An early-senescence state in aged mesenchymal stromal cells contributes to hematopoietic stem and progenitor cell clonogenic impairment through the activation of a pro-inflammatory program

Local delivery of tetramethylpyrazine eliminates the senescent phenotype of bone marrow mesenchymal stromal cells and creates an anti-inflammatory and angiogenic environment in aging mice

(2018) Bo Gao et al.   AGING CELL

Mesenchymal Stromal Cells: Clinical Challenges and Therapeutic Opportunities

(2018) Jacques Galipeau et al.   Cell Stem Cell

The bone marrow microenvironment in health and disease at a glance

(2018) Rahul Kumar et al.   JOURNAL OF CELL SCIENCE

TGF-β Signaling Accelerates Senescence of Human Bone-Derived CD271 and SSEA-4 Double-Positive Mesenchymal Stromal Cells

(2018) Hiroshi Kawamura et al.   Stem Cell Reports

FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging

(2017) Hanjun Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting cellular senescence prevents age-related bone loss in mice

(2017) Joshua N Farr et al.   NATURE MEDICINE

Performance of Edmonton Frail Scale on frailty assessment: its association with multi-dimensional geriatric conditions assessed with specific screening tools

(2017) Simone Perna et al.   BMC Geriatrics

Cellular Senescence: A Translational Perspective

(2017) James L. Kirkland et al.   EBioMedicine

Robust, universal biomarker assay to detect senescent cells in biological specimens

(2016) Konstantinos Evangelou et al.   AGING CELL

Senescence-Associated MCP-1 Secretion Is Dependent on a Decline in BMI1 in Human Mesenchymal Stromal Cells

(2016) Hye Jin Jin et al.   ANTIOXIDANTS & REDOX SIGNALING

To clear, or not to clear (senescent cells)? That is the question

(2016) Amaia Lujambio   BIOESSAYS

Bone marrow–derived CD34 − fraction: A rich source of mesenchymal stromal cells for clinical application

(2016) Daniela Maria Ingo et al.   CYTOTHERAPY

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

(2016) Eric M. Pietras et al.   NATURE CELL BIOLOGY

Tracking of Normal and Malignant Progenitor Cell Cycle Transit in a Defined Niche

(2016) Gabriel Pineda et al.   Scientific Reports

Mesenchymal Cell Contributions to the Stem Cell Niche

(2015) Youmna Kfoury et al.   Cell Stem Cell

Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors

(2015) Simon Haas et al.   Cell Stem Cell

Mesenchymal stem cell aging: Mechanisms and influences on skeletal and non-skeletal tissues

(2015) Huijuan Liu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Redox regulation of FoxO transcription factors

(2015) Lars-Oliver Klotz et al.   Redox Biology

Targeted genome editing in human repopulating haematopoietic stem cells

(2014) Pietro Genovese et al.   NATURE

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Hematopoietic stem cell niche maintenance during homeostasis and regeneration

(2014) Avital Mendelson et al.   NATURE MEDICINE

Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation

(2013) Maria Ester Bernardo et al.   Cell Stem Cell

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Loss of the Osteogenic Differentiation Potential during Senescence Is Limited to Bone Progenitor Cells and Is Dependent on p53

(2013) Geneviève Despars et al.   PLoS One

Mesenchymal Stromal Cell Characteristics Vary Depending on Their Origin

(2013) Heike Wegmeyer et al.   STEM CELLS AND DEVELOPMENT

LNGFR+THY-1+VCAM-1hi+ Cells Reveal Functionally Distinct Subpopulations in Mesenchymal Stem Cells

(2013) Yo Mabuchi et al.   Stem Cell Reports

Glucocorticoids suppress selected components of the senescence-associated secretory phenotype

(2012) Remi-Martin Laberge et al.   AGING CELL

Hematopoiesis: A Human Perspective

(2012) Sergei Doulatov et al.   Cell Stem Cell

Cellular and molecular interactions of mesenchymal stem cells in innate immunity

(2012) Grazia Maria Spaggiari et al.   IMMUNOLOGY AND CELL BIOLOGY

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapy

(2010) Martin J Hoogduijn et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells

(2010) Anthony E. Boitano et al.   SCIENCE

Direct amperometric determination of tert-butylhydroquinone in biodiesel

(2010) Thiago F. Tormin et al.   TALANTA

Mesenchymal Stromal Cells

(2009) Maria Ester Bernardo et al.   Annals of the New York Academy of Sciences

Generation of mesenchymal stromal cells in the presence of platelet lysate: a phenotypic and functional comparison of umbilical cord blood- and bone marrow-derived progenitors

(2009) M. A. Avanzini et al.   HAEMATOLOGICA

IFNα activates dormant haematopoietic stem cells in vivo

(2009) Marieke A. G. Essers et al.   NATURE

Long-term In vitro Expansion Alters the Biology of Adult Mesenchymal Stem Cells

(2008) R. Izadpanah et al.   CANCER RESEARCH

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process

(2008) Wolfgang Wagner et al.   PLoS One

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY