C3- and CR3-dependent microglial clearance protects photoreceptors in retinitis pigmentosa

Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury

(2018) Geoffrey T. Norris et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lipocalin 2 Plays an Important Role in Regulating Inflammation in Retinal Degeneration

(2018) Tanu Parmar et al.   JOURNAL OF IMMUNOLOGY

New tricks for an ancient system: Physiological and pathological roles of complement in the CNS

(2018) Andrea J. Tenner et al.   MOLECULAR IMMUNOLOGY

Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment

(2018) Yoko Okunuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy

(2018) Kenneth J. Katschke et al.   Scientific Reports

The Complement System Is Critical in Maintaining Retinal Integrity during Aging

(2018) Ryo Mukai et al.   Frontiers in Aging Neuroscience

Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau

(2018) Silvia S. Kang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration

(2018) Haihan Jiao et al.   Molecular Neurodegeneration

Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma

(2018) Alejandra Bosco et al.   MOLECULAR THERAPY

From compliment to insult: genetics of the complement system in physiology and disease in the human retina

(2017) Robert F. Mullins et al.   HUMAN MOLECULAR GENETICS

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective

(2017) Jeffrey M. Harder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct recognition of complement iC3b by integrins αXβ2and αMβ2

(2017) Shutong Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

THE PATHOPHYSIOLOGY OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION AND THE COMPLEMENT PATHWAY AS A THERAPEUTIC TARGET

(2017) David S. Boyer et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

(2017) Qiaoqiao Shi et al.   Science Translational Medicine

Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration

(2017) Brian L. Yaspan et al.   Science Translational Medicine

Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration

(2017) Raghavi Sudharsan et al.   Scientific Reports

Monocyte infiltration and proliferation reestablish myeloid cell homeostasis in the mouse retina following retinal pigment epithelial cell injury

(2017) Wenxin Ma et al.   Scientific Reports

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

(2016) Hansen Lui et al.   CELL

Targeting the complement system for the management of retinal inflammatory and degenerative diseases

(2016) Heping Xu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Microglial phagocytosis and activation underlying photoreceptor degeneration is regulated by CX3CL1-CX3CR1 signaling in a mouse model of retinitis pigmentosa

(2016) Matthew K. Zabel et al.   GLIA

Requirement for Microglia for the Maintenance of Synaptic Function and Integrity in the Mature Retina

(2016) Xu Wang et al.   JOURNAL OF NEUROSCIENCE

C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury

(2016) Sean M. Silverman et al.   Molecular Neurodegeneration

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Fate mapping reveals that microglia and recruited monocyte-derived macrophages are definitively distinguishable by phenotype in the retina

(2016) E. G. O’Koren et al.   Scientific Reports

Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration

(2015) L. Zhao et al.   EMBO Molecular Medicine

Abundance of infiltrating CD163+ cells in the retina of postmortem eyes with dry and neovascular age-related macular degeneration

(2015) Eleonora M. Lad et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Expression pattern of Ccr2 and Cx3cr1 in inherited retinal degeneration

(2015) Hideo Kohno et al.   Journal of Neuroinflammation

Live to die another way: modes of programmed cell death and the signals emanating from dying cells

(2015) Yaron Fuchs et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury

(2015) J. Harry Sweigard et al.   Science Translational Medicine

The Membrane Attack Complex in Aging Human Choriocapillaris

(2014) Robert F. Mullins et al.   AMERICAN JOURNAL OF PATHOLOGY

Suppression of Microglial Activation Is Neuroprotective in a Mouse Model of Human Retinitis Pigmentosa

(2014) B. Peng et al.   JOURNAL OF NEUROSCIENCE

Microglial phagocytosis of live neurons

(2014) Guy C. Brown et al.   NATURE REVIEWS NEUROSCIENCE

Synthesis and Propagation of Complement C3 by Microglia/Monocytes in the Aging Retina

(2014) Matt Rutar et al.   PLoS One

Neuronal Production of Lipocalin-2 as a Help-Me Signal for Glial Activation

(2014) Changhong Xing et al.   STROKE

Complement Component C3 Plays a Critical Role in Protecting the Aging Retina in a Murine Model of Age-Related Macular Degeneration

(2013) Jaimie Hoh Kam et al.   AMERICAN JOURNAL OF PATHOLOGY

Genes and mutations causing retinitis pigmentosa

(2013) S P Daiger et al.   CLINICAL GENETICS

CCR2+monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation inCx3cr1deficient mice

(2013) Florian Sennlaub et al.   EMBO Molecular Medicine

Complement expression in retinal pigment epithelial cells is modulated by activated macrophages

(2013) Chang Luo et al.   EXPERIMENTAL EYE RESEARCH

Seven new loci associated with age-related macular degeneration

(2013) Lars G Fritsche et al.   NATURE GENETICS

Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation

(2013) Wenxin Ma et al.   NEUROBIOLOGY OF AGING

Structural insight on the recognition of surface-bound opsonins by the integrin I domain of complement receptor 3

(2013) G. Bajic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clearing the Dead: Apoptotic Cell Sensing, Recognition, Engulfment, and Digestion

(2013) A. Hochreiter-Hufford et al.   Cold Spring Harbor Perspectives in Biology

Apoptotic cells can induce non-autonomous apoptosis through the TNF pathway

(2013) Ainhoa Pérez-Garijo et al.   eLife

Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination

(2012) Thomas Skripuletz et al.   BRAIN

Reduced removal of synaptic terminals from axotomized spinal motoneurons in the absence of complement C3

(2012) Alexander Berg et al.   EXPERIMENTAL NEUROLOGY

Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia

(2012) Hongjun Fu et al.   GLIA

Inflammatory priming predisposes mice to age-related retinal degeneration

(2012) Debarshi Mustafi et al.   JOURNAL OF CLINICAL INVESTIGATION

Complement receptor-3 negatively regulates the phagocytosis of degenerated myelin through tyrosine kinase Syk and cofilin

(2012) Smadar Hadas et al.   Journal of Neuroinflammation

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Clinical Evidence of Sustained Chronic Inflammatory Reaction in Retinitis Pigmentosa

(2012) Noriko Yoshida et al.   OPHTHALMOLOGY

Complement mediated apoptosis leads to the loss of retinal ganglion cells in animal model of glaucoma

(2011) Purushottam Jha et al.   MOLECULAR IMMUNOLOGY

Complement C3 Deficiency Leads to Accelerated Amyloid   Plaque Deposition and Neurodegeneration and Modulation of the Microglia/Macrophage Phenotype in Amyloid Precursor Protein Transgenic Mice

(2008) M. Maier et al.   JOURNAL OF NEUROSCIENCE