Motional dynamics of single Patched1 molecules in cilia are controlled by Hedgehog and cholesterol

Structural Basis of Smoothened Activation in Hedgehog Signaling

(2018) Pengxiang Huang et al.   CELL

How the Ciliary Membrane Is Organized Inside-Out to Communicate Outside-In

(2018) Galo Garcia et al.   CURRENT BIOLOGY

Actin filaments partition primary cilia membranes into distinct fluid corrals

(2018) Sungsu Lee et al.   JOURNAL OF CELL BIOLOGY

Cilia-Associated Oxysterols Activate Smoothened

(2018) David R. Raleigh et al.   MOLECULAR CELL

Interplay between Ciliary Ultrastructure and IFT-Train Dynamics Revealed by Single-Molecule Super-resolution Imaging

(2018) Felix Oswald et al.   Cell Reports

Single-molecule imaging reveals receptor–G protein interactions at cell surface hot spots

(2017) Titiwat Sungkaworn et al.   NATURE

Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome

(2017) Xiaoyu Shi et al.   NATURE CELL BIOLOGY

Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium

(2017) Benjamin R. Myers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Domain 4 (D4) of Perfringolysin O to Visualize Cholesterol in Cellular Membranes—The Update

(2017) Masashi Maekawa   SENSORS

Intraflagellar Transport and Ciliary Dynamics

(2017) Hiroaki Ishikawa et al.   Cold Spring Harbor Perspectives in Biology

Sterol targeting drugs reveal life cycle stage-specific differences in trypanosome lipid rafts

(2017) Aabha I. Sharma et al.   Scientific Reports

Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling

(2016) Pengxiang Huang et al.   CELL

Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy

(2016) Ekaterina Pak et al.   DEVELOPMENTAL CELL

The Continuing Mystery of Lipid Rafts

(2016) Ilya Levental et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural basis of Smoothened regulation by its extracellular domains

(2016) Eamon F. X. Byrne et al.   NATURE

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling

(2016) Giovanni Luchetti et al.   eLife

Single-molecule imaging of Hedgehog pathway protein Smoothened in primary cilia reveals binding events regulated by Patched1

(2015) Ljiljana Milenkovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of ciliary trafficking in Hedgehog receptor signaling

(2015) Jynho Kim et al.   Science Signaling

The role of ciliary trafficking in Hedgehog receptor signaling

(2015) Jynho Kim et al.   Science Signaling

Discovery and preclinical development of vismodegib

(2014) Stephen E Gould et al.   Expert Opinion on Drug Discovery

Direct evidence for BBSome-associated intraflagellar transport reveals distinct properties of native mammalian cilia

(2014) Corey L. Williams et al.   Nature Communications

Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception

(2014) Shen Yue et al.   eLife

Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis

(2014) Akash Das et al.   eLife

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Single molecule imaging reveals a major role for diffusion in the exploration of ciliary space by signaling receptors

(2013) Fan Ye et al.   eLife

Mechanisms and functions of Hedgehog signalling across the metazoa

(2011) Philip W. Ingham et al.   NATURE REVIEWS GENETICS

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer

(2010) Monique T. Barakat et al.   TRENDS IN MOLECULAR MEDICINE

Cholesterol modulation of nicotinic acetylcholine receptor surface mobility

(2009) Carlos J. Baier et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Flagellar membrane localization via association with lipid rafts

(2009) K. M. Tyler et al.   JOURNAL OF CELL SCIENCE

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

(2009) R. L. Yauch et al.   SCIENCE

Direct observation of the nanoscale dynamics of membrane lipids in a living cell

(2008) Christian Eggeling et al.   NATURE

High-density mapping of single-molecule trajectories with photoactivated localization microscopy

(2008) Suliana Manley et al.   NATURE METHODS

Super-resolution imaging in live Caulobacter crescentus cells using photoswitchable EYFP

(2008) Julie S Biteen et al.   NATURE METHODS