Nuclear F-actin counteracts nuclear deformation and promotes fork repair during replication stress

Exploiting DNA Replication Stress for Cancer Treatment

(2019) Tajinder Ubhi et al.   CANCER RESEARCH

Spatial chromatin organization and gene regulation at the nuclear lamina

(2019) Isabel Guerreiro et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The mTOR pathway: Implications for DNA replication

(2019) Noa Lamm et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Replication-Coupled DNA Repair

(2019) David Cortez   MOLECULAR CELL

Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection

(2019) V. Pragathi Masamsetti et al.   Nature Communications

Architecture and activation of phosphatidylinositol 3-kinase related kinases

(2018) Stefan Imseng et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Telomere Loop Dynamics in Chromosome End Protection

(2018) David Van Ly et al.   MOLECULAR CELL

Myosin-Driven Intracellular Transport

(2018) Margaret A. Titus   Cold Spring Harbor Perspectives in Biology

The Actin Cytoskeleton and Actin-Based Motility

(2018) Tatyana Svitkina   Cold Spring Harbor Perspectives in Biology

Removing physiological motion from intravital and clinical functional imaging data

(2018) Sean C Warren et al.   eLife

Chromosome Dynamics in Response to DNA Damage

(2018) Andrew Seeber et al.   Annual Review of Genetics

Nuclear F-actin and myosins drive relocalization of heterochromatic breaks

(2018) Christopher P. Caridi et al.   NATURE

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair

(2018) Benjamin R. Schrank et al.   NATURE

F-actin organizes the nucleus

(2017) Henna M. Moore et al.   NATURE CELL BIOLOGY

A transient pool of nuclear F-actin at mitotic exit controls chromatin organization

(2017) Christian Baarlink et al.   NATURE CELL BIOLOGY

The essential kinase ATR: ensuring faithful duplication of a challenging genome

(2017) Joshua C. Saldivar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts

(2017) Max Nobis et al.   Cell Reports

Genomic Instability in Human Pluripotent Stem Cells Arises from Replicative Stress and Chromosome Condensation Defects

(2016) Noa Lamm et al.   Cell Stem Cell

Gad8 Protein Is Found in the Nucleus Where It Interacts with the MluI Cell Cycle Box-binding Factor (MBF) Transcriptional Complex to Regulate the Response to DNA Replication Stress

(2016) Adiel Cohen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bright monomeric near-infrared fluorescent proteins as tags and biosensors for multiscale imaging

(2016) Daria M. Shcherbakova et al.   Nature Communications

rpS6 Regulates Blood-Testis Barrier Dynamics Through Arp3-Mediated Actin Microfilament Organization in Rat Sertoli Cells. An In Vitro Study

(2015) Ka-Wai Mok et al.   ENDOCRINOLOGY

Nuclear F-actin Formation and Reorganization upon Cell Spreading

(2015) Matthias Plessner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA damage induces nuclear actin filament assembly by Formin-2 and Spire-1/2 that promotes efficient DNA repair

(2015) Brittany J Belin et al.   eLife

ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress

(2014) Amit Kumar et al.   CELL

rpS6 regulates blood-testis barrier dynamics through Akt-mediated effects on MMP-9

(2014) K.-W. Mok et al.   JOURNAL OF CELL SCIENCE

Stimulation of in vivo nuclear transport dynamics of actin and its co-factors IQGAP1 and Rac1 in response to DNA replication stress

(2013) Michael A. Johnson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Lamin A/C Depletion Enhances DNA Damage-Induced Stalled Replication Fork Arrest

(2013) Mayank Singh et al.   MOLECULAR AND CELLULAR BIOLOGY

TORC2 Signaling Pathway Guarantees Genome Stability in the Face of DNA Strand Breaks

(2013) Kenji Shimada et al.   MOLECULAR CELL

FANCD2 Binds MCM Proteins and Controls Replisome Function upon Activation of S Phase Checkpoint Signaling

(2013) Gérald Lossaint et al.   MOLECULAR CELL

Replication stress links structural and numerical cancer chromosomal instability

(2013) Rebecca A. Burrell et al.   NATURE

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Surgical implantation of an abdominal imaging window for intravital microscopy

(2013) Laila Ritsma et al.   Nature Protocols

Nuclear Actin Network Assembly by Formins Regulates the SRF Coactivator MAL

(2013) C. Baarlink et al.   SCIENCE

A conserved role of IQGAP1 in regulating TOR complex 1

(2012) Y. K. Tekletsadik et al.   JOURNAL OF CELL SCIENCE

Active maintenance of nuclear actin by importin 9 supports transcription

(2012) J. Dopie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining the role of TORC1/2 in multiple myeloma

(2011) P. Maiso et al.   BLOOD

Amino Acid Signaling to mTOR Mediated by Inositol Polyphosphate Multikinase

(2011) Seyun Kim et al.   Cell Metabolism

Hydroxyurea: a key player in cancer chemotherapy

(2011) Kapish Madaan et al.   Expert Review of Anticancer Therapy

CLIP-170 and IQGAP1 Cooperatively Regulate Dendrite Morphology

(2011) L. Swiech et al.   JOURNAL OF NEUROSCIENCE

Nuclear actin and myosins: Life without filaments

(2011) Primal de Lanerolle et al.   NATURE CELL BIOLOGY

Arp2/3 complex is bound and activated by two WASP proteins

(2011) S. B. Padrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

(2010) Eva Petermann et al.   MOLECULAR CELL

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

TOR Complex 2 Controls Gene Silencing, Telomere Length Maintenance, and Survival under DNA-Damaging Conditions

(2009) M. Schonbrun et al.   MOLECULAR AND CELLULAR BIOLOGY

Cisplatin-Induced DNA Damage Activates Replication Checkpoint Signaling Components that Differentially Affect Tumor Cell Survival

(2009) J. M. Wagner et al.   MOLECULAR PHARMACOLOGY

Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression

(2008) Asako Sakaue-Sawano et al.   CELL

Intravital imaging of metastatic behavior through a mammary imaging window

(2008) Dmitriy Kedrin et al.   NATURE METHODS