Nucleic acid-sensing TLRs and autoimmunity: novel insights from structural and cell biology

The Processed Amino-Terminal Fragment of Human TLR7 Acts as a Chaperone To Direct Human TLR7 into Endosomes

(2015) Madeleine M. Hipp et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: DNase II Deficiency Prevents Activation of Autoreactive B Cells by Double-Stranded DNA Endogenous Ligands

(2015) Sudesh Pawaria et al.   JOURNAL OF IMMUNOLOGY

Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9

(2015) Umeharu Ohto et al.   NATURE

Toll-like receptor 8 senses degradation products of single-stranded RNA

(2015) Hiromi Tanji et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Suppression of systemic autoimmunity by the innate immune adaptor STING

(2015) Shruti Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNase II-dependent DNA digestion is required for DNA sensing by TLR9

(2015) Mei Po Chan et al.   Nature Communications

Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases

(2015) Atsuo Kanno et al.   Nature Communications

Toll-like receptor 8 senses degradation products of single-stranded RNA

(2015) Hiromi Tanji et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis

(2015) Christopher Jakobs et al.   PLoS One

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

Mucolipin 1 positively regulates TLR7 responses in dendritic cells by facilitating RNA transportation to lysosomes

(2014) Xiaobing Li et al.   INTERNATIONAL IMMUNOLOGY

Recruitment and Endo-Lysosomal Activation of TLR9 in Dendritic Cells Infected with Trypanosoma cruzi

(2014) D. C. Bartholomeu et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: AIM2 and Endosomal TLRs Differentially Regulate Arthritis and Autoantibody Production in DNase II–Deficient Mice

(2014) Rebecca Baum et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: The UNC93B1 Tyrosine-Based Motif Regulates Trafficking and TLR Responses via Separate Mechanisms

(2014) Karin Pelka et al.   JOURNAL OF IMMUNOLOGY

Negative Self-Regulation of TLR9 Signaling by Its N-Terminal Proteolytic Cleavage Product

(2014) Sungwook Lee et al.   JOURNAL OF IMMUNOLOGY

Endosomal Localization of TLR8 Confers Distinctive Proteolytic Processing on Human Myeloid Cells

(2014) Noriko Ishii et al.   JOURNAL OF IMMUNOLOGY

Roles of the Cleaved N-Terminal TLR3 Fragment and Cell Surface TLR3 in Double-Stranded RNA Sensing

(2014) Yusuke Murakami et al.   JOURNAL OF IMMUNOLOGY

The SKIV2L RNA exosome limits activation of the RIG-I-like receptors

(2014) Sterling C Eckard et al.   NATURE IMMUNOLOGY

UNC93B1 is essential for the plasma membrane localization and signaling of Toll-like receptor 5

(2014) J.-W. Huh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice

(2014) B. Desnues et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic variations in Toll-like receptors (TLRs 3/7/8) are associated with systemic lupus erythematosus in a Taiwanese population

(2014) Chin-Man Wang et al.   Scientific Reports

Dnase2a Deficiency Uncovers Lysosomal Clearance of Damaged Nuclear DNA via Autophagy

(2014) Yuk Yuen Lan et al.   Cell Reports

A novel antagonist of Toll-like receptors 7, 8 and 9 suppresses lupus disease-associated parameters in NZBW/F1 mice

(2013) Fu-Gang Zhu et al.   AUTOIMMUNITY

Primary blood neutrophils express a functional cell surface Toll-like receptor 9

(2013) Dennis Lindau et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TLRs to cytokines: Mechanistic insights from the imiquimod mouse model of psoriasis

(2013) Barry Flutter et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Association study of TLR-9 polymorphisms and systemic lupus erythematosus in Northern Chinese Han population

(2013) Jihui Zhang et al.   GENE

Meta-analysis demonstrates association between TLR polymorphisms and rheumatoid arthritis

(2013) Y.H. Lee et al.   GENETICS AND MOLECULAR RESEARCH

Processing of Human Toll-like Receptor 7 by Furin-like Proprotein Convertases Is Required for Its Accumulation and Activity in Endosomes

(2013) Madeleine M. Hipp et al.   IMMUNITY

Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing

(2013) Nadine Gehrke et al.   IMMUNITY

Essential role for Toll-like receptor 7 (TLR7)-unique cysteines in an intramolecular disulfide bond, proteolytic cleavage and RNA sensing

(2013) Atsuo Kanno et al.   INTERNATIONAL IMMUNOLOGY

Genetic susceptibility to SLE: Recent progress from GWAS

(2013) Yong Cui et al.   JOURNAL OF AUTOIMMUNITY

RNA recognition by human TLR8 can lead to autoimmune inflammation

(2013) Cristiana Guiducci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Acidic Amino Acid Residues in the Juxtamembrane Region of the Nucleotide-Sensing TLRs Are Important for UNC93B1 Binding and Signaling

(2013) J. Kim et al.   JOURNAL OF IMMUNOLOGY

Cooperation of TLR12 and TLR11 in the IRF8-Dependent IL-12 Response to Toxoplasma gondii Profilin

(2013) M. Raetz et al.   JOURNAL OF IMMUNOLOGY

A Toll-Like Receptor 7, 8, and 9 Antagonist Inhibits Th1 and Th17 Responses and Inflammasome Activation in a Model of IL-23-Induced Psoriasis

(2013) Weiwen Jiang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

No antigen-presentation defect in Unc93b13d/3d (3d) mice

(2013) Jacques Deguine et al.   NATURE IMMUNOLOGY

TLR9 mediates cellular protection by modulating energy metabolism in cardiomyocytes and neurons

(2013) Y. Shintani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymorphisms within Toll-like receptors are associated with systemic lupus erythematosus in a cohort of Danish females

(2013) Magdalena Janina Laska et al.   RHEUMATOLOGY

Toll-like receptor polymorphisms and rheumatoid arthritis: a systematic review

(2013) Young Ho Lee et al.   RHEUMATOLOGY INTERNATIONAL

Structural Reorganization of the Toll-Like Receptor 8 Dimer Induced by Agonistic Ligands

(2013) H. Tanji et al.   SCIENCE

An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing

(2013) Masahiro Onji et al.   Nature Communications

UNC93B1 mediates differential trafficking of endosomal TLRs

(2013) Bettina L Lee et al.   eLife

Aicardi–Goutieres syndrome, a rare neurological disease in children: A new autoimmune disorder?

(2012) Elisa Fazzi et al.   AUTOIMMUNITY REVIEWS

New developments in Toll-like receptor targeted therapeutics

(2012) Dympna J Connolly et al.   CURRENT OPINION IN PHARMACOLOGY

Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease

(2012) Alevtina Gall et al.   IMMUNITY

Noncanonical Autophagy Is Required for Type I Interferon Secretion in Response to DNA-Immune Complexes

(2012) Jill Henault et al.   IMMUNITY

Recognition of Profilin by Toll-like Receptor 12 Is Critical for Host Resistance to Toxoplasma gondii

(2012) A. Alicia Koblansky et al.   IMMUNITY

Topical Treatment with the Toll-like Receptor Agonist DIMS0150 Has Potential for Lasting Relief of Symptoms in Patients with Chronic Active Ulcerative Colitis by Restoring Glucocorticoid Sensitivity

(2012) Eugen Musch et al.   INFLAMMATORY BOWEL DISEASES

The Role of UNC93B1 Protein in Surface Localization of TLR3 Receptor and in Cell Priming to Nucleic Acid Agonists

(2012) Jelka Pohar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteolytic Processing Regulates Toll-like Receptor 3 Stability and Endosomal Localization

(2012) Rongsu Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-Specific TLR9 Trafficking in Primary APCs of Transgenic TLR9-GFP Mice

(2012) A. M. Avalos et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: TLR13 Is a Receptor for Bacterial RNA

(2012) A. Hidmark et al.   JOURNAL OF IMMUNOLOGY

Cleaved/Associated TLR3 Represents the Primary Form of the Signaling Receptor

(2012) F. Toscano et al.   JOURNAL OF IMMUNOLOGY

Human Toll-Like Receptor 8 Can Be Cool Too: Implications for Foreign RNA Sensing

(2012) Soroush T. Sarvestani et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Genetic susceptibility to lupus: the biological basis of genetic risk found in B cell signaling pathways

(2012) Samuel E. Vaughn et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Ultraviolet radiation damages self noncoding RNA and is detected by TLR3

(2012) Jamie J Bernard et al.   NATURE MEDICINE

Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes

(2012) Julien Diana et al.   NATURE MEDICINE

Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling

(2012) A. Garcia-Cattaneo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STING manifests self DNA-dependent inflammatory disease

(2012) J. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR13 Recognizes Bacterial 23S rRNA Devoid of Erythromycin Resistance-Forming Modification

(2012) M. Oldenburg et al.   SCIENCE

Human TLRs and IL-1Rs in Host Defense: Natural Insights from Evolutionary, Epidemiological, and Clinical Genetics

(2011) Jean-Laurent Casanova et al.   Annual Review of Immunology

Nucleic Acid Recognition by the Innate Immune System

(2011) Roman Barbalat et al.   Annual Review of Immunology

Transmembrane Mutations in Toll-like Receptor 9 Bypass the Requirement for Ectodomain Proteolysis and Induce Fatal Inflammation

(2011) Maria L. Mouchess et al.   IMMUNITY

Mapping a Dynamic Innate Immunity Protein Interaction Network Regulating Type I Interferon Production

(2011) Shitao Li et al.   IMMUNITY

Unc93B1 Restricts Systemic Lethal Inflammation by Orchestrating Toll-like Receptor 7 and 9 Trafficking

(2011) Ryutaro Fukui et al.   IMMUNITY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

dsRNA sensors and plasmacytoid dendritic cells in host defense and autoimmunity

(2011) Yaming Wang et al.   IMMUNOLOGICAL REVIEWS

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase

(2011) Sarah E. Ewald et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanism of Endosomal TLR Inhibition by Antimalarial Drugs and Imidazoquinolines

(2011) A. Kuznik et al.   JOURNAL OF IMMUNOLOGY

UNC93B1 Physically Associates with Human TLR8 and Regulates TLR8-Mediated Signaling

(2011) Hiroki Itoh et al.   PLoS One

Virus Entry by Endocytosis

(2010) Jason Mercer et al.   Annual Review of Biochemistry

TLR9 Is Actively Recruited to Aspergillus fumigatus Phagosomes and Requires the N-Terminal Proteolytic Cleavage Domain for Proper Intracellular Trafficking

(2010) P. V. Kasperkovitz et al.   JOURNAL OF IMMUNOLOGY

Multiple common variants for celiac disease influencing immune gene expression

(2010) Patrick C A Dubois et al.   NATURE GENETICS

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells

(2010) A. L. Blasius et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bifurcation of Toll-Like Receptor 9 Signaling by Adaptor Protein 3

(2010) M. Sasai et al.   SCIENCE

Critical Role for Asparagine Endopeptidase in Endocytic Toll-like Receptor Signaling in Dendritic Cells

(2009) Fernando E. Sepulveda et al.   IMMUNITY

Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing

(2009) Ryutaro Fukui et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of an N-Terminal Recognition Site in TLR9 That Contributes to CpG-DNA-Mediated Receptor Activation

(2009) M. E. Peter et al.   JOURNAL OF IMMUNOLOGY

Homozygosity for DNASE2 single nucleotide polymorphisms in the 5'-regulatory region is associated with rheumatoid arthritis

(2008) M Rossol et al.   ANNALS OF THE RHEUMATIC DISEASES

Ins and Outs of Major Facilitator Superfamily Antiporters

(2008) Christopher J. Law et al.   Annual Review of Microbiology

Cathepsins are required for Toll-like receptor 9 responses

(2008) Fumi Matsumoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sorting of lysosomal proteins

(2008) Thomas Braulke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

Accessing the therapeutic potential of immunostimulatory nucleic acids

(2008) Winfried Barchet et al.   CURRENT OPINION IN IMMUNOLOGY

The B Cell Receptor Governs the Subcellular Location of Toll-like Receptor 9 Leading to Hyperresponses to DNA-Containing Antigens

(2008) Akanksha Chaturvedi et al.   IMMUNITY

IRAK-4- and MyD88-Dependent Pathways Are Essential for the Removal of Developing Autoreactive B Cells in Humans

(2008) Isabelle Isnardi et al.   IMMUNITY

Commensal DNA Limits Regulatory T Cell Conversion and Is a Natural Adjuvant of Intestinal Immune Responses

(2008) Jason A. Hall et al.   IMMUNITY

Development of TLR inhibitors for the treatment of autoimmune diseases

(2008) Franck J. Barrat et al.   IMMUNOLOGICAL REVIEWS

Innate immunity to virus infection

(2008) Osamu Takeuchi et al.   IMMUNOLOGICAL REVIEWS

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

(2008) You-Me Kim et al.   NATURE

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

(2008) Sarah E. Ewald et al.   NATURE

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

(2008) Boyoun Park et al.   NATURE IMMUNOLOGY

The TLR3 signaling complex forms by cooperative receptor dimerization

(2008) J. N. Leonard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

(2008) L. Liu et al.   SCIENCE