Structural basis of sterol recognition by human hedgehog receptor PTCH1

Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm

(2019) Hongwu Qian et al.   Nature Communications

Structural basis for the recognition of Sonic Hedgehog by human Patched1

(2018) Xin Gong et al.   SCIENCE

Structures of human Patched and its complex with native palmitoylated sonic hedgehog

(2018) Xiaofeng Qi et al.   NATURE

Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex

(2018) Xiaofeng Qi et al.   SCIENCE

Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched

(2018) Yunxiao Zhang et al.   CELL

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

A Recurrent Mosaic Mutation in SMO , Encoding the Hedgehog Signal Transducer Smoothened, Is the Major Cause of Curry-Jones Syndrome

(2016) Stephen R.F. Twigg et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Hedgehog receptor function during craniofacial development

(2016) Guilherme M. Xavier et al.   DEVELOPMENTAL BIOLOGY

Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy

(2016) Ekaterina Pak et al.   DEVELOPMENTAL CELL

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog

(2016) Hanna Tukachinsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of ciliary trafficking in Hedgehog receptor signaling

(2015) Jynho Kim et al.   Science Signaling

The role of ciliary trafficking in Hedgehog receptor signaling

(2015) Jynho Kim et al.   Science Signaling

Structure of the Yeast Mitochondrial Large Ribosomal Subunit

(2014) A. Amunts et al.   SCIENCE

Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception

(2014) Shen Yue et al.   eLife

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Smoothened-Evc2 Complex Transduces the Hedgehog Signal at Primary Cilia

(2012) Karolin V. Dorn et al.   DEVELOPMENTAL CELL

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Overexpressing human membrane proteins in stably transfected and clonal human embryonic kidney 293S cells

(2012) Sarika Chaudhary et al.   Nature Protocols

Mechanisms and functions of Hedgehog signalling across the metazoa

(2011) Philip W. Ingham et al.   NATURE REVIEWS GENETICS

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural and thermodynamic analysis of the GFP:GFP-nanobody complex

(2010) Marta H. Kubala et al.   PROTEIN SCIENCE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Evidence for a role of vertebrate Disp1 in long-range Shh signaling

(2009) L. A. Etheridge et al.   DEVELOPMENT

The Hedgehog Signaling Pathway: Where Did It Come From?

(2009) George Hausmann et al.   PLOS BIOLOGY