Article
Behavioral Sciences
Claire Kostelnik, Irwin Lucki, Kwang H. Choi, Caroline A. Browne
Summary: This review outlines the increased risk of PTSD following mTBI in military populations and emphasizes the importance of establishing translationally relevant animal models. It also evaluates the translational relevance of fear conditioning paradigms and addresses the lack of research on fear memory enhancement over time post mTBI. Additionally, potential neurobiological substrates implicated in altered fear memory post mTBI are discussed.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Charlotte Oris, Samy Kahouadji, Julie Durif, Damien Bouvier, Vincent Sapin
Summary: Mild traumatic brain injury (mTBI) is a growing burden worldwide, accounting for approximately 80% of all TBI cases. In recent years, candidate biomarkers have been investigated to improve the management of mTBI patients. Blood biomarker measurement in the acute phase after a traumatic event helps reduce unnecessary CT scans and hospitalizations. S100B protein has emerged as the most widely studied and used biomarker for clinical decision making in patients with mTBI. Besides its diagnostic use, S100B plays a role in the molecular pathogenic processes accompanying acute brain injury, making it a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Critical Care Medicine
Sara M. Lippa, Louis M. French, Tracey A. Brickell, Angela E. Driscoll, Megan E. Glazer, Corie E. Tippett, Jamie K. Sullivan, Rael T. Lange
Summary: This study found that PTSD symptoms were more strongly related to cognitive performance in individuals with a history of complicated mild/moderate TBI compared to those with severe/penetrating TBI. The impact of PTSD symptoms on cognition should be considered in individuals with complicated mild/moderate TBI.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Neurosciences
Ashley L. Ware, Keith Owen Yeates, Bryce Geeraert, Xiangyu Long, Miriam H. Beauchamp, William Craig, Quynh Doan, Stephen B. Freedman, Bradley G. Goodyear, Roger Zemek, Catherine Lebel
Summary: Sophisticated network-based approaches such as structural connectomics may help detect a biomarker of mild traumatic brain injury (mTBI) in children. This study compared the structural connectome of children with mTBI or mild orthopedic injury (OI) to that of typically developing (TD) children, finding that both mTBI and OI groups demonstrated reduced global and regional network efficiency and segregation compared to TD children. This suggests a general effect of childhood injury on brain structure that could reflect pre- and postinjury factors.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Lilia A. Koza, Claudia Pena, Madison Russell, Alec C. Smith, Jacob Molnar, Maeve Devine, Natalie J. Serkova, Daniel A. Linseman
Summary: Successive traumatic brain injuries exacerbate neuroinflammation and oxidative stress. No therapeutics exist for populations at high risk of repetitive mild TBIs (rmTBIs). The preventative therapeutic effects of Immunocal & REG; for rmTBI and rmmTBI were explored.
Review
Radiology, Nuclear Medicine & Medical Imaging
Cyrus Ayubcha, Mona-Elisabeth Revheim, Andrew Newberg, Mateen Moghbel, Chaitanya Rojulpote, Thomas J. Werner, Abass Alavi
Summary: PET has been widely used in the study of traumatic brain injury (TBI) for decades, with recent focus on imaging biomarkers related to TBI and chronic traumatic encephalopathy (CTE). This review critically assesses the use of glycolysis, beta-amyloid, and tau protein radiotracers in the context of TBI, weighing their strengths and weaknesses. Despite the ongoing debate, PET remains a powerful modality in diagnosing TBI-related conditions.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Neurosciences
Daniel A. Lopez, Zachary P. Christensen, John J. Foxe, Laura R. Ziemer, Paige R. Nicklas, Edward G. Freedman
Summary: The study found that children who experienced possible mTBI or mTBI are at a higher risk of emotional or behavioral problems. However, brain metrics did not clearly mediate the relationship between mTBI and mental health outcomes.
Article
Immunology
Britahny M. Baskin, Aric F. Logsdon, Suhjung Janet Lee, Brian D. Foresi, Elaine Peskind, William A. Banks, David G. Cook, Abigail G. Schindler
Summary: In this study, repetitive blast trauma was induced in female and male mice using a blast overpressure model. The findings showed different behavioral, inflammatory, microbiome, and vascular dysfunction outcomes in female and male mice. However, only male mice exhibited adverse behavioral outcomes that lasted at least one month.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Behavioral Sciences
Fanny Degeilh, Tilmann von Soest, Lia Ferschmann, Joanne C. Beer, Malo Gaubert, Inga K. Koerte, Christian K. Tamnes
Summary: Childhood mTBI is associated with an increased risk of developing social problems, possibly due to changes in the structural development of the social brain. This study used data from the ABCD Study to examine the development of social problems and cortical thickness in social brain regions following childhood mTBI. The findings showed different developmental trajectories in social problems between children with and without mTBI, with the mTBI group showing higher levels of social problems. Both groups showed similar decreases in social brain cortical thickness.
Article
Neurosciences
Yingxi Wu, Haijian Wu, Jianxiong Zeng, Brock Pluimer, Shirley Dong, Xiaochun Xie, Xinying Guo, Tenghuan Ge, Xinyan Liang, Sudi Feng, Youzhen Yan, Jian-Fu Chen, Naomi Sta Maria, Qingyi Ma, Fernando Gomez-Pinilla, Zhen Zhao
Summary: This study demonstrates that microvascular injury plays a key role in the pathogenesis of Alzheimer's disease after mild traumatic brain injury. Restoring vascular functions may be beneficial for patients with mild TBI and potentially reduce the risk of developing AD.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Ellen Lirani-Silva, Samuel Stuart, Lucy Parrington, Kody Campbell, Laurie King
Summary: Research findings suggest impaired saccadic eye movements during walking in individuals with mTBI, but fixations remain unaffected. Future studies should investigate whether saccade outcomes are influenced by the time after the trauma and rehabilitation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cell Biology
Ruslan Prus, Olena Appelhans, Maksim Logash, Petro Pokotylo, Grzegorz Jozef Nowicki, Barbara Slusarska
Summary: Traumatic brain injury is a serious issue in modern medicine, with our study showing that mild TBI causes different histological changes in the livers of adult and juvenile rats. The most significant changes were observed on days 5-7, with compensatory phenomena prevailing on days 14-21 in both groups.
Review
Neurosciences
Nozar Aghakhani
Summary: There is growing evidence for the important role of gut microbiota in the development and progression of neurological disorders, with studies suggesting that modifying the microbiome profile can benefit patients. Animal models have shown disturbances in the GMB following TBI, with probiotic supplementation improving neurological function. However, clinical studies are needed to determine the impact of restoring gut microbiome profile on long-term outcomes for mTBI patients.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Medicine, General & Internal
Sophia Wagberg, Britt-Marie Stalnacke, Beatrice M. M. Magnusson
Summary: This study evaluates post-TBI symptoms and disabilities seven to eight years after mild TBI (mTBI), showing that women and individuals with repeated TBI experience more severe symptoms and functional decline. These findings have implications for clinical practice and research, and should be considered in rehabilitation and follow-up plans.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Zachary M. Weil, Kate Karelina, Bailey Whitehead, Ruth Velazquez-Cruz, Robin Oliverio, Mark Pinti, Divine C. Nwafor, Samuel Nicholson, Julie A. Fitzgerald, John Hollander, Candice M. Brown, Ning Zhang, A. Courtney DeVries
Summary: Recent studies have shown that traumatic brain injury (TBI) can worsen outcomes after stroke by affecting neuroimmune and neurometabolic functions. In a mouse model, TBI led to larger stroke infarcts, more severe functional deficits, and increased neuroinflammation. Treatment with the insulin sensitizing drug pioglitazone was able to prevent the exacerbation of ischemic outcomes caused by TBI, suggesting that metabolic dysfunction plays a role in these processes.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Psychology, Clinical
Casey L. Straud, John C. Moring, Willie J. Hale, Chelsea McMahon, Brian A. Moore, Monty T. Baker, Richard A. Bryant, Stacey Young-McCaughan, William C. Isler, Jose Lara-Ruiz, Cynthia L. Lancaster, Jim Mintz, Alan L. Peterson
Summary: The study aims to identify latent profiles of acute stress disorder symptoms after a blast injury and evaluate the differences in postconcussive symptoms across these profiles. The findings suggest that the severity of acute stress disorder symptoms is indicative of the severity of postconcussive symptoms and cognitive functioning problems.
PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY
(2023)
Editorial Material
Psychiatry
Gin S. Malhi, Erica Bell, Darryl Bassett, Philip Boyce, Richard Bryant, Malcolm Hopwood, Bill Lyndon, Roger Mulder, Richard Porter, Ajeet B. Singh, Greg Murray
Summary: This editorial compares the recommendations of two recently published national clinical practice guidelines for depression and highlights the agreement in advice on therapy selection and sequencing. Lifestyle and psychological interventions are emphasized, and there is broad consensus on medication choice and optimization strategies, making these guidelines a valuable resource.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Article
Neurosciences
Aleksandra Klimova, Isabella A. Breukelaar, Richard A. Bryant, Mayuresh S. Korgaonkar
Summary: This study compared the neural connectivity between mTBI and PTSD and found no significant differences between the two conditions. However, mTBI patients showed reduced connectivity compared to healthy controls in multiple regions, while PTSD patients also exhibited abnormal connectivity within these networks.
HUMAN BRAIN MAPPING
(2023)
Article
Critical Care Medicine
Anthony P. Joseph, Matthew Wallman, Elliot Scott, Ralf Ilchef, Newman Harris, Alicia Jackson, Richard A. Bryant
Summary: This proof-of-concept trial investigated whether Stepped Care could lead to better mental health and functioning in traumatic injury patients. The results showed that patients in the Stepped Care condition reported significantly less anxiety and disability at 9 months compared to those in Treatment as Usual. This study suggests that brief screening assessments following hospital discharge, combined with appropriate referral information, may lead to better functional outcomes in traumatic injury patients.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Health Care Sciences & Services
Leona Tan, Mark Deady, Olivia Mead, Rebecca M. Foright, Eric M. Brenneman, Jamie R. Yeager, Richard A. Bryant, Samuel B. Harvey
Summary: This study evaluated a web-based mind-body tactical resilience training program for first responders. The program was found to be feasible and acceptable, although improvements may be needed to enhance adherence rates. Further research using a larger and more rigorous trial design is needed to examine the effectiveness of this training as a prevention or treatment strategy for this population.
JMIR FORMATIVE RESEARCH
(2023)
Article
Psychiatry
Angela Nickerson, Yulisha Byrow, Meaghan O'Donnell, Richard A. Bryant, Vicki Mau, Tadgh Mcmahon, Joel Hoffman, Natalie Mastrogiovanni, Philippa Specker, Belinda J. Liddell
Summary: This online longitudinal study investigates the mental health impact of transitioning from low to high visa security for refugees. The results indicate that increased visa security does not necessarily lead to improved mental health and social outcomes for refugees. Permanent protection, however, is associated with significant improvements in psychological and social functioning.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychology, Clinical
Philippa Specker, Belinda J. Liddell, Meaghan O'Donnell, Richard A. Bryant, Vicki Mau, Tadgh McMahon, Yulisha Byrow, Angela Nickerson
Summary: Based on a study of a community sample of refugees (N = 1,081) over a 2-year period, it was found that emotion dysregulation preceded the development of posttraumatic stress disorder (PTSD) and was bidirectionally associated with hyperarousal and postmigration stressors. These findings provide novel evidence for understanding the mechanisms of PTSD in refugees and highlight the potential usefulness of interventions targeting these factors.
CLINICAL PSYCHOLOGICAL SCIENCE
(2023)
Article
Health Care Sciences & Services
Mark Deady, Daniel A. J. Collins, Isobel Lavender, Andrew Mackinnon, Nicholas Glozier, Richard Bryant, Helen Christensen, Samuel B. Harvey
Summary: This study aimed to evaluate the effectiveness of a smartphone-based intervention in preventing depression in workers with moderate stress levels. The results showed that the intervention group had significant reductions in depressive and anxiety symptoms, as well as improved work performance. However, the intervention did not show effectiveness in preventing clinically diagnosed depression in the intention-to-treat analysis.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Psychology, Multidisciplinary
V. Lorant, P. Smith, C. Duveau, K. Seeber, R. A. Bryant, E. Mittendorfer-Rutz, M. Melchior, J. M. Haro, M. Monzio Compagnoni, G. Corrao, J. L. Ayuso-Mateos, M. Sijbrandij, P. Nicaise
Summary: This study assessed the relationship between online advice-seeking and mental health needs, and whether different population subgroups were equally likely to seek advice. The study found that individuals with higher psychological distress were more likely to seek online advice, and women, young people, those with higher education, and those with less social support were more likely to seek advice online.
CURRENT PSYCHOLOGY
(2023)
Article
Health Care Sciences & Services
Melissa Medich, Shay L. Cannedy, Lauren C. Hoffmann, Melissa Y. Chinchilla, Jose M. Pila, Stephanie A. Chassman, Ronald A. Calderon, Alexander S. Young
Summary: Remote mental health monitoring using smartphone technology shows promise in early intervention for mental health crises. This study examines the acceptability and usability of passive mobile monitoring and self-tracking among patients with serious mental illness and their mental health clinicians, finding that most participants are receptive to the technology but have concerns about privacy and implementation challenges.
JMIR HUMAN FACTORS
(2023)
Article
Psychiatry
Richard Bryant, Katie Dawson, Suzanna Azevedo, Srishti Yadav, Jenny Tran, Jasmine Choi-Christou, Elpiniki Andrew, Joanne Beames, Dharani Keyan
Summary: This study evaluated a brief positive affect training programme to reduce anxiety, depression, and suicidality during the pandemic. The intervention led to significant reduction in depression and improvement in quality of life at the 3-month follow-up. However, there were no significant differences in anxiety, generalised anxiety, anhedonia, sleep impairment, positive or negative mood, or COVID-19 concerns.
Article
Psychology, Clinical
Richard A. A. Bryant, Suzanna Azevedo, Srishti Yadav, Dharani Keyan, Natasha Rawson, Katie Dawson, Julia Tockar, Benjamin Garber, Dusan Hadzi-Pavlovic
Summary: This study investigated the role of reliving distressing memories in the treatment of PTSD and PGD. The findings suggest that reliving functions differently in the two disorders and may involve distinct mechanisms.
EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
(2023)
Review
Psychiatry
Richard A. Bryant
Summary: Refugees have a higher rate of common mental disorders and face a lack of mental health services in low-and-middle-income countries. To address this, scalable mental health interventions have been implemented, training local lay providers to deliver evidence-based programs to refugees. However, there are limitations to these interventions, and more attention is needed on long-term benefits, mental health needs of non-responsive refugees, severe psychological disorders, and underlying mechanisms.
CAMBRIDGE PRISMS-GLOBAL MENTAL HEALTH
(2023)
Article
Health Care Sciences & Services
Aniek Woodward, Egbert Sondorp, Alexandra S. Barry, Marjolein A. Dieleman, Daniela C. Fuhr, Jacqueline E. W. Broerse, Aemal Akhtar, Manar Awwad, Ahmad Bawaneh, Richard Bryant, Marit Sijbrandij, Pim Cuijpers, Bayard Roberts, STRENGTHS Consortium
Summary: Training nonspecialists in evidence-based psychological interventions can increase community access to psychological support, but scaling up task-sharing interventions is uncommon. This study examined the scalability of a task-sharing intervention called Problem Management Plus (PM+) for Syrian refugees in Jordan. Factors influencing scalability included political momentum, stigma, gender, legal barriers, and limited resources and organizational challenges. Sustainable funding, language destigmatization, and flexibility in modalities and scheduling were recommended to promote scaling up. Lessons from scaling up PM+ and similar approaches should be widely shared.
HEALTH POLICY AND PLANNING
(2023)
Article
Health Care Sciences & Services
Alicia A. Bergman, Evelyn T. Chang, Amy N. Cohen, Sona Hovsepian, Rebecca S. Oberman, Merlyn Vinzon, Alexander S. Young
Summary: This study qualitatively examined patients' experiences with a novel, specialized patient-centered medical home for individuals with serious mental illness (SMI). The findings indicated that patients had overwhelmingly positive experiences with the care provided in the medical home, primarily due to the qualities of interpersonal communication displayed by the staff, the structural features of the collaborative care model, and other unique aspects tailored for SMI patients. Patients also reported improvements in healthcare engagement and self-management as a result of their participation in the medical home.
FAMILIES SYSTEMS & HEALTH
(2023)
