Improved Vaccine against PRRSV: Current Progress and Future Perspective

The middle half genome of interferon-inducing porcine reproductive and respiratory syndrome virus strain A2MC2 is essential for interferon induction

(2017) Zexu Ma et al.   JOURNAL OF GENERAL VIROLOGY

An interferon inducing porcine reproductive and respiratory syndrome virus vaccine candidate elicits protection against challenge with the heterologous virulent type 2 strain VR-2385 in pigs

(2017) Eve Fontanella et al.   VACCINE

Cross reactivity of immune responses to porcine reproductive and respiratory syndrome virus infection

(2017) Ignacio Correas et al.   VACCINE

Enhancing heterologous protection in pigs vaccinated with chimeric porcine reproductive and respiratory syndrome virus containing the full-length sequences of shuffled structural genes of multiple heterologous strains

(2017) Debin Tian et al.   VACCINE

Positive immunomodulatory effects of heterologous DNA vaccine- modified live vaccine, prime-boost immunization, against the highly-pathogenic PRRSV infection

(2017) Chaitawat Sirisereewan et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function

(2017) Christine Burkard et al.   PLoS Pathogens

Synthetic Toll-like receptor 7 ligand inhibits porcine reproductive and respiratory syndrome virus infection in primary porcine alveolar macrophages

(2016) Yongkun Du et al.   ANTIVIRAL RESEARCH

Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2016)

(2016) Michael J. Adams et al.   ARCHIVES OF VIROLOGY

Molecular evolution of type 2 porcine reproductive and respiratory syndrome viruses circulating in Vietnam from 2007 to 2015

(2016) Hai Quynh Do et al.   BMC Veterinary Research

Highly pathogenic porcine reproductive and respiratory syndrome virus infection and induction of apoptosis in bone marrow cells of infected piglets

(2016) Gang Wang et al.   JOURNAL OF GENERAL VIROLOGY

Infection of porcine bone marrow-derived macrophages by porcine respiratory and reproductive syndrome virus impairs phagosomal maturation

(2016) Sibapriya Chaudhuri et al.   JOURNAL OF GENERAL VIROLOGY

Porcine Reproductive and Respiratory Syndrome Virus Antagonizes JAK/STAT3 Signaling via nsp5, Which Induces STAT3 Degradation

(2016) Liping Yang et al.   JOURNAL OF VIROLOGY

Outbreak Investigation of NADC30-Like PRRSV in South-East China

(2016) C. Li et al.   Transboundary and Emerging Diseases

Commercial vaccines provide limited protection to NADC30-like PRRSV infection

(2016) Xiaofei Bai et al.   VACCINE

Modulation of Proinflammatory Cytokines in Monocyte-Derived Dendritic Cells by Porcine Reproductive and Respiratory Syndrome Virus Through Interaction with the Porcine Intercellular-Adhesion-Molecule-3-Grabbing Nonintegrin

(2016) Pablo E. Piñeyro et al.   VIRAL IMMUNOLOGY

Identification of viral genes associated with the interferon-inducing phenotype of a synthetic porcine reproductive and respiratory syndrome virus strain

(2016) Haiyan Sun et al.   VIROLOGY

Sustaining Interferon Induction by a High-Passage Atypical Porcine Reproductive and Respiratory Syndrome Virus Strain

(2016) Zexu Ma et al.   Scientific Reports

Porcine Reproductive and Respiratory Syndrome Virus (PRRSV): Pathogenesis and Interaction with the Immune System

(2016) Joan K. Lunney et al.   Annual Review of Animal Biosciences

MYH9 is an Essential Factor for Porcine Reproductive and Respiratory Syndrome Virus Infection

(2016) Jiming Gao et al.   Scientific Reports

PRRSV receptors and their roles in virus infection

(2015) Chongxu Shi et al.   ARCHIVES OF MICROBIOLOGY

Reorganization and expansion of the nidoviral family Arteriviridae

(2015) Jens H. Kuhn et al.   ARCHIVES OF VIROLOGY

A Synthetic Porcine Reproductive and Respiratory Syndrome Virus Strain Confers Unprecedented Levels of Heterologous Protection

(2015) Hiep L. X. Vu et al.   JOURNAL OF VIROLOGY

A Single Amino Acid Deletion in the Matrix Protein of Porcine Reproductive and Respiratory Syndrome Virus Confers Resistance to a Polyclonal Swine Antibody with Broadly Neutralizing Activity

(2015) Benjamin R. Trible et al.   JOURNAL OF VIROLOGY

Inactivated and subunit vaccines against porcine reproductive and respiratory syndrome: Current status and future direction

(2015) Gourapura J. Renukaradhya et al.   VACCINE

Live porcine reproductive and respiratory syndrome virus vaccines: Current status and future direction

(2015) Gourapura J. Renukaradhya et al.   VACCINE

PRRS virus receptors and their role for pathogenesis

(2015) Qingzhan Zhang et al.   VETERINARY MICROBIOLOGY

Porcine reproductive and respiratory syndrome virus (PRRSV) from the first outbreak of India shows close relationship with the highly pathogenic variant of China

(2015) T.K. Rajkhowa et al.   VETERINARY QUARTERLY

PRRSV structure, replication and recombination: Origin of phenotype and genotype diversity

(2015) Matthew A. Kappes et al.   VIROLOGY

The amino acid residues at 102 and 104 in GP5 of porcine reproductive and respiratory syndrome virus regulate viral neutralization susceptibility to the porcine serum neutralizing antibody

(2015) Baochao Fan et al.   VIRUS RESEARCH

Broadly neutralizing antibodies against the rapidly evolving porcine reproductive and respiratory syndrome virus

(2015) Sally R. Robinson et al.   VIRUS RESEARCH

Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic

(2014) J. E. Butler et al.   IMMUNOLOGIC RESEARCH

An innovative approach to induce cross-protective immunity against porcine reproductive and respiratory syndrome virus in the lungs of pigs through adjuvanted nanotechnology-based vaccination

(2014) Gourapura Renukaradhya et al.   International Journal of Nanomedicine

Adjuvanted poly(lactic-co-glycolic) acid nanoparticle-entrapped inactivated porcine reproductive and respiratory syndrome virus vaccine elicits cross-protective immune response in pigs

(2014) Gourapura Renukaradhya et al.   International Journal of Nanomedicine

Modulation of CD163 Expression by Metalloprotease ADAM17 Regulates Porcine Reproductive and Respiratory Syndrome Virus Entry

(2014) L. Guo et al.   JOURNAL OF VIROLOGY

Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 4 Antagonizes Beta Interferon Expression by Targeting the NF- B Essential Modulator

(2014) C. Huang et al.   JOURNAL OF VIROLOGY

MiR-506 inhibits PRRSV replication in MARC-145 cells via CD151

(2014) Junjing Wu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Pathology and Virus Distribution in the Lung and Lymphoid Tissues of Pigs Experimentally Inoculated with Three Distinct Type 1 PRRS Virus Isolates of Varying Pathogenicity

(2014) S. B. Morgan et al.   Transboundary and Emerging Diseases

Efficacy of an attenuated European subtype 1 porcine reproductive and respiratory syndrome virus (PRRSV) vaccine in pigs upon challenge with the East European subtype 3 PRRSV strain Lena

(2014) Ivan Trus et al.   VACCINE

Classical swine fever in China: A minireview

(2014) Yuzi Luo et al.   VETERINARY MICROBIOLOGY

Interferon Induction by RNA Viruses and Antagonism by Viral Pathogens

(2014) Yuchen Nan et al.   Viruses-Basel

Antagonizing Interferon-Mediated Immune Response by Porcine Reproductive and Respiratory Syndrome Virus

(2014) Rong Wang et al.   Biomed Research International

HIV-1 neutralizing antibodies: understanding nature's pathways

(2013) John R. Mascola et al.   IMMUNOLOGICAL REVIEWS

PK-15cells transfected with porcine CD163 by PiggyBac transposon system are susceptible to porcine reproductive and respiratory syndrome virus

(2013) Xiangpeng Wang et al.   JOURNAL OF VIROLOGICAL METHODS

Porcine Reproductive and Respiratory Syndrome Virus Nsp1  Inhibits Interferon-Activated JAK/STAT Signal Transduction by Inducing Karyopherin- 1 Degradation

(2013) R. Wang et al.   JOURNAL OF VIROLOGY

bNAber: database of broadly neutralizing HIV antibodies

(2013) Alexey M. Eroshkin et al.   NUCLEIC ACIDS RESEARCH

Broadening the Heterologous Cross-Neutralizing Antibody Inducing Ability of Porcine Reproductive and Respiratory Syndrome Virus by Breeding the GP4 or M genes

(2013) Lei Zhou et al.   PLoS One

Signal Peptide Cleavage from GP5 of PRRSV: A Minor Fraction of Molecules Retains the Decoy Epitope, a Presumed Molecular Cause for Viral Persistence

(2013) Bastian Thaa et al.   PLoS One

Enhancing neutralizing antibody production by an interferon-inducing porcine reproductive and respiratory syndrome virus strain

(2013) Rong Wang et al.   VACCINE

Toll-like receptor ligands enhance the protective effects of vaccination against porcine reproductive and respiratory syndrome virus in swine

(2013) Lili Zhang et al.   VETERINARY MICROBIOLOGY

Variable interference with interferon signal transduction by different strains of porcine reproductive and respiratory syndrome virus

(2013) Rong Wang et al.   VETERINARY MICROBIOLOGY

Molecular evolution of PRRSV in Europe: Current state of play

(2013) Tomasz Stadejek et al.   VETERINARY MICROBIOLOGY

Phylogenetic analysis and molecular characteristics of seven variant Chinese field isolates of PRRSV

(2012) Chengmin Wang et al.   BMC MICROBIOLOGY

Complete Genome Sequence of a Novel Variant Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Strain: Evidence for Recombination between Vaccine and Wild-Type PRRSV Strains

(2012) L. Wenhui et al.   JOURNAL OF VIROLOGY

Inhibitory effects of recombinant porcine interferon-α on high- and low-virulence porcine reproductive and respiratory syndrome viruses

(2012) Shijuan Dong et al.   RESEARCH IN VETERINARY SCIENCE

Effects of challenge with a virulent genotype II strain of porcine reproductive and respiratory syndrome virus on piglets vaccinated with an attenuated genotype I strain vaccine

(2012) M. Roca et al.   VETERINARY JOURNAL

Highly pathogenic porcine reproductive and respiratory syndrome virus GP5 B antigenic region is not a neutralizing antigenic region

(2012) Chao-Liang Leng et al.   VETERINARY MICROBIOLOGY

Significance of genetic variation of PRRSV ORF5 in virus neutralization and molecular determinants corresponding to cross neutralization among PRRS viruses

(2012) Won-Il Kim et al.   VETERINARY MICROBIOLOGY

Increased pathogenicity of European porcine reproductive and respiratory syndrome virus is associated with enhanced adaptive responses and viral clearance

(2012) S.B. Morgan et al.   VETERINARY MICROBIOLOGY

Dissociation of porcine reproductive and respiratory syndrome virus neutralization from antibodies specific to major envelope protein surface epitopes

(2012) Juan Li et al.   VIROLOGY

DNA shuffling of the GP3 genes of porcine reproductive and respiratory syndrome virus (PRRSV) produces a chimeric virus with an improved cross-neutralizing ability against a heterologous PRRSV strain

(2012) Lei Zhou et al.   VIROLOGY

Induction of type I interferons by a novel porcine reproductive and respiratory syndrome virus isolate

(2012) Yuchen Nan et al.   VIROLOGY

Experimental infection of United States swine with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus

(2012) Baoqing Guo et al.   VIROLOGY

Evaluation of immune responses to porcine reproductive and respiratory syndrome virus in pigs during early stage of infection under farm conditions

(2012) Varun Dwivedi et al.   Virology Journal

Genomic sequence and virulence comparison of four Type 2 porcine reproductive and respiratory syndrome virus strains

(2012) Susan L. Brockmeier et al.   VIRUS RESEARCH

Control of porcine reproductive and respiratory syndrome (PRRS) through genetic improvements in disease resistance and tolerance

(2012) Raymond R. R. Rowland et al.   Frontiers in Genetics

Porcine reproductive and respiratory syndrome virus nucleocapsid protein modulates interferon-β production by inhibiting IRF3 activation in immortalized porcine alveolar macrophages

(2011) Mingeun Sagong et al.   ARCHIVES OF VIROLOGY

Endoribonuclease activities of porcine reproductive and respiratory syndrome virus nsp11 was essential for nsp11 to inhibit IFN-β induction

(2011) Xibao Shi et al.   MOLECULAR IMMUNOLOGY

Porcine Reproductive and Respiratory Syndrome Virus isolates differ in their susceptibility to neutralization

(2011) F. Javier Martínez-Lobo et al.   VACCINE

Characterization of antigenic regions in the porcine reproductive and respiratory syndrome virus by the use of peptide-specific serum antibodies

(2011) Merijn Vanhee et al.   VACCINE

Porcine reproductive and respiratory syndrome virus (PRRSV)-specific mAbs: supporting diagnostics and providing new insights into the antigenic properties of the virus

(2011) Wander Van Breedam et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Evaluation of the immunogenicity of a transgenic tobacco plant expressing the recombinant fusion protein of GP5 of porcine reproductive and respiratory syndrome virus and B subunit of Escherichia coli heat-labile enterotoxin in pigs

(2011) Min-Yuan Chia et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Mutations in the genome of the highly pathogenic porcine reproductive and respiratory syndrome virus potentially related to attenuation

(2011) Xue Leng et al.   VETERINARY MICROBIOLOGY

The assessment of efficacy of porcine reproductive respiratory syndrome virus inactivated vaccine based on the viral quantity and inactivation methods

(2011) Hyunil Kim et al.   Virology Journal

Establishment of a DNA-launched infectious clone for a highly pneumovirulent strain of type 2 porcine reproductive and respiratory syndrome virus: Identification and in vitro and in vivo characterization of a large spontaneous deletion in the nsp2 region

(2011) Yan-Yan Ni et al.   VIRUS RESEARCH

Susceptible cell lines for the production of porcine reproductive and respiratory syndrome virus by stable transfection of sialoadhesin and CD163

(2010) Iris Delrue et al.   BMC BIOTECHNOLOGY

Pathogenesis and antigenic characterization of a new East European subtype 3 porcine reproductive and respiratory syndrome virus isolate

(2010) Uladzimir U Karniychuk et al.   BMC Veterinary Research

Dynamic Changes in Inflammatory Cytokines in Pigs Infected with Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus

(2010) Y. Liu et al.   Clinical and Vaccine Immunology

The cysteine protease domain of porcine reproductive and respiratory syndrome virus non-structural protein 2 antagonizes interferon regulatory factor 3 activation

(2010) H. Li et al.   JOURNAL OF GENERAL VIROLOGY

Porcine reproductive and respiratory syndrome virus entry into the porcine macrophage

(2010) W. Van Breedam et al.   JOURNAL OF GENERAL VIROLOGY

Porcine Reproductive and Respiratory Syndrome Virus Inhibits Type I Interferon Signaling by Blocking STAT1/STAT2 Nuclear Translocation

(2010) D. Patel et al.   JOURNAL OF VIROLOGY

The Cysteine Protease Domain of Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 2 Possesses Deubiquitinating and Interferon Antagonism Functions

(2010) Z. Sun et al.   JOURNAL OF VIROLOGY

A Variable Region in GP4 of European-Type Porcine Reproductive and Respiratory Syndrome Virus Induces Neutralizing Antibodies Against Homologous But Not Heterologous Virus Strains

(2010) Merijn Vanhee et al.   VIRAL IMMUNOLOGY

Glycosylation of minor envelope glycoproteins of porcine reproductive and respiratory syndrome virus in infectious virus recovery, receptor interaction, and immune response

(2010) Phani B. Das et al.   VIROLOGY

The structural biology of PRRSV

(2010) Terje Dokland   VIRUS RESEARCH

The ever-expanding diversity of porcine reproductive and respiratory syndrome virus

(2010) Michael P. Murtaugh et al.   VIRUS RESEARCH

GP4-specific neutralizing antibodies might be a driving force in PRRSV evolution

(2010) Sarah Costers et al.   VIRUS RESEARCH

Molecular epidemiology of PRRSV: A phylogenetic perspective

(2010) Mang Shi et al.   VIRUS RESEARCH

Immunodominant epitopes in nsp2 of porcine reproductive and respiratory syndrome virus are dispensable for replication, but play an important role in modulation of the host immune response

(2009) Z. Chen et al.   JOURNAL OF GENERAL VIROLOGY

Human Immunodeficiency Virus Type 1 Elite Neutralizers: Individuals with Broad and Potent Neutralizing Activity Identified by Using a High-Throughput Neutralization Assay together with an Analytical Selection Algorithm

(2009) M. D. Simek et al.   JOURNAL OF VIROLOGY

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

(2009) Johannes F. Scheid et al.   NATURE

Identification of two auto-cleavage products of nonstructural protein 1 (nsp1) in porcine reproductive and respiratory syndrome virus infected cells: nsp1 function as interferon antagonist

(2009) Z. Chen et al.   VIROLOGY

Porcine DC-SIGN: Molecular cloning, gene structure, tissue distribution and binding characteristics

(2008) Y.W. Huang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

A method for identification of HIV gp140 binding memory B cells in human blood

(2008) Johannes F. Scheid et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Frequency and Phenotype of Human Immunodeficiency Virus Envelope-Specific B Cells from Patients with Broadly Cross-Neutralizing Antibodies

(2008) N. A. Doria-Rose et al.   JOURNAL OF VIROLOGY

Adjuvants for porcine reproductive and respiratory syndrome virus vaccines

(2008) Wasin Charerntantanakul   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Phenotypic and functional modulation of bone marrow-derived dendritic cells by porcine reproductive and respiratory syndrome virus

(2008) Hsueh-Chen Chang et al.   VETERINARY MICROBIOLOGY

Molecular assessment of the role of envelope-associated structural proteins in cross neutralization among different PRRS viruses

(2008) Won-Il Kim et al.   VIRUS GENES

Enhanced immune responses of mice inoculated recombinant adenoviruses expressing GP5 by fusion with GP3 and/or GP4 of PRRS virus

(2008) Wenming Jiang et al.   VIRUS RESEARCH

Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning

(2007) Thomas Tiller et al.   JOURNAL OF IMMUNOLOGICAL METHODS