Review
Cell Biology
Hao Song, Juanli Chen, Jin Huang, Peng Sun, Yanming Liu, Li Xu, Chuanfei Wei, Xin Mu, Xianjie Lu, Wei Wang, Nan Zhang, Miwei Shang, Mei Mo, Wei Zhang, Hui Zhao, Fabin Han
Summary: Parkinson's disease (PD) is a common neurodegenerative disorder caused by genetic, epigenetic, and environmental factors. Recent advance in genomics and epigenetics have revealed epigenetic mechanisms in PD. These epigenetic modifications include DNA methylation, post-translational histone modifications, chromatin remodeling, and RNA-based mechanisms, which regulate cellular functions in almost all cells. Epigenetic alterations are involved in multiple aspects of neuronal development and neurodegeneration in PD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Futaba Inoue, Kenbun Sone, Yusuke Toyohara, Yu Takahashi, Asako Kukita, Aki Hara, Ayumi Taguchi, Michihiro Tanikawa, Tetsushi Tsuruga, Yutaka Osuga
Summary: Epigenetic changes play a crucial role in endometrial cancer, including DNA methylation and histone modification. There are currently inhibitors targeting epigenetic regulators in preclinical studies and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Chao Yang, Dan Li, Dehong Teng, Yueru Zhou, Lei Zhang, Zhangfeng Zhong, Guan-Jun Yang
Summary: This review discusses the research on the pathogenesis of rheumatoid arthritis (RA) in the past five years based on epigenetic modifications, providing new methods and strategies for the diagnosis and treatment of this disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Daniela Mauceri
Summary: Pain is an unpleasant sensation resulting from tissue damage, and when it persists after the injury has resolved, it becomes pathological. The transition from acute to chronic pain involves plasticity events along the neural pathways and alterations in gene expression. Epigenetic mechanisms play a crucial role in these adaptive processes in the nervous system.
Review
Biochemistry & Molecular Biology
Bibiana Torok, Csilla Lea Fazekas, Adrienn Szabo, Dora Zelena
Summary: Vasopressin, acting through V2, V1a, and V1b receptors, regulates kidney water resorption, blood pressure, stress-axis, social behavior, and memory. Its implication in depression and schizophrenia may involve epigenetic changes such as DNA methylation, histone modification, and micro RNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Liangjie Xu, Cuicui Zhou, Yi Liang, Tinpan Fan, Fen Zhang, Xinxin Chen, Wei Yuan
Summary: This article reviews the interaction between epigenetic modifications and the functions of myeloid-derived suppressor cells (MDSCs), and briefly introduces how the accumulation and function of MDSCs caused by epigenetic modifications impact disease development, providing a promising therapeutic strategy for related disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Fayaz Ahmad Mir, Ayeman Amanullah, Buddhi Prakash Jain, Zeeshan Hyderi, Akash Gautam
Summary: Gene expression in the brain undergoes significant changes during memory acquisition, recall, and forgetfulness. Non-genetic factors such as environmental elements, epigenetic changes, and lifestyle have gained attention in understanding the causes of neurodegenerative diseases and age-related dementia. Epigenetic modifications play a crucial role in regulating gene expression in all living organisms. Genes associated with aging and memory disorders related to neurodegeneration are regulated by epigenetic processes including DNA methylation, histone acetylation, and mRNA editing. Understanding the mechanisms behind these epigenetic changes could lead to effective treatments for neurodegeneration and age-induced dementia.
AGEING RESEARCH REVIEWS
(2023)
Review
Cell Biology
Yung-Che Chen, Yu-Ping Chang, Kuo-Tung Huang, Po-Yuan Hsu, Chang-Chun Hsiao, Meng-Chih Lin
Summary: ACO is characterized by persistent airflow limitation and features of both asthma and COPD, associated with higher frequency and severity of exacerbations, faster lung function decline, and higher healthcare cost. Systemic inflammation in COPD and asthma is driven by Th1 and Th2 immune responses, with potential contributions to airway remodeling in ACO.
Review
Biology
Wenlong Du, Guojun Shi, Chun-Min Shan, Zhiming Li, Bing Zhu, Songtao Jia, Qing Li, Zhiguo Zhang
Summary: This review summarizes the recent advances in the molecular mechanisms of epigenetic inheritance, discusses the potential impacts on normal development and diseases, and outlines future research directions in this field.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Review
Plant Sciences
Kajal Samantara, Aalok Shiv, Lorenna Lopes de Sousa, Karansher Singh Sandhu, Parichita Priyadarshini, Sourav Ranjan Mohapatra
Summary: Epigenetics is an important mechanism that can help plants cope with various stressors by altering gene expression without involving changes in DNA sequences. It provides diversity to aid plants in responding to the impacts of climate change.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Article
Biochemistry & Molecular Biology
Wei Wang, Xiaolong Du, Mingxing Chu, Xiaoyun He
Summary: This study investigated the effects of photoperiod on the expression and epigenetic changes of the GNAQ gene. The results showed that photoperiod can induce DNA methylation in the core promoter region and histone acetylation in the promoter region of the GNAQ gene. These findings are important for understanding the role of epigenetic modifications in reproduction in sheep.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Annie L. Miller, Rebekah E. James, Alan R. Harvey, Dragana Trifunovic, Livia S. Carvalho
Summary: Elucidating the cellular changes in degenerating photoreceptors of people with inherited retinal diseases (IRDs) could lead to neuroprotective therapies to prevent vision loss and preserve functional vision. Epigenetic modifications, specifically DNA methylation and histone modifications, have been found to contribute to cell death in IRDs. Targeting these alterations shows therapeutic potential for treating IRDs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Rachel J. Kehrberg, Namita Bhyravbhatla, Surinder K. Batra, Sushil Kumar
Summary: Cancer-associated fibroblasts (CAFs), a significant component of the tumor microenvironment (TME), contribute to cancer progression through the secretion of extracellular matrix (ECM), growth factors, and metabolites. It is now well recognized that CAFs are a heterogenous population with ablation experiments leading to reduced tumor growth and single-cell RNA sequencing demonstrating CAF subgroups. CAFs lack genetic mutations yet substantially differ from their normal stromal precursors.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Review
Biochemistry & Molecular Biology
Qiong Wu, Anders E. Berglund, Arnold B. Etame
Summary: Glioblastoma is highly resistant to standard therapies and the durability of response to the best chemotherapy agent, Temozolomide, is often short-lived due to tumor resistance. The need for therapies that can provide synergy to chemoradiation is urgent, as adaptive resistance evolution in GBM is facilitated through treatment-induced epigenetic modifications. Understanding and targeting these epigenetic modifications associated with GBM resistance is a top priority.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Medicinal
Fumiaki Tanemoto, Imari Mimura
Summary: Recent epidemiological evidence supports a causal relationship between acute kidney injury (AKI) episodes and subsequent progression to chronic kidney disease (CKD). The interaction among various components of the kidney and epigenetic alterations play a significant role in this transition. Timely and target-specific epigenetic interventions at different stages of the AKI-to-CKD transition are crucial for future therapeutic applications.