Targeting PML in triple negative breast cancer elicits growth suppression and senescence

Hallmarks of Cellular Senescence

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Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer

(2018) Rengyun Liu et al.   Nature Communications

A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche

(2018) Jlenia Guarnerio et al.   Nature Communications

PML is a ROS sensor activating p53 upon oxidative stress

(2017) Michiko Niwa-Kawakita et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PIM1: a promising target in patients with triple-negative breast cancer

(2017) Wen Zhao et al.   MEDICAL ONCOLOGY

Establishment of highly metastatic KRAS mutant lung cancer cell sublines in long-term three-dimensional low attachment cultures

(2017) Tomoyuki Nakano et al.   PLoS One

Histone MacroH2A1: A Chromatin Point of Intersection between Fasting, Senescence and Cellular Regeneration

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Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer

(2016) Roman Camarda et al.   NATURE MEDICINE

PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression

(2016) Dai Horiuchi et al.   NATURE MEDICINE

PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer

(2016) Fara Brasó-Maristany et al.   NATURE MEDICINE

Stratification and therapeutic potential of PML in metastatic breast cancer

(2016) Natalia Martín-Martín et al.   Nature Communications

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

PML is required for telomere stability in non-neoplastic human cells

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Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer

(2014) Diletta Di Mitri et al.   NATURE

Lamin B1 fluctuations have differential effects on cellular proliferation and senescence

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An effect size filter improves the reproducibility in spectral counting-based comparative proteomics

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PML, SUMOylation, and Senescence

(2013) Lisa Ivanschitz et al.   Frontiers in Oncology

PML: Not all about Tumor Suppression

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A metabolic prosurvival role for PML in breast cancer

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MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition

(2012) Dai Horiuchi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Unconventional Secretion is a Major Contributor of Cancer Cell Line Secretomes

(2012) Laura Villarreal et al.   MOLECULAR & CELLULAR PROTEOMICS

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

(2012) Christina Curtis et al.   NATURE

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

(2012) Keisuke Ito et al.   NATURE MEDICINE

Single-vector inducible lentiviral RNAi system for oncology target validation

(2011) Dmitri Wiederschain et al.   CELL CYCLE

p16INK4a-mediated suppression of telomerase in normal and malignant human breast cells

(2010) Alexey V. Bazarov et al.   AGING CELL

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

(2010) Hui-Kuan Lin et al.   NATURE

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

A Prostatic Intraepithelial Neoplasia-Dependent p27Kip1 Checkpoint Induces Senescence and Inhibits Cell Proliferation and Cancer Progression

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Oncogene Addiction

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Pim Kinases Promote Cell Cycle Progression by Phosphorylating and Down-regulating p27Kip1 at the Transcriptional and Posttranscriptional Levels

(2008) D. Morishita et al.   CANCER RESEARCH

PML targeting eradicates quiescent leukaemia-initiating cells

(2008) Keisuke Ito et al.   NATURE