Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function

Nucleic acids delivery methods for genome editing in zygotes and embryos: the old, the new, and the old-new

(2016) Masahiro Sato et al.   Biology Direct

Highly Efficient Mouse Genome Editing by CRISPR Ribonucleoprotein Electroporation of Zygotes

(2016) Sean Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Replacement of Porcine CD163 Scavenger Receptor Cysteine-Rich Domain 5 with a CD163-Like Homolog Confers Resistance of Pigs to Genotype 1 but Not Genotype 2 Porcine Reproductive and Respiratory Syndrome Virus

(2016) Kevin D. Wells et al.   JOURNAL OF VIROLOGY

Mammalian interspecies substitution of immune modulatory alleles by genome editing

(2016) Simon G. Lillico et al.   Scientific Reports

PRRSV receptors and their roles in virus infection

(2015) Chongxu Shi et al.   ARCHIVES OF MICROBIOLOGY

Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease

(2015) Wenning Qin et al.   GENETICS

Direct Injection of CRISPR/Cas9-Related mRNA into Cytoplasm of Parthenogenetically Activated Porcine Oocytes Causes Frequent Mosaicism for Indel Mutations

(2015) Masahiro Sato et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus

(2015) Kristin M Whitworth et al.   NATURE BIOTECHNOLOGY

PRRSV structure, replication and recombination: Origin of phenotype and genotype diversity

(2015) Matthew A. Kappes et al.   VIROLOGY

CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury

(2015) Hirokuni Akahori et al.   Nature Communications

GONAD: Genome-editing via Oviductal Nucleic Acids Delivery system: a novel microinjection independent genome engineering method in mice

(2015) Gou Takahashi et al.   Scientific Reports

Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease

(2015) Wenning Qin et al.   GENETICS

Electroporation enables the efficient mRNA delivery into the mouse zygotes and facilitates CRISPR/Cas9-based genome editing

(2015) Masakazu Hashimoto et al.   Scientific Reports

Use of the CRISPR/Cas9 System to Produce Genetically Engineered Pigs from In Vitro-Derived Oocytes and Embryos1

(2014) Kristin M. Whitworth et al.   BIOLOGY OF REPRODUCTION

Simple knockout by electroporation of engineered endonucleases into intact rat embryos

(2014) Takehito Kaneko et al.   Scientific Reports

The impact of breed and tissue compartment on the response of pig macrophages to lipopolysaccharide

(2013) Ronan Kapetanovic et al.   BMC GENOMICS

Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System

(2013) Baohui Chen et al.   CELL

Arterivirus molecular biology and pathogenesis

(2013) E. J. Snijder et al.   JOURNAL OF GENERAL VIROLOGY

Comparative Analysis of Monocyte Subsets in the Pig

(2013) L. Fairbairn et al.   JOURNAL OF IMMUNOLOGY

An Intact Sialoadhesin (Sn/SIGLEC1/CD169) Is Not Required for Attachment/Internalization of the Porcine Reproductive and Respiratory Syndrome Virus

(2013) R. S. Prather et al.   JOURNAL OF VIROLOGY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Live pigs produced from genome edited zygotes

(2013) Simon G. Lillico et al.   Scientific Reports

Identification of porcine reproductive and respiratory syndrome virus ORF1a-encoded non-structural proteins in virus-infected cells

(2012) Y. Li et al.   JOURNAL OF GENERAL VIROLOGY

Analyses of pig genomes provide insight into porcine demography and evolution

(2012) Martien A. M. Groenen et al.   NATURE

Template-based protein structure modeling using the RaptorX web server

(2012) Morten Källberg et al.   Nature Protocols

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Increased pathogenicity of European porcine reproductive and respiratory syndrome virus is associated with enhanced adaptive responses and viral clearance

(2012) S.B. Morgan et al.   VETERINARY MICROBIOLOGY

Porcine reproductive and respiratory syndrome virus (PRRSV) causes apoptosis during its replication in fetal implantation sites

(2011) Uladzimir U. Karniychuk et al.   MICROBIAL PATHOGENESIS

Genetic and phenotypic characterization of a 2006 United States porcine reproductive and respiratory virus isolate associated with high morbidity and mortality in the field

(2011) Phillip C. Gauger et al.   VIRUS RESEARCH

Scavenger receptor CD163, a Jack-of-all-trades and potential target for cell-directed therapy

(2010) Hanne Van Gorp et al.   MOLECULAR IMMUNOLOGY

Identification of the CD163 Protein Domains Involved in Infection of the Porcine Reproductive and Respiratory Syndrome Virus

(2009) H. Van Gorp et al.   JOURNAL OF VIROLOGY

Definition of subtypes in the European genotype of porcine reproductive and respiratory syndrome virus: nucleocapsid characteristics and geographical distribution in Europe

(2008) Tomasz Stadejek et al.   ARCHIVES OF VIROLOGY

The macrophage scavenger receptor CD163 functions as an innate immune sensor for bacteria

(2008) B. O. Fabriek et al.   BLOOD

Sialoadhesin and CD163 join forces during entry of the porcine reproductive and respiratory syndrome virus

(2008) H. Van Gorp et al.   JOURNAL OF GENERAL VIROLOGY

Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection in wild boars

(2008) Gerald Reiner et al.   VETERINARY MICROBIOLOGY

Membrane markers of the immune cells in swine: an update

(2008) Laurence Piriou-Guzylack et al.   VETERINARY RESEARCH