Diabetic Retinopathy and NADPH Oxidase-2: A Sweet Slippery Road

Retinopathy in a Diet-Induced Type 2 Diabetic Rat Model, and Role of Epigenetic Modifications

(2020) Renu A. Kowluru   DIABETES

Nox (NADPH Oxidase) 1, Nox4, and Nox5 Promote Vascular Permeability and Neovascularization in Retinopathy

(2020) Devy Deliyanti et al.   HYPERTENSION

Photoreceptor cells and RPE contribute to the development of diabetic retinopathy

(2020) Deoye Tonade et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Mitochondrial Stability in Diabetic Retinopathy: Lessons Learned From Epigenetics

(2019) Renu A. Kowluru   DIABETES

Association of Statin Therapy With Prevention of Vision-Threatening Diabetic Retinopathy

(2019) Eugene Yu-Chuan Kang et al.   JAMA Ophthalmology

New insights into the mechanisms of diabetic complications: role of lipids and lipid metabolism

(2019) Stephanie Eid et al.   DIABETOLOGIA

Functional Regulation of an Oxidative Stress Mediator, Rac1, in Diabetic Retinopathy

(2019) Ghulam Mohammad et al.   MOLECULAR NEUROBIOLOGY

Advances in epigenetics link genetics to the environment and disease

(2019) Giacomo Cavalli et al.   NATURE

The Regulatory Role of Rac1, a Small Molecular Weight GTPase, in the Development of Diabetic Retinopathy

(2019) Nikhil Sahajpal et al.   Journal of Clinical Medicine

Effect of NADPH oxidase 1 and 4 blockade in activated human retinal endothelial cells

(2018) Binoy Appukuttan et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Compartmentalisation of RAC1 signalling

(2018) Aishwarya Payapilly et al.   CURRENT OPINION IN CELL BIOLOGY

Role of endoplasmic reticulum stress in 12/15-lipoxygenase-induced retinal microvascular dysfunction in a mouse model of diabetic retinopathy

(2018) Khaled Elmasry et al.   DIABETOLOGIA

A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4 ) gene with severe diabetic retinopathy in type 2 diabetes

(2018) Weihua Meng et al.   ACTA OPHTHALMOLOGICA

Adaptor protein p66Shc- a link between cytosolic and mitochondrial dysfunction in the development of diabetic retinopathy

(2018) Manish Mishra et al.   ANTIOXIDANTS & REDOX SIGNALING

Post-Translational Modification and Subcellular Distribution of Rac1: An Update

(2018) Abdalla Abdrabou et al.   Cells

Treatment of cardiovascular pathology with epigenetically active agents: Focus on natural and synthetic inhibitors of DNA methylation and histone deacetylation

(2017) Dimitry A. Chistiakov et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Dual Inhibition of NOX2 and Receptor Tyrosine Kinase by BJ-1301 Enhances Anticancer Therapy Efficacy via Suppression of Autocrine-Stimulatory Factors in Lung Cancer

(2017) Jaya Gautam et al.   MOLECULAR CANCER THERAPEUTICS

Diabetic retinopathy and transcriptional regulation of a small molecular weight G-Protein, Rac1

(2016) Renu A. Kowluru et al.   EXPERIMENTAL EYE RESEARCH

Dynamic DNA methylation of matrix metalloproteinase-9 in the development of diabetic retinopathy

(2016) Renu A Kowluru et al.   LABORATORY INVESTIGATION

Hyperlipidemia and the development of diabetic retinopathy: Comparison between type 1 and type 2 animal models

(2016) Renu A. Kowluru et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Oxidative stress, mitochondrial damage and diabetic retinopathy

(2015) Renu A. Kowluru et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Tiam1-Rac1 Axis Promotes Activation of p38 MAP Kinase in the Development of Diabetic Retinopathy: Evidence for a Requisite Role for Protein Palmitoylation

(2015) Rajakrishnan Veluthakal et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Nutrition Transition and the Global Diabetes Epidemic

(2015) Barry M. Popkin   Current Diabetes Reports

Redox mechanisms in pathological angiogenesis in the retina: roles for NADPH oxidase

(2015) Elsa Chan et al.   CURRENT PHARMACEUTICAL DESIGN

Molecular Mechanism of Transcriptional Regulation of Matrix Metalloproteinase-9 in Diabetic Retinopathy

(2015) Manish Mishra et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase

(2015) Ahmed S. Ibrahim et al.   JOURNAL OF LIPID RESEARCH

Phagocyte-like NADPH oxidase [Nox2] in cellular dysfunction in models of glucolipotoxicity and diabetes

(2014) Anjaneyulu Kowluru et al.   BIOCHEMICAL PHARMACOLOGY

Rho protein GTPases and their interactions with NFκB: crossroads of inflammation and matrix biology

(2014) Louis Tong et al.   BIOSCIENCE REPORTS

TIAM1–RAC1 signalling axis-mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy

(2014) Renu A. Kowluru et al.   DIABETOLOGIA

Physical activity and inactivity patterns in India – results from the ICMR-INDIAB study (Phase-1) [ICMR-INDIAB-5]

(2014) Ranjit M Anjana et al.   International Journal of Behavioral Nutrition and Physical Activity

Targeting histone methyltransferase EZH2 as cancer treatment

(2014) Y. Kondo   JOURNAL OF BIOCHEMISTRY

Reactive oxygen species, Nox and angiotensin II in angiogenesis: implications for retinopathy

(2013) Jennifer L. Wilkinson-Berka et al.   CLINICAL SCIENCE

Triamcinolone Acetonide Inhibits p38MAPK Activation and Neuronal Apoptosis in Early Diabetic Retinopathy

(2013) X. Zhang et al.   CURRENT MOLECULAR MEDICINE

NADPH Oxidase as a Therapeutic Target for Oxalate Induced Injury in Kidneys

(2013) Sunil Joshi et al.   Oxidative Medicine and Cellular Longevity

Regulation of Small GTPases by GEFs, GAPs, and GDIs

(2013) Jacqueline Cherfils et al.   PHYSIOLOGICAL REVIEWS

Epigenetic Modifications and Diabetic Retinopathy

(2013) Renu A. Kowluru et al.   Biomed Research International

The NADPH Oxidase Family and its Inhibitors

(2012) Paulina Kleniewska et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Upregulation of phagocyte-like NADPH oxidase by cytokines in pancreatic beta-cells: Attenuation of oxidative and nitrosative stress by 2-bromopalmitate

(2012) Abiy M. Mohammed et al.   BIOCHEMICAL PHARMACOLOGY

Epigenetics and the environment: emerging patterns and implications

(2012) Robert Feil et al.   NATURE REVIEWS GENETICS

Diabetic Retinopathy

(2012) David A. Antonetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Friendly, and not so friendly, roles of Rac1 in islet β-cell function: Lessons learnt from pharmacological and molecular biological approaches

(2011) Anjaneyulu Kowluru   BIOCHEMICAL PHARMACOLOGY

Rac signaling in breast cancer: A tale of GEFs and GAPs

(2011) Eva Wertheimer et al.   CELLULAR SIGNALLING

A palmitoylation switch mechanism regulates Rac1 function and membrane organization

(2011) Inmaculada Navarro-Lérida et al.   EMBO JOURNAL

New nucleoside analogs for patients with hematological malignancies

(2011) Tadeusz Robak   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Mitochondrial Rac1 GTPase Import and Electron Transfer from CytochromecAre Required for Pulmonary Fibrosis

(2011) Heather L. Osborn-Heaford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetics

(2010) Mark E. Cooper et al.   CIRCULATION RESEARCH

Activation of Protein Kinase C Isoforms and Its Impact on Diabetic Complications

(2010) Pedro Geraldes et al.   CIRCULATION RESEARCH

Calcium Dobesilate Inhibits the Alterations in Tight Junction Proteins and Leukocyte Adhesion to Retinal Endothelial Cells Induced by Diabetes

(2010) E. C. Leal et al.   DIABETES

Epigenetics and gene expression

(2010) E R Gibney et al.   HEREDITY

Matrix metalloproteinase-2 in the development of diabetic retinopathy and mitochondrial dysfunction

(2010) Ghulam Mohammad et al.   LABORATORY INVESTIGATION

Epigenetics: A Molecular Link Between Environmental Factors and Type 2 Diabetes

(2009) Charlotte Ling et al.   DIABETES

Epigenetic responses to environmental change and their evolutionary implications

(2009) B. M. Turner   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells

(2009) P.-O. Esteve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nuclear Import of the Small GTPase Rac1 is Mediated by the Direct Interaction with Karyopherin α2

(2009) Kirstin Sandrock et al.   TRAFFIC

Epigenetic Cross-Talk between DNA Methylation and Histone Modifications in Human Cancers

(2009) Yutaka Kondo   YONSEI MEDICAL JOURNAL

NADPH Oxidase-Dependent Signaling in Endothelial Cells: Role in Physiology and Pathophysiology

(2008) Randall S. Frey et al.   ANTIOXIDANTS & REDOX SIGNALING

Projection of Diabetic Retinopathy and Other Major Eye Diseases Among People With Diabetes Mellitus

(2008) Jinan B. Saaddine   ARCHIVES OF OPHTHALMOLOGY

Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division

(2008) David Michaelson et al.   JOURNAL OF CELL BIOLOGY