Recent Advances in PRRS Virus Receptors and the Targeting of Receptor–Ligand for Control

CD163ΔSRCR5 MARC-145 Cells Resist PRRSV-2 Infection via Inhibiting Virus Uncoating, Which Requires the Interaction of CD163 With Calpain 1

(2020) Piao Yu et al.   Frontiers in Microbiology

Lipopolysaccharide Downregulates CD163 Expression to Inhibit PRRSV Infection via TLR4-NF-κB Pathway

(2020) Zhenbang Zhu et al.   Frontiers in Microbiology

Small molecules block the interaction between porcine reproductive and respiratory syndrome virus and CD163 receptor and the infection of pig cells

(2020) Chang Huang et al.   Virology Journal

CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance

(2020) Kui Xu et al.   eLife

CD163 Antibodies Inhibit PRRSV Infection via Receptor Blocking and Transcription Suppression

(2020) Huiling Xu et al.   Vaccines

A Triple Amino Acid Substitution at Position 88/94/95 in Glycoprotein GP2a of Type 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV1) Is Responsible for Adaptation to MARC-145 Cells

(2019) Jiexiong Xie et al.   Viruses-Basel

Kinetics of the expression of CD163 and CD107a in the lung and tonsil of pigs after infection with PRRSV-1 strains of different virulence

(2019) Jose M. Sánchez-Carvajal et al.   VETERINARY RESEARCH COMMUNICATIONS

Establishment and evaluation of a PRRSV-sensitive porcine endometrial epithelial cell line by transfecting SV40 large T antigen

(2019) Kang Zhang et al.   BMC Veterinary Research

The 40 kDa Linear Polyethylenimine Inhibits Porcine Reproductive and Respiratory Syndrome Virus Infection by Blocking Its Attachment to Permissive Cells

(2019) Jie Wang et al.   Viruses-Basel

Direct Interaction Between CD163 N-Terminal Domain and MYH9 C-Terminal Domain Contributes to Porcine Reproductive and Respiratory Syndrome Virus Internalization by Permissive Cells

(2019) Gaopeng Hou et al.   Frontiers in Microbiology

Highly Efficient Generation of Pigs Harboring a Partial Deletion of the CD163 SRCR5 Domain, Which Are Fully Resistant to Porcine Reproductive and Respiratory Syndrome Virus 2 Infection

(2019) Chunhe Guo et al.   Frontiers in Immunology

MYH9 Aggregation Induced by Direct Interaction With PRRSV GP5 Ectodomain Facilitates Viral Internalization by Permissive Cells

(2019) Biyun Xue et al.   Frontiers in Microbiology

A simple and efficient method for the generation of a porcine alveolar macrophage cell line for high-efficiency Porcine reproductive and respiratory syndrome virus 2 infection

(2019) Xiangpeng Wang et al.   JOURNAL OF VIROLOGICAL METHODS

MYH9 Key Amino Acid Residues Identified by the Anti-Idiotypic Antibody to Porcine Reproductive and Respiratory Syndrome Virus Glycoprotein 5 Involve in the Virus Internalization by Porcine Alveolar Macrophages

(2019) Liangliang Li et al.   Viruses-Basel

CD163 knockout pigs are fully resistant to highly pathogenic porcine reproductive and respiratory syndrome virus

(2018) Huaqiang Yang et al.   ANTIVIRAL RESEARCH

Recombinant MYH9 protein C-terminal domain blocks porcine reproductive and respiratory syndrome virus internalization by direct interaction with viral glycoprotein 5

(2018) Liangliang Li et al.   ANTIVIRAL RESEARCH

Pigs lacking the scavenger receptor cysteine-rich domain 5 of CD163 are resistant to PRRSV-1 infection.

(2018) Christine Burkard et al.   JOURNAL OF VIROLOGY

Recombinant adenovirus-delivered soluble CD163 and sialoadhesin receptors protected pigs from porcine reproductive and respiratory syndrome virus infection

(2018) Wenlong Xia et al.   VETERINARY MICROBIOLOGY

Nonstructural proteins nsp2TF and nsp2N of porcine reproductive and respiratory syndrome virus (PRRSV) play important roles in suppressing host innate immune responses

(2018) Y. Li et al.   VIROLOGY

The prevalent status and genetic diversity of porcine reproductive and respiratory syndrome virus in China: a molecular epidemiological perspective

(2018) Zhenhua Guo et al.   Virology Journal

Porcine alveolar macrophage CD163 abundance is a pivotal switch for porcine reproductive and respiratory syndrome virus infection

(2018) Tong-Yun Wang et al.   Oncotarget

Molecular cloning of porcine Siglec-3, Siglec-5 and Siglec-10, and identification of Siglec-10 as an alternative receptor for porcine reproductive and respiratory syndrome virus (PRRSV)

(2017) Jiexiong Xie et al.   JOURNAL OF GENERAL VIROLOGY

Antiviral Strategies against PRRSV Infection

(2017) Taofeng Du et al.   TRENDS IN MICROBIOLOGY

Splenic CD163+ macrophages as targets of porcine reproductive and respiratory virus: Role of Siglecs

(2017) María Yuste et al.   VETERINARY MICROBIOLOGY

Dual infections of CD163 expressing NPTr epithelial cells with influenza A virus and PRRSV

(2017) Chantale Provost et al.   VETERINARY MICROBIOLOGY

Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function

(2017) Christine Burkard et al.   PLoS Pathogens

Improved Vaccine against PRRSV: Current Progress and Future Perspective

(2017) Yuchen Nan et al.   Frontiers in Microbiology

Knockout of maternal CD163 protects fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV)

(2017) Randall S. Prather et al.   Scientific Reports

The Crystal Structure of the Fifth Scavenger Receptor Cysteine-Rich Domain of Porcine CD163 Reveals an Important Residue Involved in Porcine Reproductive and Respiratory Syndrome Virus Infection

(2016) Hongfang Ma et al.   JOURNAL OF VIROLOGY

Replacement of Porcine CD163 Scavenger Receptor Cysteine-Rich Domain 5 with a CD163-Like Homolog Confers Resistance of Pigs to Genotype 1 but Not Genotype 2 Porcine Reproductive and Respiratory Syndrome Virus

(2016) Kevin D. Wells et al.   JOURNAL OF VIROLOGY

Porcine Reproductive and Respiratory Syndrome Virus (PRRSV): Pathogenesis and Interaction with the Immune System

(2016) Joan K. Lunney et al.   Annual Review of Animal Biosciences

MYH9 is an Essential Factor for Porcine Reproductive and Respiratory Syndrome Virus Infection

(2016) Jiming Gao et al.   Scientific Reports

Reorganization and expansion of the nidoviral family Arteriviridae

(2015) Jens H. Kuhn et al.   ARCHIVES OF VIROLOGY

A Single Amino Acid Deletion in the Matrix Protein of Porcine Reproductive and Respiratory Syndrome Virus Confers Resistance to a Polyclonal Swine Antibody with Broadly Neutralizing Activity

(2015) Benjamin R. Trible et al.   JOURNAL OF VIROLOGY

Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus

(2015) Kristin M Whitworth et al.   NATURE BIOTECHNOLOGY

PRRSV structure, replication and recombination: Origin of phenotype and genotype diversity

(2015) Matthew A. Kappes et al.   VIROLOGY

Proteolytic processing of the porcine reproductive and respiratory syndrome virus replicase

(2015) Yanhua Li et al.   VIRUS RESEARCH

Use of the CRISPR/Cas9 System to Produce Genetically Engineered Pigs from In Vitro-Derived Oocytes and Embryos1

(2014) Kristin M. Whitworth et al.   BIOLOGY OF REPRODUCTION

Modulation of CD163 Expression by Metalloprotease ADAM17 Regulates Porcine Reproductive and Respiratory Syndrome Virus Entry

(2014) L. Guo et al.   JOURNAL OF VIROLOGY

Simian Hemorrhagic Fever Virus Cell Entry Is Dependent on CD163 and Uses a Clathrin-Mediated Endocytosis-Like Pathway

(2014) Yíngyún Caì et al.   JOURNAL OF VIROLOGY

MiR-506 inhibits PRRSV replication in MARC-145 cells via CD151

(2014) Junjing Wu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Inhibition of porcine reproductive and respiratory syndrome virus infection by recombinant adenovirus- and/or exosome-delivered the artificial microRNAs targeting sialoadhesin and CD163 receptors

(2014) Li Zhu et al.   Virology Journal

MYPT1 regulates contractility and microtubule acetylation to modulate integrin adhesions and matrix assembly

(2014) E. Emily Joo et al.   Nature Communications

PK-15cells transfected with porcine CD163 by PiggyBac transposon system are susceptible to porcine reproductive and respiratory syndrome virus

(2013) Xiangpeng Wang et al.   JOURNAL OF VIROLOGICAL METHODS

An Intact Sialoadhesin (Sn/SIGLEC1/CD169) Is Not Required for Attachment/Internalization of the Porcine Reproductive and Respiratory Syndrome Virus

(2013) R. S. Prather et al.   JOURNAL OF VIROLOGY

Porcine reproductive and respiratory syndrome virus infection is associated with an increased number of Sn-positive and CD8-positive cells in the maternal–fetal interface

(2013) U.U. Karniychuk et al.   VIRUS RESEARCH

Additive inhibition of porcine reproductive and respiratory syndrome virus infection with the soluble sialoadhesin and CD163 receptors

(2013) Yang Chen et al.   VIRUS RESEARCH

Heparan Sulfate: A Ubiquitous Glycosaminoglycan with Multiple Roles in Immunity

(2013) David Anak Simon Davis et al.   Frontiers in Immunology

Different expression patterns of PRRSV mediator genes in the lung tissues of PRRSV resistant and susceptible pigs

(2012) Chenglan Jiang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Arterivirus Minor Envelope Proteins Are a Major Determinant of Viral Tropism in Cell Culture

(2012) D. Tian et al.   JOURNAL OF VIROLOGY

Comparative analysis of immune responses following experimental infection of pigs with European porcine reproductive and respiratory syndrome virus strains of differing virulence

(2012) Eefke Weesendorp et al.   VETERINARY MICROBIOLOGY

Increased pathogenicity of European porcine reproductive and respiratory syndrome virus is associated with enhanced adaptive responses and viral clearance

(2012) S.B. Morgan et al.   VETERINARY MICROBIOLOGY

Chimeric viruses containing the N-terminal ectodomains of GP5 and M proteins of porcine reproductive and respiratory syndrome virus do not change the cellular tropism of equine arteritis virus

(2012) Zhengchun Lu et al.   VIROLOGY

Novel structural protein in porcine reproductive and respiratory syndrome virus encoded by an alternative ORF5 present in all arteriviruses

(2011) C. R. Johnson et al.   JOURNAL OF GENERAL VIROLOGY

Emergence of novel European genotype porcine reproductive and respiratory syndrome virus in mainland China

(2011) N. Chen et al.   JOURNAL OF GENERAL VIROLOGY

Human telomerase reverse transcriptase-immortalized porcine monomyeloid cell lines for the production of porcine reproductive and respiratory syndrome virus

(2011) Mingeun Sagong et al.   JOURNAL OF VIROLOGICAL METHODS

Siglecs Facilitate HIV-1 Infection of Macrophages through Adhesion with Viral Sialic Acids

(2011) Zhongcheng Zou et al.   PLoS One

Deletion of the cytoplasmic domain of CD163 enhances porcine reproductive and respiratory syndrome virus replication

(2010) Yoo Jin Lee et al.   ARCHIVES OF VIROLOGY

Pathogenesis and antigenic characterization of a new East European subtype 3 porcine reproductive and respiratory syndrome virus isolate

(2010) Uladzimir U Karniychuk et al.   BMC Veterinary Research

Platelet activation induced by a murine monoclonal antibody directed against a novel tetra-span antigen

(2010) J. J. Roberts et al.   BRITISH JOURNAL OF HAEMATOLOGY

Characterization of the Specific Interaction between Sialoadhesin and Sialylated Campylobacter jejuni Lipooligosaccharides

(2010) A. P. Heikema et al.   INFECTION AND IMMUNITY

Scavenger receptor CD163, a Jack-of-all-trades and potential target for cell-directed therapy

(2010) Hanne Van Gorp et al.   MOLECULAR IMMUNOLOGY

Glycosylation of minor envelope glycoproteins of porcine reproductive and respiratory syndrome virus in infectious virus recovery, receptor interaction, and immune response

(2010) Phani B. Das et al.   VIROLOGY

The structural biology of PRRSV

(2010) Terje Dokland   VIRUS RESEARCH

A brief review of CD163 and its role in PRRSV infection

(2010) Siao-Kun W. Welch et al.   VIRUS RESEARCH

Hemoglobin and Heme Scavenger Receptors

(2009) Marianne Jensby Nielsen et al.   ANTIOXIDANTS & REDOX SIGNALING

The porcine reproductive and respiratory syndrome virus requires trafficking through CD163-positive early endosomes, but not late endosomes, for productive infection

(2009) Hanne Van Gorp et al.   ARCHIVES OF VIROLOGY

Scavenger receptors: role in innate immunity and microbial pathogenesis

(2009) Thomas Areschoug et al.   CELLULAR MICROBIOLOGY

Generation of a porcine alveolar macrophage cell line for the growth of porcine reproductive and respiratory syndrome virus

(2009) Yoo Jin Lee et al.   JOURNAL OF VIROLOGICAL METHODS

Identification of the CD163 Protein Domains Involved in Infection of the Porcine Reproductive and Respiratory Syndrome Virus

(2009) H. Van Gorp et al.   JOURNAL OF VIROLOGY

The Minor Envelope Glycoproteins GP2a and GP4 of Porcine Reproductive and Respiratory Syndrome Virus Interact with the Receptor CD163

(2009) P. B. Das et al.   JOURNAL OF VIROLOGY

Modulation of CD163 receptor expression and replication of porcine reproductive and respiratory syndrome virus in porcine macrophages

(2009) John B. Patton et al.   VIRUS RESEARCH

Porcine DC-SIGN: Molecular cloning, gene structure, tissue distribution and binding characteristics

(2008) Y.W. Huang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Sialoadhesin and CD163 join forces during entry of the porcine reproductive and respiratory syndrome virus

(2008) H. Van Gorp et al.   JOURNAL OF GENERAL VIROLOGY

Generation of internal image monoclonal anti-idiotypic antibodies against idiotypic antibodies to GP5 antigen of porcine reproductive and respiratory syndrome virus

(2008) En-Min Zhou et al.   JOURNAL OF VIROLOGICAL METHODS

Sialoadhesin Expressed on IFN-Induced Monocytes Binds HIV-1 and Enhances Infectivity

(2008) Hans Rempel et al.   PLoS One