Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition

Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination

(2018) Zita Hubler et al.   NATURE

Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states

(2018) Ioannis Manolaridis et al.   NATURE

Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease

(2017) Bitna Yi et al.   JOURNAL OF NEUROCHEMISTRY

Dendrogenin A drives LXR to trigger lethal autophagy in cancers

(2017) Gregory Segala et al.   Nature Communications

Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design

(2016) Tatiana Y. Hargrove et al.   JOURNAL OF LIPID RESEARCH

Crystal structure of the human σ1 receptor

(2016) Hayden R. Schmidt et al.   NATURE

Crystal structure of the epithelial calcium channel TRPV6

(2016) Kei Saotome et al.   NATURE

Structure of human Niemann–Pick C1 protein

(2016) Xiaochun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DHCR7: A vital enzyme switch between cholesterol and vitamin D production

(2016) Anika V. Prabhu et al.   PROGRESS IN LIPID RESEARCH

Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer

(2016) L. Zhang et al.   Science Translational Medicine

Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection

(2015) Feiran Lu et al.   eLife

Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways

(2015) Matthew A Mitsche et al.   eLife

Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum

(2014) Xiaochun Li et al.   NATURE

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

(2014) Julia Kozlitina et al.   NATURE GENETICS

TM6SF2 and MAC30, new enzyme homologs in sterol metabolism and common metabolic disease

(2014) Luis Sanchez-Pulido et al.   Frontiers in Genetics

A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma

(2012) Jeffrey G. McDonald et al.   JOURNAL OF LIPID RESEARCH

Clinical, molecular and biochemical characterization of nine Spanish families with Conradi-Hünermann-Happle syndrome: new insights into X-linked dominant chondrodysplasia punctata with a comprehensive review of the literature

(2011) J. Cañueto et al.   BRITISH JOURNAL OF DERMATOLOGY

Biosynthesis of Cholesterol and Other Sterols

(2011) W. David Nes   CHEMICAL REVIEWS

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Malformation syndromes caused by disorders of cholesterol synthesis

(2010) Forbes D. Porter et al.   JOURNAL OF LIPID RESEARCH

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Tamoxifen and AEBS ligands induced apoptosis and autophagy in breast cancer cells through the stimulation of sterol accumulation

(2009) Philippe de Medina et al.   Autophagy

Ligands of the antiestrogen-binding site induce active cell death and autophagy in human breast cancer cells through the modulation of cholesterol metabolism

(2009) P de Medina et al.   CELL DEATH AND DIFFERENTIATION

The pharmacology of sigma-1 receptors

(2009) Tangui Maurice et al.   PHARMACOLOGY & THERAPEUTICS

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Identification of essential amino acid residues in a sterol 8,7-isomerase fromZea maysreveals functional homology and diversity with the isomerases of animal and fungal origin

(2008) Alain Rahier et al.   BIOCHEMICAL JOURNAL