Regulation and Functions of 15-Lipoxygenases in Human Macrophages

Proteomic analysis reveals a protective role of specific macrophage subsets in liver repair

(2019) Wenting Yang et al.   Scientific Reports

Enzymatically oxidized phospholipids assume center stage as essential regulators of innate immunity and cell death

(2019) Valerie B. O’Donnell et al.   Science Signaling

Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome

(2019) Markus Werner et al.   FASEB JOURNAL

Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

(2018) Oliver Werz et al.   Nature Communications

Macrophage-Derived Protein S Facilitates Apoptotic Polymorphonuclear Cell Clearance by Resolution Phase Macrophages and Supports Their Reprogramming

(2018) Delphine Lumbroso et al.   Frontiers in Immunology

The evolutionary hypothesis of reaction specificity of mammalian ALOX15 orthologs

(2018) Hartmut Kuhn et al.   PROGRESS IN LIPID RESEARCH

A Novel Function for 15-Lipoxygenases in Cholesterol Homeostasis and CCL17 Production in Human Macrophages

(2018) Ryan G. Snodgrass et al.   Frontiers in Immunology

Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies

(2018) Nikhlesh K. Singh et al.   PROGRESS IN LIPID RESEARCH

Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease

(2017) Stefan Uderhardt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

(2017) Lidia Bosurgi et al.   SCIENCE

Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice

(2017) Wenliang Zhang et al.   Scientific Reports

Membrane-dependent Activities of Human 15-LOX-2 and Its Murine Counterpart

(2016) Gunes Bender et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolutionary alteration of ALOX15 specificity optimizes the biosynthesis of antiinflammatory and proresolving lipoxins

(2016) Susan Adel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Basophil-derived IL-4 plays versatile roles in immunity

(2016) Yoshinori Yamanishi et al.   Seminars in Immunopathology

An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques

(2016) Gabrielle Fredman et al.   Nature Communications

Macrophages: Development and Tissue Specialization

(2015) Chen Varol et al.   Annual Review of Immunology

Mammalian lipoxygenases and their biological relevance

(2015) Hartmut Kuhn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

History of interleukin-4

(2015) William E. Paul   CYTOKINE

15-Lipoxygenase inhibitors: a patent review

(2015) Hamid Sadeghian et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15)

(2015) Igor Ivanov et al.   GENE

AMP-activated Protein Kinase Suppresses Arachidonate 15-Lipoxygenase Expression in Interleukin 4-polarized Human Macrophages

(2015) Dmitry Namgaladze et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

12/15-lipoxygenase–mediated enzymatic lipid oxidation regulates DC maturation and function

(2015) Tobias Rothe et al.   JOURNAL OF CLINICAL INVESTIGATION

Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct

(2014) U. M. Gundra et al.   BLOOD

Tumor-suppressive functions of 15-Lipoxygenase-2 and RB1CC1 in prostate cancer

(2014) Mahipal Suraneni et al.   CELL CYCLE

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Interleukin-4-Mediated 15-Lipoxygenase-1 Trans-Activation Requires UTX Recruitment and H3K27me3 Demethylation at the Promoter in A549 Cells

(2014) Hongya Han et al.   PLoS One

15-Lipoxygenase Promotes Chronic Hypoxia–Induced Pulmonary Artery Inflammation via Positive Interaction With Nuclear Factor-κB

(2013) Jing Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases

(2013) Matthew Spite et al.   Cell Metabolism

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

(2013) Ari B. Molofsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expression and regulation of 12/15-lipoxygenases in human primary macrophages

(2012) Sophia J.A. Wuest et al.   ATHEROSCLEROSIS

New families of bioactive oxidized phospholipids generated by immune cells: identification and signaling actions

(2012) V. B. O'Donnell et al.   BLOOD

IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages

(2012) Ashish Bhattacharjee et al.   FREE RADICAL BIOLOGY AND MEDICINE

12/15-Lipoxygenase Orchestrates the Clearance of Apoptotic Cells and Maintains Immunologic Tolerance

(2012) Stefan Uderhardt et al.   IMMUNITY

Identification of novel markers of alternative activation and potential endogenous PPARγ ligand production mechanisms in human IL-4 stimulated differentiating macrophages

(2012) Zsolt Czimmerer et al.   IMMUNOBIOLOGY

Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis

(2012) Shunxing Rong et al.   JOURNAL OF LIPID RESEARCH

Cholesteryl ester acyl oxidation and remodeling in murine macrophages: formation of oxidized phosphatidylcholine

(2012) Patrick M. Hutchins et al.   JOURNAL OF LIPID RESEARCH

Arachidonate 15-Lipoxygenase Type B Knockdown Leads to Reduced Lipid Accumulation and Inflammation in Atherosclerosis

(2012) Lisa U. Magnusson et al.   PLoS One

Transcriptional Regulation of 15-Lipoxygenase Expression by Histone H3 Lysine 4 Methylation/Demethylation

(2012) Cheng Liu et al.   PLoS One

12- and 15-lipoxygenases in human carotid atherosclerotic lesions: Associations with cerebrovascular symptoms

(2011) Karl Gertow et al.   ATHEROSCLEROSIS

Esterified eicosanoids: Generation, characterization and function

(2011) Victoria J. Hammond et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Transcriptomic analyses of murine resolution-phase macrophages

(2011) M. J. Stables et al.   BLOOD

Identification of the Orphan G Protein-coupled Receptor GPR31 as a Receptor for 12-(S)-Hydroxyeicosatetraenoic Acid

(2011) Yande Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Electrospray MS/MS reveals extensive and nonspecific oxidation of cholesterol esters in human peripheral vascular lesions

(2011) Patrick M. Hutchins et al.   JOURNAL OF LIPID RESEARCH

Saturated-efferocytosis generates pro-resolving CD11blow macrophages: Modulation by resolvins and glucocorticoids

(2010) Sagie Schif-Zuck et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Monocyte 15-Lipoxygenase Gene Expression Requires ERK1/2 MAPK Activity

(2010) A. Bhattacharjee et al.   JOURNAL OF IMMUNOLOGY

Transgenic expression of 15-lipoxygenase 2 (15-LOX2) in mouse prostate leads to hyperplasia and cell senescence

(2010) M V Suraneni et al.   ONCOGENE

Overexpression of Human 15( S )-Lipoxygenase-1 in RAW Macrophages Leads to Increased Cholesterol Mobilization and Reverse Cholesterol Transport

(2009) Ginny L. Weibel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

15-Lipoxygenase-2 is expressed in macrophages in human carotid plaques and regulated by hypoxia-inducible factor-1α

(2009) L. M. Hultén et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators

(2008) Aksam J. Merched et al.   FASEB JOURNAL

The relationship between the fatty acid composition of immune cells and their function

(2008) Philip C. Calder   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS