Ageing of the gut microbiome: Potential influences on immune senescence and inflammageing

Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries

(2020) Tarini Shankar Ghosh et al.   GUT

Fecal microbiota transplantation to maintain remission in Crohn’s disease: a pilot randomized controlled study

(2020) Harry Sokol et al.   Microbiome

Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells

(2020) Elizabeth C. Rosser et al.   Cell Metabolism

Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells

(2020) Clarissa Campbell et al.   NATURE

Lactobacillus reuteri 5454 and Bifidobacterium animalis ssp. lactis 5764 improve colitis while differentially impacting dendritic cells maturation and antimicrobial responses

(2020) Jiří Hrdý et al.   Scientific Reports

Vitamin Biosynthesis by Human Gut Butyrate-Producing Bacteria and Cross-Feeding in Synthetic Microbial Communities

(2020) Eva C. Soto-Martin et al.   mBio

Altered Composition of Gut Microbiota in Depression: A Systematic Review

(2020) Zahra Amirkhanzadeh Barandouzi et al.   Frontiers in Psychiatry

A human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating the microbiota/taurine/tight junction axis

(2020) Shokouh Ahmadi et al.   JCI Insight

Inflammaging, hormesis and the rationale for anti-aging strategies

(2020) Aurelia Santoro et al.   AGEING RESEARCH REVIEWS

Microbiomes other than the gut: inflammaging and age-related diseases

(2020) Aurelia Santoro et al.   Seminars in Immunopathology

Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

(2020) Alfonsina D’Amato et al.   Microbiome

The Super-Donor Phenomenon in Fecal Microbiota Transplantation

(2019) Brooke C. Wilson et al.   Frontiers in Cellular and Infection Microbiology

Supplementation with Bifidobacterium longum Bar33 and Lactobacillus helveticus Bar13 mixture improves immunity in elderly and old mice

(2019) A. Finamore et al.   NUTRITION

Comparison of the Gut Microbiota of Centenarians in Longevity Villages of South Korea with Those of Other Age Groups

(2019) Bong-Soo Kim et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Influence of aging on germinal centre reaction and antibody response to inactivated influenza virus antigens in mice: sex-based differences

(2019) Nevena Arsenović-Ranin et al.   BIOGERONTOLOGY

The Association Between Objectively Measured Physical Activity and the Gut Microbiome Among Older Community Dwelling Men

(2019) Lisa Langsetmo et al.   Journal of Nutrition Health & Aging

Antibiotic-Induced Disruption of Gut Microbiota Alters Local Metabolomes and Immune Responses

(2019) Lin Sun et al.   Frontiers in Cellular and Infection Microbiology

Outer membrane vesicles engineered to express membrane-bound antigen program dendritic cells for cross-presentation to CD8+ T cells

(2019) Sjoerd T.T. Schetters et al.   Acta Biomaterialia

Physical activity, multimorbidity, and life expectancy: a UK Biobank longitudinal study

(2019) Yogini V. Chudasama et al.   BMC Medicine

The gut microbiota influences skeletal muscle mass and function in mice

(2019) Shawon Lahiri et al.   Science Translational Medicine

Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis

(2019) Chandran Ramakrishna et al.   Nature Communications

Heterochronic faecal transplantation boosts gut germinal centres in aged mice

(2019) Marisa Stebegg et al.   Nature Communications

Age-Associated Changes in Gut Microbiota and Dietary Components Related with the Immune System in Adulthood and Old Age: A Cross-Sectional Study

(2019) Nuria Salazar et al.   Nutrients

The Impact of Pectin Supplementation on Intestinal Barrier Function in Healthy Young Adults and Healthy Elderly

(2019) Wilms et al.   Nutrients

Gut Microbiota, Muscle Mass and Function in Aging: A Focus on Physical Frailty and Sarcopenia

(2019) Andrea Ticinesi et al.   Nutrients

Response kinetics reveal novel features of ageing in murine T cells

(2019) Daan K. J. Pieren et al.   Scientific Reports

Vitamin D Regulates the Microbiota to Control the Numbers of RORγt/FoxP3+ Regulatory T Cells in the Colon

(2019) Margherita T. Cantorna et al.   Frontiers in Immunology

Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy

(2019) Rosina Pryor et al.   CELL

Investigation of the Effects of Microbiota on Exercise Physiological Adaption, Performance, and Energy Utilization Using a Gnotobiotic Animal Model

(2019) Wen-Ching Huang et al.   Frontiers in Microbiology

Fecal microbiota transplantation alleviated Alzheimer’s disease-like pathogenesis in APP/PS1 transgenic mice

(2019) Jing Sun et al.   Translational Psychiatry

Bile acid metabolites control TH17 and Treg cell differentiation

(2019) Saiyu Hang et al.   NATURE

Gut microbiome diversity is associated with sleep physiology in humans

(2019) Robert P. Smith et al.   PLoS One

Host- and Microbiota-Derived Extracellular Vesicles, Immune Function, and Disease Development

(2019) Laurence Macia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut Microbial, Inflammatory and Metabolic Signatures in Older People with Physical Frailty and Sarcopenia: Results from the BIOSPHERE Study

(2019) Anna Picca et al.   Nutrients

Inflammageing and metaflammation: The yin and yang of type 2 diabetes

(2018) Francesco Prattichizzo et al.   AGEING RESEARCH REVIEWS

Aging and Alzheimer’s disease: Comparison and associations from molecular to system level

(2018) Xian Xia et al.   AGING CELL

Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids

(2018) Kristina Martinez-Guryn et al.   Cell Host & Microbe

Reduced dynamic range of antiviral innate immune responses in aging

(2018) Ryan D. Molony et al.   EXPERIMENTAL GERONTOLOGY

Incidence and Treatment of Patients Diagnosed With Inflammatory Bowel Diseases at 60 Years or Older in Sweden

(2018) Åsa H. Everhov et al.   GASTROENTEROLOGY

Immune regulation by microbiome metabolites

(2018) Chang H. Kim   IMMUNOLOGY

Exercise Alters Gut Microbiota Composition and Function in Lean and Obese Humans

(2018) JACOB M. ALLEN et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Interbacterial mechanisms of colonization resistance and the strategies pathogens use to overcome them

(2018) Matthew T. Sorbara et al.   Mucosal Immunology

Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts

(2018) Ramón Estruch et al.   NEW ENGLAND JOURNAL OF MEDICINE

The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence

(2018) Siew-Min Ong et al.   Cell Death & Disease

Effects of a galacto-oligosaccharide-rich diet on fecal microbiota and metabolite profiles in mice

(2018) W. Cheng et al.   Food & Function

Age-related differences in humoral and cellular immune responses after primary immunisation: indications for stratified vaccination schedules

(2018) Angelika Wagner et al.   Scientific Reports

Shifts on Gut Microbiota Associated to Mediterranean Diet Adherence and Specific Dietary Intakes on General Adult Population

(2018) Izaskun Garcia-Mantrana et al.   Frontiers in Microbiology

Physical Activity, Sitting Time, and Mortality From Inflammatory Diseases in Older Adults

(2018) Verónica Cabanas-Sánchez et al.   Frontiers in Physiology

Respiratory Disease following Viral Lung Infection Alters the Murine Gut Microbiota

(2018) Helen T. Groves et al.   Frontiers in Immunology

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

(2018) Tamas Fulop et al.   Frontiers in Immunology

Intestinal Microbiota Disruption Reduces Regulatory T Cells and Increases Respiratory Viral Infection Mortality Through Increased IFNγ Production

(2018) Mitchell H. Grayson et al.   Frontiers in Immunology

Composition and richness of the serum microbiome differ by age and link to systemic inflammation

(2018) Thomas W. Buford et al.   GeroScience

Myeloid cell-derived tumor necrosis factor-alpha promotes sarcopenia and regulates muscle cell fusion with aging muscle fibers

(2018) Ying Wang et al.   AGING CELL

Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic Improvements

(2018) Salvatore Fabbiano et al.   Cell Metabolism

Greater Microbial Translocation and Vulnerability to Metabolic Disease in Healthy Aged Female Monkeys

(2018) Quentin N. Wilson et al.   Scientific Reports

Human-origin probiotic cocktail increases short-chain fatty acid production via modulation of mice and human gut microbiome

(2018) Ravinder Nagpal et al.   Scientific Reports

Caloric restriction promotes functional changes involving short-chain fatty acid biosynthesis in the rat gut microbiota

(2018) Alessandro Tanca et al.   Scientific Reports

Association between Cigarette Smoking Status and Composition of Gut Microbiota: Population-Based Cross-Sectional Study

(2018) Su Hwan Lee et al.   Journal of Clinical Medicine

Therapeutic faecal microbiota transplantation controls intestinal inflammation through IL10 secretion by immune cells

(2018) Claudia Burrello et al.   Nature Communications

Microbiome-Modulated Metabolites at the Interface of Host Immunity

(2017) Eran Blacher et al.   JOURNAL OF IMMUNOLOGY

Human Monocyte Subsets Are Transcriptionally and Functionally Altered in Aging in Response to Pattern Recognition Receptor Agonists

(2017) Talibah U. Metcalf et al.   JOURNAL OF IMMUNOLOGY

Biological Aging and the Human Gut Microbiota

(2017) Vincent J Maffei et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

(2017) Annamaria Cattaneo et al.   NEUROBIOLOGY OF AGING

Caloric restriction improves health and survival of rhesus monkeys

(2017) Julie A. Mattison et al.   Nature Communications

Regulation of life span by the gut microbiota in the short-lived African turquoise killifish

(2017) Patrick Smith et al.   eLife

Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice

(2017) Floris Fransen et al.   Frontiers in Immunology

Outer Membrane Vesicles Prime and Activate Macrophage Inflammasomes and Cytokine Secretion In Vitro and In Vivo

(2017) Jessica D. Cecil et al.   Frontiers in Immunology

The effect of age on the intestinal mucus thickness, microbiota composition and immunity in relation to sex in mice

(2017) Marlies Elderman et al.   PLoS One

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

(2017) T. Harach et al.   Scientific Reports

Effect of caloric restriction on gut permeability, inflammation markers, and fecal microbiota in obese women

(2017) Beate Ott et al.   Scientific Reports

Gut microbiome alterations in Alzheimer’s disease

(2017) Nicholas M. Vogt et al.   Scientific Reports

Peptidoglycan from the gut microbiota governs the lifespan of circulating phagocytes at homeostasis

(2016) C. B. Hergott et al.   BLOOD

Butyrate inhibits interleukin-17 and generates Tregs to ameliorate colorectal colitis in rats

(2016) Mingming Zhang et al.   BMC GASTROENTEROLOGY

Gut Microbiota and Extreme Longevity

(2016) Elena Biagi et al.   CURRENT BIOLOGY

Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer’s Patch T Follicular Helper Cells

(2016) Fei Teng et al.   IMMUNITY

Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases

(2016) Mingming Sun et al.   JOURNAL OF GASTROENTEROLOGY

Reduced intestinal motility, mucosal barrier function, and inflammation in aged monkeys

(2016) E. L. Mitchell et al.   Journal of Nutrition Health & Aging

Gram-negative bacterial molecules associate with Alzheimer disease pathology

(2016) Xinhua Zhan et al.   NEUROLOGY

The Effect of Diet and Exercise on Intestinal Integrity and Microbial Diversity in Mice

(2016) Sara C. Campbell et al.   PLoS One

Signatures of early frailty in the gut microbiota

(2016) Matthew A. Jackson et al.   Genome Medicine

Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study

(2016) Monika Puzianowska-Kuźnicka et al.   Immunity & Ageing

Functional metagenomic profiling of intestinal microbiome in extreme ageing

(2016) Simone Rampelli et al.   Aging-US

Age-Related Changes of Plasma Bile Acid Concentrations in Healthy Adults—Results from the Cross-Sectional KarMeN Study

(2016) Lara Frommherz et al.   PLoS One

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease

(2016) Myles R. Minter et al.   Scientific Reports

Reduced naïve CD8+T-cell priming efficacy in elderly adults

(2015) Olivia Briceño et al.   AGING CELL

The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging

(2015) Michael E. Walsh et al.   AGING CELL

Loss of Phagocytic and Antigen Cross-Presenting Capacity in Aging Dendritic Cells Is Associated with Mitochondrial Dysfunction

(2015) Claire A. Chougnet et al.   JOURNAL OF IMMUNOLOGY

The gut microbiota modulates host amino acid and glutathione metabolism in mice

(2015) A. Mardinoglu et al.   Molecular Systems Biology

The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment

(2015) Xuan Zhang et al.   NATURE MEDICINE

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Gut microbe-derived extracellular vesicles induce insulin resistance, thereby impairing glucose metabolism in skeletal muscle

(2015) Youngwoo Choi et al.   Scientific Reports

High incidence of hospitalisation due to infectious gastroenteritis in older people associated with poor self-rated health

(2015) Yingxi Chen et al.   BMJ Open

Fecal microbiota transplantation and bacterial consortium transplantation have comparable effects on the re-establishment of mucosal barrier function in mice with intestinal dysbiosis

(2015) Ming Li et al.   Frontiers in Microbiology

Probiotic strain Bacillus subtilis CU1 stimulates immune system of elderly during common infectious disease period: a randomized, double-blind placebo-controlled study

(2015) Marie Lefevre et al.   Immunity & Ageing

Mediterranean Diet and Age-Related Cognitive Decline

(2015) Cinta Valls-Pedret et al.   JAMA Internal Medicine

Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial

(2015) Estefanía Toledo et al.   JAMA Internal Medicine

The Treatment-Naive Microbiome in New-Onset Crohn’s Disease

(2014) Dirk Gevers et al.   Cell Host & Microbe

Segmented Filamentous Bacteria Antigens Presented by Intestinal Dendritic Cells Drive Mucosal Th17 Cell Differentiation

(2014) Yoshiyuki Goto et al.   IMMUNITY

An age-related numerical and functional deficit in CD19+CD24hiCD38hiB cells is associated with an increase in systemic autoimmunity

(2013) Niharika A. Duggal et al.   AGING CELL

Microbiota transplantation restores normal fecal bile acid composition in recurrent Clostridium difficile infection

(2013) Alexa R. Weingarden et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence

(2013) E. Sapey et al.   BLOOD

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Thymic rejuvenation and aging

(2013) Melissa S Ventevogel et al.   CURRENT OPINION IN IMMUNOLOGY

Immunomodulatory effects of a probiotic drink containing Lactobacillus casei Shirota in healthy older volunteers

(2013) Honglin Dong et al.   EUROPEAN JOURNAL OF NUTRITION

Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages

(2013) Katrin Haselow et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Age-Associated Remodeling of the Intestinal Epithelial Barrier

(2013) L. Tran et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Microbial colonization influences early B-lineage development in the gut lamina propria

(2013) Duane R. Wesemann et al.   NATURE

Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile

(2013) Els van Nood et al.   NEW ENGLAND JOURNAL OF MEDICINE

Extracellular Vesicles Derived from Gut Microbiota, Especially Akkermansia muciniphila, Protect the Progression of Dextran Sulfate Sodium-Induced Colitis

(2013) Chil-sung Kang et al.   PLoS One

Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function

(2012) Anna C. Hearps et al.   AGING CELL

Reduced release and binding of perforin at the immunological synapse underlies the age-related decline in natural killer cell cytotoxicity

(2012) Jon Hazeldine et al.   AGING CELL

Efficacy of daily intake of Lactobacillus casei Shirota on respiratory symptoms and influenza vaccination immune response: a randomized, double-blind, placebo-controlled trial in healthy elderly nursing home residents

(2012) Karolien Van Puyenbroeck et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Outer Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease Protection

(2012) Yue Shen et al.   Cell Host & Microbe

Immune aging and autoimmunity

(2012) Jörg J. Goronzy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

(2012) Anne Vrieze et al.   GASTROENTEROLOGY

Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway

(2012) Riko Ichikawa et al.   IMMUNOLOGY

Gut microbiota composition correlates with diet and health in the elderly

(2012) Marcus J. Claesson et al.   NATURE

Symptomatic atherosclerosis is associated with an altered gut metagenome

(2012) Fredrik H. Karlsson et al.   Nature Communications

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

(2011) R. M. Gadaleta et al.   GUT

Reversible Senescence in Human CD4+CD45RA+CD27- Memory T Cells

(2011) D. Di Mitri et al.   JOURNAL OF IMMUNOLOGY

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

(2011) G. D. Wu et al.   SCIENCE

Recognition and Degradation of Plant Cell Wall Polysaccharides by Two Human Gut Symbionts

(2011) Eric C. Martens et al.   PLOS BIOLOGY

Inflammatory markers in population studies of aging

(2010) Tushar Singh et al.   AGEING RESEARCH REVIEWS

Potentiation of Th17 cytokines in aging process contributes to the development of colitis

(2010) Xinshou Ouyang et al.   CELLULAR IMMUNOLOGY

Ageing is associated with diminished apoptotic cell clearance in vivo

(2010) T. Aprahamian et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

(2010) Hsin-Jung Wu et al.   IMMUNITY

Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans

(2010) Carles Ubeda et al.   JOURNAL OF CLINICAL INVESTIGATION

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians

(2010) Elena Biagi et al.   PLoS One

Composition, variability, and temporal stability of the intestinal microbiota of the elderly

(2010) M. J. Claesson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

(2010) J. L. Round et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation

(2010) L. Dethlefsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Malnutrition in the UK: where does it begin?

(2010) C. A. Russell et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Reversible Microbial Colonization of Germ-Free Mice Reveals the Dynamics of IgA Immune Responses

(2010) S. Hapfelmeier et al.   SCIENCE

Aging is associated with a numerical and functional decline in plasmacytoid dendritic cells, whereas myeloid dendritic cells are relatively unaltered in human peripheral blood

(2009) Yu Jing et al.   HUMAN IMMUNOLOGY

The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity

(2009) P. Vavassori et al.   JOURNAL OF IMMUNOLOGY

A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials

(2009) Thierry Boge et al.   VACCINE

Voluntary Running Exercise Alters Microbiota Composition and Increases n-Butyrate Concentration in the Rat Cecum

(2008) Megumi MATSUMOTO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY