Self-DNA Sensing by cGAS-STING and TLR9 in Autoimmunity: Is the Cytoskeleton in Control?

Actin Remodeling Defects Leading to Autoinflammation and Immune Dysregulation

(2021) Riccardo Papa et al.   Frontiers in Immunology

Actin cables and comet tails organize mitochondrial networks in mitosis

(2021) Andrew S. Moore et al.   NATURE

VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease

(2020) Jeonghan Kim et al.   SCIENCE

mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

(2020) Long Shuang Huang et al.   IMMUNITY

Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity

(2020) Chun Zhou et al.   IMMUNITY

Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease

(2020) Ethan R. Roy et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular mechanisms and cellular functions of cGAS–STING signalling

(2020) Karl-Peter Hopfner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Kinesin-1 regulates antigen cross-presentation through the scission of tubulations from early endosomes in dendritic cells

(2020) Meriem Belabed et al.   Nature Communications

STING couples with PI3K to regulate actin reorganization during BCR activation

(2020) Yukai Jing et al.   Science Advances

Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson–Gilford Progeria Syndrome

(2020) Xiaodong Mu et al.   AGING CELL

Nuclear Membrane Rupture and Its Consequences

(2020) John Maciejowski et al.   Annual Review of Cell and Developmental Biology

Interferon-Independent Activities of Mammalian STING Mediate Antiviral Response and Tumor Immune Evasion

(2020) Jianjun Wu et al.   IMMUNITY

A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome

(2020) Zimu Deng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling

(2020) Alice Lepelley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STEEP mediates STING ER exit and activation of signaling

(2020) Bao-cun Zhang et al.   NATURE IMMUNOLOGY

Wiskott-Aldrich syndrome protein restricts cGAS-STING activation by dsDNA immune complexes

(2020) Giulia Maria Piperno et al.   JCI Insight

ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration

(2020) Gururaj Rao Kidiyoor et al.   Nature Communications

MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway

(2020) Junhong Guan et al.   CANCER CELL

Molecular and spatial mechanisms governing STING signalling

(2020) Katherine R. Balka et al.   FEBS Journal

Nuclear F-actin counteracts nuclear deformation and promotes fork repair during replication stress

(2020) Noa Lamm et al.   NATURE CELL BIOLOGY

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

(2019) Xiang Gui et al.   NATURE

Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA

(2019) Katherine C. Barnett et al.   CELL

How I manage patients with Wiskott Aldrich syndrome

(2019) Elizabeth Rivers et al.   BRITISH JOURNAL OF HAEMATOLOGY

Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS

(2019) Matthieu Gratia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: BCAP Promotes Lupus-like Disease and TLR-Mediated Type I IFN Induction in Plasmacytoid Dendritic Cells

(2019) Talyn Chu et al.   JOURNAL OF IMMUNOLOGY

A STING to inflammation and autoimmunity

(2019) Vijay Kumar   JOURNAL OF LEUKOCYTE BIOLOGY

Monocytes contribute to DNA sensing through the TBK1 signaling pathway in type 1 diabetes patients

(2019) Irena Zentsova et al.   JOURNAL OF AUTOIMMUNITY

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

TMEM203 is a binding partner and regulator of STING-mediated inflammatory signaling in macrophages

(2019) Yang Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Actin and Actin-Binding Proteins in DNA Repair

(2019) Verena Hurst et al.   TRENDS IN CELL BIOLOGY

Self-DNA at the Epicenter of SLE: Immunogenic Forms, Regulation, and Effects

(2019) Chetna Soni et al.   Frontiers in Immunology

SLC19A1 transports immunoreactive cyclic dinucleotides

(2019) Rutger D. Luteijn et al.   NATURE

The Golgi apparatus and cell polarity: Roles of the cytoskeleton, the Golgi matrix, and Golgi membranes

(2019) Yamini Ravichandran et al.   CURRENT OPINION IN CELL BIOLOGY

Toll-like receptor signaling in macrophages is regulated by extracellular substrate stiffness and Rho-associated coiled-coil kinase (ROCK1/2)

(2018) Erika Gruber et al.   INTERNATIONAL IMMUNOLOGY

Neutrophils drive type I interferon production and autoantibodies in patients with Wiskott-Aldrich syndrome

(2018) Karla E. Cervantes-Luevano et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Autonomous role of Wiskott-Aldrich syndrome platelet deficiency in inducing autoimmunity and inflammation

(2018) Lucia Sereni et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

HRS–WASH axis governs actin-mediated endosomal recycling and cell invasion

(2018) Ewan MacDonald et al.   JOURNAL OF CELL BIOLOGY

Triggered recruitment of ESCRT machinery promotes endolysosomal repair

(2018) Michael L. Skowyra et al.   SCIENCE

DNA as a self-antigen: nature and regulation

(2018) Chetna Soni et al.   CURRENT OPINION IN IMMUNOLOGY

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair

(2018) Benjamin R. Schrank et al.   NATURE

Innate Immune Signals Induce Anterograde Endosome Transport Promoting MHC Class I Cross-Presentation

(2018) Mirjana Weimershaus et al.   Cell Reports

The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum

(2018) Sonal Srikanth et al.   NATURE IMMUNOLOGY

IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion

(2018) Katerina Gkirtzimanaki et al.   Cell Reports

Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling

(2017) Meng Michelle Xu et al.   IMMUNITY

Regulation of Mitochondrial Structure and Dynamics by the Cytoskeleton and Mechanical Factors

(2017) Erzsébet Bartolák-Suki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cellular functions of WASP family proteins at a glance

(2017) Olga Alekhina et al.   JOURNAL OF CELL SCIENCE

Clinical Manifestations and Pathophysiological Mechanisms of the Wiskott-Aldrich Syndrome

(2017) Fabio Candotti   JOURNAL OF CLINICAL IMMUNOLOGY

The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling

(2017) Alexander R. van Vliet et al.   MOLECULAR CELL

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

IRF3 and type I interferons fuel a fatal response to myocardial infarction

(2017) Kevin R King et al.   NATURE MEDICINE

Mechanistic principles underlying regulation of the actin cytoskeleton by phosphoinositides

(2017) Yosuke Senju et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type I interferon-mediated autoinflammation due to DNase II deficiency

(2017) Mathieu P. Rodero et al.   Nature Communications

Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells

(2017) Pamela P. Lee et al.   Nature Communications

FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42

(2017) Frieda Kage et al.   Scientific Reports

Importance of Nucleic Acid Recognition in Inflammation and Autoimmunity

(2016) Franck J. Barrat et al.   Annual Review of Medicine

Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P

(2016) Rui Dong et al.   CELL

Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity

(2016) Vanja Sisirak et al.   CELL

Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus

(2016) Simone Caielli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of the type I interferon response in neurological forms of Gaucher disease

(2016) Einat B. Vitner et al.   Journal of Neuroinflammation

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Myosins, Actin and Autophagy

(2016) Antonina J. Kruppa et al.   TRAFFIC

Deletion of Wiskott–Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells

(2016) Marisa A. P. Baptista et al.   Nature Communications

Novel Coronin7 interactions with Cdc42 and N-WASP regulate actin organization and Golgi morphology

(2016) Kurchi Bhattacharya et al.   Scientific Reports

New Insights into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation

(2016) Hang Yang et al.   Frontiers in Immunology

Diseases caused by mutations inORAI1andSTIM1

(2015) Rodrigo S. Lacruz et al.   Annals of the New York Academy of Sciences

WHAMM Directs the Arp2/3 Complex to the ER for Autophagosome Biogenesis through an Actin Comet Tail Mechanism

(2015) David J. Kast et al.   CURRENT BIOLOGY

DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity

(2015) Anetta Härtlova et al.   IMMUNITY

Nucleic acid-sensing TLRs and autoimmunity: novel insights from structural and cell biology

(2015) Karin Pelka et al.   IMMUNOLOGICAL REVIEWS

Broad spectrum of autoantibodies in patients with Wiskott-Aldrich syndrome and X-linked thrombocytopenia

(2015) Elena Crestani et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

(2015) Marina Vietri et al.   NATURE

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane

(2015) Na Mi et al.   NATURE CELL BIOLOGY

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

(2015) Daxing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor

(2015) Spencer A. Freeman et al.   Nature Communications

Actin nucleation by WH2 domains at the autophagosome

(2015) Amanda S. Coutts et al.   Nature Communications

Mechanical Role of Actin Dynamics in the Rheology of the Golgi Complex and in Golgi-Associated Trafficking Events

(2014) David Guet et al.   CURRENT BIOLOGY

INF2-Mediated Severing through Actin Filament Encirclement and Disruption

(2014) Pinar S. Gurel et al.   CURRENT BIOLOGY

Trafficking of endosomal Toll-like receptors

(2014) Bettina L. Lee et al.   TRENDS IN CELL BIOLOGY

Dnase2a Deficiency Uncovers Lysosomal Clearance of Damaged Nuclear DNA via Autophagy

(2014) Yuk Yuen Lan et al.   Cell Reports

Wiskott–Aldrich Syndrome protein deficiency perturbs the homeostasis of B-cell compartment in humans

(2013) Maria Carmina Castiello et al.   JOURNAL OF AUTOIMMUNITY

Wiskott-Aldrich syndrome protein–mediated actin dynamics control type-I interferon production in plasmacytoid dendritic cells

(2013) Francesca Prete et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of a Missense Variant in LNPEP that Confers Psoriasis Risk

(2013) Hui Cheng et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

An Actin-Dependent Step in Mitochondrial Fission Mediated by the ER-Associated Formin INF2

(2013) F. Korobova et al.   SCIENCE

NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

(2013) R. Khandpur et al.   Science Translational Medicine

Under lock and key: Spatiotemporal regulation of WASP family proteins coordinates separate dynamic cellular processes

(2013) Lauren E. Burianek et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

UNC93B1 mediates differential trafficking of endosomal TLRs

(2013) Bettina L Lee et al.   eLife

Cytosolic sensing of extracellular self-DNA transported into monocytes by the antimicrobial peptide LL37

(2012) G. Chamilos et al.   BLOOD

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

STING manifests self DNA-dependent inflammatory disease

(2012) J. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoimmunity in Wiskott–Aldrich Syndrome: An Unsolved Enigma

(2012) Marco Catucci et al.   Frontiers in Immunology

Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus

(2011) Sulaiman M Al-Mayouf et al.   NATURE GENETICS

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

(2011) G. S. Garcia-Romo et al.   Science Translational Medicine

Nucleic acid sensing Toll-like receptors in autoimmunity

(2010) Sarah E Ewald et al.   CURRENT OPINION IN IMMUNOLOGY

WASH and the Arp2/3 complex regulate endosome shape and trafficking

(2010) Steve N. Duleh et al.   Cytoskeleton

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

(2010) Joo-Yong Lee et al.   EMBO JOURNAL

The Membrane Skeleton Controls Diffusion Dynamics and Signaling through the B Cell Receptor

(2010) Bebhinn Treanor et al.   IMMUNITY

Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation

(2010) Kazuhito Gotoh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ultrastructural characterization of giant endosomes induced by GTPase-deficient Rab5

(2009) Catherine Sem Wegener et al.   HISTOCHEMISTRY AND CELL BIOLOGY

TLR9 traffics through the Golgi complex to localize to endolysosomes and respond to CpG DNA

(2008) Annapoorani Chockalingam et al.   IMMUNOLOGY AND CELL BIOLOGY

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

(2008) Sarah E. Ewald et al.   NATURE