期刊
EPMA JOURNAL
卷 12, 期 2, 页码 155-176出版社
SPRINGER INT PUBL AG
DOI: 10.1007/s13167-021-00242-5
关键词
Predictive preventive personalized medicine (3PM; PPPM); Phytochemicals; Flavonoids; Flavanones; Flavonols; Flavones; Flavanols; Isoflavonoids; Chalcones; Anthocyanidins; Anti-cancer agents; Drug-sensitizing effect; Targeted therapy; Radiotherapy; Chemotherapy; Immunotherapy; Therapy resistance; Anti-inflammation; Anti-bacterial; Anti-viral; COVID-19; Signalling pathways; Therapy efficacy; Nano-carrier delivery; Disease management; Health economy; Health policy
资金
- Scientific Grant Agency of the Ministry of Education, Science, Research and Sport of the Slovak Republic (Bratislava, Slovak Republic) [VEGA 1/0136/19]
- Slovak Research and Development Agency [APVV-16-0021]
- LISPER project [313011V446]
- European Association for Predictive, Preventive and Personalised Medicine
- Projekt DEAL
The cost-efficacy of current cancer treatments presents a challenge in healthcare and imposes a significant economic burden on societies worldwide. Utilizing flavonoids and their nano-technological derivatives is being extensively considered for their multi-faceted anti-cancer effects, which could contribute to overall cost-effective cancer management and prevention. Research focusing on the potential of flavonoids to enhance anti-cancer therapeutic effects and improve therapeutic outcomes by targeting molecular pathways is discussed in the context of predictive, preventive, and personalized medicine.
Cost-efficacy of currently applied treatments is an issue in overall cancer management challenging healthcare and causing tremendous economic burden to societies around the world. Consequently, complex treatment models presenting concepts of predictive diagnostics followed by targeted prevention and treatments tailored to the personal patient profiles earn global appreciation as benefiting the patient, healthcare economy, and the society at large. In this context, application of flavonoids as a spectrum of compounds and their nano-technologically created derivatives is extensively under consideration, due to their multi-faceted anti-cancer effects applicable to the overall cost-effective cancer management, primary, secondary, and even tertiary prevention. This article analyzes most recently updated data focused on the potent capacity of flavonoids to promote anti-cancer therapeutic effects and interprets all the collected research achievements in the frame-work of predictive, preventive, and personalized (3P) medicine. Main pillars considered are: - Predictable anti-neoplastic, immune-modulating, drug-sensitizing effects; - Targeted molecular pathways to improve therapeutic outcomes by increasing sensitivity of cancer cells and reversing their resistance towards currently applied therapeutic modalities.
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