Osteocrin attenuates inflammation, oxidative stress, apoptosis, and cardiac dysfunction in doxorubicin‐induced cardiotoxicity

Matrine attenuates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via maintaining AMPKα/UCP2 pathway

(2019) Can Hu et al.   Acta Pharmaceutica Sinica B

Glabridin Prevents Doxorubicin-Induced Cardiotoxicity Through Gut Microbiota Modulation and Colonic Macrophage Polarization in Mice

(2019) Keqing Huang et al.   Frontiers in Pharmacology

Physical activity and muscle–brain crosstalk

(2019) Bente Klarlund Pedersen   Nature Reviews Endocrinology

Activation of cGMP/PKG/p65 signaling associated with PDE5‐Is downregulates CCL5 secretion by CD8 + T cells in benign prostatic hyperplasia

(2019) Song Jin et al.   PROSTATE

FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT

(2019) Xin Zhang et al.   CELL DEATH AND DIFFERENTIATION

Blood Pressure–Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase

(2019) Oleksandra Prysyazhna et al.   CIRCULATION

Empagliflozin prevents cardiomyopathy via sGC-cGMP-PKG pathway in type 2 diabetes mice

(2019) Mei Xue et al.   CLINICAL SCIENCE

p53 prevents doxorubicin cardiotoxicity independently of its prototypical tumor suppressor activities

(2019) Jie Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular vesicle-mediated macrophage activation: An insight into the mechanism of thioredoxin-mediated immune activation

(2019) Chontida Yarana et al.   Redox Biology

T-bet deficiency attenuates cardiac remodelling in rats

(2018) Zhen-Guo Ma et al.   BASIC RESEARCH IN CARDIOLOGY

A New Secretory Peptide of Natriuretic Peptide Family, Osteocrin, Suppresses the Progression of Congestive Heart Failure After Myocardial InfarctionNovelty and Significance

(2018) Takahiro Miyazaki et al.   CIRCULATION RESEARCH

A77 1726 (leflunomide) blocks and reverses cardiac hypertrophy and fibrosis in mice

(2018) Zhen-Guo Ma et al.   CLINICAL SCIENCE

Protein Kinase G Activation Reverses Oxidative Stress and Restores Osteoblast Function and Bone Formation in Male Mice With Type 1 Diabetes

(2018) Hema Kalyanaraman et al.   DIABETES

CTRP3 protected against doxorubicin-induced cardiac dysfunction, inflammation and cell death via activation of Sirt1

(2018) Yu-Pei Yuan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Rosmarinic acid attenuates cardiac fibrosis following long-term pressure overload via AMPKα/Smad3 signaling

(2018) Xin Zhang et al.   Cell Death & Disease

Interleukin-12p35 Knock Out Aggravates Doxorubicin-Induced Cardiac Injury and Dysfunction by Aggravating the Inflammatory Response, Oxidative Stress, Apoptosis and Autophagy in Mice

(2018) Jing Ye et al.   EBioMedicine

C1q-tumour necrosis factor-related protein-3 exacerbates cardiac hypertrophy in mice

(2018) Zhen-Guo Ma et al.   CARDIOVASCULAR RESEARCH

Isoquercitrin Attenuated Cardiac Dysfunction Via AMPKα-Dependent Pathways in LPS-Treated Mice

(2018) Si-Hui Huang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation

(2018) Jing Lu et al.   Acta Pharmaceutica Sinica B

Protective effects of acute exercise prior to doxorubicin on cardiac function of breast cancer patients: A proof-of-concept RCT

(2017) A.A. Kirkham et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Circulating osteocrin stimulates bone growth by limiting C-type natriuretic peptide clearance

(2017) Yugo Kanai et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardioprotective effects of fibroblast growth factor 21 against doxorubicin-induced toxicity via the SIRT1/LKB1/AMPK pathway

(2017) Shudong Wang et al.   Cell Death & Disease

Piperine Attenuates Pathological Cardiac Fibrosis Via PPAR-γ/AKT Pathways

(2017) Zhen-Guo Ma et al.   EBioMedicine

Protection against cardiac hypertrophy by geniposide involves the GLP-1 receptor / AMPKα signalling pathway

(2016) Zhen-Guo Ma et al.   BRITISH JOURNAL OF PHARMACOLOGY

Osteocrin, a peptide secreted from the heart and other tissues, contributes to cranial osteogenesis and chondrogenesis in zebrafish

(2016) Ayano Chiba et al.   DEVELOPMENT

Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Iα Oxidation

(2016) Oleksandra Prysyazhna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Muscle Mass During Chemotherapy Is Predictive for Poor Survival of Patients With Metastatic Colorectal Cancer

(2016) Susanne Blauwhoff-Buskermolen et al.   JOURNAL OF CLINICAL ONCOLOGY

NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages

(2016) Jong-Seok Moon et al.   NATURE MEDICINE

The ever-expanding myokinome: discovery challenges and therapeutic implications

(2016) Martin Whitham et al.   NATURE REVIEWS DRUG DISCOVERY

Gp130-mediated STAT3 activation by S-propargyl-cysteine, an endogenous hydrogen sulfide initiator, prevents doxorubicin-induced cardiotoxicity

(2016) J Wu et al.   Cell Death & Disease

Exercise training does not affect anthracycline antitumor efficacy while attenuating cardiac dysfunction

(2015) Traci L. Parry et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Thioredoxin-2 Inhibits Mitochondrial Reactive Oxygen Species Generation and Apoptosis Stress Kinase-1 Activity to Maintain Cardiac Function

(2015) Q. Huang et al.   CIRCULATION

Musclin is an activity-stimulated myokine that enhances physical endurance

(2015) Ekaterina Subbotina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adeno-Associated Virus Vectors as Therapeutic and Investigational Tools in the Cardiovascular System

(2014) Serena Zacchigna et al.   CIRCULATION RESEARCH

Endothelial NADPH Oxidase-2 Promotes Interstitial Cardiac Fibrosis and Diastolic Dysfunction Through Proinflammatory Effects and Endothelial-Mesenchymal Transition

(2014) Colin E. Murdoch et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Prevention of Anthracycline-Induced Cardiotoxicity

(2014) Pimprapa Vejpongsa et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Heart Failure Gene Therapy

(2013) Sven T. Pleger et al.   CIRCULATION RESEARCH

Exercise Mitigates Cardiac Doxorubicin Accumulation and Preserves Function in the Rat

(2013) Brock T. Jensen et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Protein kinase G oxidation is a major cause of injury during sepsis

(2013) O. Rudyk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low Myocardial Protein Kinase G Activity in Heart Failure With Preserved Ejection Fraction

(2012) Loek van Heerebeek et al.   CIRCULATION

cGMP-Dependent Activation of Protein Kinase G Precludes Disulfide Activation

(2012) Joseph Robert Burgoyne et al.   HYPERTENSION

Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies

(2012) Yanti Octavia et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Muscles, exercise and obesity: skeletal muscle as a secretory organ

(2012) Bente K. Pedersen et al.   Nature Reviews Endocrinology

Modulation of Anthracycline-Induced Cardiotoxicity by Aerobic Exercise in Breast Cancer

(2011) Jessica M. Scott et al.   CIRCULATION

Doxorubicin and sorafenib improves survival in patients with advanced hepatocellular carcinoma

(2011) Lisa Hutchinson   Nature Reviews Clinical Oncology

Noninvasive molecular imaging of apoptosis in vivo using a modified firefly luciferase substrate, Z-DEVD-aminoluciferin

(2010) J Hickson et al.   CELL DEATH AND DIFFERENTIATION

HGF suppresses high glucose-mediated oxidative stress in mesangial cells by activation of PKG and inhibition of PKA

(2010) Li Hui et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction

(2010) A. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Osteocrin – Beyond just another bone protein?

(2009) P. Moffatt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Phosphodiesterase-5 Inhibitor, Tadalafil, Protects Against Myocardial Ischemia/Reperfusion Through Protein-Kinase G-Dependent Generation of Hydrogen Sulfide

(2009) F. N. Salloum et al.   CIRCULATION

Hydrogen Sulfide Regulates Cardiac Function and Structure in Adriamycin-Induced Cardiomyopathy

(2009) Yu-Wen Su et al.   CIRCULATION JOURNAL

Toll-like receptor-4 deficiency attenuates doxorubicin-induced cardiomyopathy in mice

(2008) Alexander Riad et al.   EUROPEAN JOURNAL OF HEART FAILURE

Analysis of AAV Serotypes 1–9 Mediated Gene Expression and Tropism in Mice After Systemic Injection

(2008) Carmela Zincarelli et al.   MOLECULAR THERAPY