Morphological Heterogeneity of the Endoplasmic Reticulum within Neurons and Its Implications in Neurodegeneration

Axonal Endoplasmic Reticulum Dynamics and Its Roles in Neurodegeneration

(2020) Zeynep Öztürk et al.   Frontiers in Neuroscience

A central role of the endoplasmic reticulum in the cell emerges from its functional contact sites with multiple organelles

(2020) Celso Almeida et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Membrane Curvature Catalyzes Lipid Droplet Assembly

(2020) Alexandre Santinho et al.   CURRENT BIOLOGY

Novel contact sites between lipid droplets, early endosomes, and the endoplasmic reticulum

(2020) Robert G. Parton et al.   JOURNAL OF LIPID RESEARCH

The Mitochondria-Associated ER Membranes Are Novel Subcellular Locations Enriched for Inflammatory-Responsive MicroRNAs

(2020) Wang-Xia Wang et al.   MOLECULAR NEUROBIOLOGY

Measurements of neuronal morphological variation across the rat neocortex

(2020) Robert Friedman   NEUROSCIENCE LETTERS

Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells

(2020) Stephen D. Carter et al.   Science Advances

Endoplasmic Reticulum Membrane and Contact Site Dynamics in Autophagy Regulation and Stress Response

(2020) Etienne Morel   Frontiers in Cell and Developmental Biology

Ca2+ signaling and lipid transfer ‘pas a deux’ at ER-PM contact sites orchestrate cell migration

(2020) Khaled Machaca   CELL CALCIUM

Miga-mediated endoplasmic reticulum–mitochondria contact sites regulate neuronal homeostasis

(2020) Lingna Xu et al.   eLife

Endoplasmic Reticulum Lumenal Indicators in Drosophila Reveal Effects of HSP-Related Mutations on Endoplasmic Reticulum Calcium Dynamics

(2020) Megan K. Oliva et al.   Frontiers in Neuroscience

Self-Association of Purified Reconstituted ER Luminal Spacer Climp63

(2020) Jinghua Zhao et al.   Frontiers in Cell and Developmental Biology

Endoplasmic reticulum visits highly active spines and prevents runaway potentiation of synapses

(2020) Alberto Perez-Alvarez et al.   Nature Communications

Endomembranes: Unsung Heroes of Mechanobiology?

(2020) Santosh Phuyal et al.   Frontiers in Bioengineering and Biotechnology

Mitochondria-ER Tethering in Neurodegenerative Diseases

(2020) Reza Raeisossadati et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Amyloid β-Peptide Increases Mitochondria-Endoplasmic Reticulum Contact Altering Mitochondrial Function and Autophagosome Formation in Alzheimer’s Disease-Related Models

(2020) Nuno Santos Leal et al.   Cells

A disease causing ATLASTIN 3 mutation affects multiple endoplasmic reticulum-related pathways

(2019) Laura Behrendt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Coming together to define membrane contact sites

(2019) Luca Scorrano et al.   Nature Communications

Feedback-Driven Mechanisms between Microtubules and the Endoplasmic Reticulum Instruct Neuronal Polarity

(2019) Ginny G. Farías et al.   NEURON

Rab18 Collaborates with Rab7 to Modulate Lysosomal and Autophagy Activities in the Nervous System: an Overlapping Mechanism for Warburg Micro Syndrome and Charcot-Marie-Tooth Neuropathy Type 2B

(2019) Fang-Shin Nian et al.   MOLECULAR NEUROBIOLOGY

Cerebellar ataxia disease–associated Snx14 promotes lipid droplet growth at ER–droplet contacts

(2019) Sanchari Datta et al.   JOURNAL OF CELL BIOLOGY

Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity

(2019) Maria S. Ioannou et al.   CELL

Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments

(2019) Anne-Sophie Hafner et al.   SCIENCE

Conserved role for Ataxin‐2 in mediating endoplasmic reticulum dynamics

(2019) Urko del Castillo et al.   TRAFFIC

Lipid Metabolism Crosstalk in the Brain: Glia and Neurons

(2019) Casey N. Barber et al.   Frontiers in Cellular Neuroscience

Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy

(2019) Ramachandra M. Bhaskara et al.   Nature Communications

Automated 3D Axonal Morphometry of White Matter

(2019) Ali Abdollahzadeh et al.   Scientific Reports

The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation

(2019) Dongfang Li et al.   Cell Reports

REEP3 and REEP4 determine the tubular morphology of the endoplasmic reticulum during mitosis

(2019) Darshan Kumar et al.   MOLECULAR BIOLOGY OF THE CELL

Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

(2019) Sarah H. Shahmoradian et al.   NATURE NEUROSCIENCE

Reticulon and CLIMP-63 regulate nanodomain organization of peripheral ER tubules

(2019) Guang Gao et al.   PLOS BIOLOGY

Modulation of autophagy by RTN-1C: role in autophagosome biogenesis

(2019) Manuela D’ Eletto et al.   Cell Death & Disease

Dynamic constriction and fission of endoplasmic reticulum membranes by reticulon

(2019) Javier Espadas et al.   Nature Communications

NeurodegenERation: The Central Role for ER Contacts in Neuronal Function and Axonopathy, Lessons From Hereditary Spastic Paraplegias and Related Diseases

(2019) Philippa C. Fowler et al.   Frontiers in Neuroscience

Lipid metabolic pathways converge in motor neuron degenerative diseases

(2019) Olivia J Rickman et al.   BRAIN

A Complete Electron Microscopy Volume of the Brain of Adult Drosophila melanogaster

(2018) Zhihao Zheng et al.   CELL

Architecture of Lipid Droplets in Endoplasmic Reticulum Is Determined by Phospholipid Intrinsic Curvature

(2018) Vineet Choudhary et al.   CURRENT BIOLOGY

Chromatolysis: Do injured axons regenerate poorly when ribonucleases attack rough endoplasmic reticulum, ribosomes and RNA?

(2018) Lawrence David Falcon Moon   Developmental Neurobiology

Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions

(2018) Dijin Xu et al.   JOURNAL OF CELL BIOLOGY

Axonal endoplasmic reticulum is very narrow

(2018) Mark Terasaki   JOURNAL OF CELL SCIENCE

Quantification of anisotropy and orientation in 3D electron microscopy and diffusion tensor imaging in injured rat brain

(2018) Raimo A. Salo et al.   NEUROIMAGE

Endoplasmic Reticulum–Mitochondrial Contactology: Structure and Signaling Functions

(2018) György Csordás et al.   TRENDS IN CELL BIOLOGY

Endoplasmic reticulum and mitochondria in diseases of motor and sensory neurons: a broken relationship?

(2018) Nathalie Bernard-Marissal et al.   Cell Death & Disease

Seipin deficiency in mice causes loss of dopaminergic neurons via aggregation and phosphorylation of α-synuclein and neuroinflammation

(2018) Ling Wang et al.   Cell Death & Disease

The role of endoplasmic reticulum-mitochondria contact sites in the control of glucose homeostasis: an update

(2018) Jennifer Rieusset   Cell Death & Disease

Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory

(2018) Adam C. Frank et al.   Nature Communications

Activity-dependent decrease in contact areas between subsurface cisterns and plasma membrane of hippocampal neurons

(2018) Jung-Hwa Tao-Cheng   Molecular Brain

The atlastin membrane anchor forms an intramembrane hairpin that does not span the phospholipid bilayer

(2018) Miguel A. Betancourt-Solis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic nanoscale morphology of the ER surveyed by STED microscopy

(2018) Lena K. Schroeder et al.   JOURNAL OF CELL BIOLOGY

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DrosophilaAtlastin in motor neurons is required for locomotion and presynaptic function

(2017) Cristian De Gregorio et al.   JOURNAL OF CELL SCIENCE

ER stress and the unfolded protein response in neurodegeneration

(2017) Claudio Hetz et al.   Nature Reviews Neurology

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Contacts between the endoplasmic reticulum and other membranes in neurons

(2017) Yumei Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling of axonal endoplasmic reticulum network by spastic paraplegia proteins

(2017) Belgin Yalçın et al.   eLife

Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy

(2017) Paolo Grumati et al.   eLife

Substantia nigra ultrastructural pathology in schizophrenia

(2017) Courtney K. Walker et al.   SCHIZOPHRENIA RESEARCH

Seipin regulates ER–lipid droplet contacts and cargo delivery

(2016) Veijo T Salo et al.   EMBO JOURNAL

Reep1null mice reveal a converging role for hereditary spastic paraplegia proteins in lipid droplet regulation

(2016) Benoît Renvoisé et al.   HUMAN MOLECULAR GENETICS

Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington’s disease pathology

(2016) Ying Mao et al.   HUMAN MOLECULAR GENETICS

The effects of ER morphology on synaptic structure and function inDrosophila melanogaster

(2016) James B. Summerville et al.   JOURNAL OF CELL SCIENCE

Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination

(2016) Monika S. Brill et al.   NEURON

Shaping the Endoplasmic Reticulum into a Social Network

(2016) Hong Zhang et al.   TRENDS IN CELL BIOLOGY

Seipin is required for converting nascent to mature lipid droplets

(2016) Huajin Wang et al.   eLife

Cooperation of the ER-shaping proteins atlastin, lunapark, and reticulons to generate a tubular membrane network

(2016) Songyu Wang et al.   eLife

NOGO-A/RTN4A and NOGO-B/RTN4B are simultaneously expressed in epithelial, fibroblast and neuronal cells and maintain ER morphology

(2016) Olli Rämö et al.   Scientific Reports

Hereditary spastic paraplegia-linked REEP1 modulates endoplasmic reticulum/mitochondria contacts

(2015) Youngshin Lim et al.   ANNALS OF NEUROLOGY

Form Follows Function: The Importance of Endoplasmic Reticulum Shape

(2015) L.M. Westrate et al.   Annual Review of Biochemistry

Development of Dendritic Form and Function

(2015) Julie L. Lefebvre et al.   Annual Review of Cell and Developmental Biology

Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila

(2015) Andrew P. Bailey et al.   CELL

Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration

(2015) Lucy Liu et al.   CELL

The endoplasmic reticulum: structure, function and response to cellular signaling

(2015) Dianne S. Schwarz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Membrane contact sites, gateways for lipid homeostasis

(2015) Sujoy Lahiri et al.   CURRENT OPINION IN CELL BIOLOGY

Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis

(2015) Chihiro Ebihara et al.   HUMAN MOLECULAR GENETICS

Three distinct ribosome assemblies modulated by translation are the building blocks of polysomes

(2015) Gabriella Viero et al.   JOURNAL OF CELL BIOLOGY

Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer’s disease

(2015) M G Sharoar et al.   MOLECULAR PSYCHIATRY

Regulation of endoplasmic reticulum turnover by selective autophagy

(2015) Aliaksandr Khaminets et al.   NATURE

Structure and function of ER membrane contact sites with other organelles

(2015) Melissa J. Phillips et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

α-Synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in Parkinson's disease

(2015) Joel J. Credle et al.   NEUROBIOLOGY OF DISEASE

Three-Dimensional Electron Microscopy Reconstruction of Degenerative Dopaminergic Neurons Surrounded by Activated Microglia in Substantia Nigra

(2015) Kazuhiko Nakadate et al.   ULTRASTRUCTURAL PATHOLOGY

Spastin Binds to Lipid Droplets and Affects Lipid Metabolism

(2015) Chrisovalantis Papadopoulos et al.   PLoS Genetics

Membrane-shaping disorders: a common pathway in axon degeneration

(2014) Christian A. Hübner et al.   BRAIN

ER Contact Sites Define the Position and Timing of Endosome Fission

(2014) Ashley A. Rowland et al.   CELL

Neuronal polarization in vivo: Growing in a complex environment

(2014) Yasuhiro Funahashi et al.   CURRENT OPINION IN NEUROBIOLOGY

Neuregulin-1 is concentrated in the postsynaptic subsurface cistern of C-bouton inputs to α-motoneurons and altered during motoneuron diseases

(2014) Xavier Gallart-Palau et al.   FASEB JOURNAL

Rab18 and a Rab18 GEF complex are required for normal ER structure

(2014) Andreas Gerondopoulos et al.   JOURNAL OF CELL BIOLOGY

ER-phagy mediates selective degradation of endoplasmic reticulum independently of the core autophagy machinery

(2014) S. Schuck et al.   JOURNAL OF CELL SCIENCE

ER sheet persistence is coupled to myosin 1c–regulated dynamic actin filament arrays

(2014) Merja Joensuu et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial Fission: Regulation and ER Connection

(2014) Hakjoo Lee et al.   MOLECULES AND CELLS

Snx14 Regulates Neuronal Excitability, Promotes Synaptic Transmission, and Is Imprinted in the Brain of Mice

(2014) Hsien-Sung Huang et al.   PLoS One

The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase

(2014) J. M. Inloes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lunapark stabilizes nascent three-way junctions in the endoplasmic reticulum

(2014) Shuliang Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A model for the generation and interconversion of ER morphologies

(2014) Tom Shemesh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic analysis of human substantia nigra identifies novel candidates involved in Parkinson's disease pathogenesis

(2014) Virginie Licker et al.   PROTEOMICS

Swimming against the tide: investigations of the C-bouton synapse

(2014) Adam S. Deardorff et al.   Frontiers in Neural Circuits

Spatiotemporal dynamics of dendritic spines in the living brain

(2014) Chia-Chien Chen et al.   Frontiers in Neuroanatomy

Rapid regulation of endoplasmic reticulum dynamics in dendritic spines by NMDA receptor activation

(2014) Ai Na Ng et al.   Molecular Brain

Upstream deregulation of calcium signaling in Parkinson’s disease

(2014) Pilar Rivero-Ríos et al.   Frontiers in Molecular Neuroscience

REEP1 and REEP2 proteins are preferentially expressed in neuronal and neuronal-like exocytotic tissues

(2013) Carl M. Hurt et al.   BRAIN RESEARCH

Stacked Endoplasmic Reticulum Sheets Are Connected by Helicoidal Membrane Motifs

(2013) Mark Terasaki et al.   CELL

Enlargement of the Nissl substance as a manifestation of early damage to spinal cord motoneurons in amyotrophic lateral sclerosis

(2013) Dorota Dziewulska et al.   CLINICAL NEUROPATHOLOGY

Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets

(2013) Florian Wilfling et al.   DEVELOPMENTAL CELL

REEP3/4 Ensure Endoplasmic Reticulum Clearance from Metaphase Chromatin and Proper Nuclear Envelope Architecture

(2013) Anne-Lore Schlaitz et al.   DEVELOPMENTAL CELL

Anatomy and function of cholinergic C bouton inputs to motor neurons

(2013) Emily C. Witts et al.   JOURNAL OF ANATOMY

Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains

(2013) Adam Kassan et al.   JOURNAL OF CELL BIOLOGY

A spastic paraplegia mouse model reveals REEP1-dependent ER shaping

(2013) Christian Beetz et al.   JOURNAL OF CLINICAL INVESTIGATION

A Conserved Role for Atlastin GTPases in Regulating Lipid Droplet Size

(2013) Robin W. Klemm et al.   Cell Reports

Cellular Pathways of Hereditary Spastic Paraplegia

(2012) Craig Blackstone   Annual Review of Neuroscience

Local Zones of Endoplasmic Reticulum Complexity Confine Cargo in Neuronal Dendrites

(2012) Tingting Cui-Wang et al.   CELL

A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum

(2012) S Varadarajan et al.   CELL DEATH AND DIFFERENTIATION

Progressive sheet-to-tubule transformation is a general mechanism for endoplasmic reticulum partitioning in dividing mammalian cells

(2012) Maija Puhka et al.   MOLECULAR BIOLOGY OF THE CELL

Glucose Regulated Protein 78 Diminishes α-Synuclein Neurotoxicity in a Rat Model of Parkinson Disease

(2012) Marina S Gorbatyuk et al.   MOLECULAR THERAPY

ER network formation requires a balance of the dynamin-like GTPase Sey1p and the Lunapark family member Lnp1p

(2012) Shuliang Chen et al.   NATURE CELL BIOLOGY

Rab10 GTPase regulates ER dynamics and morphology

(2012) Amber R. English et al.   NATURE CELL BIOLOGY

Endoplasmic reticulum–mitochondria contacts: function of the junction

(2012) Ashley A. Rowland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation of the Unfolded Protein Response Is an Early Event in Alzheimer’s and Parkinson’s Disease

(2012) Jeroen J.M. Hoozemans et al.   Neurodegenerative Diseases

Ultrastructure of Synapses in the Mammalian Brain

(2012) K. M. Harris et al.   Cold Spring Harbor Perspectives in Biology

Location matters: the endoplasmic reticulum and protein trafficking in dendrites

(2011) Omar A Ramírez et al.   BIOLOGICAL RESEARCH

N88S seipin mutant transgenic mice develop features of seipinopathy/BSCL2-related motor neuron disease via endoplasmic reticulum stress

(2011) Takuya Yagi et al.   HUMAN MOLECULAR GENETICS

A 3D analysis of yeast ER structure reveals how ER domains are organized by membrane curvature

(2011) Matt West et al.   JOURNAL OF CELL BIOLOGY

Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes

(2011) X. Bian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Staying in touch: the molecular era of organelle contact sites

(2011) Yael Elbaz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mechanisms Determining the Morphology of the Peripheral ER

(2010) Yoko Shibata et al.   CELL

Further assembly required: construction and dynamics of the endoplasmic reticulum network

(2010) Seong H Park et al.   EMBO REPORTS

ER sliding dynamics and ER–mitochondrial contacts occur on acetylated microtubules

(2010) Jonathan R. Friedman et al.   JOURNAL OF CELL BIOLOGY

Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network

(2010) Seong H. Park et al.   JOURNAL OF CLINICAL INVESTIGATION

Induction of the unfolded protein response by α-synuclein in experimental models of Parkinson’s disease

(2010) Arianna Bellucci et al.   JOURNAL OF NEUROCHEMISTRY

Yip1A Structures the Mammalian Endoplasmic Reticulum

(2010) Kaitlyn M. Dykstra et al.   MOLECULAR BIOLOGY OF THE CELL

Myosin-Va transports the endoplasmic reticulum into the dendritic spines of Purkinje neurons

(2010) Wolfgang Wagner et al.   NATURE CELL BIOLOGY

The Spine Apparatus, Synaptopodin, and Dendritic Spine Plasticity

(2010) Menahem Segal et al.   NEUROSCIENTIST

Induction of cortical endoplasmic reticulum by dimerization of a coatomer-binding peptide anchored to endoplasmic reticulum membranes

(2010) G. Lavieu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reticulon Short Hairpin Transmembrane Domains Are Used to Shape ER Tubules

(2010) Nesia Zurek et al.   TRAFFIC

α-Synuclein and dopamine at the crossroads of Parkinson's disease

(2010) Lara Lourenço Venda et al.   TRENDS IN NEUROSCIENCES

How and why does the endoplasmic reticulum move?: Figure 1

(2009) Becky Bola et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Pleiotropic effects of spastin on neurite growth depending on expression levels

(2009) Elena Riano et al.   JOURNAL OF NEUROCHEMISTRY

Homotypic fusion of ER membranes requires the dynamin-like GTPase Atlastin

(2009) Genny Orso et al.   NATURE

STIM1-induced precortical and cortical subdomains of the endoplasmic reticulum

(2009) L. Orci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STIM1 Is a MT-Plus-End-Tracking Protein Involved in Remodeling of the ER

(2008) Ilya Grigoriev et al.   CURRENT BIOLOGY

Ataxin-2 associates with rough endoplasmic reticulum

(2008) Simone van de Loo et al.   EXPERIMENTAL NEUROLOGY

The Reticulon and Dp1/Yop1p Proteins Form Immobile Oligomers in the Tubular Endoplasmic Reticulum

(2008) Yoko Shibata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial alterations in Parkinson’s disease: new clues

(2008) Miquel Vila et al.   JOURNAL OF NEUROCHEMISTRY

Quantitative and Functional Analyses of Spastin in the Nervous System: Implications for Hereditary Spastic Paraplegia

(2008) J. M. Solowska et al.   JOURNAL OF NEUROSCIENCE

The Microtubule-severing Proteins Spastin and Katanin Participate Differently in the Formation of Axonal Branches

(2008) Wenqian Yu et al.   MOLECULAR BIOLOGY OF THE CELL

Spinal anterior horn cells in sporadic amyotrophic lateral sclerosis show ribosomal detachment from, and cisternal distention of the rough endoplasmic reticulum

(2008) K. Oyanagi et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY