Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 37, Issue -, Pages 961-965Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0370961
Keywords
actin; dynein; endoplasmic reticulum; kinesin; microtubule; migration
Categories
Funding
- Biotechnology and Biological Sciences Research Council [G012652]
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The ER (endoplasmic reticulum) is a fascinating organelle that is highly dynamic, undergoing constant movement and reorganization. it has many key roles, including protein synthesis, folding and trafficking, calcium homoeostasis and lipid synthesis. it can expand in size when needed, and the balance between tubular and lamellar regions can be altered. The distribution and organization of the ER depends on both motile and static interactions with microtubules and the actin cytoskeleton. In the present paper, we review how the ER moves, and consider why this movement may be important for ER and cellular function.
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