WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy

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NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1

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WIPI proteins: essential PtdIns3P effectors at the nascent autophagosome

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Atg17/FIP200 localizes to perilysosomal Ref(2)P aggregates and promotes autophagy by activation of Atg1 inDrosophila

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Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

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Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2

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Neutral Lipid Stores and Lipase PNPLA5 Contribute to Autophagosome Biogenesis

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WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

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WIPI-dependent autophagy during neutrophil differentiation of NB4 acute promyelocytic leukemia cells

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Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2

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FIP200 regulates targeting of Atg16L1 to the isolation membrane

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Omegasomes: PI3P platforms that manufacture autophagosomes

(2013) Rebecca Roberts et al.   Essays in Biochemistry

The Atg8 family: multifunctional ubiquitin-like key regulators of autophagy

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Phosphoinositide 3-kinases as accelerators and brakes of autophagy

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Autophagy Has a Significant Role in Determining Skin Color by Regulating Melanosome Degradation in Keratinocytes

(2013) Daiki Murase et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Emerging regulation and functions of autophagy

(2013) Patricia Boya et al.   NATURE CELL BIOLOGY

The autophagosome: origins unknown, biogenesis complex

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ULK1 Regulates Melanin Levels in MNT-1 Cells Independently of mTORC1

(2013) Eyal Kalie et al.   PLoS One

The incredible ULKs

(2012) Sebastian Alers et al.   Cell Communication and Signaling

Structure-based Analyses Reveal Distinct Binding Sites for Atg2 and Phosphoinositides in Atg18

(2012) Yasunori Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global Detection of Protein Kinase D-dependent Phosphorylation Events in Nocodazole-treated Human Cells

(2012) Mirita Franz-Wachtel et al.   MOLECULAR & CELLULAR PROTEOMICS

Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets

(2012) Anoop Kumar G. Velikkakath et al.   MOLECULAR BIOLOGY OF THE CELL

Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex–dependent and –independent autophagy

(2012) Noor Gammoh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural and functional characterization of the two phosphoinositide binding sites of PROPPINs, a β-propeller protein family

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The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation

(2011) Mario Mauthe et al.   Autophagy

The tuberous sclerosis complex: balancing proliferation and survival

(2011) Romana Tomasoni et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

The WD40 Repeat PtdIns(3)P-Binding Protein EPG-6 Regulates Progression of Omegasomes to Autophagosomes

(2011) Qun Lu et al.   DEVELOPMENTAL CELL

WIPI1 Coordinates Melanogenic Gene Transcription and Melanosome Formation via TORC1 Inhibition

(2011) Hsiang Ho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Freeze-fracture replica immunolabelling reveals human WIPI-1 and WIPI-2 as membrane proteins of autophagosomes

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Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis

(2011) Max R. Banko et al.   MOLECULAR CELL

Ca2+/Calmodulin-Dependent Kinase (CaMK) Signaling via CaMKI and AMP-Activated Protein Kinase Contributes to the Regulation of WIPI-1 at the Onset of Autophagy

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

(2010) Eisuke Itakura et al.   Autophagy

Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation

(2010) Hannah E.J. Polson et al.   Autophagy

Proteogenomics of Pristionchus pacificus reveals distinct proteome structure of nematode models

(2010) N. Borchert et al.   GENOME RESEARCH

Identification of a Nuclear Export Signal in the Catalytic Subunit of AMP-activated Protein Kinase

(2010) Nevzat Kazgan et al.   MOLECULAR BIOLOGY OF THE CELL

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function

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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

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Regulation of membrane biogenesis in autophagy via PI3P dynamics

(2010) Takeshi Noda et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Tuberous sclerosis complex: linking cancer to metabolism

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LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

(2009) R. J. Shaw   Acta Physiologica

mNUDC is required for plus-end-directed transport of cytoplasmic dynein and dynactins by kinesin-1

(2009) Masami Yamada et al.   EMBO JOURNAL

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

The Atg18-Atg2 Complex Is Recruited to Autophagic Membranes via Phosphatidylinositol 3-Phosphate and Exerts an Essential Function

(2008) Keisuke Obara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy

(2008) Naonobu Fujita et al.   MOLECULAR BIOLOGY OF THE CELL

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG

(2008) Eisuke Itakura et al.   MOLECULAR BIOLOGY OF THE CELL

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY