The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction

Effects of cigarette smoke, cessation and switching to a candidate modified risk tobacco product on the liver inApoe−/−mice – a systems toxicology analysis

(2016) Giuseppe Lo Sasso et al.   INHALATION TOXICOLOGY

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

(2016) Paolo Zanoni et al.   SCIENCE

High-resolution time and spatial imaging of tobacco and its pyrolysis products during a cigarette puff by microprobe sampling photoionisation mass spectrometry

(2015) R. Hertz-Schünemann et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Sex differences in coronary artery disease: Pathological observations

(2015) Kazuyuki Yahagi et al.   ATHEROSCLEROSIS

Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains

(2015) Maciej Cabanski et al.   INFLAMMATION RESEARCH

Is atherosclerotic disease associated with organic components of ambient fine particles?

(2015) Andrew J. Keebaugh et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Effects of Cigarette Smoke, Cessation, and Switching to Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism inC57BL/6andApoe−/−Mice—An Integrative Systems Toxicology Analysis

(2015) Bjoern Titz et al.   TOXICOLOGICAL SCIENCES

An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe−/−Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes

(2015) Blaine Phillips et al.   TOXICOLOGICAL SCIENCES

The Role of An Experimental Model of Atherosclerosis: apoE-knockout Mice in Developing New Drugs against Atherogenesis

(2015) Jacek Jawien   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The Effects of Diet on Occlusive Coronary Artery Atherosclerosis and Myocardial Infarction in Scavenger Receptor Class B, Type 1/Low-Density Lipoprotein Receptor Double Knockout Mice

(2014) Mark Fuller et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Beijing ambient particle exposure accelerates atherosclerosis in ApoE knockout mice by upregulating visfatin expression

(2014) Qiang Wan et al.   CELL STRESS & CHAPERONES

Systems Toxicology: From Basic Research to Risk Assessment

(2014) Shana J. Sturla et al.   CHEMICAL RESEARCH IN TOXICOLOGY

CD36-Dependent 7-Ketocholesterol Accumulation in Macrophages Mediates Progression of Atherosclerosis in Response to Chronic Air Pollution Exposure

(2014) Xiaoquan Rao et al.   CIRCULATION RESEARCH

Intestinal lipid absorption and lipoprotein formation

(2014) M. Mahmood Hussain   CURRENT OPINION IN LIPIDOLOGY

Engine exhaust particulate and gas phase contributions to vascular toxicity

(2014) Matthew Campen et al.   INHALATION TOXICOLOGY

The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: IV. Vascular effects of repeated inhalation exposure to a mixture of five inorganic gases

(2014) J. L. Mauderly et al.   INHALATION TOXICOLOGY

A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability

(2014) Héctor De León et al.   Journal of Translational Medicine

Cigarette-smoke-induced atherogenic lipid profiles in plasma and vascular tissue of apolipoprotein E-deficient mice are attenuated by smoking cessation

(2013) Michael Lietz et al.   ATHEROSCLEROSIS

Apolipoprotein E deficiency and a mouse model of accelerated liver aging

(2013) F. Bonomini et al.   BIOGERONTOLOGY

Reverse causal reasoning: applying qualitative causal knowledge to the interpretation of high-throughput data

(2013) Natalie L Catlett et al.   BMC BIOINFORMATICS

Diesel Exhaust Particles Impair Endothelial Progenitor Cells, Compromise Endothelial Integrity, Reduce Neoangiogenesis, and Increase Atherogenesis in Mice

(2013) Janine Pöss et al.   Cardiovascular Toxicology

Mouse Models to Study the Effect of Cardiovascular Risk Factors on Brain Structure and Cognition

(2013) Diewertje I Bink et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Betaine supplement alleviates hepatic triglyceride accumulation of apolipoprotein E deficient mice via reducing methylation of peroxisomal proliferator-activated receptor alpha promoter

(2013) Lijun Wang et al.   Lipids in Health and Disease

Diesel exhaust particulate increases the size and complexity of lesions in atherosclerotic mice

(2013) Mark R Miller et al.   Particle and Fibre Toxicology

The Effect of PPE-Induced Emphysema and Chronic LPS-Induced Pulmonary Inflammation on Atherosclerosis Development in APOE*3-LEIDEN Mice

(2013) P. Padmini S. J Khedoe et al.   PLoS One

Cigarette smoke induces molecular responses in respiratory tissues of ApoE−/− mice that are progressively deactivated upon cessation

(2013) Stéphanie Boué et al.   TOXICOLOGY

Quantitative assessment of biological impact using transcriptomic data and mechanistic network models

(2013) Ty M. Thomson et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Beijing ambient particle exposure accelerates atherosclerosis in ApoE knockout mice

(2013) Tian Chen et al.   TOXICOLOGY LETTERS

Activation of the TLR4 signaling pathway and abnormal cholesterol efflux lead to emphysema in ApoE-deficient mice

(2012) Monica Goldklang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Apolipoprotein B Secretory Regulation by Degradation

(2012) Sven-Olof Olofsson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Modulation of atherogenic lipidome by cigarette smoke in apolipoprotein E-deficient mice

(2012) Stéphanie Boué et al.   ATHEROSCLEROSIS

The biological effects of subacute inhalation of diesel exhaust following addition of cerium oxide nanoparticles in atherosclerosis-prone mice

(2012) Flemming R. Cassee et al.   ENVIRONMENTAL RESEARCH

Exposure to diesel exhaust upregulates COX-2 expression in ApoE knockout mice

(2012) Ni Bai et al.   INHALATION TOXICOLOGY

Identification of chemical components of combustion emissions that affect pro-atherosclerotic vascular responses in mice

(2012) Steven K. Seilkop et al.   INHALATION TOXICOLOGY

Atherogenic and pulmonary responses of ApoE- and LDL receptor-deficient mice to sidestream cigarette smoke

(2012) Sung Gu Han et al.   TOXICOLOGY

Changes in atherosclerotic plaques induced by inhalation of diesel exhaust

(2011) Ni Bai et al.   ATHEROSCLEROSIS

Systemic Manifestations of COPD

(2011) Yvonne Nussbaumer-Ochsner et al.   CHEST

Comparative Lipidomics Profiling of Human Atherosclerotic Plaques

(2011) Christin Stegemann et al.   Circulation-Cardiovascular Genetics

A network-based approach to quantifying the impact of biologically active substances

(2011) Julia Hoeng et al.   DRUG DISCOVERY TODAY

Animal Models of Cardiovascular Diseases

(2011) Carlos Zaragoza et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Exposure to diesel exhaust up-regulates iNOS expression in ApoE knockout mice

(2011) Ni Bai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Hazardous Compounds in Tobacco Smoke

(2011) Reinskje Talhout et al.   International Journal of Environmental Research and Public Health

Effects of smoking and smoking cessation on lipids and lipoproteins: Outcomes from a randomized clinical trial

(2010) Adam D. Gepner et al.   AMERICAN HEART JOURNAL

Mitochondrial Oxidative Stress Significantly Influences Atherogenic Risk and Cytokine-Induced Oxidant Production

(2010) Corey M. Harrison et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Dietary coenzyme Q10 does not protect against cigarette smoke-augmented atherosclerosis in apoE-deficient mice

(2010) C. Gary Gairola et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cigarette smoking and chronic liver diseases

(2010) J. Altamirano et al.   GUT

Atherosclerosis lesion progression during inhalation exposure to environmental tobacco smoke: A comparison to concentrated ambient air fine particles exposure

(2010) Lung Chi Chen et al.   INHALATION TOXICOLOGY

Comparative effects of inhaled diesel exhaust and ambient fine particles on inflammation, atherosclerosis, and vascular dysfunction

(2010) Chunli Quan et al.   INHALATION TOXICOLOGY

Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD

(2010) Gnanapragasam Arunachalam et al.   Journal of Inflammation-London

Proceedings from the Scientific Symposium: Sex Differences in Cardiovascular Disease and Implications for Therapies

(2010) C. Noel Bairey Merz et al.   JOURNAL OF WOMENS HEALTH

Enhanced platelet reactivity and thrombosis in Apoe-/- mice exposed to cigarette smoke is attenuated by P2Y12 antagonism

(2010) Anping Dong et al.   THROMBOSIS RESEARCH

Cigarette smoke enhances abdominal aortic aneurysm formation in angiotensin II-treated apolipoprotein E-deficient mice

(2010) Katrin Stolle et al.   TOXICOLOGY LETTERS

High-Density Lipoprotein Transport Through Aortic Endothelial Cells Involves Scavenger Receptor BI and ATP-Binding Cassette Transporter G1

(2009) Lucia Rohrer et al.   CIRCULATION RESEARCH

Use of β-Adrenoceptor Antagonists in Older Patients with Chronic Obstructive Pulmonary Disease and Cardiovascular Co-Morbidity

(2009) Miranda R Andrus et al.   DRUGS & AGING

Cigarette smoking exacerbates nonalcoholic fatty liver disease in obese rats

(2009) Lorenzo Azzalini et al.   HEPATOLOGY

Lymphotoxin β receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of agedApoE−/−mice

(2009) Rolf Gräbner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Biochemical Evidence of Atherosclerosis Progression Mediated by Increased Oxidative Stress in Apolipoprotein E–Deficient Spontaneously Hyperlipidemic Mice Exposed to Chronic Cigarette Smoke

(2009) Masaru Kunitomo et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Modest vasomotor dysfunction induced by low doses of C60 fullerenes in apolipoprotein E knockout mice with different degree of atherosclerosis

(2009) Lise K Vesterdal et al.   Particle and Fibre Toxicology

The Strategic Dialogue on Tobacco Harm Reduction: a vision and blueprint for action in the US

(2009) M. Zeller et al.   TOBACCO CONTROL

Ambient Particulates Alter Vascular Function through Induction of Reactive Oxygen and Nitrogen Species

(2009) Zhekang Ying et al.   TOXICOLOGICAL SCIENCES

Inhaled diesel emissions alter atherosclerotic plaque composition in ApoE−/− mice

(2009) Matthew J. Campen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Apoetm1Unc mice have impaired alveologenesis, low lung function, and rapid loss of lung function

(2008) Donald Massaro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Suppressing PTEN Activity by Tobacco Smoke Plus Interleukin-1β Modulates Dissociation of VE-Cadherin/β-Catenin Complexes in Endothelium

(2008) Silvia S. Barbieri et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Progression of atherosclerosis in the Apo E−/− model: 12-Month exposure to cigarette mainstream smoke combined with high-cholesterol/fat diet

(2008) K. von Holt et al.   ATHEROSCLEROSIS

Ambient Particulate Pollutants in the Ultrafine Range Promote Early Atherosclerosis and Systemic Oxidative Stress

(2008) Jesus A. Araujo et al.   CIRCULATION RESEARCH

COPD-related morbidity and mortality after smoking cessation: status of the evidence

(2008) N. S. Godtfredsen et al.   EUROPEAN RESPIRATORY JOURNAL

Ambient Air Particulate Matter Exposure and Tissue Factor Expression in Atherosclerosis

(2008) Qinghua Sun et al.   INHALATION TOXICOLOGY

Molecular processes that handle — and mishandle — dietary lipids

(2008) Kevin Jon Williams   JOURNAL OF CLINICAL INVESTIGATION

The Association of Cigarette Smoking With Enhanced Platelet Inhibition by Clopidogrel

(2008) Kevin P. Bliden et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cigarette Smoke Exposure Promotes Arterial Thrombosis and Vessel Remodeling after Vascular Injury in Apolipoprotein E-Deficient Mice

(2008) Marco R. Schroeter et al.   JOURNAL OF VASCULAR RESEARCH

LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies

(2008) Anna P. Lillis et al.   PHYSIOLOGICAL REVIEWS

The contribution of ApoB and ApoA1 measurements to cardiovascular risk assessment

(2007) M. Andrikoula et al.   DIABETES OBESITY & METABOLISM