HBO1 is required for the maintenance of leukaemia stem cells

Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome

(2018) Brian T. Weinert et al.   CELL

MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity

(2018) Anna Skucha et al.   Nature Communications

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

(2018) Jonathan B. Baell et al.   NATURE

ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference

(2017) Geoffrey P. Dann et al.   NATURE

Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2

(2017) Ye Tao et al.   NUCLEIC ACIDS RESEARCH

Histone-binding of DPF2 mediates its repressive role in myeloid differentiation

(2017) Ferdinand M. Huber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cancer epigenome: Concepts, challenges, and therapeutic opportunities

(2017) Mark A. Dawson   SCIENCE

Functional interdependence of BRD4 and DOT1L in MLL leukemia

(2016) Omer Gilan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

deepTools2: a next generation web server for deep-sequencing data analysis

(2016) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing

(2016) Andrew Keniry et al.   Epigenetics & Chromatin

Functional interdependence of BRD4 and DOT1L in MLL leukemia

(2016) Omer Gilan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia

(2016) Konstantinos Tzelepis et al.   Cell Reports

Diffraction-geometry refinement in theDIALSframework

(2016) David G. Waterman et al.   Acta Crystallographica Section D-Structural Biology

Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2

(2015) S. A. Kinkel et al.   BLOOD

Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance

(2015) D. Grimwade et al.   BLOOD

MYST2 acetyltransferase expression and Histone H4 Lysine acetylation are suppressed in AML

(2015) Tim Sauer et al.   EXPERIMENTAL HEMATOLOGY

BET inhibitor resistance emerges from leukaemia stem cells

(2015) Chun Yew Fong et al.   NATURE

Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains

(2015) Junwei Shi et al.   NATURE BIOTECHNOLOGY

The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias

(2015) Vincent-Philippe Lavallée et al.   NATURE GENETICS

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

BloodSpot: a database of gene expression profiles and transcriptional programs for healthy and malignant haematopoiesis

(2015) Frederik Otzen Bagger et al.   NUCLEIC ACIDS RESEARCH

Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells

(2015) I. A. Tchasovnikarova et al.   SCIENCE

HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia

(2015) Gabriela Brumatti et al.   Oncotarget

Quantitative ChIP-Seq Normalization Reveals Global Modulation of the Epigenome

(2014) David A. Orlando et al.   Cell Reports

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A powerful molecular synergy between mutant Nucleophosmin and Flt3-ITD drives acute myeloid leukemia in mice

(2013) A Mupo et al.   LEUKEMIA

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The role of HOX genes in normal hematopoiesis and acute leukemia

(2012) R A Alharbi et al.   LEUKEMIA

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

(2011) Johannes Zuber et al.   NATURE

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

ROAST: rotation gene set tests for complex microarray experiments

(2010) Di Wu et al.   BIOINFORMATICS

HBO1 Is Required for H3K14 Acetylation and Normal Transcriptional Activity during Embryonic Development

(2010) A. J. Kueh et al.   MOLECULAR AND CELLULAR BIOLOGY

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Moz and Retinoic Acid Coordinately Regulate H3K9 Acetylation, Hox Gene Expression, and Segment Identity

(2009) Anne K. Voss et al.   DEVELOPMENTAL CELL

HBO1 HAT Complexes Target Chromatin throughout Gene Coding Regions via Multiple PHD Finger Interactions with Histone H3 Tail

(2009) Nehmé Saksouk et al.   MOLECULAR CELL

The ground state of embryonic stem cell self-renewal

(2008) Qi-Long Ying et al.   NATURE

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Polycomb Repressive Complex 2 (PRC2) Restricts Hematopoietic Stem Cell Activity

(2008) Ian J Majewski et al.   PLOS BIOLOGY