Role of ex vivo Expanded Mesenchymal Stromal Cells in Determining Hematopoietic Stem Cell Transplantation Outcome

Bone marrow adipose cells – cellular interactions and changes with obesity

(2020) Parastoo Boroumand et al.   JOURNAL OF CELL SCIENCE

Dynamic responses of the haematopoietic stem cell niche to diverse stresses

(2020) Antoniana Batsivari et al.   NATURE CELL BIOLOGY

CCL2 and CXCL12 Derived from Mesenchymal Stromal Cells Cooperatively Polarize IL-10+ Tissue Macrophages to Mitigate Gut Injury

(2020) Jayeeta Giri et al.   Cell Reports

Bone Marrow-Derived and Elicited Peritoneal Macrophages Are Not Created Equal: The Questions Asked Dictate the Cell Type Used

(2020) Cheryl M. Zajd et al.   Frontiers in Immunology

Extended in vitro culture of primary human mesenchymal stem cells downregulates Brca1 ‐related genes and impairs DNA double‐strand break recognition

(2020) Xuanwen Bao et al.   FEBS Open Bio

Extracellular Vesicles After Allogeneic Hematopoietic Cell Transplantation: Emerging Role in Post-Transplant Complications

(2020) Giuseppe Lia et al.   Frontiers in Immunology

Glutathione dynamics determine the therapeutic efficacy of mesenchymal stem cells for graft-versus-host disease via CREB1-NRF2 pathway

(2020) Jisun Lim et al.   Science Advances

The Role of Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles (MSC-EVs) in Normal and Abnormal Hematopoiesis and Their Therapeutic Potential

(2020) Aristea K. Batsali et al.   Journal of Clinical Medicine

Mesenchymal Stromal Cell Secretome for Severe COVID-19 Infections: Premises for the Therapeutic Use

(2020) Elia Bari et al.   Cells

Mesenchymal Stem Cell-Derived Extracellular Vesicles: Challenges in Clinical Applications

(2020) Austin Gowen et al.   Frontiers in Cell and Developmental Biology

Intranasal delivery of mesenchymal stem cell secretome repairs the brain of Alzheimer’s mice

(2020) Giulia Santamaria et al.   CELL DEATH AND DIFFERENTIATION

Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma

(2020) Karin Golan et al.   BLOOD

Mesenchymal Stem Cell Secretome as an Emerging Cell-Free Alternative for Improving Wound Repair

(2020) Parinaz Ahangar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Preconditioned and Genetically Modified Stem Cells for Myocardial Infarction Treatment

(2020) Kamila Raziyeva et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Apoptotic bodies derived from mesenchymal stem cells promote cutaneous wound healing via regulating the functions of macrophages

(2020) Jin Liu et al.   Stem Cell Research & Therapy

Phase I clinical trial of intra‐bone marrow cotransplantation of mesenchymal stem cells in cord blood transplantation

(2020) Tatsunori Goto et al.   Stem Cells Translational Medicine

Spheroid Culture of Mesenchymal Stromal Cells Results in Morphorheological Properties Appropriate for Improved Microcirculation

(2019) Stefanie Tietze et al.   Advanced Science

Molecular signature of human bone marrow-derived mesenchymal stromal cell subsets

(2019) Selim Kuçi et al.   Scientific Reports

Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation

(2019) Agnieszka Czechowicz et al.   Nature Communications

Bone marrow stromal cells from β-thalassemia patients have impaired hematopoietic supportive capacity

(2019) Stefania Crippa et al.   JOURNAL OF CLINICAL INVESTIGATION

Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis

(2019) Zengdi Zhang et al.   HAEMATOLOGICA

Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response

(2019) Giulia Schiroli et al.   Cell Stem Cell

An early-senescence state in aged mesenchymal stromal cells contributes to hematopoietic stem and progenitor cell clonogenic impairment through the activation of a pro-inflammatory program

(2019) Daniela Gnani et al.   AGING CELL

The bone marrow microenvironment at single-cell resolution

(2019) Anastasia N. Tikhonova et al.   NATURE

Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells

(2019) Fumio Nakahara et al.   NATURE CELL BIOLOGY

Bone-derived Nestin-positive mesenchymal stem cells improve cardiac function via recruiting cardiac endothelial cells after myocardial infarction

(2019) Dihan Lu et al.   Stem Cell Research & Therapy

Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping

(2019) Nicolas Severe et al.   Cell Stem Cell

Early growth response 1 regulates hematopoietic support and proliferation in human primary bone marrow stromal cells

(2019) Hongzhe Li et al.   HAEMATOLOGICA

Pro-inflammatory Aorta-Associated Macrophages Are Involved in Embryonic Development of Hematopoietic Stem Cells

(2019) Samanta Antonella Mariani et al.   IMMUNITY

The mesenchymal stem cell secretome as an acellular regenerative therapy for liver disease

(2019) Julia Driscoll et al.   JOURNAL OF GASTROENTEROLOGY

Activation of Toll-like Receptor 2 (TLR2) induces Interleukin-6 trans-signaling

(2019) Charlotte M. Flynn et al.   Scientific Reports

The role of mesenchymal stem cells in hematopoietic stem cell transplantation: prevention and treatment of graft-versus-host disease

(2019) Lu Zhao et al.   Stem Cell Research & Therapy

Long-term culture of mesenchymal stem cells impairs ATM-dependent recognition of DNA breaks and increases genetic instability

(2019) Daniela Hladik et al.   Stem Cell Research & Therapy

Emerging Role of Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Pathogenesis of Haematological Malignancies

(2019) Juçara Gastaldi Cominal et al.   Stem Cells International

The Immunomodulatory Functions of Mesenchymal Stromal/Stem Cells Mediated via Paracrine Activity

(2019) Yueyuan Zhou et al.   Journal of Clinical Medicine

Mesenchymal Stem Cells for Perianal Crohn’s Disease

(2019) Michele Carvello et al.   Cells

Enhancement of therapeutic potential of mesenchymal stem cell-derived extracellular vesicles

(2019) Kyong-Su Park et al.   Stem Cell Research & Therapy

Adipose Mesenchymal Extracellular Vesicles as Alpha-1-Antitrypsin Physiological Delivery Systems for Lung Regeneration

(2019) Bari et al.   Cells

Mesenchymal Stem Cells in the Adult Human Liver: Hype or Hope?

(2019) Irina V. Kholodenko et al.   Cells

The Role of Macrophages in Bone Marrow Injury and Hematopoietic Reconstitution

(2019) Wen Ju et al.   BLOOD

Nuclear shape, protrusive behaviour and in vivo retention of human bone marrow mesenchymal stromal cells is controlled by Lamin-A/C expression

(2019) Yvonne L. Dorland et al.   Scientific Reports

Novel Cryopreservation Approach Providing Off-the-Shelf Availability of Human Multipotent Mesenchymal Stromal Cells for Clinical Applications

(2019) Olena Rogulska et al.   Stem Cells International

PDGFB-expressing mesenchymal stem cells improve human hematopoietic stem cell engraftment in immunodeficient mice

(2019) Xiuxiu Yin et al.   BONE MARROW TRANSPLANTATION

Apelin+ Endothelial Niche Cells Control Hematopoiesis and Mediate Vascular Regeneration after Myeloablative Injury

(2019) Qi Chen et al.   Cell Stem Cell

Trends in mesenchymal stem cell clinical trials 2004‐2018: Is efficacy optimal in a narrow dose range?

(2019) Maciej Kabat et al.   Stem Cells Translational Medicine

Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in the Treatment of Glaucoma

(2019) C. Randall Harrell et al.   Stem Cells International

Bone Marrow-Derived Mesenchymal Stromal Cells: A Novel Target to Optimize Hematopoietic Stem Cell Transplantation Protocols in Hematological Malignancies and Rare Genetic Disorders

(2019) Stefania Crippa et al.   Journal of Clinical Medicine

Extracellular vesicles in the hematopoietic microenvironment

(2018) John T. Butler et al.   HAEMATOLOGICA

Preconditioning influences mesenchymal stem cell properties in vitro and in vivo

(2018) Chenxia Hu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Stem Cell Secretome and Its Effect on Cellular Mechanisms Relevant to Wound Healing

(2018) Se-Ra Park et al.   MOLECULAR THERAPY

Macrophages ameliorate bone marrow inflammatory injury and promote hematopoiesis in mice following hematopoietic stem cell transplantation

(2018) Jianlin Qiao et al.   Experimental and Therapeutic Medicine

Neural Regulation of Bone and Bone Marrow

(2018) Maria Maryanovich et al.   Cold Spring Harbor Perspectives in Medicine

Extracellular vesicles in the hematopoietic microenvironment

(2018) John T. Butler et al.   HAEMATOLOGICA

Mesenchymal Stem Cell Migration during Bone Formation and Bone Diseases Therapy

(2018) Peihong Su et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pro inflammatory stimuli enhance the immunosuppressive functions of adipose mesenchymal stem cells-derived exosomes

(2018) Rossana Domenis et al.   Scientific Reports

3D models of the bone marrow in health and disease: yesterday, today, and tomorrow

(2018) Annamarija Raic et al.   MRS Communications

Dual cholinergic signals regulate daily migration of hematopoietic stem cells and leukocytes

(2018) Andrés García-García et al.   BLOOD

Trained murine mesenchymal stem cells have anti-inflammatory effect on macrophages, but defective regulation on T-cell proliferation

(2018) Tzuhua Lin et al.   FASEB JOURNAL

Osteogenic niche in the regulation of normal hematopoiesis and leukemogenesis

(2018) Phuong M. Le et al.   HAEMATOLOGICA

A Subset of Paracrine Factors as Efficient Biomarkers for Predicting Vascular Regenerative Efficacy of Mesenchymal Stromal/Stem Cells

(2018) Hyun-Kyung Kim et al.   STEM CELLS

Short-term physiological hypoxia potentiates the therapeutic function of mesenchymal stem cells

(2018) Ben Antebi et al.   Stem Cell Research & Therapy

Improving hematopoietic recovery through modeling and modulation of the mesenchymal stromal cell secretome

(2018) Frances D. Liu et al.   Stem Cell Research & Therapy

Pilot Production of Mesenchymal Stem/Stromal Freeze-Dried Secretome for Cell-Free Regenerative Nanomedicine: A Validated GMP-Compliant Process

(2018) Elia Bari et al.   Cells

Impact of osteoblast maturation on their paracrine growth enhancing activity on cord blood progenitors

(2017) Manal Alsheikh et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Effects Of Hypoxia in Long-Term In Vitro Expansion of Human Bone Marrow Derived Mesenchymal Stem Cells

(2017) Annelise Pezzi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Versatile humanized niche model enables study of normal and malignant human hematopoiesis

(2017) Ander Abarrategi et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of p38MAPK potentiates mesenchymal stem cell therapy against myocardial infarction injury in rats

(2017) Zhiling Zhang et al.   Molecular Medicine Reports

Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF

(2017) Bo O. Zhou et al.   NATURE CELL BIOLOGY

Differential cytokine contributions of perivascular haematopoietic stem cell niches

(2017) Noboru Asada et al.   NATURE CELL BIOLOGY

Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation

(2017) Antonio Galleu et al.   Science Translational Medicine

Human Bone Marrow Mesenchymal Stromal Cell-Derived Osteoblasts Promote the Expansion of Hematopoietic Progenitors Through Beta-Catenin and Notch Signaling Pathways

(2017) Matthew Michalicka et al.   STEM CELLS AND DEVELOPMENT

Inducing Heat Shock Proteins Enhances the Stemness of Frozen–Thawed Adipose Tissue-Derived Stem Cells

(2017) Shahensha Shaik et al.   STEM CELLS AND DEVELOPMENT

Biological and functional characterization of bone marrow-derived mesenchymal stromal cells from patients affected by primary immunodeficiency

(2017) Nadia Starc et al.   Scientific Reports

The Bone Marrow Microenvironment in Health and Myeloid Malignancy

(2017) Marta Galán-Díez et al.   Cold Spring Harbor Perspectives in Medicine

Concise Review: Multifaceted Characterization of Human Mesenchymal Stem Cells for Use in Regenerative Medicine

(2017) Rebekah M. Samsonraj et al.   Stem Cells Translational Medicine

Mouse Genetic Analysis of Bone Marrow Stem Cell Niches: Technological Pitfalls, Challenges, and Translational Considerations

(2017) Kevin G. Chen et al.   Stem Cell Reports

Marrow Adipose Tissue: Skeletal Location, Sexual Dimorphism, and Response to Sex Steroid Deficiency

(2017) Beata Lecka-Czernik et al.   Frontiers in Endocrinology

Hepatocyte growth factor secreted by bone marrow stem cell reduce ER stress and improves repair in alveolar epithelial II cells

(2017) Izabela Nita et al.   Scientific Reports

Human Primary Bone Marrow Mesenchymal Stromal Cells and Their in vitro Progenies Display Distinct Transcriptional Profile Signatures

(2017) Roshanak Ghazanfari et al.   Scientific Reports

Mesenchymal stem cells enhance α-synuclein clearance via M2 microglia polarization in experimental and human parkinsonian disorder

(2016) Hyun Jung Park et al.   ACTA NEUROPATHOLOGICA

Isolation and characterization of primary bone marrow mesenchymal stromal cells

(2016) Hongzhe Li et al.   Annals of the New York Academy of Sciences

Good responses but high TRM in adult patients after MSC therapy for GvHD

(2016) U Salmenniemi et al.   BONE MARROW TRANSPLANTATION

Bone marrow–derived CD34 − fraction: A rich source of mesenchymal stromal cells for clinical application

(2016) Daniela Maria Ingo et al.   CYTOTHERAPY

Three-dimensional co-culture of mesenchymal stromal cells and differentiated osteoblasts on human bio-derived bone scaffolds supports active multi-lineage hematopoiesis in vitro: Functional implication of the biomimetic HSC niche

(2016) Xiaobing Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Distinct bone marrow blood vessels differentially regulate haematopoiesis

(2016) Tomer Itkin et al.   NATURE

Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche

(2016) James Y. Chen et al.   NATURE

Safer conditioning for blood stem cell transplants

(2016) Alessandro Aiuti et al.   NATURE BIOTECHNOLOGY

Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin

(2016) Rahul Palchaudhuri et al.   NATURE BIOTECHNOLOGY

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

(2016) Eric M. Pietras et al.   NATURE CELL BIOLOGY

A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells

(2016) Andreas Reinisch et al.   NATURE MEDICINE

The bone marrow pericyte: an orchestrator of vascular niche

(2016) Giuseppe Mangialardi et al.   Regenerative Medicine

TLR3 or TLR4 Activation Enhances Mesenchymal Stromal Cell-Mediated Treg Induction via Notch Signaling

(2016) Iran Rashedi et al.   STEM CELLS

Enhanced Hematopoietic Stem Cell Self-Renewal-Promoting Ability of Clonal Primary Mesenchymal Stromal/Stem cells Versus Their Osteogenic Progeny

(2016) Qiling He et al.   STEM CELLS

Effects of Freeze–Thawing and Intravenous Infusion on Mesenchymal Stromal Cell Gene Expression

(2016) Martin J. Hoogduijn et al.   STEM CELLS AND DEVELOPMENT

High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo

(2016) Claire S. Koechlein et al.   Nature Communications

Biodistribution, migration and homing of systemically applied mesenchymal stem/stromal cells

(2016) Johannes Leibacher et al.   Stem Cell Research & Therapy

Downregulation of Melanoma Cell Adhesion Molecule (MCAM/CD146) Accelerates Cellular Senescence in Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells

(2016) Hye Jin Jin et al.   Stem Cells Translational Medicine

In VitroExpansion of Bone Marrow Derived Mesenchymal Stem Cells Alters DNA Double Strand Break Repair of Etoposide Induced DNA Damage

(2016) Ian Hare et al.   Stem Cells International

Modulation of Immunoregulatory Properties of Mesenchymal Stromal Cells by Toll-Like Receptors: Potential Applications on GVHD

(2016) Bruno Sangiorgi et al.   Stem Cells International

Bone Marrow GvHD after Allogeneic Hematopoietic Stem Cell Transplantation

(2016) Martin Szyska et al.   Frontiers in Immunology

Bone Marrow Adipose Tissue: To Be or Not To Be a Typical Adipose Tissue?

(2016) Pierre Hardouin et al.   Frontiers in Endocrinology

Homing and migration of mesenchymal stromal cells: How to improve the efficacy of cell therapy?

(2016) Ann De Becker et al.   World Journal of Stem Cells

In vitro differentiation of porcine aortic vascular precursor cells to endothelial and vascular smooth muscle cells

(2015) Andrea Zaniboni et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Bone marrow stem cells: current and emerging concepts

(2015) Simón Méndez-Ferrer et al.   Annals of the New York Academy of Sciences

TGF-  signaling in the control of hematopoietic stem cells

(2015) U. Blank et al.   BLOOD

Clinical significance of high-dose cytarabine added to cyclophosphamide/total-body irradiation in bone marrow or peripheral blood stem cell transplantation for myeloid malignancy

(2015) Yasuyuki Arai et al.   Journal of Hematology & Oncology

Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications

(2015) Sweta Rani et al.   MOLECULAR THERAPY

Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal

(2015) Melih Acar et al.   NATURE

Neural Regulation of Hematopoiesis, Inflammation, and Cancer

(2015) Maher Hanoun et al.   NEURON

Early hematopoiesis and macrophage development

(2015) Kathleen E. McGrath et al.   SEMINARS IN IMMUNOLOGY

Fanconi Anemia Mesenchymal Stromal Cells-Derived Glycerophospholipids Skew Hematopoietic Stem Cell Differentiation Through Toll-Like Receptor Signaling

(2015) Surya Amarachintha et al.   STEM CELLS

Notch Receptor-Ligand Engagement Maintains Hematopoietic Stem Cell Quiescence and Niche Retention

(2015) Weihuan Wang et al.   STEM CELLS

Mesenchymal Stromal Cells Protect Against Caspase 3-Mediated Apoptosis of CD19+Peripheral B Cells Through Contact-Dependent Upregulation of VEGF

(2015) Marc E. Healy et al.   STEM CELLS AND DEVELOPMENT

The Role of Reactive Oxygen Species in Mesenchymal Stem Cell Adipogenic and Osteogenic Differentiation: A Review

(2015) Fatemeh Atashi et al.   STEM CELLS AND DEVELOPMENT

STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling

(2015) Nadine Haetscher et al.   Nature Communications

Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues

(2015) Erica L. Scheller et al.   Nature Communications

Mesenchymal stromal cells enhance the engraftment of hematopoietic stem cells in an autologous mouse transplantation model

(2015) María Fernández-García et al.   Stem Cell Research & Therapy

Differential ability of MSCs isolated from placenta and cord as feeders for supporting ex vivo expansion of umbilical cord blood derived CD34+ cells

(2015) Darshana Kadekar et al.   Stem Cell Research & Therapy

Vascular Platform to Define Hematopoietic Stem Cell Factors and Enhance Regenerative Hematopoiesis

(2015) Michael G. Poulos et al.   Stem Cell Reports

New Insights into Wnt–Lrp5/6–β-Catenin Signaling in Mechanotransduction

(2015) Kyung Shin Kang et al.   Frontiers in Endocrinology

Reactive Oxygen Species Regulate Hematopoietic Stem Cell Self-Renewal, Migration and Development, As Well As Their Bone Marrow Microenvironment

(2014) Aya Ludin et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts

(2014) M. Krevvata et al.   BLOOD

Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone Marrow

(2014) Bo O. Zhou et al.   Cell Stem Cell

Mesenchymal stromal cells infusions improve refractory chronic graft versus host disease through an increase of CD5+ regulatory B cells producing interleukin 10

(2014) Y Peng et al.   LEUKEMIA

MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease

(2014) L Kordelas et al.   LEUKEMIA

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

(2014) Anjali P. Kusumbe et al.   NATURE

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone

(2014) Saravana K. Ramasamy et al.   NATURE

Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells

(2014) M. Ono et al.   Science Signaling

Cell Senescence Abrogates the Therapeutic Potential of Human Mesenchymal Stem Cells in the Lethal Endotoxemia Model

(2014) Juan Carlos Sepúlveda et al.   STEM CELLS

Do Cryopreserved Mesenchymal Stromal Cells Display Impaired Immunomodulatory and Therapeutic Properties?

(2014) Guido Moll et al.   STEM CELLS

Direct Cell-Cell Contact between Mesenchymal Stem Cells and Endothelial Progenitor Cells Induces a Pericyte-Like Phenotype In Vitro

(2014) Markus Loibl et al.   Biomed Research International

Treatment of Graft versus Host Disease with Mesenchymal Stromal Cells: A Phase I Study on 40 Adult and Pediatric Patients

(2013) Martino Introna et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Perivascular support of human hematopoietic stem/progenitor cells

(2013) M. Corselli et al.   BLOOD

Co-transplantation of third-party umbilical cord blood-derived MSCs promotes engraftment in children undergoing unrelated umbilical cord blood transplantation

(2013) S H Lee et al.   BONE MARROW TRANSPLANTATION

Overexpression of the Mesenchymal Stem Cell Cxcr4 Gene in Irradiated Mice Increases the Homing Capacity of These Cells

(2013) Wei Chen et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

SLAM Family Markers Resolve Functionally Distinct Subpopulations of Hematopoietic Stem Cells and Multipotent Progenitors

(2013) Hideyuki Oguro et al.   Cell Stem Cell

Mesenchymal stem cells secretome: a new paradigm for central nervous system regeneration?

(2013) Fábio G. Teixeira et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The mesenchymal stromal cells dilemma—does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road?

(2013) Jacques Galipeau   CYTOTHERAPY

Current and future approaches to treat graft failure after allogeneic hematopoietic stem cell transplantation

(2013) Franco Locatelli et al.   EXPERT OPINION ON PHARMACOTHERAPY

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

(2013) Adam Greenbaum et al.   NATURE

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

Arteriolar niches maintain haematopoietic stem cell quiescence

(2013) Yuya Kunisaki et al.   NATURE

Onset of heterogeneity in culture-expanded bone marrow stromal cells

(2013) Matthew J. Whitfield et al.   Stem Cell Research

Concise Review: Current Concepts in Bone Marrow Microenvironmental Regulation of Hematopoietic Stem and Progenitor Cells

(2013) Julianne N. P. Smith et al.   STEM CELLS

Hypoxic Culture Conditions as a Solution for Mesenchymal Stem Cell Based Regenerative Therapy

(2013) Nazmul Haque et al.   TheScientificWorldJOURNAL

Quantifying Mesenchymal Stem Cells in the Mononuclear Cell Fraction of Bone Marrow Samples Obtained for Cell Therapy

(2013) M. Alvarez-Viejo et al.   TRANSPLANTATION PROCEEDINGS

Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation

(2013) Luke C. Davies et al.   Nature Communications

Signal Transduction by Vascular Endothelial Growth Factor Receptors

(2013) S. Koch et al.   Cold Spring Harbor Perspectives in Medicine

An experimental model for the study of collagen fibers in skeletal muscle

(2012) Eliziane Nitz de Carvalho Calvi et al.   Acta Cirurgica Brasileira

First- and Second-Line Systemic Treatment of Acute Graft-versus-Host Disease: Recommendations of the American Society of Blood and Marrow Transplantation

(2012) Paul J. Martin et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Mesenchymal Stromal Cell Cryopreservation

(2012) Sabrina Renzi et al.   BIOPRESERVATION AND BIOBANKING

FGF signaling facilitates postinjury recovery of mouse hematopoietic system

(2012) M. Zhao et al.   BLOOD

FGF-2 expands murine hematopoietic stem and progenitor cells via proliferation of stromal cells, c-Kit activation, and CXCL12 down-regulation

(2012) T. Itkin et al.   BLOOD

N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells

(2012) A. M. Greenbaum et al.   BLOOD

Wnt/β-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts

(2012) Rongrong Zhang et al.   BONE

Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular Disease

(2012) Sudhir H. Ranganath et al.   Cell Stem Cell

Marrow Fat and the Bone Microenvironment: Developmental, Functional, and Pathological Implications

(2012) Clifford J. Rosen et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Primary Mesenchymal Stem and Progenitor Cells from Bone Marrow Lack Expression of CD44 Protein

(2012) Hong Qian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow

(2012) Anna Mansour et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clinical applications of mesenchymal stem cells

(2012) Shihua Wang et al.   Journal of Hematology & Oncology

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

Cord-Blood Engraftment with Ex Vivo Mesenchymal-Cell Coculture

(2012) Marcos de Lima et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of mesenchymal stem cell therapy in Crohn’s disease

(2012) Jignesh Dalal et al.   PEDIATRIC RESEARCH

Imatinib resistance and microcytic erythrocytosis in a KitV558 ;T669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor

(2012) B. Bosbach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells

(2012) E. Taniguchi Ishikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Concise Review: Hematopoietic Stem Cell Aging, Life Span, and Transplantation

(2012) Gary Van Zant et al.   Stem Cells Translational Medicine

Early Growth Response Genes Signaling Supports Strong Paracrine Capability of Mesenchymal Stem Cells

(2012) Kenichi Tamama et al.   Stem Cells International

Mesenchymal Stem Cells Home to Sites of Injury and Inflammation

(2012) Kristine C. Rustad et al.   Advances in Wound Care

The Potential for Resident Lung Mesenchymal Stem Cells to Promote Functional Tissue Regeneration: Understanding Microenvironmental Cues

(2012) Robert F. Foronjy et al.   Cells

Novel treatment concepts for graft-versus-host disease

(2011) D. Wolf et al.   BLOOD

CD146 expression on primary nonhematopoietic bone marrow stem cells is correlated with in situ localization

(2011) A. Tormin et al.   BLOOD

Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

(2011) Satoshi Yamazaki et al.   CELL

Culture of human mesenchymal stem cells at low oxygen tension improves growth and genetic stability by activating glycolysis

(2011) J C Estrada et al.   CELL DEATH AND DIFFERENTIATION

Cryopreserved mesenchymal stromal cells display impaired immunosuppressive properties as a result of heat-shock response and impaired interferon-γ licensing

(2011) Moïra François et al.   CYTOTHERAPY

Mesenchymal stem cells expanded in vitro with human serum for the treatment of acute and chronic graft-versus-host disease: results of a phase I/II clinical trial

(2011) J. A. Perez-Simon et al.   HAEMATOLOGICA

Mesenchymal stromal cell therapy for steroid-refractory acute and chronic graft versus host disease: a phase 1 study

(2011) Richard Herrmann et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization

(2011) Kana Miyamoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone marrow CD169+macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

(2011) Andrew Chow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuroprotective response after photodynamic therapy: Role of vascular endothelial growth factor

(2011) Misa Suzuki et al.   Journal of Neuroinflammation

Human MSC Suppression Correlates With Cytokine Induction of Indoleamine 2,3-Dioxygenase and Bystander M2 Macrophage Differentiation

(2011) Moïra François et al.   MOLECULAR THERAPY

The Role of Vascular Actors in Two Dimensional Dialogue of Human Bone Marrow Stromal Cell and Endothelial Cell for Inducing Self-Assembled Network

(2011) Haiyan Li et al.   PLoS One

Stem Cell Interactions in a Bone Marrow Niche

(2011) Joan Isern et al.   Current Osteoporosis Reports

MSCs in Hematopoietic Cell Transplantation

(2010) Edwin M. Horwitz et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

(2010) I. G. Winkler et al.   BLOOD

Co-infusion of ex vivo-expanded, parental MSCs prevents life-threatening acute GVHD, but does not reduce the risk of graft failure in pediatric patients undergoing allogeneic umbilical cord blood transplantation

(2010) M E Bernardo et al.   BONE MARROW TRANSPLANTATION

Mesenchymal Stromal Cells Expressing ErbB-2/neu Elicit Protective Antibreast Tumor Immunity In vivo, Which Is Paradoxically Suppressed by IFN-  and Tumor Necrosis Factor-  Priming

(2010) R. Romieu-Mourez et al.   CANCER RESEARCH

“Mesenchymal” Stem Cells in Human Bone Marrow (Skeletal Stem Cells): A Critical Discussion of Their Nature, Identity, and Significance in Incurable Skeletal Disease

(2010) Paolo Bianco et al.   HUMAN GENE THERAPY

The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche

(2010) Yoshiki Omatsu et al.   IMMUNITY

The Notch pathway in the developing hematopoietic system

(2010) Anna Bigas et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Umbilical Cord-Derived Mesenchymal Stromal Cells Modulate Monocyte Function to Suppress T Cell Proliferation

(2010) A. J. Cutler et al.   JOURNAL OF IMMUNOLOGY

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

(2010) Marc H. G. P. Raaijmakers et al.   NATURE

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

The therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer's disease

(2010) Hyun Ju Lee et al.   NEUROSCIENCE LETTERS

A New Mesenchymal Stem Cell (MSC) Paradigm: Polarization into a Pro-Inflammatory MSC1 or an Immunosuppressive MSC2 Phenotype

(2010) Ruth S. Waterman et al.   PLoS One

N-Cadherin is expressed on human hematopoietic progenitor cells and mediates interaction with human mesenchymal stromal cells

(2010) Frederik Wein et al.   Stem Cell Research

Blood-forming stem cells are nervous: Direct and indirect regulation of immature human CD34+ cells by the nervous system

(2009) Alexander Kalinkovich et al.   BRAIN BEHAVIOR AND IMMUNITY

High incidence of haemophagocytic syndrome following umbilical cord blood transplantation for adults

(2009) Shinsuke Takagi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Engraftment and Reconstitution of Hematopoiesis Is Dependent on VEGFR2-Mediated Regeneration of Sinusoidal Endothelial Cells

(2009) Andrea T. Hooper et al.   Cell Stem Cell

Results of a pilot study on the use of third-party donor mesenchymal stromal cells in cord blood transplantation in adults

(2009) Rosa Gonzalo-Daganzo et al.   CYTOTHERAPY

Characterization of bone marrow-derived mesenchymal stromal cells (MSC) based on gene expression profiling of functionally defined MSC subsets

(2009) Ariane Tormin et al.   CYTOTHERAPY

Cotransplantation with MSCs improves engraftment of HSCs after autologous intra-bone marrow transplantation in nonhuman primates

(2009) Shigeo Masuda et al.   EXPERIMENTAL HEMATOLOGY

Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment

(2009) Olaia Naveiras et al.   NATURE

The HGF/c-Met Axis Synergizes with G-CSF in the Mobilization of Hematopoietic Stem/Progenitor Cells

(2009) Ali Jalili et al.   STEM CELLS AND DEVELOPMENT

Cryopreservation of Adherent Cells: Strategies to Improve Cell Viability and Function After Thawing

(2009) Rita Malpique et al.   TISSUE ENGINEERING PART C-METHODS

Transplantation of ex-vivo culture-expanded parental haploidentical mesenchymal stem cells to promote engraftment in pediatric recipients of unrelated donor umbilical cord blood: results of a phase I–II clinical trial

(2008) M L MacMillan et al.   BONE MARROW TRANSPLANTATION

Treatment of refractory acute GVHD with third-party MSC expanded in platelet lysate-containing medium

(2008) M von Bonin et al.   BONE MARROW TRANSPLANTATION

MAPKs as Mediators of Cell Fate Determination: an Approach to Neurodegenerative Diseases

(2008) G. Tredici et al.   CURRENT MEDICINAL CHEMISTRY

Isolation and characterization of CD146+ multipotent mesenchymal stromal cells

(2008) Antonio Sorrentino et al.   EXPERIMENTAL HEMATOLOGY

Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells

(2008) E Spaeth et al.   GENE THERAPY

Culturing of Human Mesenchymal Stem Cells as Three-dimensional Aggregates Induces Functional Expression of CXCR4 That Regulates Adhesion to Endothelial Cells

(2008) Irina A. Potapova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study

(2008) Katarina Le Blanc et al.   LANCET

Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche

(2008) Cristina Lo Celso et al.   NATURE

Detection of functional haematopoietic stem cell niche using real-time imaging

(2008) Yucai Xie et al.   NATURE

Haematopoietic stem cell release is regulated by circadian oscillations

(2008) Simón Méndez-Ferrer et al.   NATURE

Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process

(2008) Wolfgang Wagner et al.   PLoS One

Osteoblastic regulation of B lymphopoiesis is mediated by Gs -dependent signaling pathways

(2008) J. Y. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling pathways governing stem-cell fate

(2007) U. Blank et al.   BLOOD

Age-related changes in human bone marrow-derived mesenchymal stem cells: Consequences for cell therapies

(2007) A. Stolzing et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Chemokine CXCL12 enhances proliferation in pre-B-ALL via STAT5 activation

(2007) Frida Mowafi et al.   PEDIATRIC BLOOD & CANCER

Toll-Like Receptors 3 and 4 Are Expressed by Human Bone Marrow-Derived Mesenchymal Stem Cells and Can Inhibit Their T-Cell Modulatory Activity by Impairing Notch Signaling

(2007) Francesco Liotta et al.   STEM CELLS