Bone marrow stem cells: current and emerging concepts

Megakaryocytes are essential for HSC quiescence through the production of thrombopoietin

(2014) Ayako Nakamura-Ishizu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning

(2014) B. Saez et al.   BLOOD

Estrogen Signaling Selectively Induces Apoptosis of Hematopoietic Progenitors and Myeloid Neoplasms without Harming Steady-State Hematopoiesis

(2014) Abel Sánchez-Aguilera et al.   Cell Stem Cell

Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone Marrow

(2014) Bo O. Zhou et al.   Cell Stem Cell

Vasculature-Associated Cells Expressing Nestin in Developing Bones Encompass Early Cells in the Osteoblast and Endothelial Lineage

(2014) Noriaki Ono et al.   DEVELOPMENTAL CELL

Osterix Marks Distinct Waves of Primitive and Definitive Stromal Progenitors during Bone Marrow Development

(2014) Toshihide Mizoguchi et al.   DEVELOPMENTAL CELL

Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells

(2014) Meng Zhao et al.   NATURE MEDICINE

Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion

(2014) Ingmar Bruns et al.   NATURE MEDICINE

The neural crest is a source of mesenchymal stem cells with specialized hematopoietic stem cell niche function

(2014) Joan Isern et al.   eLife

Clonal Analysis Unveils Self-Renewing Lineage-Restricted Progenitors Generated Directly from Hematopoietic Stem Cells

(2013) Ryo Yamamoto et al.   CELL

Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

(2013) María Casanova-Acebes et al.   CELL

Matrix-Embedded Osteocytes Regulate Mobilization of Hematopoietic Stem/Progenitor Cells

(2013) Noboru Asada et al.   Cell Stem Cell

Deciphering Hematopoietic Stem Cells in Their Niches: A Critical Appraisal of Genetic Models, Lineage Tracing, and Imaging Strategies

(2013) Chacko Joseph et al.   Cell Stem Cell

SLAM Family Markers Resolve Functionally Distinct Subpopulations of Hematopoietic Stem Cells and Multipotent Progenitors

(2013) Hideyuki Oguro et al.   Cell Stem Cell

Non-parallel recombination limits cre-loxP-based reporters as precise indicators of conditional genetic manipulation

(2013) Jing Liu et al.   GENESIS

Specificity and efficiency of reporter expression in adult neural progenitors vary substantially among nestin-CreERT2lines

(2013) Min-Yu Sun et al.   JOURNAL OF COMPARATIVE NEUROLOGY

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

(2013) Adam Greenbaum et al.   NATURE

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

Arteriolar niches maintain haematopoietic stem cell quiescence

(2013) Yuya Kunisaki et al.   NATURE

Osterix-Cre Labeled Progenitor Cells Contribute to the Formation and Maintenance of the Bone Marrow Stroma

(2013) Yaling Liu et al.   PLoS One

Self-Renewing Human Bone Marrow Mesenspheres Promote Hematopoietic Stem Cell Expansion

(2013) Joan Isern et al.   Cell Reports

Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2r null mice is enhanced by transgenic expression of membrane-bound human SCF

(2012) M. A. Brehm et al.   BLOOD

Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation

(2012) S. Takagi et al.   BLOOD

Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration

(2012) Dongsu Park et al.   Cell Stem Cell

Identification of a clonally expanding haematopoietic compartment in bone marrow

(2012) Lin Wang et al.   EMBO JOURNAL

Tetracyclines Convert the Osteoclastic-Differentiation Pathway of Progenitor Cells To Produce Dendritic Cell-like Cells

(2012) S. Kinugawa et al.   JOURNAL OF IMMUNOLOGY

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

(2011) Satoshi Yamazaki et al.   CELL

In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche

(2011) Joji Fujisaki et al.   NATURE

Tracking single hematopoietic stem cells in vivo using high-throughput sequencing in conjunction with viral genetic barcoding

(2011) Rong Lu et al.   NATURE BIOTECHNOLOGY

Guanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cells

(2011) A. Sanchez-Aguilera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diabetes Impairs Hematopoietic Stem Cell Mobilization by Altering Niche Function

(2011) F. Ferraro et al.   Science Translational Medicine

Loss of Cxcl12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppression

(2010) Y.-S. Tzeng et al.   BLOOD

JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia

(2010) J. Li et al.   BLOOD

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

(2010) I. G. Winkler et al.   BLOOD

Osteoblast Precursors, but Not Mature Osteoblasts, Move into Developing and Fractured Bones along with Invading Blood Vessels

(2010) Christa Maes et al.   DEVELOPMENTAL CELL

The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche

(2010) Yoshiki Omatsu et al.   IMMUNITY

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

(2010) Marc H. G. P. Raaijmakers et al.   NATURE

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Mice expressing GFP and CreER in osteochondro progenitor cells in the periosteum

(2009) Aya Kawanami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of Nkx6-2-Derived Neocortical Interneuron Lineages

(2009) Vitor H. Sousa et al.   CEREBRAL CORTEX

Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment

(2009) Olaia Naveiras et al.   NATURE

IFNα activates dormant haematopoietic stem cells in vivo

(2009) Marieke A. G. Essers et al.   NATURE

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

CXCR4 is required for the quiescence of primitive hematopoietic cells

(2008) Yuchun Nie et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Endochondral ossification is required for haematopoietic stem-cell niche formation

(2008) Charles K. F. Chan et al.   NATURE

Haematopoietic stem cell release is regulated by circadian oscillations

(2008) Simón Méndez-Ferrer et al.   NATURE