Regulation of Tissue Inflammation by 12-Lipoxygenases

12/15-Lipoxygenase Deficiency Impairs Neutrophil Granulopoiesis and Lung Proinflammatory Responses to Aspergillus fumigatus

(2020) Joseph J. Mackel et al.   JOURNAL OF IMMUNOLOGY

Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells

(2020) Stéphane Demine et al.   Stem Cell Research & Therapy

Histopathologic Changes and SARS-CoV-2 Immunostaining in the Lung of a Patient With COVID-19

(2020) Huilan Zhang et al.   ANNALS OF INTERNAL MEDICINE

Arachidonate 12S-lipoxygenase of platelet-type in hepatic stellate cells of methionine and choline-deficient diet-fed mice

(2020) Yoshiko Mori et al.   JOURNAL OF BIOCHEMISTRY

Systemic deficiency of mouse arachidonate 15‐lipoxygenase induces defective erythropoiesis and transgenic expression of the human enzyme rescues this phenotype

(2020) Marlena Rademacher et al.   FASEB JOURNAL

HFD-induced hepatic lipid accumulation and inflammation are decreased in Factor D deficient mouse

(2020) Hiromi Tsuru et al.   Scientific Reports

Coronavirus disease 2019: investigational therapies in the prevention and treatment of hyperinflammation

(2020) Isabelle Amigues et al.   Expert Review of Clinical Immunology

Cutting Edge: Severe SARS-CoV-2 Infection in Humans Is Defined by a Shift in the Serum Lipidome, Resulting in Dysregulation of Eicosanoid Immune Mediators

(2020) Benjamin Schwarz et al.   JOURNAL OF IMMUNOLOGY

Impact of 12/15-Lipoxygenase on Brain Injury After Subarachnoid Hemorrhage

(2019) Thomas Gaberel et al.   STROKE

Platelet-type 12-lipoxygenase deletion provokes a compensatory 12/15-lipoxygenase increase that exacerbates oxidative stress in islet β-cells

(2019) Abass M. Conteh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma oxylipins respond in a linear dose-response manner with increased intake of EPA and DHA: results from a randomized controlled trial in healthy humans

(2019) Annika I Ostermann et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Neuroinflammation: friend and foe for ischemic stroke

(2019) Richard L. Jayaraj et al.   Journal of Neuroinflammation

Regulation and Functions of 15-Lipoxygenases in Human Macrophages

(2019) Ryan G. Snodgrass et al.   Frontiers in Pharmacology

Ischemia reperfusion injury promotes recurrence of hepatocellular carcinoma in fatty liver via ALOX12-12HETE-GPR31 signaling axis

(2019) Faji Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

Female mice carrying a defective Alox15 gene are protected from experimental colitis via sustained maintenance of the intestinal epithelial barrier function

(2018) Saskia Kroschwald et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Altered expression of cyclooxygenase-2, 12-lipoxygenase, inducible nitric oxide synthase-2 and surfactant protein D in lungs of patients with pulmonary injury caused by sulfur mustard

(2018) Eisa Tahmasbpour et al.   DRUG AND CHEMICAL TOXICOLOGY

An In Vivo Zebrafish Model for Interrogating ROS-Mediated Pancreatic β-Cell Injury, Response, and Prevention

(2018) Abhishek A. Kulkarni et al.   Oxidative Medicine and Cellular Longevity

Omega-6 fatty acids and inflammation

(2018) Jacqueline K. Innes et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Arachidonic acid: Physiological roles and potential health benefits – A review

(2018) Hatem Tallima et al.   Journal of Advanced Research

Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications

(2018) A.D. Dobrian et al.   PHARMACOLOGY & THERAPEUTICS

Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies

(2018) Nikhlesh K. Singh et al.   PROGRESS IN LIPID RESEARCH

12-Lipoxygenase Inhibitor Improves Functions of Cytokine-Treated Human Islets and Type 2 Diabetic Islets

(2017) Kaiwen Ma et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

An ALOX12–12-HETE–GPR31 signaling axis is a key mediator of hepatic ischemia–reperfusion injury

(2017) Xiao-Jing Zhang et al.   NATURE MEDICINE

Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice

(2017) Wenliang Zhang et al.   Scientific Reports

Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis

(2017) Bibhuti B. Mishra et al.   Nature Microbiology

Sensitivity profile of the human EndoC-βH1 beta cell line to proinflammatory cytokines

(2016) Ewa Gurgul-Convey et al.   DIABETOLOGIA

DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation

(2016) Melody G. Duvall et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction

(2016) Giuseppe Lo Sasso et al.   Journal of Translational Medicine

The respiratory tract microbiome and lung inflammation: a two-way street

(2016) G B Huffnagle et al.   Mucosal Immunology

Insulitis in the pathogenesis of type 1 diabetes

(2016) Alberto Pugliese   PEDIATRIC DIABETES

Distinct differences in the responses of the human pancreatic β-cell line EndoC-βH1 and human islets to proinflammatory cytokines

(2015) Bryndon J. Oleson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Mammalian lipoxygenases and their biological relevance

(2015) Hartmut Kuhn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Essential phospholipids prevent islet damage induced by proinflammatory cytokines and hypoxic conditions

(2015) Rauf Shahbazov et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Expression Pattern of 12-Lipoxygenase in Human Islets With Type 1 Diabetes and Type 2 Diabetes

(2015) Wojciech J. Grzesik et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Minireview: 12-Lipoxygenase and Islet β-Cell Dysfunction in Diabetes

(2015) Sarah A. Tersey et al.   MOLECULAR ENDOCRINOLOGY

The Lipoxygenases: Their Regulation and Implication in Alzheimer’s Disease

(2015) Grzegorz A. Czapski et al.   NEUROCHEMICAL RESEARCH

Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease

(2015) Mariana Verdelho Machado et al.   PLoS One

Lipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipids

(2014) Sean S. Davies et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Analysis, physiological and clinical significance of 12-HETE: A neglected platelet-derived 12-lipoxygenase product

(2014) Benedetta Porro et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

12-Lipoxygenase Promotes Obesity-Induced Oxidative Stress in Pancreatic Islets

(2014) S. A. Tersey et al.   MOLECULAR AND CELLULAR BIOLOGY

Reduced Dietary Omega-6 to Omega-3 Fatty Acid Ratio and 12/15-Lipoxygenase Deficiency Are Protective against Chronic High Fat Diet-Induced Steatohepatitis

(2014) Milos Lazic et al.   PLoS One

From immunobiology to β-cell biology: The changing perspective on type 1 diabetes

(2014) Aarthi Maganti et al.   Islets

Lessons on Conditional Gene Targeting in Mouse Adipose Tissue

(2013) K. Y. Lee et al.   DIABETES

12/15-Lipoxygenase Mediates High-fat Diet-induced Endothelial Tight Junction Disruption and Monocyte Transmigration

(2013) Venkatesh Kundumani-Sridharan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systemic Disease during Streptococcus pneumoniae Acute Lung Infection Requires 12-Lipoxygenase-Dependent Inflammation

(2013) R. Bhowmick et al.   JOURNAL OF IMMUNOLOGY

Deletion of 12/15-Lipoxygenase Alters Macrophage and Islet Function in NOD-Alox15null Mice, Leading to Protection against Type 1 Diabetes Development

(2013) Shamina M. Green-Mitchell et al.   PLoS One

12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma

(2013) Ulaganathan Mabalirajan et al.   Scientific Reports

Beta Cell Dysfunction and Insulin Resistance

(2013) Marlon E. Cerf   Frontiers in Endocrinology

DNA Hypomethylation atALOX12Is Associated with Persistent Wheezing in Childhood

(2012) Eva Morales et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke

(2012) Kazim Yigitkanli et al.   ANNALS OF NEUROLOGY

Islet  -Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model

(2012) S. A. Tersey et al.   DIABETES

Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis

(2012) Naoki Tanaka et al.   HEPATOLOGY

Essential fatty acids as functional components of foods- a review

(2012) Narinder Kaur et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis

(2012) Shunxing Rong et al.   JOURNAL OF LIPID RESEARCH

Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation

(2012) Kenneth N. Ikei et al.   JOURNAL OF LIPID RESEARCH

Adipose Tissue-Specific Deletion of 12/15-Lipoxygenase Protects Mice from the Consequences of a High-Fat Diet

(2012) Banumathi K. Cole et al.   MEDIATORS OF INFLAMMATION

Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction

(2012) Jessica R. Weaver et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease

(2011) Jesper Z. Haeggström et al.   CHEMICAL REVIEWS

Progressive Erosion of  -Cell Function Precedes the Onset of Hyperglycemia in the NOD Mouse Model of Type 1 Diabetes

(2011) D. Ize-Ludlow et al.   DIABETES

Identification of the Orphan G Protein-coupled Receptor GPR31 as a Receptor for 12-(S)-Hydroxyeicosatetraenoic Acid

(2011) Yande Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Etiology and pathogenesis of Parkinson's disease

(2011) Anthony H. Schapira et al.   MOVEMENT DISORDERS

Neuroinflammation in Parkinson's disease

(2011) Etienne C. Hirsch et al.   PARKINSONISM & RELATED DISORDERS

Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development

(2011) U. Haas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative Damage in Ischemic Stroke Revealed Using Multiple Biomarkers

(2011) Raymond C.S. Seet et al.   STROKE

Differential expression and localization of 12/15 lipoxygenases in adipose tissue in human obese subjects

(2010) Anca D. Dobrian et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Amelioration of the Alzheimer's Disease Phenotype by Absence of 12/15-Lipoxygenase

(2010) Hengxuan Yang et al.   BIOLOGICAL PSYCHIATRY

Interferon regulatory factor-8−driven myeloid differentiation is regulated by 12/15-lipoxygenase−mediated redox signaling

(2010) Michelle Kinder et al.   EXPERIMENTAL HEMATOLOGY

12-Lipoxygenase Products Reduce Insulin Secretion and β-Cell Viability in Human Islets

(2010) K. Ma et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

12/15-Lipoxygenase Is an Interleukin-13 and Interferon-γCounterregulated-Mediator of Allergic Airway Inflammation

(2010) Alexa R. Lindley et al.   MEDIATORS OF INFLAMMATION

Functional and pathological roles of the 12- and 15-lipoxygenases

(2010) Anca D. Dobrian et al.   PROGRESS IN LIPID RESEARCH

Omega-3 Fatty Acids and Inflammatory Processes

(2010) Philip C. Calder   Nutrients

CREB-Mediated IL-6 Expression Is Required for 15(S)-Hydroxyeicosatetraenoic Acid–Induced Vascular Smooth Muscle Cell Migration

(2009) Koteswara R. Chava et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Resolvins and protectins: mediating solutions to inflammation

(2009) Payal Kohli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in  -Cells

(2009) L. G. Grunnet et al.   DIABETES

Perspectives on recent advances in the understanding and treatment of Parkinson’s disease

(2009) A. H. Schapira et al.   EUROPEAN JOURNAL OF NEUROLOGY

Improved Survival and Reduced Vascular Permeability by Eliminating or Blocking 12/15-Lipoxygenase in Mouse Models of Acute Lung Injury (ALI)

(2009) A. Zarbock et al.   JOURNAL OF IMMUNOLOGY

12/15-Lipoxygenase Is Required for the Early Onset of High Fat Diet-Induced Adipose Tissue Inflammation and Insulin Resistance in Mice

(2009) Dorothy D. Sears et al.   PLoS One

12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by western diet

(2008) Craig S. Nunemaker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Induction of arachidonate 12-lipoxygenase (Alox15) in intestine of iron-deficient rats correlates with the production of biologically active lipid mediators

(2008) James F. Collins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mice Lacking 12/15-Lipoxygenase Have Attenuated Airway Allergic Inflammation and Remodeling

(2008) Cecilia K. Andersson et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Analysis of islet inflammation in human type 1 diabetes

(2008) A. Willcox et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

12/15-Lipoxygenase deficiency protects mice from allergic airways inflammation and increases secretory IgA levels

(2008) Amanda R. Hajek et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY