Iron overload inhibits late stage autophagic flux leading to insulin resistance

Increased intracellular iron in mouse primary hepatocytes in vitro causes activation of the Akt pathway but decreases its response to insulin

(2018) Joe Varghese et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Activity-based sensing fluorescent probes for iron in biological systems

(2018) Allegra T Aron et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Iron overload induces G1 phase arrest and autophagy in murine preosteoblast cells

(2018) Wan-Jing Cen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Iron overload promotes mitochondrial fragmentation in mesenchymal stromal cells from myelodysplastic syndrome patients through activation of the AMPK/MFF/Drp1 pathway

(2018) Qingqing Zheng et al.   Cell Death & Disease

Adiponectin improves insulin sensitivity via activation of autophagic flux

(2017) Penny Ahlstrom et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Iron depletion suppresses mTORC1-directed signalling in intestinal Caco-2 cells via induction of REDD1

(2016) Ailsa Watson et al.   CELLULAR SIGNALLING

Chronic Iron Overload Results in Impaired Bacterial Killing of THP-1 Derived Macrophage through the Inhibition of Lysosomal Acidification

(2016) Jun-Kai Kao et al.   PLoS One

Emerging role of autophagy in mediating widespread actions of ADIPOQ/adiponectin

(2015) Aimin Xu et al.   Autophagy

Experimental animal model to study iron overload and iron chelation and review of other such models

(2015) Khushnooma Italia et al.   BLOOD CELLS MOLECULES AND DISEASES

mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival

(2015) M. J. Munson et al.   EMBO JOURNAL

Pressure Overload-Induced Cardiac Dysfunction in Aged Male Adiponectin Knockout Mice Is Associated With Autophagy Deficiency

(2015) James Won Suk Jahng et al.   ENDOCRINOLOGY

Current and future treatment strategies for iron overload cardiomyopathy

(2015) Suwakon Wongjaikam et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Defective autophagosome trafficking contributes to impaired autophagic flux in coronary arterial myocytes lacking CD38 gene

(2014) Yang Zhang et al.   CARDIOVASCULAR RESEARCH

Adiponectin Stimulates Autophagy and Reduces Oxidative Stress to Enhance Insulin Sensitivity During High-Fat Diet Feeding in Mice

(2014) Ying Liu et al.   DIABETES

Iron, Oxidative Stress and Gestational Diabetes

(2014) Taifeng Zhuang et al.   Nutrients

Iron and Diabetes Risk

(2013) Judith A. Simcox et al.   Cell Metabolism

Autophagy regulation by nutrient signaling

(2013) Ryan C Russell et al.   CELL RESEARCH

Effect of carvedilol on cardiomyocyte apoptosis in a rat model of myocardial infarction: A role for toll-like receptor 4

(2013) Yan Xu et al.   INDIAN JOURNAL OF PHARMACOLOGY

Molecular Imaging of Labile Iron(II) Pools in Living Cells with a Turn-On Fluorescent Probe

(2013) Ho Yu Au-Yeung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Induction of Autophagic Cell Death in the Rat Brain Caused by Iron

(2012) Gao Chen et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Mechanisms of Mammalian Iron Homeostasis

(2012) Kostas Pantopoulos et al.   BIOCHEMISTRY

Efficacy and toxicity of intravenous iron in a mouse model of critical care anemia*

(2012) Nicholas Heming et al.   CRITICAL CARE MEDICINE

Iron homeostasis in the Metabolic Syndrome

(2012) Christian Datz et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Adipocyte iron regulates adiponectin and insulin sensitivity

(2012) J. Scott Gabrielsen et al.   JOURNAL OF CLINICAL INVESTIGATION

The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR

(2011) Dan Egan et al.   Autophagy

Regulation of cellular iron metabolism

(2011) Jian Wang et al.   BIOCHEMICAL JOURNAL

Non-transferrin bound iron: A key role in iron overload and iron toxicity

(2011) Pierre Brissot et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis

(2011) W. Chen et al.   BLOOD

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Iron sensing and signalling

(2011) Rayko Evstatiev et al.   GUT

Lipocalin-2 Induces Cardiomyocyte Apoptosis by Increasing Intracellular Iron Accumulation

(2011) Guoxiong Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disorders associated with systemic or local iron overload: from pathophysiology to clinical practice

(2011) Giada Sebastiani et al.   Metallomics

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Dietary iron restriction or iron chelation protects from diabetes and loss of β-cell function in the obese (ob/ob lep−/−) mouse

(2010) Robert C. Cooksey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective Mammalian Target of Rapamycin (mTOR) Inhibitor for the Treatment of Cancer

(2010) Qingsong Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

The role of iron in type 2 diabetes in humans

(2008) Swapnil N. Rajpathak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Oxidative Stress and Iron Homeostasis: Mechanistic and Health Aspects

(2008) Dimitrios Galaris et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

(2008) Taichi Hara et al.   JOURNAL OF CELL BIOLOGY