CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance

Highly Efficient Generation of Pigs Harboring a Partial Deletion of the CD163 SRCR5 Domain, Which Are Fully Resistant to Porcine Reproductive and Respiratory Syndrome Virus 2 Infection

(2019) Chunhe Guo et al.   Frontiers in Immunology

Aminopeptidase N-null neonatal piglets are protected from transmissible gastroenteritis virus but not porcine epidemic diarrhea virus

(2019) Lei Luo et al.   Scientific Reports

The use of cells from ANPEP knockout pigs to evaluate the role of aminopeptidase N (APN) as a receptor for porcine deltacoronavirus (PDCoV)

(2019) Ana Stoian et al.   VIROLOGY

CD163 knockout pigs are fully resistant to highly pathogenic porcine reproductive and respiratory syndrome virus

(2018) Huaqiang Yang et al.   ANTIVIRAL RESEARCH

Porcine Deltacoronavirus Engages the Transmissible Gastroenteritis Virus Functional Receptor Porcine Aminopeptidase N for Infectious Cellular Entry

(2018) Bin Wang et al.   JOURNAL OF VIROLOGY

Broad receptor engagement of an emerging global coronavirus may potentiate its diverse cross-species transmissibility

(2018) Wentao Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aminopeptidase-N-independent entry of porcine epidemic diarrhea virus into Vero or porcine small intestine epithelial cells

(2018) Chun-Miao Ji et al.   VIROLOGY

Contribution of porcine aminopeptidase N to porcine deltacoronavirus infection

(2018) Xinyu Zhu et al.   Emerging Microbes & Infections

Resistance to coronavirus infection in amino peptidase N-deficient pigs

(2018) Kristin M. Whitworth et al.   TRANSGENIC RESEARCH

Vaccines for porcine epidemic diarrhea virus and other swine coronaviruses

(2017) Volker Gerdts et al.   VETERINARY MICROBIOLOGY

CRISPR/Cas9-mediated ApoE-/- and LDLR-/- double gene knockout in pigs elevates serum LDL-C and TC levels

(2017) Lei Huang et al.   Oncotarget

Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function

(2017) Christine Burkard et al.   PLoS Pathogens

Monocyte-lymphocyte cross-communication via soluble CD163 directly links innate immune system activation and adaptive immune system suppression following ischemic stroke

(2017) Grant C. O’Connell et al.   Scientific Reports

The Crystal Structure of the Fifth Scavenger Receptor Cysteine-Rich Domain of Porcine CD163 Reveals an Important Residue Involved in Porcine Reproductive and Respiratory Syndrome Virus Infection

(2016) Hongfang Ma et al.   JOURNAL OF VIROLOGY

Replacement of Porcine CD163 Scavenger Receptor Cysteine-Rich Domain 5 with a CD163-Like Homolog Confers Resistance of Pigs to Genotype 1 but Not Genotype 2 Porcine Reproductive and Respiratory Syndrome Virus

(2016) Kevin D. Wells et al.   JOURNAL OF VIROLOGY

Isolation, genomic characterization, and pathogenicity of a Chinese porcine deltacoronavirus strain CHN-HN-2014

(2016) Nan Dong et al.   VETERINARY MICROBIOLOGY

Porcine deltacoronavirus (PDCoV) infection suppresses RIG-I-mediated interferon-β production

(2016) Jingyi Luo et al.   VIROLOGY

Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus

(2015) Kristin M Whitworth et al.   NATURE BIOTECHNOLOGY

Highly efficient CRISPR/Cas9-mediated transgene knockin at the H11 locus in pigs

(2015) Jinxue Ruan et al.   Scientific Reports

Generation of CRISPR/Cas9-mediated gene-targeted pigs via somatic cell nuclear transfer

(2014) Xiaoqing Zhou et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Quantitative Proteomic Analysis Reveals That Transmissible Gastroenteritis Virus Activates the JAK-STAT1 Signaling Pathway

(2014) Kang An et al.   JOURNAL OF PROTEOME RESEARCH

Modulation of CD163 Expression by Metalloprotease ADAM17 Regulates Porcine Reproductive and Respiratory Syndrome Virus Entry

(2014) L. Guo et al.   JOURNAL OF VIROLOGY

Occurrence and investigation of enteric viral infections in pigs with diarrhea in China

(2013) Qian Zhang et al.   ARCHIVES OF VIROLOGY

Filtration of sea louse,Lepeophtheirus salmonis, copepodids by the blue mussel,Mytilus edulis, and the Atlantic sea scallop,Placopecten magellanicus, under different flow, light and copepodid-density regimes

(2013) A Bartsch et al.   JOURNAL OF FISH DISEASES

Discovery of Seven Novel Mammalian and Avian Coronaviruses in the Genus Deltacoronavirus Supports Bat Coronaviruses as the Gene Source of Alphacoronavirus and Betacoronavirus and Avian Coronaviruses as the Gene Source of Gammacoronavirus and Deltacoronavirus

(2012) P. C. Y. Woo et al.   JOURNAL OF VIROLOGY

Structural Bases of Coronavirus Attachment to Host Aminopeptidase N and Its Inhibition by Neutralizing Antibodies

(2012) Juan Reguera et al.   PLoS Pathogens

N-acetylpenicillamine inhibits the replication of porcine reproductive and respiratory syndrome virus in vitro

(2010) Yunbo Jiang et al.   VETERINARY RESEARCH COMMUNICATIONS

Identification of the CD163 Protein Domains Involved in Infection of the Porcine Reproductive and Respiratory Syndrome Virus

(2009) H. Van Gorp et al.   JOURNAL OF VIROLOGY

Modulation of CD163 receptor expression and replication of porcine reproductive and respiratory syndrome virus in porcine macrophages

(2009) John B. Patton et al.   VIRUS RESEARCH

Sialoadhesin and CD163 join forces during entry of the porcine reproductive and respiratory syndrome virus

(2008) H. Van Gorp et al.   JOURNAL OF GENERAL VIROLOGY

Developmental capacity of porcine nuclear transfer embryos correlate with levels of chromatin-remodeling transcripts in donor cells

(2008) Luca Magnani et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT