Nanomedicine-based delivery strategies for nucleic acid gene inhibitors in inflammatory diseases

Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation

(2021) Christopher M. Bobba et al.   Nature Communications

Determinants of Phagosomal pH During Host-Pathogen Interactions

(2021) Johannes Westman et al.   Frontiers in Cell and Developmental Biology

Nanomaterial Delivery Systems for mRNA Vaccines

(2021) Michael D. Buschmann et al.   Vaccines

mRNA Transfection-Induced Activation of Primary Human Monocytes and Macrophages: Dependence on Carrier System and Nucleotide Modification

(2020) Hanieh Moradian et al.   Scientific Reports

Optimizing synthetic nucleic acid and protein nanocarriers: The chemical evolution approach

(2020) Franziska Freitag et al.   ADVANCED DRUG DELIVERY REVIEWS

Nanoparticles Modified with Cell-Penetrating Peptides: Conjugation Mechanisms, Physicochemical Properties, and Application in Cancer Diagnosis and Therapy

(2020) Isabel Gessner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phosphorothioate modified oligonucleotide–protein interactions

(2020) Stanley T Crooke et al.   NUCLEIC ACIDS RESEARCH

T-cell targeted pulmonary siRNA delivery for the treatment of asthma

(2020) Tobias W. M. Keil et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Nanomedicines for the delivery of glucocorticoids and nucleic acids as potential alternatives in the treatment of rheumatoid arthritis

(2020) Zhibo Yu et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Recent advancements in liposome technology

(2020) Nina Filipczak et al.   ADVANCED DRUG DELIVERY REVIEWS

miR-155 antagomir protect against DSS-induced colitis in mice through regulating Th17/Treg cell balance by Jarid2/Wnt/β-catenin

(2020) Feng Zhu et al.   BIOMEDICINE & PHARMACOTHERAPY

Single‐Dose Pharmacokinetics and Pharmacodynamics of Transthyretin Targeting N‐acetylgalactosamine–Small Interfering Ribonucleic Acid Conjugate, Vutrisiran, in Healthy Subjects

(2020) Bahru A. Habtemariam et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Treatment of acute lung inflammation by pulmonary delivery of anti-TNF-α siRNA with PAMAM dendrimers in a murine model

(2020) Adam Bohr et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Advances in oligonucleotide drug delivery

(2020) Thomas C. Roberts et al.   NATURE REVIEWS DRUG DISCOVERY

In Vitro and In Vivo Assessment of PEGylated PEI for Anti-IL-8/CxCL-1 siRNA Delivery to the Lungs

(2020) Alan J. Hibbitts et al.   Nanomaterials

A Novel Smad7 Genetic Variant Mapping on the Genomic Region Targeted by Mongersen Is Associated with Crohn’s Disease

(2020) Davide Di Fusco et al.   Biomedicines

Nanoparticle-siRNA: A potential strategy for rheumatoid arthritis therapy?

(2020) Naibo Feng et al.   JOURNAL OF CONTROLLED RELEASE

Cell penetrating peptides: A versatile vector for co-delivery of drug and genes in cancer

(2020) Muhammad Muzamil Khan et al.   JOURNAL OF CONTROLLED RELEASE

RNA interference-mediated suppression of TNF-α converting enzyme as an alternative anti-TNF-α therapy for rheumatoid arthritis

(2020) Yoonsung Song et al.   JOURNAL OF CONTROLLED RELEASE

Orally Delivered Antisense Oligodeoxyribonucleotides of TNF-α via Polysaccharide-Based Nanocomposites Targeting Intestinal Inflammation

(2019) Bingchao Duan et al.   Advanced Healthcare Materials

In-Depth Characterization of Monocyte-Derived Macrophages using a Mass Cytometry-Based Phagocytosis Assay

(2019) Daniel Schulz et al.   Scientific Reports

Recent Advances in Cell Penetrating Peptide-Based Anticancer Therapies

(2019) Justine Habault et al.   MOLECULES

Lipid- and polymer-based plexes as therapeutic carriers for bioactive molecules

(2019) Pravin Shende et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases

(2019) Meenu Mehta et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo

(2019) Annabelle Biscans et al.   JOURNAL OF CONTROLLED RELEASE

Lipidoid-siRNA Nanoparticle-Mediated IL-1β Gene Silencing for Systemic Arthritis Therapy in a Mouse Model

(2019) Ping Song et al.   MOLECULAR THERAPY

Oligonucleotides—A Novel Promising Therapeutic Option for IBD

(2019) Patrizio Scarozza et al.   Frontiers in Pharmacology

miR-155 in the Resolution of Atherosclerosis

(2019) Robyn Bruen et al.   Frontiers in Pharmacology

Carriers Break Barriers in Drug Delivery: Endocytosis and Endosomal Escape of Gene Delivery Vectors

(2019) Isabelle M. S. Degors et al.   ACCOUNTS OF CHEMICAL RESEARCH

Effect of thermal and shear stresses in the spray drying process on the stability of siRNA dry powders

(2019) Jingya Wu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle

(2019) Thazha P Prakash et al.   NUCLEIC ACIDS RESEARCH

Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics

(2019) Jayesh A. Kulkarni et al.   ACCOUNTS OF CHEMICAL RESEARCH

si RNA Targeting and Treatment of Gastrointestinal Diseases

(2019) Rachel Chevalier   CTS-Clinical and Translational Science

Lipidoid-polymer hybrid nanoparticles loaded with TNF siRNA suppress inflammation after intra-articular administration in a murine experimental arthritis model

(2019) Manon A.A. Jansen et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A study of the endocytosis mechanism and transendothelial activity of lung-targeted GALA-modified liposomes

(2019) Sarochin Santiwarangkool et al.   JOURNAL OF CONTROLLED RELEASE

Monocyte/Macrophage Abnormalities Specific to Rheumatoid Arthritis Are Linked to miR-155 and Are Differentially Modulated by Different TNF Inhibitors

(2019) Audrey Paoletti et al.   JOURNAL OF IMMUNOLOGY

Transfection reagent Lipofectamine triggers type I interferon signaling activation in macrophages

(2019) Xiaomin Guo et al.   IMMUNOLOGY AND CELL BIOLOGY

The role of liposomes in clinical nanomedicine development. What now? Now what?

(2019) Daan J.A. Crommelin et al.   JOURNAL OF CONTROLLED RELEASE

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

(2019) Akin Akinc et al.   Nature Nanotechnology

Effective lung-targeted RNAi in mice with peptide-based delivery of nucleic acid

(2019) Kaido Kurrikoff et al.   Scientific Reports

Endosomal Size and Membrane Leakiness Influence Proton Sponge-Based Rupture of Endosomal Vesicles

(2018) Lotte M. P. Vermeulen et al.   ACS Nano

Oligonucleotide-Based Therapies for Inflammatory Bowel Disease

(2018) Gerolamo Bevivino et al.   BIODRUGS

The proton sponge hypothesis: Fable or fact?

(2018) Lotte M.P. Vermeulen et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

siRNA-mediated c - Rel knockdown ameliorates collagen-induced arthritis in mice

(2018) Tingting Fan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

In vivo therapeutic efficacy of TNFα silencing by folate-PEG-chitosan-DEAE/siRNA nanoparticles in arthritic mice

(2018) Qin Shi et al.   International Journal of Nanomedicine

Lipid nanoparticles with minimum burst release of TNF-α siRNA show strong activity against rheumatoid arthritis unresponsive to methotrexate

(2018) Abdulaziz M. Aldayel et al.   JOURNAL OF CONTROLLED RELEASE

Aptamer-guided siRNA-loaded nanomedicines for systemic gene silencing in CD-44 expressing murine triple-negative breast cancer model

(2018) Walhan Alshaer et al.   JOURNAL OF CONTROLLED RELEASE

Elucidating the role of surface chemistry on cationic phosphorus dendrimer–siRNA complexation

(2018) Marco A. Deriu et al.   Nanoscale

Notch-1 siRNA and Methotrexate towards a Multifunctional Approach in Rhematoid Arthritis Management: a Nanomedicine Approach

(2018) Guang Zhao et al.   PHARMACEUTICAL RESEARCH

Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility

(2018) Jayesh A. Kulkarni et al.   Nucleic Acid Therapeutics

GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics

(2018) Aaron D. Springer et al.   Nucleic Acid Therapeutics

Anti-Inflammatory MicroRNAs and Their Potential for Inflammatory Diseases Treatment

(2018) Alireza Tahamtan et al.   Frontiers in Immunology

Dendrimer as a new potential carrier for topical delivery of siRNA: A comparative study of dendriplex vs. lipoplex for delivery of TNF-α siRNA

(2018) Palpandi Pandi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

TNFα gene silencing mediated by orally targeted nanoparticles combined with interleukin-22 for synergistic combination therapy of ulcerative colitis

(2018) Bo Xiao et al.   JOURNAL OF CONTROLLED RELEASE

Inhibition of miR-155 Limits Neuroinflammation and Improves Functional Recovery After Experimental Traumatic Brain Injury in Mice

(2018) Rebecca J. Henry et al.   Neurotherapeutics

The great escape: how cationic polyplexes overcome the endosomal barrier

(2018) Tanja Bus et al.   Journal of Materials Chemistry B

Combination of NF-kB targeted siRNA and methotrexate in a hybrid nanocarrier towards the effective treatment in rheumatoid arthritis

(2018) Weifeng Duan et al.   JOURNAL OF NANOBIOTECHNOLOGY

Dendrimers Show Promise for siRNA and microRNA Therapeutics

(2018) Volha Dzmitruk et al.   Pharmaceutics

Super-resolution Imaging of Proton Sponge-Triggered Rupture of Endosomes and Cytosolic Release of Small Interfering RNA

(2018) Marcin Wojnilowicz et al.   ACS Nano

Alicaforsen for the treatment of inflammatory bowel disease

(2017) Vipul Jairath et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Adenovirus-Mediated Small Interfering RNA Targeting TAK1 Ameliorates Joint Inflammation with Collagen-Induced Arthritis in Mice

(2017) Xinjing Luo et al.   INFLAMMATION

DOP073 Submucosal injection of the oligonucleotide STNM01 is able to induce clinical remission, mucosal healing and histological response in left-sided ulcerative colitis patients with moderate-to-severe disease

(2017) R. Atreya et al.   Journal of Crohns & Colitis

Acid-Sensitive Sheddable PEGylated, Mannose-Modified Nanoparticles Increase the Delivery of Betamethasone to Chronic Inflammation Sites in a Mouse Model

(2017) Hannah L. O’Mary et al.   MOLECULAR PHARMACEUTICS

Lipid Nanoparticle Systems for Enabling Gene Therapies

(2017) Pieter R. Cullis et al.   MOLECULAR THERAPY

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

(2017) Rajesha Rupaimoole et al.   NATURE REVIEWS DRUG DISCOVERY

Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol

(2017) Kausik K. Ray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of miR-142-5P ameliorates disease in mouse models of experimental colitis

(2017) Nicolette W. Duijvis et al.   PLoS One

Inhibition of microRNA-34a ameliorates murine collagen-induced arthritis

(2017) Qiujie Dang et al.   Experimental and Therapeutic Medicine

Molecular Mechanisms of Antisense Oligonucleotides

(2017) Stanley T. Crooke   Nucleic Acid Therapeutics

Cholesterol-Containing Nuclease-Resistant siRNA Accumulates in Tumors in a Carrier-free Mode and Silences MDR1 Gene

(2017) Ivan V. Chernikov et al.   Molecular Therapy-Nucleic Acids

The role of microRNAs in the pathogenesis of autoimmune diseases

(2016) Ji-Qing Chen et al.   AUTOIMMUNITY REVIEWS

Utilization of nanoparticle technology in rheumatoid arthritis treatment

(2016) Sanam Dolati et al.   BIOMEDICINE & PHARMACOTHERAPY

Systemic delivery of small interfering RNA targeting nuclear factor κB in mice with collagen-induced arthritis using arginine-histidine-cysteine based oligopeptide-modified polymer nanomicelles

(2016) Takanori Kanazawa et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Targeted delivery of siRNA to activated T cells via transferrin-polyethylenimine (Tf-PEI) as a potential therapy of asthma

(2016) Yuran Xie et al.   JOURNAL OF CONTROLLED RELEASE

Colonic gene silencing using siRNA-loaded calcium phosphate/PLGA nanoparticles ameliorates intestinal inflammation in vivo

(2016) Annika Frede et al.   JOURNAL OF CONTROLLED RELEASE

In vivo inhibition of miR-155 significantly alters post-stroke inflammatory response

(2016) Juan Carlos Pena-Philippides et al.   Journal of Neuroinflammation

Nanoparticle Multivalency Directed Shifting of Cellular Uptake Mechanism

(2016) Chumki Dalal et al.   Journal of Physical Chemistry C

Splice-switching antisense oligonucleotides as therapeutic drugs

(2016) Mallory A. Havens et al.   NUCLEIC ACIDS RESEARCH

Combination Therapy for Ulcerative Colitis: Orally Targeted Nanoparticles Prevent Mucosal Damage and Relieve Inflammation

(2016) Bo Xiao et al.   Theranostics

Inhibition of miR-155 Protects Against LPS-induced Cardiac Dysfunction and Apoptosis in Mice

(2016) Hui Wang et al.   Molecular Therapy-Nucleic Acids

Efficient and Non-Toxic Biological Response Carrier Delivering TNF-α shRNA for Gene Silencing in a Murine Model of Rheumatoid Arthritis

(2016) Jialin Song et al.   Frontiers in Immunology

Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides

(2015) Richard S. Geary et al.   ADVANCED DRUG DELIVERY REVIEWS

Dual-modified liposomes with a two-photon-sensitive cell penetrating peptide and NGR ligand for siRNA targeting delivery

(2015) Yang Yang et al.   BIOMATERIALS

The dendritic effect illustrated with phosphorus dendrimers

(2015) Anne-Marie Caminade et al.   CHEMICAL SOCIETY REVIEWS

Notch1 targeting siRNA delivery nanoparticles for rheumatoid arthritis therapy

(2015) Min Ju Kim et al.   JOURNAL OF CONTROLLED RELEASE

A New Approach for the Treatment of Arthritis in Mice with a Novel Conjugate of an Anti-C5aR1 Antibody and C5 Small Interfering RNA

(2015) Gaurav Mehta et al.   JOURNAL OF IMMUNOLOGY

Supramolecular Organization and siRNA Binding of Hyaluronic Acid-Coated Lipoplexes for Targeted Delivery to the CD44 Receptor

(2015) Thais L. Nascimento et al.   LANGMUIR

Potential Use of Thioalkylated Mannose-Modified Dendrimer (G3)/α-Cyclodextrin Conjugate as an NF-κB siRNA Carrier for the Treatment of Fulminant Hepatitis

(2015) Keiichi Motoyama et al.   MOLECULAR PHARMACEUTICS

Nanoparticle uptake: The phagocyte problem

(2015) Heather Herd Gustafson et al.   Nano Today

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

(2015) Anders Wittrup et al.   NATURE BIOTECHNOLOGY

Oral SMAD7 antisense oligonucleotide proves effective for Crohn's disease

(2015) Katrina Ray   Nature Reviews Gastroenterology & Hepatology

TNF biology, pathogenic mechanisms and emerging therapeutic strategies

(2015) George D. Kalliolias et al.   Nature Reviews Rheumatology

Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease

(2015) Giovanni Monteleone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stereochemical bias introduced during RNA synthesis modulates the activity of phosphorothioate siRNAs

(2015) Hartmut Jahns et al.   Nature Communications

M2 polarization enhances silica nanoparticle uptake by macrophages

(2015) Jessica Hoppstädter et al.   Frontiers in Pharmacology

Advances in systemic siRNA delivery

(2015) Q. Leng et al.   DRUGS OF THE FUTURE

Functionalizing Liposomes with anti-CD44 Aptamer for Selective Targeting of Cancer Cells

(2014) Walhan Alshaer et al.   BIOCONJUGATE CHEMISTRY

Nanoparticles With Surface Antibody Against CD98 and Carrying CD98 Small Interfering RNA Reduce Colitis in Mice

(2014) Bo Xiao et al.   GASTROENTEROLOGY

CCR5 small interfering RNA ameliorated joint inflammation in rats with adjuvant-induced arthritis

(2014) Hongmei Duan et al.   IMMUNOLOGY LETTERS

Peptide-siRNA nanocomplexes targeting NF-κB subunit p65 suppress nascent experimental arthritis

(2014) Hui-fang Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Carbosilane dendrimers as gene delivery agents for the treatment of HIV infection

(2014) Ana Judith Perisé-Barrios et al.   JOURNAL OF CONTROLLED RELEASE

Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

(2014) Jayaprakash K. Nair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Contrasting phagosome pH regulation and maturation in human M1 and M2 macrophages

(2014) Johnathan Canton et al.   MOLECULAR BIOLOGY OF THE CELL

Therapeutic Aerosol Bioengineering of siRNA for the Treatment of Inflammatory Lung Disease by TNFα Gene Silencing in Macrophages

(2014) Ciara Kelly et al.   MOLECULAR PHARMACEUTICS

Peptides Used in the Delivery of Small Noncoding RNA

(2014) Ravi S. Shukla et al.   MOLECULAR PHARMACEUTICS

RNAi Therapies: Drugging the Undruggable

(2014) S. Y. Wu et al.   Science Translational Medicine

Phosphorothioates, Essential Components of Therapeutic Oligonucleotides

(2014) Fritz Eckstein   Nucleic Acid Therapeutics

Folic acid conjugated chitosan for targeted delivery of siRNA to activated macrophages in vitro and in vivo

(2014) Chuanxu Yang et al.   Journal of Materials Chemistry B

Dendrimers: synthesis, applications, and properties

(2014) Elham Abbasi et al.   Nanoscale Research Letters

Preclinical Studies on Intestinal Administration of Antisense Oligonucleotides as a Model for Oral Delivery for Treatment of Duchenne Muscular Dystrophy

(2014) Maaike van Putten et al.   Molecular Therapy-Nucleic Acids

The role of miRNA in inflammation and autoimmunity

(2013) Ram Pyare Singh et al.   AUTOIMMUNITY REVIEWS

Dexamethasone-conjugated polyethylenimine/MIF siRNA complex regulation of particulate matter-induced airway inflammation

(2013) Moonhwan Choi et al.   BIOMATERIALS

Mannosylated bioreducible nanoparticle-mediated macrophage-specific TNF-α RNA interference for IBD therapy

(2013) Bo Xiao et al.   BIOMATERIALS

Gene silencing of TNF-alpha in a murine model of acute colitis using a modified cyclodextrin delivery system

(2013) J. McCarthy et al.   JOURNAL OF CONTROLLED RELEASE

Enhanced bioavailability of orally administered antisense oligonucleotide to nuclear factor kappa B mRNA after microencapsulation with albumin

(2013) Mohammad Nasir Uddin et al.   JOURNAL OF DRUG TARGETING

Targeting Intestinal Inflammation With CD98 siRNA/PEI–loaded Nanoparticles

(2013) Hamed Laroui et al.   MOLECULAR THERAPY

TNF-α Gene Silencing Using Polymerized siRNA/Thiolated Glycol Chitosan Nanoparticles for Rheumatoid Arthritis

(2013) So Jin Lee et al.   MOLECULAR THERAPY

Phosphorus Dendrimers as Carriers of siRNA—Characterisation of Dendriplexes

(2013) Malgorzata Ferenc et al.   MOLECULES

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

(2013) Gaurav Sahay et al.   NATURE BIOTECHNOLOGY

MicroRNA control in the development of systemic autoimmunity

(2013) Ruozhen Hu et al.   ARTHRITIS RESEARCH & THERAPY

TRPM2 links oxidative stress to NLRP3 inflammasome activation

(2013) Zhenyu Zhong et al.   Nature Communications

Targeting receptor-mediated endocytotic pathways with nanoparticles: Rationale and advances

(2012) Shi Xu et al.   ADVANCED DRUG DELIVERY REVIEWS

Liposomal drug delivery systems: From concept to clinical applications

(2012) Theresa M. Allen et al.   ADVANCED DRUG DELIVERY REVIEWS

microRNA Regulation of Inflammatory Responses

(2012) Ryan M. O'Connell et al.   Annual Review of Immunology

CD98 Positive Eosinophils Contribute to T Helper 1 Pattern Inflammation

(2012) Fu-Min Xue et al.   PLoS One

Size-dependent mechanism of cargo sorting during lysosome-phagosome fusion is controlled by Rab34

(2012) B. Kasmapour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA

(2012) Nathan M Belliveau et al.   Molecular Therapy-Nucleic Acids

Amino-Functionalized Polystyrene Nanoparticles Activate the NLRP3 Inflammasome in Human Macrophages

(2011) Oleg Lunov et al.   ACS Nano

Effect of IL-10 antisense gene therapy in severely burned mice intradermally infected with MRSA

(2011) Akira Asai et al.   IMMUNOBIOLOGY

Synthesis, Characterization, and in Vivo Delivery of siRNA-Squalene Nanoparticles Targeting Fusion Oncogene in Papillary Thyroid Carcinoma

(2011) Mouna Raouane et al.   JOURNAL OF MEDICINAL CHEMISTRY

MicroRNA Delivery by Cationic Lipoplexes for Lung Cancer Therapy

(2011) Yun Wu et al.   MOLECULAR PHARMACEUTICS

Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells

(2011) Genc Basha et al.   MOLECULAR THERAPY

Systemic Delivery of Tumor Suppressor microRNA Mimics Using a Neutral Lipid Emulsion Inhibits Lung Tumors in Mice

(2011) Phong Trang et al.   MOLECULAR THERAPY

Functionalized STAT1 siRNA nanoparticles regress rheumatoid arthritis in a mouse model

(2011) Robert I Scheinman et al.   Nanomedicine

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

Comparison of Polymeric siRNA Nanocarriers in a Murine LPS-Activated Macrophage Cell Line: Gene Silencing, Toxicity and Off-Target Gene Expression

(2011) Linda B. Jensen et al.   PHARMACEUTICAL RESEARCH

siRNA-Like Double-Stranded RNAs Are Specifically Protected Against Degradation in Human Cell Extract

(2011) John A. H. Hoerter et al.   PLoS One

Nanotherapeutic approaches for the treatment of rheumatoid arthritis

(2011) Christine T. N. Pham   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Dual TNF-α/Cyclin D1 Gene Silencing With an Oral Polymeric Microparticle System as a Novel Strategy for the Treatment of Inflammatory Bowel Disease

(2011) Christina Kriegel et al.   Clinical and Translational Gastroenterology

Tumor-Selective Delivery of Macromolecular Drugs via the EPR Effect: Background and Future Prospects

(2010) Hiroshi Maeda   BIOCONJUGATE CHEMISTRY

Gene delivery using dimethyldidodecylammonium bromide-coated PLGA nanoparticles

(2010) François Fay et al.   BIOMATERIALS

Fast membrane association is a crucial factor in the peptide pep-1 translocation mechanism: A kinetic study followed by surface plasmon resonance

(2010) Sónia Troeira Henriques et al.   BIOPOLYMERS

Biomedical applications of dendrimers: a tutorial

(2010) Meredith A. Mintzer et al.   CHEMICAL SOCIETY REVIEWS

Off-Target Effects Related to the Phosphorothioate Modification of Nucleic Acids

(2010) Johannes Winkler et al.   ChemMedChem

Up-regulation of MicroRNA-155 in Macrophages Contributes to Increased Tumor Necrosis Factor α (TNFα) Production via Increased mRNA Half-life in Alcoholic Liver Disease

(2010) Shashi Bala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Orally delivered thioketal nanoparticles loaded with TNF-α–siRNA target inflammation and inhibit gene expression in the intestines

(2010) D. Scott Wilson et al.   NATURE MATERIALS

siRNA delivery systems for cancer treatment

(2009) Yu-Kyoung Oh et al.   ADVANCED DRUG DELIVERY REVIEWS

Delivery of endocytosed membrane proteins to the lysosome

(2009) Paul R. Pryor et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Characterization of endocytosis of transferrin-coated PLGA nanoparticles by the blood–brain barrier

(2009) Jiang Chang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Intratracheally instilled mannosylated cationic liposome/NFκB decoy complexes for effective prevention of LPS-induced lung inflammation

(2009) Wassana Wijagkanalan et al.   JOURNAL OF CONTROLLED RELEASE

Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

(2009) Myriam Aouadi et al.   NATURE

A three-dimensional view of the molecular machinery of RNA interference

(2009) Martin Jinek et al.   NATURE

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

TARGETED DELIVERY OF siRNA TO CELL DEATH PROTEINS IN SEPSIS

(2009) Pavan Brahmamdam et al.   SHOCK

Efficient suppression of murine arthritis by combined anticytokine small interfering RNA lipoplexes

(2008) Maroun Khoury et al.   ARTHRITIS AND RHEUMATISM

Imaging and imagination: understanding the endo-lysosomal system

(2008) Eline Meel et al.   HISTOCHEMISTRY AND CELL BIOLOGY

In vivo gene delivery in the mouse lung with lactosylated polyethylenimine, questioning the relevance of in vitro experiments

(2008) Stéphanie Grosse et al.   JOURNAL OF CONTROLLED RELEASE

Chitosan/siRNA Nanoparticle–mediated TNF-α Knockdown in Peritoneal Macrophages for Anti-inflammatory Treatment in a Murine Arthritis Model

(2008) Kenneth A Howard et al.   MOLECULAR THERAPY

Systems Biology of Growth Factor-Induced Receptor Endocytosis

(2008) Yaara Zwang et al.   TRAFFIC

PLGA Nanoparticle−Peptide Conjugate Effectively Targets Intercellular Cell-Adhesion Molecule-1

(2007) Na Zhang et al.   BIOCONJUGATE CHEMISTRY

Efficient gene silencing in metastatic tumor by siRNA formulated in surface-modified nanoparticles

(2007) Shyh-Dar Li et al.   JOURNAL OF CONTROLLED RELEASE

Oral Delivery of Antisense Oligonucleotides in Man

(2007) Lloyd G. Tillman et al.   JOURNAL OF PHARMACEUTICAL SCIENCES