) Fiona T. M. Chang et al.   NUCLEIC ACIDS RESEARCH

Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma

(2013) P. W. Lewis et al.   SCIENCE

Placing the HIRA Histone Chaperone Complex in the Chromatin Landscape

(2013) Nikolay A. Pchelintsev et al.   Cell Reports

The PML-Interacting Protein DAXX: Histone Loading Gets into the Picture

(2013) Paolo Salomoni   Frontiers in Oncology

DAXX-dependent supply of soluble (H3.3-H4) dimers to PML bodies pending deposition into chromatin

(2012) E. Delbarre et al.   GENOME RESEARCH

A manually curated network of the PML nuclear body interactome reveals an important role for PML-NBs in SUMOylation dynamics

(2012) Ellen Van Damme et al.   International Journal of Biological Sciences

Acute promyelocytic leukemia, arsenic, and PML bodies

(2012) Hugues de Thé et al.   JOURNAL OF CELL BIOLOGY

Compromised genomic integrity impedes muscle growth after Atrx inactivation

(2012) Michael S. Huh et al.   JOURNAL OF CLINICAL INVESTIGATION

DAXX envelops a histone H3.3–H4 dimer for H3.3-specific recognition

(2012) Simon J. Elsässer et al.   NATURE

Transcription in the maintenance of centromere chromatin identity

(2012) F. L. Chan et al.   NUCLEIC ACIDS RESEARCH

Genome-wide functions of PML–RARα in acute promyelocytic leukaemia

(2011) S Saeed et al.   BRITISH JOURNAL OF CANCER

Defective survival of proliferating Sertoli cells and androgen receptor function in a mouse model of the ATR-X syndrome

(2011) Stefan Bagheri-Fam et al.   HUMAN MOLECULAR GENETICS

Dynamics of Histone H3 Deposition In Vivo Reveal a Nucleosome Gap-Filling Mechanism for H3.3 to Maintain Chromatin Integrity

(2011) Dominique Ray-Gallet et al.   MOLECULAR CELL

SUMOylation promotes de novo targeting of HP1α to pericentric heterochromatin

(2011) Christèle Maison et al.   NATURE GENETICS

Splitting of H3-H4 tetramers at transcriptionally active genes undergoing dynamic histone exchange

(2011) Y. Katan-Khaykovich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Viral Ubiquitin Ligase Has Substrate Preferential SUMO Targeted Ubiquitin Ligase Activity that Counteracts Intrinsic Antiviral Defence

(2011) Chris Boutell et al.   PLoS Pathogens

PML-RARα/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia

(2010) Joost H.A. Martens et al.   CANCER CELL

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

(2010) Aaron D. Goldberg et al.   CELL

The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3

(2010) P. Drane et al.   GENES & DEVELOPMENT

ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells

(2010) L. H. Wong et al.   GENOME RESEARCH

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

(2010) P. W. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Partitioning of Histone H3-H4 Tetramers During DNA Replication-Dependent Chromatin Assembly

(2010) M. Xu et al.   SCIENCE

PML Nuclear Bodies

(2010) V. Lallemand-Breitenbach et al.   Cold Spring Harbor Perspectives in Biology

Histone H3.3 incorporation provides a unique and functionally essential telomeric chromatin in embryonic stem cells

(2009) L. H. Wong et al.   GENOME RESEARCH

Transcription of the Herpes Simplex Virus Latency-Associated Transcript Promotes the Formation of Facultative Heterochromatin on Lytic Promoters

(2009) A. R. Cliffe et al.   JOURNAL OF VIROLOGY

The Polycomb Group Protein Bmi1 Binds to the Herpes Simplex Virus 1 Latent Genome and Maintains Repressive Histone Marks during Latency

(2009) D. L. Kwiatkowski et al.   JOURNAL OF VIROLOGY

New insights into the role of PML in tumour suppression

(2008) P Salomoni et al.   CELL RESEARCH

The Histone Variant H3.3 Regulates Gene Expression during Lytic Infection with Herpes Simplex Virus Type 1

(2008) B. J. Placek et al.   JOURNAL OF VIROLOGY

Human UBN1 Is an Ortholog of Yeast Hpc2p and Has an Essential Role in the HIRA/ASF1a Chromatin-Remodeling Pathway in Senescent Cells

(2008) G. Banumathy et al.   MOLECULAR AND CELLULAR BIOLOGY

Cell cycle control of centromeric repeat transcription and heterochromatin assembly

(2008) Ee Sin Chen et al.   NATURE

RNAi, heterochromatin and the cell cycle

(2008) Anna Kloc et al.   TRENDS IN GENETICS