Article
Biochemistry & Molecular Biology
Georgia Levidou, Konstantinos Palamaris, Alexandros G. Sykaras, Georgios Andreadakis, Christos Masaoutis, Irene Theochari, Penelope Korkolopoulou, Dimitra Rontogianni, Stamatios Theocharis
Summary: This study reveals a significant interaction between CENP-A and HJURP in thymic epithelial tumors (TETs). Furthermore, the cytoplasmic immunostaining pattern of CENP-A may have a favorable prognostic value.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Nandini Karthik, Jane Jia Hui Lee, Joshua Ling Jun Soon, Hsin Yao Chiu, Amos Hong Pheng Loh, Derrick Sek Tong Ong, Wai Leong Tam, Reshma Taneja
Summary: This study reveals that histone variant H3.3 is overexpressed in alveolar rhabdomyosarcoma (ARMS), impacting the migration and invasion ability of tumor cells and correlating with metastasis and prognosis in ARMS. Mechanistically, melanoma cell adhesion molecule (MCAM) is identified as a direct downstream target of H3.3, and its overexpression rescues cell migration and invasion in H3F3A-depleted cells. Furthermore, G9a, an upstream regulator of H3F3A, is discovered. This study uncovers a novel H3.3-dependent axis and establishes the potential of MCAM as a therapeutic target for high-risk ARMS patients.
JOURNAL OF PATHOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yi Ching Esther Wan, Kui Ming Chan
Summary: Oncohistones have become a new focus in cancer epigenetics research, with recent studies uncovering thousands of histone mutations in cancer. Unlike previously identified oncohistones, the newly discovered mutations are located within the histone fold domain and impact gene expression through different mechanisms. Recent characterization of selected H2B has highlighted previously unappreciated roles of oncohistones in nucleosome stability, chromatin accessibility, and chromatin remodeling.
Review
Plant Sciences
Valentin Joly, Yannick Jacob
Summary: This study summarizes recent discoveries in plants regarding the role of H3.1 in chromatin replication, genomic stability, epigenetic inheritance, and its interaction with DNA polymerase epsilon.
CURRENT OPINION IN PLANT BIOLOGY
(2023)
Article
Multidisciplinary Sciences
William Villiers, Audrey Kelly, Xiaohan He, James Kaufman-Cook, Abdurrahman Elbasir, Halima Bensmail, Paul Lavender, Richard Dillon, Borbala Mifsud, Cameron S. Osborne
Summary: The PML-RARA gene fusion is the characteristic driver of Acute Promyelocytic Leukaemia (APL) and is known to bind to the genome. Here, the authors characterise the impact of PML-RARA on gene regulation in APL cell lines and patient samples using transcriptomics, epigenomics, and machine learning.
NATURE COMMUNICATIONS
(2023)
Review
Cell Biology
Faith M. Joseph, Nicolas L. Young
Summary: Post-translational modifications (PTMs) of histones play a key role in DNA-based processes and contribute to cell differentiation and gene function by adding an extra layer of regulation. Variations in histone sequences within each family of histones expand the chromatin repertoire and provide further mechanisms for regulation and signaling. However, much remains unknown about variant-specific PTMs and their role in regulating chromatin due to limited technologies and appropriate reagents.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Review
Oncology
Fengyi Guo, Hongjing Wang
Summary: This review summarizes the classification and mechanisms of action of histone deacetylase and the clinical application of their inhibitors in ovarian cancer. Histone deacetylase inhibitors show promising potential as anti-cancer drugs, and combination therapy with other anticancer drugs for synergistic effects can improve efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Shahnawaz Rehman, Mohammad Aatif, Zeeshan Rafi, Mohd Yasir Khan, Uzma Shahab, Saheem Ahmad, Mohd Farhan
Summary: The non-enzymatic glycosylation or non-enzymatic covalent modifications (NECMs) or glycation of cellular proteins result in the generation and accumulation of advanced glycation end products (AGEs) that are associated with the epigenetics of cancer. Epigenetic modifications are inheritable changes without alterations in the sequences of DNA. Glycation-mediated epigenetic mechanisms change the accessibility of transcriptional factors to DNA via rearrangement or modification in the chromatin structure and collaborate with gene regulation in the pathogenesis of cancer.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Futaba Inoue, Kenbun Sone, Yusuke Toyohara, Yu Takahashi, Asako Kukita, Aki Hara, Ayumi Taguchi, Michihiro Tanikawa, Tetsushi Tsuruga, Yutaka Osuga
Summary: Epigenetic changes play a crucial role in endometrial cancer, including DNA methylation and histone modification. There are currently inhibitors targeting epigenetic regulators in preclinical studies and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Jayden Sterling, Sharleen V. Menezes, Ramzi H. Abbassi, Lenka Munoz
Summary: Histone lysine demethylases (KDMs) are enzymes that remove methylation marks on lysines in nucleosomes' histone tails, regulating gene transcription and playing important roles in cancer development. KDMs can have activating or repressing effects on gene transcription, regulating the expression of oncogenes and tumor suppressors.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Cell Biology
Joyce Taylor-Papadimitriou, Joy M. Burchell
Summary: This review focuses on the role of PcG and TrxG complexes in the epigenetic regulation of gene expression and discusses the regulation of suppressive and active marks by methylases and demethylases. Mutations in histone methylases and demethylases in cancer can lead to repression of genes or activation of oncogenes.
Review
Cell Biology
Xueren Li, Chunjing Feng, Shouchun Peng
Summary: Respiratory diseases, including lung cancer and pulmonary fibrosis, are associated with increased mortality and healthcare burden. Genetic information alone cannot fully explain respiratory diseases, and epigenetic mechanisms also play a role in genetic information transmission. Studying the role of altered epigenetic modifications is important for understanding the pathophysiological processes and causal relationships of lung diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Foteinos-Ioannis Dimitrakopoulos, Anastasia Kottorou, Aspasia Tzezou
Summary: Breast cancer, the most common cancer in women, poses a challenge in therapeutic management for hormone receptor-positive patients due to resistance mechanisms. Molecular mechanisms involved in endocrine resistance include changes in hormone receptor signaling, activation of parallel pathways, cell cycle regulator modifications, transcription factor activation, and stem cell activity changes. Epigenetic changes, such as DNA methylation, histone modifications, and ncRNAs alterations, play a pivotal role not only in breast cancer progression but also in resistance to endocrine therapy.
Review
Medicine, Research & Experimental
Ningxin Qu, Ting Luan, Naiquan Liu, Chenhui Kong, Le Xu, Hong Yu, Ye Kang, Ye Han
Summary: HNF4 alpha, a transcription factor, plays a vital role in regulating functional genes and biological processes. Aberrant expression of HNF4 alpha is associated with tumor progression and metastasis, potentially by affecting downstream target genes and signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Baoyu Chen, Yuwen Zhu, Junliang Chen, Yifei Feng, Yong Xu
Summary: This study reveals that differential TCL expression in malignant colorectal cancer cells is associated with histone H3K9 methylation, and the lysine demethylase KDM4B is essential for TCL transcription. KDM4B interacts with the transcription factor ERG1 to activate TCL transcription by facilitating the assembly of pre-initiation complex on the TCL promoter, ultimately influencing migration and invasion of CRC cells. Additionally, upregulation of KDM4B in advanced stage CRC specimens suggests it may serve as a potential therapeutic target for CRC intervention.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)