Sterol regulation of developmental and oncogenic Hedgehog signaling

A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols

(2021) Renhong Yan et al.   SCIENCE

Smoothened-activating lipids drive resistance to CDK4/6 inhibition in Hedgehog-associated medulloblastoma cells and preclinical models

(2021) Vikas Daggubati et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanistic Insights into the Generation and Transduction of Hedgehog Signaling

(2020) Xiaofeng Qi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structural basis for itraconazole-mediated NPC1 inhibition

(2020) Tao Long et al.   Nature Communications

Oxysterols: From physiological tuners to pharmacological opportunities

(2020) Andrew J. Brown et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2

(2020) Hongwu Qian et al.   CELL

Developmental and regenerative paradigms of cilia regulated hedgehog signaling

(2020) Daniel Kopinke et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling

(2020) Naotaka Tsutsumi et al.   eLife

Structure of human Dispatched-1 provides insights into Hedgehog ligand biogenesis

(2020) Hongwen Chen et al.   Life Science Alliance

Distinct Cation Gradients Power Cholesterol Transport at Different Key Points in the Hedgehog Signaling Pathway

(2020) Kostadin Petrov et al.   DEVELOPMENTAL CELL

Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling

(2020) Xiaofeng Qi et al.   Nature Chemical Biology

AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma

(2020) Catherine D. Yao et al.   Nature Communications

Cholesterol access in cellular membranes controls Hedgehog signaling

(2020) Arun Radhakrishnan et al.   Nature Chemical Biology

Bile acid biosynthesis in Smith-Lemli-Opitz syndrome bypassing cholesterol: Potential importance of pathway intermediates

(2020) Jonas Abdel-Khalik et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Motional dynamics of single Patched1 molecules in cilia are controlled by Hedgehog and cholesterol

(2019) Lucien E. Weiss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Misactivation of Hedgehog signaling causes inherited and sporadic cancers

(2019) David R. Raleigh et al.   JOURNAL OF CLINICAL INVESTIGATION

Membrane Protein–Lipid Interactions Probed Using Mass Spectrometry

(2019) Jani Reddy Bolla et al.   Annual Review of Biochemistry

Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi

(2019) Xiaofeng Qi et al.   NATURE

Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition

(2019) Tao Long et al.   Nature Communications

Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm

(2019) Hongwu Qian et al.   Nature Communications

Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling

(2019) Christiane Kowatsch et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism

(2019) Amalie F. Rudolf et al.   Nature Chemical Biology

Structural basis of sterol recognition by human hedgehog receptor PTCH1

(2019) Chao Qi et al.   Science Advances

Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins

(2019) Mikael B.L. Winkler et al.   CELL

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

(2019) Maia Kinnebrew et al.   eLife

Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma

(2018) Renata E. Gordon et al.   CLINICAL CANCER RESEARCH

Structural basis for the recognition of Sonic Hedgehog by human Patched1

(2018) Xin Gong et al.   SCIENCE

Lanosterol Synthase Regulates Human Rhinovirus Replication in Human Bronchial Epithelial Cells

(2018) Christopher McCrae et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Crystal structure of the Frizzled 4 receptor in a ligand-free state

(2018) Shifan Yang et al.   NATURE

Structures of human Patched and its complex with native palmitoylated sonic hedgehog

(2018) Xiaofeng Qi et al.   NATURE

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2011–2015

(2018) Quinn T Ostrom et al.   NEURO-ONCOLOGY

Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex

(2018) Xiaofeng Qi et al.   SCIENCE

Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched

(2018) Yunxiao Zhang et al.   CELL

From Drosophila segmentation to human cancer therapy

(2018) Philip W. Ingham   DEVELOPMENT

Cilia-Associated Oxysterols Activate Smoothened

(2018) David R. Raleigh et al.   MOLECULAR CELL

Comment on ‘Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol’

(2018) Kevin C Courtney et al.   eLife

Hedgehog signaling drives medulloblastoma growth via CDK6

(2017) David R. Raleigh et al.   JOURNAL OF CLINICAL INVESTIGATION

Irreversible growth plate fusions in children with medulloblastoma treated with a targeted hedgehog pathway inhibitor

(2017) Giles W. Robinson et al.   Oncotarget

Interaction of Cholesterol with Perfringolysin O: What Have We Learned from Functional Analysis?

(2017) Sergey Savinov et al.   Toxins

Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling

(2016) Pengxiang Huang et al.   CELL

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

(2016) Xin Gong et al.   CELL

Differential cytotoxic effects of 7-dehydrocholesterol-derived oxysterols on cultured retina-derived cells: Dependence on sterol structure, cell type, and density

(2016) Bruce A. Pfeffer et al.   EXPERIMENTAL EYE RESEARCH

Posaconazole, a Second-Generation Triazole Antifungal Drug, Inhibits the Hedgehog Signaling Pathway and Progression of Basal Cell Carcinoma

(2016) B. Chen et al.   MOLECULAR CANCER THERAPEUTICS

Structural basis of Smoothened regulation by its extracellular domains

(2016) Eamon F. X. Byrne et al.   NATURE

Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma

(2016) Ximena Bonilla et al.   NATURE GENETICS

Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols

(2016) Navdar Sever et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Triazoles inhibit cholesterol export from lysosomes by binding to NPC1

(2016) Michael N. Trinh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling

(2016) Giovanni Luchetti et al.   eLife

Patched1 and Patched2 inhibit Smoothened non-cell autonomously

(2016) Brock Roberts et al.   eLife

Induction Hedgehog pathway inhibition followed by combined-modality radiotherapy for basal cell carcinoma

(2015) D.R. Raleigh et al.   BRITISH JOURNAL OF DERMATOLOGY

Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma

(2015) Scott X. Atwood et al.   CANCER CELL

Reduced cholesterol levels impair Smoothened activation in Smith–Lemli–Opitz syndrome

(2015) Robert Blassberg et al.   HUMAN MOLECULAR GENETICS

Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog–Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032

(2015) Giles W. Robinson et al.   JOURNAL OF CLINICAL ONCOLOGY

Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein

(2015) Jeroen R.P.M. Strating et al.   Cell Reports

Comprehensive analysis of patched domain-containing genes reveals a unique evolutionary pattern

(2014) Y. Zhong et al.   GENETICS AND MOLECULAR RESEARCH

Germline Mutations inSUFUCause Gorlin Syndrome–Associated Childhood Medulloblastoma and Redefine the Risk Associated WithPTCH1Mutations

(2014) Miriam J. Smith et al.   JOURNAL OF CLINICAL ONCOLOGY

Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1

(2014) Sandeep Goyal et al.   JOURNAL OF LIPID RESEARCH

Desmosterolosis: an illustration of diagnostic ambiguity of cholesterol synthesis disorders

(2014) Cristina Dias et al.   Orphanet Journal of Rare Diseases

Hedgehog Pathway Modulation by Multiple Lipid Binding Sites on the Smoothened Effector of Signal Response

(2013) Benjamin R. Myers et al.   DEVELOPMENTAL CELL

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling

(2013) Daniel Nedelcu et al.   Nature Chemical Biology

Use of mutant 125I-Perfringolysin O to probe transport and organization of cholesterol in membranes of animal cells

(2013) A. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment of Smith-Lemli-Opitz syndrome and other sterol disorders

(2012) Melissa D. Svoboda et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Role of epoxide hydrolases in lipid metabolism

(2012) Christophe Morisseau   BIOCHIMIE

Oxysterol Gradient Generation by Lymphoid Stromal Cells Guides Activated B Cell Movement during Humoral Responses

(2012) Tangsheng Yi et al.   IMMUNITY

Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma

(2012) Aleksandar Sekulic et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural Basis of Wnt Recognition by Frizzled

(2012) C. Y. Janda et al.   SCIENCE

Human PTCHD3 nulls: rare copy number and sequence variants suggest a non-essential gene

(2011) Mohammad M Ghahramani Seno et al.   BMC Medical Genetics

Identification of Luminal Loop 1 of Scap Protein as the Sterol Sensor That Maintains Cholesterol Homeostasis

(2011) Massoud Motamed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome

(2011) Libin Xu et al.   JOURNAL OF LIPID RESEARCH

Oxysterols direct B-cell migration through EBI2

(2011) Changlu Liu et al.   NATURE

Oxysterols direct immune cell migration via EBI2

(2011) Sébastien Hannedouche et al.   NATURE

DHCEO accumulation is a critical mediator of pathophysiology in a Smith–Lemli–Opitz syndrome model

(2011) Libin Xu et al.   NEUROBIOLOGY OF DISEASE

Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: A report from the Children's Oncology Group

(2011) Joseph G. Pressey et al.   PEDIATRIC BLOOD & CANCER

Desmosterol, the main sterol in rabbit semen: distribution among semen subfractions and its role in the in vitro spermatozoa acrosome reaction and motility

(2010) Evangelia Mourvaki et al.   ASIAN JOURNAL OF ANDROLOGY

Accessibility of Cholesterol in Endoplasmic Reticulum Membranes and Activation of SREBP-2 Switch Abruptly at a Common Cholesterol Threshold

(2010) Anna Sokolov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biological activities of 7-dehydrocholesterol-derived oxysterols: implications for Smith-Lemli-Opitz syndrome

(2010) Zeljka Korade et al.   JOURNAL OF LIPID RESEARCH

Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene-negative alveolar rhabdomyosarcoma

(2010) A Zibat et al.   ONCOGENE

Structural Ties between Cholesterol Transport and Morphogen Signaling

(2009) J. Fernando Bazan et al.   CELL

Tow (Target of Wingless), a novel repressor of the Hedgehog pathway in Drosophila

(2009) Katie L. Ayers et al.   DEVELOPMENTAL BIOLOGY

Cholesterol and desmosterol in two sperm populations separated on Sil-Select gradient

(2009) A. Zalata et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

(2009) Charles M. Rudin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

(2009) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

(2009) R. L. Yauch et al.   SCIENCE

The Hedgehog Signaling Pathway: Where Did It Come From?

(2009) George Hausmann et al.   PLOS BIOLOGY

24(S),25-Epoxycholesterol: A messenger for cholesterol homeostasis

(2008) Andrew J. Brown   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY